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Kinase Fusion Gene:CAMK4_TRPV3 |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CAMK4_TRPV3 | KinaseFusionDB ID: KFG890 | FusionGDB2.0 ID: KFG890 | Hgene | Tgene | Gene symbol | CAMK4 | TRPV3 | Gene ID | 814 | 162514 | |
| Gene name | calcium/calmodulin dependent protein kinase IV | transient receptor potential cation channel subfamily V member 3 | ||||||||||
| Synonyms | CaMK IV|CaMK-GR|CaMKIV|caMK | FNEPPK2|OLMS|OLMS1|VRL3 | ||||||||||
| Cytomap | 5q22.1 | 17p13.2 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | calcium/calmodulin-dependent protein kinase type IVCAM kinase IVCAM kinase- GRbrain Ca(2+)-calmodulin-dependent protein kinase type IVbrain Ca++-calmodulin-dependent protein kinase type IVcalcium/calmodulin-dependent protein kinase type IV catalytic | transient receptor potential cation channel subfamily V member 3VRL-3vanilloid receptor-like 3vanilloid receptor-related osmotically activated channel protein | ||||||||||
| Modification date | 20240407 | 20240305 | ||||||||||
| UniProtAcc | Q16566 | Q8NET8 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000282356, ENST00000512453, ENST00000512890, | ENST00000301365, ENST00000572519, ENST00000576742, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CAMK4 [Title/Abstract] AND TRPV3 [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CAMK4(110614918)-TRPV3(3414247), # samples:1 | |||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CAMK4 | GO:0045893 | positive regulation of DNA-templated transcription | 8855261 |
| Kinase Fusion gene breakpoints across CAMK4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across TRPV3 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| ChiTaRS5.0 | AW899117 | CAMK4 | chr5 | 110614918 | TRPV3 | chr17 | 3414247 |
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Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
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Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
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Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:110614918/:3414247) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CAMK4 | TRPV3 |
| FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:17909078, ECO:0000269|PubMed:18829949, ECO:0000269|PubMed:7961813, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8855261, ECO:0000269|PubMed:8980227, ECO:0000269|PubMed:9154845}. | FUNCTION: Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
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Kinase-Substrate Information of CAMK4_TRPV3 |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| CAMK4 | Q16566 | human | HDAC5 | Q9UQL6 | S498 | RPLSRtQsSPLPQsP | |
| CAMK4 | Q16566 | human | CREB1 | P16220 | S119 | EILsRRPsyRkILND | pKID |
| CAMK4 | Q16566 | human | HNRNPL | P14866 | S544 | GkSERSssGLLEWES | |
| CAMK4 | Q16566 | human | NOVA2 | Q9UNW9 | T27 | VCTKRsNtGEEGEYF | |
| CAMK4 | Q16566 | human | NOVA2 | Q9UNW9 | S194 | EQVHKAVsAIVQKVQ | KH_1 |
| CAMK4 | Q16566 | human | PHB2 | Q99623 | S91 | RARPRkIssPTGSkD | Band_7 |
| CAMK4 | Q16566 | human | CAMK2A | Q9UQM7-2 | S332 | DGVKkRKssssVQLM | |
| CAMK4 | Q16566 | human | RELA | Q04206 | S536 | sGDEDFSsIADMDFS | |
| CAMK4 | Q16566 | human | NOVA2 | Q9UNW9 | S25 | EVVCTKRsNtGEEGE | |
| CAMK4 | Q16566 | human | HDAC5 | Q9UQL6 | S259 | FPLRkTAsEPNLKVR | |
| CAMK4 | Q16566 | human | STMN1 | P16949 | S16 | kELEKrAsGQAFELI | Stathmin |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| CAMK4 | ID | Description | 0.00e+00 |
| CAMK4 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 1.06e-03 |
| CAMK4 | GO:0051090 | regulation of DNA-binding transcription factor activity | 2.72e-03 |
| CAMK4 | GO:0043434 | response to peptide hormone | 2.72e-03 |
| CAMK4 | GO:0035729 | cellular response to hepatocyte growth factor stimulus | 2.72e-03 |
| CAMK4 | GO:0035728 | response to hepatocyte growth factor | 2.77e-03 |
| CAMK4 | GO:1904385 | cellular response to angiotensin | 8.44e-03 |
| CAMK4 | GO:1990776 | response to angiotensin | 9.06e-03 |
| CAMK4 | GO:0000381 | regulation of alternative mRNA splicin | 2.23e-04 |
| CAMK4 | GO:0002931 | response to ischemia | 1.66e-02 |
| CAMK4 | GO:0071300 | cellular response to retinoic acid | 1.66e-02 |
| CAMK4 | GO:1901224 | positive regulation of non-canonical NF-kappaB signal transduction | 1.66e-02 |
| CAMK4 | GO:0000380 | alternative mRNA splicin | 3.85e-04 |
| CAMK4 | GO:0009410 | response to xenobiotic stimulus | 2.19e-02 |
| CAMK4 | GO:0009615 | response to virus | 2.19e-02 |
| CAMK4 | GO:0048732 | gland development | 2.19e-02 |
| CAMK4 | GO:0007409 | axonogenesis | 2.19e-02 |
| CAMK4 | GO:0032526 | response to retinoic acid | 2.52e-02 |
| CAMK4 | GO:0048024 | regulation of mRNA splicin | 8.72e-04 |
| CAMK4 | GO:0098773 | skin epidermis development | 3.18e-02 |
| CAMK4 | GO:0050684 | regulation of mRNA processing | 3.18e-02 |
| CAMK4 | GO:0030879 | mammary gland development | 3.23e-02 |
| CAMK4 | GO:0008277 | regulation of G protein-coupled receptor signaling pathway | 3.39e-02 |
| CAMK4 | GO:0014074 | response to purine-containing compound | 3.39e-02 |
| CAMK4 | GO:0002753 | cytosolic pattern recognition receptor signaling pathway | 3.39e-02 |
| CAMK4 | GO:0038061 | non-canonical NF-kappaB signal transduction | 3.39e-02 |
| CAMK4 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 3.39e-02 |
| CAMK4 | GO:0043484 | regulation of RNA splicing | 4.75e-02 |
| CAMK4 | GO:0032869 | cellular response to insulin stimulus | 5.63e-02 |
| CAMK4 | GO:1901654 | response to ketone | 5.63e-02 |
| CAMK4 | GO:0050821 | protein stabilization | 5.63e-02 |
| CAMK4 | GO:0071222 | cellular response to lipopolysaccharide | 5.63e-02 |
| CAMK4 | GO:0002221 | pattern recognition receptor signaling pathway | 5.63e-02 |
| CAMK4 | GO:0060430 | lung saccule development | 5.63e-02 |
| CAMK4 | GO:0070391 | response to lipoteichoic acid | 5.63e-02 |
| CAMK4 | GO:0071223 | cellular response to lipoteichoic acid | 5.63e-02 |
| CAMK4 | GO:0071219 | cellular response to molecule of bacterial origin | 5.63e-02 |
| CAMK4 | GO:0033234 | negative regulation of protein sumoylation | 5.63e-02 |
| CAMK4 | GO:0061370 | testosterone biosynthetic process | 5.63e-02 |
| CAMK4 | GO:1904424 | regulation of GTP binding | 5.63e-02 |
| CAMK4 | GO:0002758 | innate immune response-activating signaling pathway | 5.63e-02 |
| CAMK4 | GO:0010944 | negative regulation of transcription by competitive promoter binding | 5.63e-02 |
| CAMK4 | GO:0048012 | hepatocyte growth factor receptor signaling pathway | 5.63e-02 |
| CAMK4 | GO:0051098 | regulation of binding | 5.63e-02 |
| CAMK4 | GO:0071216 | cellular response to biotic stimulus | 5.63e-02 |
| CAMK4 | GO:0032868 | response to insulin | 5.63e-02 |
| CAMK4 | GO:0002357 | defense response to tumor cell | 5.63e-02 |
| CAMK4 | GO:0031115 | negative regulation of microtubule polymerization | 5.63e-02 |
| CAMK4 | GO:0032494 | response to peptidoglycan | 5.63e-02 |
| CAMK4 | GO:0070493 | thrombin-activated receptor signaling pathway | 5.63e-02 |
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Related Drugs to CAMK4_TRPV3 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CAMK4-TRPV3 and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
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Related Diseases to CAMK4_TRPV3 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
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