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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:CAV1_MET

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: CAV1_MET
	KinaseFusionDB ID: KFG940
	FusionGDB2.0 ID: KFG940
		Hgene	Tgene
	Gene symbol	CAV1	MET
	Gene ID	857	8731
	Gene name	caveolin 1	RNA guanine-7 methyltransferase
	Synonyms	BSCL3\|CGL3\|LCCNS\|MSTP085\|PPH3\|VIP21	CMT1\|CMT1c\|MET\|Met\|N7-MTase\|RG7MT1\|cm1p\|hCMT1\|hMet
	Cytomap	7q31.2	18p11.21
	Type of gene	protein-coding	protein-coding
	Description	caveolin-1caveolin 1, caveolae protein, 22kDacell growth-inhibiting protein 32	mRNA cap guanine-N7 methyltransferaseRNA (guanine-7-) methyltransferasehcm1pmRNA (guanine-7-)methyltransferasemRNA (guanine-N(7)-)-methyltransferasemRNA cap methyltransferase
	Modification date	20240411	20240403
	UniProtAcc	Q03135	Q9H1A3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000341049, ENST00000393470, ENST00000405348, ENST00000393468, ENST00000393467,	ENST00000397752, ENST00000318493, ENST00000436117, ENST00000495962, ENST00000539704,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: CAV1 [Title/Abstract] AND MET [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MET(116340338)-CAV1(116199000), # samples:3

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CAV1	GO:0009617	response to bacterium	24625804
Hgene	CAV1	GO:0010875	positive regulation of cholesterol efflux	24576892
Hgene	CAV1	GO:0031295	T cell costimulation	17287217
Hgene	CAV1	GO:0031623	receptor internalization	25893292
Hgene	CAV1	GO:0032570	response to progesterone	12388746
Hgene	CAV1	GO:0033137	negative regulation of peptidyl-serine phosphorylation	18081315
Hgene	CAV1	GO:0033138	positive regulation of peptidyl-serine phosphorylation	18081315
Hgene	CAV1	GO:0043627	response to estrogen	12388746
Hgene	CAV1	GO:0051480	regulation of cytosolic calcium ion concentration	19052258
Hgene	CAV1	GO:0060070	canonical Wnt signaling pathway	16890161
Hgene	CAV1	GO:0072584	caveolin-mediated endocytosis	19931615
Hgene	CAV1	GO:1900027	regulation of ruffle assembly	24625804
Hgene	CAV1	GO:2000535	regulation of entry of bacterium into host cell	24625804
Tgene	MET	GO:0006370	7-methylguanosine mRNA capping	27422871

Kinase Fusion gene breakpoints across CAV1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across MET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CCLE	UM-UC-13	CAV1	chr7	116166743	MET	chr7	116395409

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000341049	ENST00000397752	CAV1	chr7	116166743	MET	chr7	116395409	5207	888

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000341049_ENST00000397752_CAV1_chr7_116166743_MET_chr7_116395409_length(amino acids)=888
MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKVFPNSAPLEGGTRLTICGWDFGFRR
NNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL
NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSV
PRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKG
NDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFF
LWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDI
SSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMK
DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVAD
FGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:116340338/chr7:116199000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CAV1 Q03135	MET Q9H1A3
FUNCTION: May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (PubMed:17287217). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292). {ECO:0000250\|UniProtKB:P49817, ECO:0000269\|PubMed:11751885, ECO:0000269\|PubMed:17287217, ECO:0000269\|PubMed:19262564, ECO:0000269\|PubMed:25893292}.	FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450). Mediates methylation of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid) (PubMed:33563959). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269\|PubMed:33563959, ECO:0000269\|PubMed:34562450}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	3	9	657_739	567	765	Domain	Note=IPT/TIG 2
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	657_739	567	1391	Domain	Note=IPT/TIG 2
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	657_739	567	1409	Domain	Note=IPT/TIG 2
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	3	9	742_836	567	765	Domain	Note=IPT/TIG 3
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	742_836	567	1391	Domain	Note=IPT/TIG 3
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	742_836	567	1409	Domain	Note=IPT/TIG 3
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	3	9	1078_1345	567	765	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	1078_1345	567	1391	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159
Tgene	CAV1	116166743	MET	116395409	ENST00000341049	4	21	1078_1345	567	1409	Domain	Note=Protein kinase;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00159

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>83_CAV1_MET	ENST00000341049	ENST00000397752	CAV1	chr7	116166743	MET	chr7	116395409	MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKVFPNSAPLEGGTRLTICGWDFGFRR NNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSV PRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKG NDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFF LWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDI SSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMK DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVAD FGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL	888
3D view using mol* of 83_CAV1_MET

PDB file >>>TKFP_140_CAV1_MET	ENST00000341049	ENST00000397752	CAV1	chr7	116166743	MET	chr7	116395409	MSGGKYVDSEGHLYTVPIREQGNIYKPNNKAMADELSEKQVYDAHTKEIDLVNRDPKHLNDDVVKVFPNSAPLEGGTRLTICGWDFGFRR NNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYL NSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSV PRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKG NDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFF LWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDI SSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMK DFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVAD FGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPL	888_CAV1_MET

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_244_MET_CAV1_vs_HKFP_245_MET_CAV1_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

CAV1_MET does not have any known PDB structures.

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pLDDT score distribution

all_data/KinaseFusionDB_T_Results/KinaseFusionDB_T_ViolinPlots/83_CAV1_MET.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

83_CAV1_MET.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB

Site score

Size

Dscore

Volume

Exposure

Enclosure

Contact

Phobic

Philic

Balance

Don/Acc

Residues

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

83_CAV1_MET_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
83_CAV1_MET-DOCK_HTVS_1-001	Lapatinib	-8.82498	-8.913780000000001	-69.5851
83_CAV1_MET-DOCK_HTVS_1-001	Lapatinib	-8.68261	-8.771410000000001	-66.1516
83_CAV1_MET-DOCK_HTVS_1-001	Dacomitinib	-7.7682899999999995	-7.876589999999999	-56.2737
83_CAV1_MET-DOCK_HTVS_1-001	Dacomitinib	-7.7682899999999995	-7.876589999999999	-56.2737
83_CAV1_MET-DOCK_HTVS_1-001	Acalabrutinib	-7.75736	-7.77146	-38.9864
83_CAV1_MET-DOCK_HTVS_1-001	Acalabrutinib	-7.75736	-7.77146	-38.9864
83_CAV1_MET-DOCK_HTVS_1-001	Dacomitinib	-7.73537	-7.84437	-55.8637
83_CAV1_MET-DOCK_HTVS_1-001	Nilotinib	-7.65897	-7.79857	-50.5098
83_CAV1_MET-DOCK_HTVS_1-001	Nilotinib	-7.65897	-7.79857	-50.5098
83_CAV1_MET-DOCK_HTVS_1-001	Lapatinib	-7.48085	-8.64925	-58.9421
83_CAV1_MET-DOCK_HTVS_1-001	Lapatinib	-7.48085	-8.64925	-58.9421
83_CAV1_MET-DOCK_HTVS_1-001	Sorafenib	-7.148289999999999	-7.16039	-59.4221
83_CAV1_MET-DOCK_HTVS_1-001	Sorafenib	-7.148289999999999	-7.16039	-59.4221
83_CAV1_MET-DOCK_HTVS_1-001	Futibatinib	-7.01853	-7.01853	-50.7491
83_CAV1_MET-DOCK_HTVS_1-001	Binimetinib	-6.965210000000001	-6.973910000000001	-35.3012
83_CAV1_MET-DOCK_HTVS_1-001	Binimetinib	-6.965210000000001	-6.973910000000001	-35.3012
83_CAV1_MET-DOCK_HTVS_1-001	Ripretinib	-6.95565	-6.96265	-52.0865
83_CAV1_MET-DOCK_HTVS_1-001	Ripretinib	-6.95565	-6.96265	-52.0865
83_CAV1_MET-DOCK_HTVS_1-001	Futibatinib	-6.8633	-6.8633	-46.0313
83_CAV1_MET-DOCK_HTVS_1-001	Upadacitinib	-6.70223	-6.7032300000000005	-32.0254

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Kinase-Substrate Information of CAV1_MET

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase	Kinase UniProt Acc	Kinase species	Substrate	Substrate UniProt Acc	Substrate phosphorylated residues	Substrate phosphorylated sites (+/-7AA)	Domain
MET	P08581	human	MST1R	Q04912	Y1353	SALLGDHyVQLPATy
MET	P08581	human	FIS1	Q9Y3D6	Y38	sKSTQFEyAWCLVRS	Fis1_TPR_N
MET	P08581	human	IRS1	P35568	Y612	tLHtDDGyMPMsPGV
MET	P08581	human	PTK2	Q05397	Y925	DRsNDkVyENVtGLV	Focal_AT
MET	P08581	human	MET	P08581	Y1349	stFIGEHyVHVNAty
MET	P08581	human	MET	P08581	Y1365	NVKCVAPyPsLLssE
MET	P08581	human	IRS1	P35568	Y896	EPKsPGEyVNIEFGS
MET	P08581	human	PTK2	Q05397	Y577	yMEDstyyKAsKGKL	PK_Tyr_Ser-Thr
MET	P08581	human	RHOA	P61586	Y42	VPTVFENyVADIEVD	Ras
MET	P08581	human	MST1R	Q04912	Y1360	yVQLPATyMNLGPST
MET	P08581	human	MST1R	Q04912	Y1238	RDILDREyysVQQHR	PK_Tyr_Ser-Thr
MET	P08581	human	IQGAP1	P46940	Y1510	LVkLQQtyAALNskA	RasGAP_C
MET	P08581	human	PTK2	Q05397	Y407	IIDEEDtytMPSTRD
MET	P08581	human	MET	P08581	Y1230	FGLARDMyDkEyysV	PK_Tyr_Ser-Thr
MET	P08581	human	PARP1	P09874	Y907	MVSKSANyCHTSQGD	PARP
MET	P08581	human	SHC1	P29353	Y427	ELFDDPsyVNVQNLD
MET	P08581	human	MET	P08581	Y1356	yVHVNAtyVNVKCVA
MET	P08581	human	PTK2	Q05397	Y5	___MAAAyLDPNLNH
MET	P08581	human	PTK2	Q05397	Y397	sVsEtDDyAEIIDEE
MET	P08581	human	PTK2	Q05397	Y861	PIGNQHIyQPVGKPD
MET	P08581	human	PBK	Q96KB5	Y74	NPICNDHyRsVyQkR	Pkinase
MET	P08581	human	PTK2	Q05397	Y194	ALEKKSNyEVLEkDV	FERM_M
MET	P08581	human	MET	P08581	Y1234	RDMyDkEyysVHNkt	PK_Tyr_Ser-Thr
MET	P08581	human	PTK2	Q05397	Y576	RyMEDstyyKAsKGK	PK_Tyr_Ser-Thr
MET	P08581	human	INSR	P06213	Y1185	FGMTRDIyEtDyyRk	PK_Tyr_Ser-Thr
MET	P08581	human	MET	P08581	Y1235	DMyDkEyysVHNktG	PK_Tyr_Ser-Thr
MET	P08581	human	GSK3B	P49841	Y56	DRPQEVSyTDTKVIG	Pkinase
MET	P08581	human	MST1R	Q04912	Y1239	DILDREyysVQQHRH	PK_Tyr_Ser-Thr

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase	GOID	GO term	P.adjust
MET	ID	Description	0.00e+00
MET	GO:0033674	positive regulation of kinase activity	4.44e-07
MET	GO:0051347	positive regulation of transferase activity	9.31e-07
MET	GO:0071375	cellular response to peptide hormone stimulus	5.90e-06
MET	GO:1901653	cellular response to peptide	1.35e-05
MET	GO:0032869	cellular response to insulin stimulus	2.06e-05
MET	GO:0043434	response to peptide hormone	2.06e-05
MET	GO:0032868	response to insulin	6.57e-05
MET	GO:0045860	positive regulation of protein kinase activity	7.26e-05
MET	GO:0008286	insulin receptor signaling pathway	8.83e-05
MET	GO:0005979	regulation of glycogen biosynthetic process	8.83e-05
MET	GO:0010962	regulation of glucan biosynthetic process	8.83e-05
MET	GO:0043467	regulation of generation of precursor metabolites and energy	1.23e-04
MET	GO:0070873	regulation of glycogen metabolic process	1.40e-04
MET	GO:0032885	regulation of polysaccharide biosynthetic process	1.41e-04
MET	GO:0045936	negative regulation of phosphate metabolic process	1.52e-04
MET	GO:0010563	negative regulation of phosphorus metabolic process	1.52e-04
MET	GO:0005978	glycogen biosynthetic process	1.72e-04
MET	GO:0009250	glucan biosynthetic process	1.72e-04
MET	GO:0032881	regulation of polysaccharide metabolic process	1.72e-04
MET	GO:0016051	carbohydrate biosynthetic process	4.12e-04
MET	GO:0000271	polysaccharide biosynthetic process	4.65e-04
MET	GO:0005977	glycogen metabolic process	6.80e-04
MET	GO:0044042	glucan metabolic process	7.00e-04
MET	GO:0031016	pancreas development	7.00e-04
MET	GO:1900543	negative regulation of purine nucleotide metabolic process	7.39e-04
MET	GO:0045980	negative regulation of nucleotide metabolic process	8.69e-04
MET	GO:0006112	energy reserve metabolic process	8.90e-04
MET	GO:0043491	phosphatidylinositol 3-kinase/protein kinase B signal transduction	9.74e-04
MET	GO:0005976	polysaccharide metabolic process	1.25e-03
MET	GO:0043255	regulation of carbohydrate biosynthetic process	1.32e-03
MET	GO:0007173	epidermal growth factor receptor signaling pathway	1.35e-03
MET	GO:0045725	positive regulation of glycogen biosynthetic process	1.35e-03
MET	GO:0015980	energy derivation by oxidation of organic compounds	1.44e-03
MET	GO:0062012	regulation of small molecule metabolic process	1.44e-03
MET	GO:0070875	positive regulation of glycogen metabolic process	1.59e-03
MET	GO:0038127	ERBB signaling pathway	1.79e-03
MET	GO:0001952	regulation of cell-matrix adhesion	1.79e-03
MET	GO:0071902	positive regulation of protein serine/threonine kinase activity	2.45e-03
MET	GO:1903578	regulation of ATP metabolic process	2.89e-03
MET	GO:0030010	establishment of cell polarity	3.21e-03
MET	GO:0070507	regulation of microtubule cytoskeleton organization	3.41e-03
MET	GO:1902410	mitotic cytokinetic process	3.41e-03
MET	GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	3.91e-03
MET	GO:0043410	positive regulation of MAPK cascade	4.19e-03
MET	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	4.21e-03
MET	GO:0001667	ameboidal-type cell migration	4.74e-03
MET	GO:0006109	regulation of carbohydrate metabolic process	4.74e-03
MET	GO:0035305	negative regulation of dephosphorylation	5.05e-03
MET	GO:0031334	positive regulation of protein-containing complex assembly	5.26e-03

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Related Drugs to CAV1_MET

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning CAV1-MET and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1	Fusion gene - drug pair 2	PMID	Publication date	DOI	Study title
CAV1-MET AND Crizotinib	CAV1-MET AND Osimertinib	31122565	2019-6	10.1016/j.jtho.2019.01.025	A Novel CAV1-MET Fusion in SCLC Transformation Responds to Crizotinib and Osimertinib Treatment.

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Related Diseases to CAV1_MET

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

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Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date