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Center for Computational Systems Medicine
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Kinase Fusion Gene Summary

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Kinase Fusion Gene Sample Information

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Kinase Fusion ORF Analysis

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Kinase Fusion Amino Acid Sequences

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Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

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Kinase Fusion Protein Structures

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Comparison of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

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pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.

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Ramachandran Plot of Kinase Fusion Protein Structure

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Potential Active Site Information

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Virtual Screening Results

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Kinase-Substrate Information

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Related Drugs with This Kinase Fusion Protein

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Related Disease with This Kinase Fusion Protein

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Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CAPZA2_MET

Kinase Fusion Protein Summary

check button Kinase Fusion gene summary
Kinase Fusion partner gene informationKinase Fusion gene name: CAPZA2_MET
KinaseFusionDB ID: KFG913
FusionGDB2.0 ID: KFG913
HgeneTgene
Gene symbol

CAPZA2

MET

Gene ID

830

8731

Gene namecapping actin protein of muscle Z-line subunit alpha 2RNA guanine-7 methyltransferase
SynonymsCAPPA2|CAPZCMT1|CMT1c|MET|Met|N7-MTase|RG7MT1|cm1p|hCMT1|hMet
Cytomap

7q31.2

18p11.21

Type of geneprotein-codingprotein-coding
DescriptionF-actin-capping protein subunit alpha-2F-actin capping protein alpha-2 subunitcapZ alpha-2capping actin protein of muscle Z-line alpha subunit 2capping protein (actin filament) muscle Z-line, alpha 2epididymis secretory sperm binding proteinmRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
Modification date2024041120240403
UniProtAcc

P47755

Q9H1A3

Ensembl transtripts involved in fusion geneENST idsENST00000466023, ENST00000361183, 
ENST00000458284, ENST00000490693, 
ENST00000318493, ENST00000397752, 
ENST00000436117, ENST00000495962, 
ENST00000539704, 
Context (manual curation of fusion genes in KinaseFusionDB)

PubMed: CAPZA2 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]

Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer (pmid: 28512244)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CAPZA2(116550365)-MET(116409699), # samples:2
CAPZA2(116528244)-MET(116395409), # samples:2
CAPZA2(116528244)-MET(116414935), # samples:2
MET(116399544)-CAPZA2(116528181), # samples:2
check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMET

GO:0006370

7-methylguanosine mRNA capping

27422871


check buttonKinase Fusion gene breakpoints across CAPZA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonKinase Fusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Kinase Fusion Gene Sample Information

check buttonKinase Fusion gene information.
check button Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceSampleHgeneHchrHbpTgeneTchrTbp
ChimerDB4TCGA-HU-8238-01ACAPZA2chr7

116502704

METchr7

116435709

ChimerDB4TCGA-G7-6793CAPZA2chr7

116528244

METchr7

116395409

ChimerDB4TCGA-78-7220-01ACAPZA2chr7

116528244

METchr7

116414935

ChimerDB4TCGA-AR-A1AN-01ACAPZA2chr7

116550365

METchr7

116409699

CCLEJHUEM-7CAPZA2chr7

116502704

METchr7

116335804

CCLECaki-2CAPZA2chr7

116502704

METchr7

116422042

CCLEJHUEM-7CAPZA2chr7

116502704

METchr7

116339125

CCLEHEC-59CAPZA2chr7

116502704

METchr7

116395409

CCLEESO51CAPZA2chr7

116502704

METchr7

116371722

CCLEMKN-45CAPZA2chr7

116502704

METchr7

116371722

CCLEMKN-45CAPZA2chr7

116538889

METchr7

116403104



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Kinase Fusion ORF Analysis


check buttonKinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.
HenstTenstHgeneHchrHbpTgeneTchrTbpSeq length
(transcript)		Seq length
(amino acids)
ENST00000361183ENST00000397752CAPZA2chr7116502704METchr71164220423091242
ENST00000361183ENST00000397752CAPZA2chr7116502704METchr71163954094912849
ENST00000361183ENST00000397752CAPZA2chr7116502704METchr711637172254131016
ENST00000361183ENST00000397752CAPZA2chr7116538889METchr71164031044429688
ENST00000361183ENST00000397752CAPZA2chr7116550365METchr71164096994576737
ENST00000361183ENST00000397752CAPZA2chr7116528244METchr71164149353649428

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Kinase Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116502704_MET_chr7_116422042_length(amino acids)=242
MPPPPPRFVARRKMADLEEQLSDEEKNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVH
NKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRP

--------------------------------------------------------------

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116502704_MET_chr7_116395409_length(amino acids)=849
MPPPPPRFVARRKMADLEEQLSDEEKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMN
KHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFA
VKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNL
QLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLL
KLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSP
TTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFN
EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN
ETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT
TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH

--------------------------------------------------------------

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116502704_MET_chr7_116371722_length(amino acids)=1016
MPPPPPRFVARRKMADLEEQLSDEEKTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQ
VVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSG
TWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGH
GTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETS
IFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLD
GILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQA
ISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYR
ATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYH
GTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGF
GLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLW
ELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAP

--------------------------------------------------------------

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116538889_MET_chr7_116403104_length(amino acids)=688
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPEL
VQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS
PLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG
AKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSE

--------------------------------------------------------------

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116550365_MET_chr7_116409699_length(amino acids)=737
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED

--------------------------------------------------------------

>ENST00000361183_ENST00000397752_CAPZA2_chr7_116528244_MET_chr7_116414935_length(amino acids)=428
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms



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Kinase Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116550365/chr7:116409699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CAPZA2

P47755

MET

Q9H1A3

FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:34562450}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.

check button - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote


check button - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).
PartnerHgeneeneHbpTgeneeneTbpENSTBPexonTotalExonProtein feature lociBPlociTotalLenFeatureNote
TgeneCAPZA2116502704MET116371722ENST0000036118309563_655400765DomainNote=IPT/TIG 1
TgeneCAPZA2116502704MET116371722ENST00000361183121563_6554001391DomainNote=IPT/TIG 1
TgeneCAPZA2116502704MET116371722ENST00000361183121563_6554001409DomainNote=IPT/TIG 1
TgeneCAPZA2116502704MET116422042ENST0000036118309563_6550765DomainNote=IPT/TIG 1
TgeneCAPZA2116528244MET116414935ENST0000036118309563_6550765DomainNote=IPT/TIG 1
TgeneCAPZA2116550365MET116409699ENST0000036118309563_6550765DomainNote=IPT/TIG 1
TgeneCAPZA2116502704MET116371722ENST0000036118309657_739400765DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116371722ENST00000361183121657_7394001391DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116371722ENST00000361183121657_7394001409DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116395409ENST0000036118339657_739567765DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116395409ENST00000361183421657_7395671391DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116395409ENST00000361183421657_7395671409DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116422042ENST0000036118309657_7390765DomainNote=IPT/TIG 2
TgeneCAPZA2116528244MET116414935ENST0000036118309657_7390765DomainNote=IPT/TIG 2
TgeneCAPZA2116550365MET116409699ENST0000036118309657_7390765DomainNote=IPT/TIG 2
TgeneCAPZA2116502704MET116371722ENST0000036118309742_836400765DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116371722ENST00000361183121742_8364001391DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116371722ENST00000361183121742_8364001409DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116395409ENST0000036118339742_836567765DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116395409ENST00000361183421742_8365671391DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116395409ENST00000361183421742_8365671409DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116422042ENST0000036118309742_8360765DomainNote=IPT/TIG 3
TgeneCAPZA2116528244MET116414935ENST0000036118309742_8360765DomainNote=IPT/TIG 3
TgeneCAPZA2116550365MET116409699ENST0000036118309742_8360765DomainNote=IPT/TIG 3
TgeneCAPZA2116502704MET116371722ENST00000361183091078_1345400765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116371722ENST000003611831211078_13454001391DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116371722ENST000003611831211078_13454001409DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116395409ENST00000361183391078_1345567765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116395409ENST000003611834211078_13455671391DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116395409ENST000003611834211078_13455671409DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116422042ENST00000361183091078_13450765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116528244MET116414935ENST00000361183091078_13450765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116528244MET116414935ENST0000036118313211078_134510091391DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116528244MET116414935ENST0000036118313211078_134510271409DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116538889MET116403104ENST00000361183791078_1345754765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116538889MET116403104ENST000003611839211078_13457881391DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116538889MET116403104ENST000003611839211078_13458061409DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116550365MET116409699ENST00000361183091078_13450765DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116550365MET116409699ENST0000036118310211078_13458611391DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116550365MET116409699ENST0000036118310211078_13458791409DomainNote=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00159
TgeneCAPZA2116502704MET116422042ENST000003611830927_5150765DomainNote=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
TgeneCAPZA2116528244MET116414935ENST000003611830927_5150765DomainNote=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352
TgeneCAPZA2116550365MET116409699ENST000003611830927_5150765DomainNote=Sema;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00352


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Kinase Fusion Protein Structures

check button CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)HenstTenstHgeneHchrHbpTgeneTchrTbpAA seqLen(AA seq)
PDB file >>>80_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116528244METchr7116414935
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP
428
3D view using mol* of 80_CAPZA2_MET
PDB file >>>TKFP_130_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116502704METchr7116422042
MPPPPPRFVARRKMADLEEQLSDEEKNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVH
NKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRP
242_CAPZA2_MET
PDB file >>>TKFP_131_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116502704METchr7116395409
MPPPPPRFVARRKMADLEEQLSDEEKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMN
KHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFA
VKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNL
QLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLL
KLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSP
TTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFN
EVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRN
ETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFT
TKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVH
849_CAPZA2_MET
3D view using mol* of TKFP_131_CAPZA2_MET
PDB file >>>TKFP_132_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116502704METchr7116371722
MPPPPPRFVARRKMADLEEQLSDEEKTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQ
VVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSG
TWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGH
GTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETS
IFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLD
GILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQA
ISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYR
ATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYH
GTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGF
GLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLW
ELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAP
1016_CAPZA2_MET
3D view using mol* of TKFP_132_CAPZA2_MET
PDB file >>>TKFP_133_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116538889METchr7116403104
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQACQH
RSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSC
ENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYD
ARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPEL
VQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGS
PLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTG
AKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSE
688_CAPZA2_MET
3D view using mol* of TKFP_133_CAPZA2_MET
PDB file >>>TKFP_134_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116550365METchr7116409699
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNLDQFTPVKIEGYEDQVLIT
EHGDLGNGKFLDPKNRICFKFDHLRKEATDPRPCEVENAVESWRTSVETALRAYVKEHYPNGVCTVYGKKIDGQQTIIACIESHQFQAKN
FWNGRWRSEWKFTITPSTTQVVGILKIQGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKV
IVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFP
NSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGK
KIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMK
YLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPP
YPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSED
737_CAPZA2_MET
3D view using mol* of TKFP_134_CAPZA2_MET
PDB file >>>TKFP_135_CAPZA2_METENST00000361183ENST00000397752CAPZA2chr7116528244METchr7116414935
MPPPPPRFVARRKMADLEEQLSDEEKVRIAAKFIIHAPPGEFNEVFNDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVH
IDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSL
LGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDK
EYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHP
428_CAPZA2_MET
3D view using mol* of TKFP_135_CAPZA2_MET


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Comparison of Fusion Protein Isoforms

check button Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.
3D view using mol* of viewer/superimpose_isoforms/TKFP_130_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_130_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_130_CAPZA2_MET_vs_TKFP_133_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_130_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_130_CAPZA2_MET_vs_TKFP_135_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_131_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_131_CAPZA2_MET_vs_TKFP_133_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_131_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_131_CAPZA2_MET_vs_TKFP_135_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_132_CAPZA2_MET_vs_TKFP_133_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_132_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_132_CAPZA2_MET_vs_TKFP_135_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_133_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_133_CAPZA2_MET_vs_TKFP_135_CAPZA2_MET_superimposed.pdb.html
3D view using mol* of viewer/superimpose_isoforms/TKFP_134_CAPZA2_MET_vs_TKFP_135_CAPZA2_MET_superimposed.pdb.html

check button Comparison of the Secondary Structures of Fusion Protein Isoforms
./secondary_str/TKFP_131_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_131_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
./secondary_str/TKFP_131_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_131_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_132_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET.png
./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_133_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
./secondary_str/TKFP_134_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_134_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_130_CAPZA2_MET.png
./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_131_CAPZA2_MET.png
./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_132_CAPZA2_MET.png
./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_133_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_133_CAPZA2_MET.png
./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png
secondary structure of ./secondary_str/TKFP_135_CAPZA2_MET_vs_TKFP_134_CAPZA2_MET.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CAPZA2_MET does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/80_CAPZA2_MET.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_131_CAPZA2_MET_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_132_CAPZA2_MET_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_133_CAPZA2_MET_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_134_CAPZA2_MET_updated_violin_plot.pngall_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/TKFP_135_CAPZA2_MET_updated_violin_plot.png
check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.
80_CAPZA2_MET.png
all structure sitemap plddt3 80_CAPZA2_MET.png
80_CAPZA2_MET.png
all structure sitemap plddt4 80_CAPZA2_MET.png
TKFP_131_CAPZA2_MET.png
all structure sitemap plddt3 TKFP_131_CAPZA2_MET.png
TKFP_132_CAPZA2_MET.png
all structure sitemap plddt3 TKFP_132_CAPZA2_MET.png
TKFP_133_CAPZA2_MET.png
all structure sitemap plddt3 TKFP_133_CAPZA2_MET.png
TKFP_134_CAPZA2_MET.png
all structure sitemap plddt3 TKFP_134_CAPZA2_MET.png
TKFP_135_CAPZA2_MET.png
all structure sitemap plddt3 TKFP_135_CAPZA2_MET.png


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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Kinase Fusion AA seq ID in KinaseFusionDBSite scoreSizeDscoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
TKFP_131_CAPZA2_MET1.0681041.104247.6460.5740.7550.950.8750.8850.9891.814Chain A: 543,544,545,551,567,569,590,599,614,616,6
17,618,619,622,623,625,626,667,668,670,680,681,689
,690,693
TKFP_132_CAPZA2_MET1.072971.054190.0220.4360.8221.0350.5391.120.4811.584Chain A: 715,738,740,741,746,749,750,753,754,757,8
50,851,852,853,854,855,858,859
TKFP_133_CAPZA2_MET1.0753291.05873.6210.4680.811.0270.6861.1540.5941.34Chain A: 301,302,304,382,383,384,385,386,387,390,3
92,406,408,410,412,413,415,417,418,421,422,425,426
,429,438,453,455,456,457,458,459,460,461,462,465,4
66,469,472,500,502,506,507,509,519,520,521,522,523
,524,525,526,527,528,529,530,531,533,541,542,544
TKFP_134_CAPZA2_MET1.0311351.088406.7980.5850.6680.8860.8010.7751.0331.341Chain A: 394,395,396,397,398,399,433,434,435,436,4
37,438,459,460,461,462,463,467,471,495,497,498,499
,572,573,576,577,579,580,581
TKFP_135_CAPZA2_MET1.1081101.182448.6440.4790.7350.9171.5570.612.5534.433Chain A: 27,28,30,31,32,34,35,36,273,275,285,293,2
94,327,328,329,330,331,332,335,407,408,411

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Ramachandran Plot of Kinase Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

80_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET
TKFP_131_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET
TKFP_132_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET
TKFP_133_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET
TKFP_134_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET
TKFP_135_CAPZA2_MET_ramachandran.png
all structure CAPZA2-MET

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Virtual Screening Results


check button Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.
5'-kinase fusion protein case
3'-kinase fusion protein case
all structure CAPZA2-MET

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check button Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.
Fusion gene name infoDrugDocking scoreGlide g scoreGlide energy
80_CAPZA2_MET-DOCK_HTVS_1-001Upadacitinib-5.8794699999999995-5.88047-34.8169
80_CAPZA2_MET-DOCK_HTVS_1-001Larotrectinib-5.38754-5.38754-42.1827
80_CAPZA2_MET-DOCK_HTVS_1-001Regorafenib-5.26851-5.26851-36.135999999999996
80_CAPZA2_MET-DOCK_HTVS_1-001Lenvatinib-5.02342-5.02342-42.8297
80_CAPZA2_MET-DOCK_HTVS_1-001Axitinib-4.940580000000001-4.94378-43.8369
80_CAPZA2_MET-DOCK_HTVS_1-001Netarsudil-4.91971-4.93081-45.1942
80_CAPZA2_MET-DOCK_HTVS_1-001Netarsudil-4.91971-4.93081-45.1942
80_CAPZA2_MET-DOCK_HTVS_1-001Axitinib-4.81711-4.82031-37.056999999999995
80_CAPZA2_MET-DOCK_HTVS_1-001Crizotinib-4.66346-4.9996599999999995-36.0896
80_CAPZA2_MET-DOCK_HTVS_1-001Crizotinib-4.66346-4.9996599999999995-36.0896
80_CAPZA2_MET-DOCK_HTVS_1-001Pazopanib-4.65033-4.65723-38.0848
80_CAPZA2_MET-DOCK_HTVS_1-001Pazopanib-4.65033-4.65723-38.0848
80_CAPZA2_MET-DOCK_HTVS_1-001Acalabrutinib-4.60041-4.61451-45.5385
80_CAPZA2_MET-DOCK_HTVS_1-001Acalabrutinib-4.60041-4.61451-45.5385
80_CAPZA2_MET-DOCK_HTVS_1-001Abrocitinib-4.5583599999999995-4.569459999999999-38.4238
80_CAPZA2_MET-DOCK_HTVS_1-001Abrocitinib-4.5583599999999995-4.569459999999999-38.4238
80_CAPZA2_MET-DOCK_HTVS_1-001Acalabrutinib-4.52987-4.54397-43.6577
80_CAPZA2_MET-DOCK_HTVS_1-001Acalabrutinib-4.52987-4.54397-43.6577
80_CAPZA2_MET-DOCK_HTVS_1-001Selpercatinib-4.51061-4.54111-39.9155
80_CAPZA2_MET-DOCK_HTVS_1-001Selpercatinib-4.51061-4.54111-39.9155

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Kinase-Substrate Information of CAPZA2_MET


check button Phosphorylation target of the kinase
(phosphosite, 03-17-2024)
KinaseKinase UniProt AccKinase speciesSubstrateSubstrate UniProt AccSubstrate phosphorylated residuesSubstrate phosphorylated sites (+/-7AA)Domain
METP08581humanMST1RQ04912Y1353SALLGDHyVQLPATy
METP08581humanFIS1Q9Y3D6Y38sKSTQFEyAWCLVRSFis1_TPR_N
METP08581humanIRS1P35568Y612tLHtDDGyMPMsPGV
METP08581humanPTK2Q05397Y925DRsNDkVyENVtGLVFocal_AT
METP08581humanMETP08581Y1349stFIGEHyVHVNAty
METP08581humanMETP08581Y1365NVKCVAPyPsLLssE
METP08581humanIRS1P35568Y896EPKsPGEyVNIEFGS
METP08581humanPTK2Q05397Y577yMEDstyyKAsKGKLPK_Tyr_Ser-Thr
METP08581humanRHOAP61586Y42VPTVFENyVADIEVDRas
METP08581humanMST1RQ04912Y1360yVQLPATyMNLGPST
METP08581humanMST1RQ04912Y1238RDILDREyysVQQHRPK_Tyr_Ser-Thr
METP08581humanIQGAP1P46940Y1510LVkLQQtyAALNskARasGAP_C
METP08581humanPTK2Q05397Y407IIDEEDtytMPSTRD
METP08581humanMETP08581Y1230FGLARDMyDkEyysVPK_Tyr_Ser-Thr
METP08581humanPARP1P09874Y907MVSKSANyCHTSQGDPARP
METP08581humanSHC1P29353Y427ELFDDPsyVNVQNLD
METP08581humanMETP08581Y1356yVHVNAtyVNVKCVA
METP08581humanPTK2Q05397Y5___MAAAyLDPNLNH
METP08581humanPTK2Q05397Y397sVsEtDDyAEIIDEE
METP08581humanPTK2Q05397Y861PIGNQHIyQPVGKPD
METP08581humanPBKQ96KB5Y74NPICNDHyRsVyQkRPkinase
METP08581humanPTK2Q05397Y194ALEKKSNyEVLEkDVFERM_M
METP08581humanMETP08581Y1234RDMyDkEyysVHNktPK_Tyr_Ser-Thr
METP08581humanPTK2Q05397Y576RyMEDstyyKAsKGKPK_Tyr_Ser-Thr
METP08581humanINSRP06213Y1185FGMTRDIyEtDyyRkPK_Tyr_Ser-Thr
METP08581humanMETP08581Y1235DMyDkEyysVHNktGPK_Tyr_Ser-Thr
METP08581humanGSK3BP49841Y56DRPQEVSyTDTKVIGPkinase
METP08581humanMST1RQ04912Y1239DILDREyysVQQHRHPK_Tyr_Ser-Thr


check button Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

check button Enriched GO biological processes of the phosphorylation target genes of the kinase
KinaseGOIDGO termP.adjust
METIDDescription0.00e+00
METGO:0033674positive regulation of kinase activity4.44e-07
METGO:0051347positive regulation of transferase activity9.31e-07
METGO:0071375cellular response to peptide hormone stimulus5.90e-06
METGO:1901653cellular response to peptide1.35e-05
METGO:0032869cellular response to insulin stimulus2.06e-05
METGO:0043434response to peptide hormone2.06e-05
METGO:0032868response to insulin6.57e-05
METGO:0045860positive regulation of protein kinase activity7.26e-05
METGO:0008286insulin receptor signaling pathway8.83e-05
METGO:0005979regulation of glycogen biosynthetic process8.83e-05
METGO:0010962regulation of glucan biosynthetic process8.83e-05
METGO:0043467regulation of generation of precursor metabolites and energy1.23e-04
METGO:0070873regulation of glycogen metabolic process1.40e-04
METGO:0032885regulation of polysaccharide biosynthetic process1.41e-04
METGO:0045936negative regulation of phosphate metabolic process1.52e-04
METGO:0010563negative regulation of phosphorus metabolic process1.52e-04
METGO:0005978glycogen biosynthetic process1.72e-04
METGO:0009250glucan biosynthetic process1.72e-04
METGO:0032881regulation of polysaccharide metabolic process1.72e-04
METGO:0016051carbohydrate biosynthetic process4.12e-04
METGO:0000271polysaccharide biosynthetic process4.65e-04
METGO:0005977glycogen metabolic process6.80e-04
METGO:0044042glucan metabolic process7.00e-04
METGO:0031016pancreas development7.00e-04
METGO:1900543negative regulation of purine nucleotide metabolic process7.39e-04
METGO:0045980negative regulation of nucleotide metabolic process8.69e-04
METGO:0006112energy reserve metabolic process8.90e-04
METGO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transduction9.74e-04
METGO:0005976polysaccharide metabolic process1.25e-03
METGO:0043255regulation of carbohydrate biosynthetic process1.32e-03
METGO:0007173epidermal growth factor receptor signaling pathway1.35e-03
METGO:0045725positive regulation of glycogen biosynthetic process1.35e-03
METGO:0015980energy derivation by oxidation of organic compounds1.44e-03
METGO:0062012regulation of small molecule metabolic process1.44e-03
METGO:0070875positive regulation of glycogen metabolic process1.59e-03
METGO:0038127ERBB signaling pathway1.79e-03
METGO:0001952regulation of cell-matrix adhesion1.79e-03
METGO:0071902positive regulation of protein serine/threonine kinase activity2.45e-03
METGO:1903578regulation of ATP metabolic process2.89e-03
METGO:0030010establishment of cell polarity3.21e-03
METGO:0070507regulation of microtubule cytoskeleton organization3.41e-03
METGO:1902410mitotic cytokinetic process3.41e-03
METGO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction3.91e-03
METGO:0043410positive regulation of MAPK cascade4.19e-03
METGO:2000058regulation of ubiquitin-dependent protein catabolic process4.21e-03
METGO:0001667ameboidal-type cell migration4.74e-03
METGO:0006109regulation of carbohydrate metabolic process4.74e-03
METGO:0035305negative regulation of dephosphorylation5.05e-03
METGO:0031334positive regulation of protein-containing complex assembly5.26e-03

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Related Drugs to CAPZA2_MET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

check button Distribution of the number of studies mentioning CAPZA2-MET and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1Fusion gene - drug pair 2PMIDPublication dateDOIStudy title

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Related Diseases to CAPZA2_MET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)
MeSH IDMeSH term

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource


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Clinical Trials of the Found Drugs/Small Molecules


check button Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

check button Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion GeneKinase InhibitorNCT IDStudy StatusPhasesDisease# EnrolmentDate