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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CAMKK2_KDM2B

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: CAMKK2_KDM2B
	KinaseFusionDB ID: KFG898
	FusionGDB2.0 ID: KFG898
		Hgene	Tgene
	Gene symbol	CAMKK2	KDM2B
	Gene ID	10645	84678
	Gene name	calcium/calmodulin dependent protein kinase kinase 2	lysine demethylase 2B
	Synonyms	CAMKK\|CAMKKB	CXXC2\|FBXL10\|Fbl10\|JHDM1B\|PCCX2
	Cytomap	12q24.31	12q24.31
	Type of gene	protein-coding	protein-coding
	Description	calcium/calmodulin-dependent protein kinase kinase 2CAMKK beta proteincaM-KK 2caM-KK betacaM-kinase kinase 2caM-kinase kinase betacalcium/calmodulin-dependent protein kinase betacalcium/calmodulin-dependent protein kinase kinase 2, beta	lysine-specific demethylase 2BCXXC-type zinc finger protein 2F-box and leucine-rich repeat protein 10F-box protein FBL10F-box/LRR-repeat protein 10JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein[Histone-H3]-lysine-36 demethy
	Modification date	20240403	20240416
	UniProtAcc	Q96RR4	Q8NHM5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000324774, ENST00000337174, ENST00000347034, ENST00000392473, ENST00000392474, ENST00000402834, ENST00000404169, ENST00000412367, ENST00000446440, ENST00000538733, ENST00000545538, ENST00000535524,	ENST00000377071, ENST00000536437, ENST00000538046, ENST00000542973, ENST00000377069, ENST00000543852,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: CAMKK2 [Title/Abstract] AND KDM2B [Title/Abstract] AND fusion [Title/Abstract] Mutational Analysis of Gene Fusions Predicts Novel MHC Class I–Restricted T-Cell Epitopes and Immune Signatures in a Subset of Prostate Cancer (pmid: 28954787)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CAMKK2(121708701)-KDM2B(121891147), # samples:5

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CAMKK2	GO:0006468	protein phosphorylation	11395482
Hgene	CAMKK2	GO:0046777	protein autophosphorylation	11395482
Tgene	KDM2B	GO:0006338	chromatin remodeling	16943429

Kinase Fusion gene breakpoints across CAMKK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across KDM2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
ChimerDB4	TCGA-AB-2817-03A	CAMKK2	chr12	121682943	KDM2B	chr12	121891147
ChimerDB4	TCGA-EJ-5509-01A	CAMKK2	chr12	121711859	KDM2B	chr12	121932468
ChimerDB4	TCGA-EJ-A46B-01A	CAMKK2	chr12	121707331	KDM2B	chr12	121932468
ChimerDB4	TCGA-EJ-A65J-01A	CAMKK2	chr12	121708701	KDM2B	chr12	121891147
ChimerDB4	TCGA-LN-A4A2-01A	CAMKK2	chr12	121706441	KDM2B	chr12	121891147
ChimerDB4	TCGA-G9-6333-01A	CAMKK2	chr12	121675497	KDM2B	chr12	121954666
ChimerDB4	TCGA-EJ-A65J	CAMKK2	chr12	121735341	KDM2B	chr12	121951205
ChimerDB4	TCGA-EJ-A65J	CAMKK2	chr12	121735342	KDM2B	chr12	121891147
ChimerDB4	TCGA-EJ-A65J	CAMKK2	chr12	121735342	KDM2B	chr12	121951205
ChimerDB4	TCGA-B5-A3S1-01A	CAMKK2	chr12	121734441	KDM2B	chr12	121868272

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000412367	ENST00000377069	CAMKK2	chr12	121682943	KDM2B	chr12	121891147	4837	708

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000412367_ENST00000377069_CAMKK2_chr12_121682943_KDM2B_chr12_121891147_length(amino acids)=708
MGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEE
GKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRS
ECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDE
LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR
PPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSY
LSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA
LCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSI

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:121708701/chr12:121891147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAMKK2 Q96RR4	KDM2B Q8NHM5
FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269\|PubMed:11395482, ECO:0000269\|PubMed:12935886, ECO:0000269\|PubMed:21957496, ECO:0000269\|PubMed:9662074}.	FUNCTION: Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable). {ECO:0000269\|PubMed:16362057, ECO:0000269\|PubMed:17994099, ECO:0000269\|PubMed:26237645, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

474474474517517517517

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	14	15	165_446	1	499	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	14	16	165_446	1	491	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	14	16	165_446	1	546	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	14	16	165_446	1	557	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	15	16	165_446	1	542	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	15	17	165_446	1	534	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Hgene	CAMKK2	121682943	KDM2B	121891147	ENST00000412367	15	17	165_446	1	589	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>54_CAMKK2_KDM2B	ENST00000412367	ENST00000377069	CAMKK2	chr12	121682943	KDM2B	chr12	121891147	MGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEE GKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRS ECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDE LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR PPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSY LSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA LCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSI	708
3D view using mol* of 54_CAMKK2_KDM2B

PDB file >>>HKFP_78_CAMKK2_KDM2B	ENST00000412367	ENST00000377069	CAMKK2	chr12	121682943	KDM2B	chr12	121891147	MGPASAVKLAANRTTAGARRRRTRCRKCEACLRTECGECHFCKDMKKFGGPGRMKQSCIMRQCIAPVLPHTAVCLVCGEAGKEDTVEEEE GKFNLMLMECSICNEIIHPGCLKIKESEGVVNDELPNCWECPKCNHAGKTGKQKRGPGFKYASNLPGSLLKEQKMNRDNKEGQEPAKRRS ECEEAPRRRSDEHSKKVPPDGLLRRKSDDVHLRKKRKYEKPQELSGRKRLKPGKEDKLFRKKRRSWKNAEDRMALANKPLRRFKQEPEDE LPEAPPKTRESDHSRSSSPTAGPSTEGAEGPEEKKKVKMRRKRRLPNKELSRELSKELNHEIQRTENSLANENQQPIKSEPESEGEEPKR PPGICERPHRFSKGLNGTPRELRHQLGPSLRSPPRVISRPPPSVSPPKCIQMERHVIRPPPISPPPDSLPLDDGAAHVMHREVWMAVFSY LSHQDLCVCMRVCRTWNRWCCDKRLWTRIDLNHCKSITPLMLSGIIRRQPVSLDLSWTNISKKQLSWLINRLPGLRDLVLSGCSWIAVSA LCSSSCPLLRTLDVQWVEGLKDAQMRDLLSPPTDNRPGQMDNRSKLRNIVELRLAGLDITDASLRLIIRHMPLLSKLHLSYCNHVTDQSI	708_CAMKK2_KDM2B

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CAMKK2_KDM2B does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

54_CAMKK2_KDM2B.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

54_CAMKK2_KDM2B_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Temsirolimus	-5.49796	-5.49936	-53.7956
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Belumosudil	-5.22221	-5.22991	-50.6423
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Tofacitinib	-5.20573	-5.217230000000001	-32.2103
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Tofacitinib	-5.20573	-5.217230000000001	-32.2103
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Cabozantinib	-5.1657	-5.2107	-35.3345
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Cabozantinib	-5.1657	-5.2107	-35.3345
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Belumosudil	-5.09732	-5.10502	-50.423
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Temsirolimus	-5.017930000000001	-5.01933	-49.0829
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Neratinib	-4.88207	-5.064369999999999	-51.668
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Neratinib	-4.88207	-5.064369999999999	-51.668
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Tepotinib	-4.859380000000001	-4.86048	-45.4947
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Zanubrutinib	-4.84057	-4.84057	-45.1801
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Everolimus	-4.78999	-4.79139	-49.802
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Lapatinib	-4.72508	-5.89348	-51.3892
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Lapatinib	-4.72508	-5.89348	-51.3892
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Dacomitinib	-4.70896	-4.81726	-39.1741
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Dacomitinib	-4.70896	-4.81726	-39.1741
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Dacomitinib	-4.70826	-4.81726	-39.1741
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Asciminib	-4.70793	-5.07103	-43.4583
54_CAMKK2_KDM2B-DOCK_HTVS_1-001	Asciminib	-4.6691400000000005	-5.13414	-39.3482

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Kinase-Substrate Information of CAMKK2_KDM2B

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
CAMKK2	Q96RR4	human	SIRT1	Q96EB6	S47	DGPGLERsPGEPGGA
CAMKK2	Q96RR4	human	PRKAA1	Q13131	T183	sDGEFLRtsCGsPNy	Pkinase
CAMKK2	Q96RR4	human	SIRT1	Q96EB6	S27	ADREAAssPAGEPLR
CAMKK2	Q96RR4	human	CAMKK2	Q96RR4	T85	GQEVPLDtSGSQARP
CAMKK2	Q96RR4	human	PRKAA2	P54646	T172	sDGEFLRtsCGsPNy	Pkinase
CAMKK2	Q96RR4	human	AKT1	P31749	T308	kDGAtMKtFCGtPEy	Pkinase

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
CAMKK2	ID	Description	0.00e+00
CAMKK2	GO:0034599	cellular response to oxidative stress	3.92e-07
CAMKK2	GO:0062197	cellular response to chemical stress	4.74e-07
CAMKK2	GO:0045913	positive regulation of carbohydrate metabolic process	4.74e-07
CAMKK2	GO:0010506	regulation of autophagy	5.19e-07
CAMKK2	GO:1901655	cellular response to ketone	6.30e-07
CAMKK2	GO:0006979	response to oxidative stress	6.30e-07
CAMKK2	GO:0071380	cellular response to prostaglandin E stimulus	6.46e-07
CAMKK2	GO:0055089	fatty acid homeostasis	6.86e-07
CAMKK2	GO:0071379	cellular response to prostaglandin stimulus	1.19e-06
CAMKK2	GO:0032006	regulation of TOR signaling	1.33e-06
CAMKK2	GO:0062013	positive regulation of small molecule metabolic process	1.33e-06
CAMKK2	GO:0034695	response to prostaglandin E	1.33e-06
CAMKK2	GO:0010508	positive regulation of autophagy	1.33e-06
CAMKK2	GO:0034614	cellular response to reactive oxygen species	1.37e-06
CAMKK2	GO:2000756	regulation of peptidyl-lysine acetylation	1.66e-06
CAMKK2	GO:0031929	TOR signaling	1.66e-06
CAMKK2	GO:0034694	response to prostaglandin	2.35e-06
CAMKK2	GO:0006109	regulation of carbohydrate metabolic process	2.38e-06
CAMKK2	GO:0090311	regulation of protein deacetylation	2.78e-06
CAMKK2	GO:0000302	response to reactive oxygen species	3.03e-06
CAMKK2	GO:1901654	response to ketone	3.06e-06
CAMKK2	GO:1901983	regulation of protein acetylation	4.20e-06
CAMKK2	GO:0042593	glucose homeostasis	5.80e-06
CAMKK2	GO:0033500	carbohydrate homeostasis	5.80e-06
CAMKK2	GO:0042149	cellular response to glucose starvation	6.31e-06
CAMKK2	GO:0006476	protein deacetylation	9.55e-06
CAMKK2	GO:0035601	protein deacylation	1.43e-05
CAMKK2	GO:0018394	peptidyl-lysine acetylation	1.44e-05
CAMKK2	GO:0098732	macromolecule deacylation	1.49e-05
CAMKK2	GO:0062012	regulation of small molecule metabolic process	1.49e-05
CAMKK2	GO:0032007	negative regulation of TOR signaling	1.68e-05
CAMKK2	GO:0097009	energy homeostasis	1.91e-05
CAMKK2	GO:0031331	positive regulation of cellular catabolic process	2.58e-05
CAMKK2	GO:0006631	fatty acid metabolic process	2.63e-05
CAMKK2	GO:1903432	regulation of TORC1 signaling	2.98e-05
CAMKK2	GO:0038202	TORC1 signaling	3.41e-05
CAMKK2	GO:0031400	negative regulation of protein modification process	3.41e-05
CAMKK2	GO:0097306	cellular response to alcohol	3.73e-05
CAMKK2	GO:0006473	protein acetylation	3.97e-05
CAMKK2	GO:0045833	negative regulation of lipid metabolic process	4.57e-05
CAMKK2	GO:0031667	response to nutrient levels	5.06e-05
CAMKK2	GO:0032070	regulation of deoxyribonuclease activity	5.19e-05
CAMKK2	GO:1903943	regulation of hepatocyte apoptotic process	5.19e-05
CAMKK2	GO:1904179	positive regulation of adipose tissue development	5.19e-05
CAMKK2	GO:0008286	insulin receptor signaling pathway	5.65e-05
CAMKK2	GO:0099004	calmodulin dependent kinase signaling pathway	6.07e-05
CAMKK2	GO:0043467	regulation of generation of precursor metabolites and energy	7.45e-05
CAMKK2	GO:1903008	organelle disassembly	8.46e-05
CAMKK2	GO:0043543	protein acylation	8.46e-05

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Related Drugs to CAMKK2_KDM2B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning CAMKK2-KDM2B and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

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Related Diseases to CAMKK2_KDM2B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date