| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Kinase Fusion Gene:CBL_MST1R |
Kinase Fusion Protein Summary |
 Kinase Fusion gene summary |
| Kinase Fusion partner gene information | Kinase Fusion gene name: CBL_MST1R | KinaseFusionDB ID: KFG941 | FusionGDB2.0 ID: KFG941 | Hgene | Tgene | Gene symbol | CBL | MST1R | Gene ID | 867 | 4486 | |
| Gene name | Cbl proto-oncogene | macrophage stimulating 1 receptor | ||||||||||
| Synonyms | C-CBL|CBL2|FRA11B|NSLL|RNF55 | CD136|CDw136|NPCA3|PTK8|RON|SEA|p185-Ron | ||||||||||
| Cytomap | 11q23.3 | 3p21.31 | ||||||||||
| Type of gene | protein-coding | protein-coding | ||||||||||
| Description | E3 ubiquitin-protein ligase CBLCas-Br-M (murine) ecotropic retroviral transforming sequenceCbl proto-oncogene, E3 ubiquitin protein ligaseRING finger protein 55RING-type E3 ubiquitin transferase CBLcasitas B-lineage lymphoma proto-oncogenefragile si | macrophage-stimulating protein receptorMSP receptorPTK8 protein tyrosine kinase 8S13 avian erythroblastosis oncogene homologS13 erythroblastosis oncogene homologc-met-related tyrosine kinase | ||||||||||
| Modification date | 20240407 | 20240411 | ||||||||||
| UniProtAcc | Q75N03 | Q04912 | ||||||||||
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000264033, | ENST00000296474, ENST00000344206, | |||||||||
| Context (manual curation of fusion genes in KinaseFusionDB) | PubMed: CBL [Title/Abstract] AND MST1R [Title/Abstract] AND fusion [Title/Abstract] | |||||||||||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ||||||||||||
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CBL | GO:0016567 | protein ubiquitination | 17974561 |
| Tgene | MST1R | GO:0009615 | response to virus | 12676986 |
| Tgene | MST1R | GO:0043406 | positive regulation of MAP kinase activity | 12676986 |
| Tgene | MST1R | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | 12676986 |
| Kinase Fusion gene breakpoints across CBL (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Kinase Fusion gene breakpoints across MST1R (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
Top |
Kinase Fusion Gene Sample Information |
| Kinase Fusion gene information. |
| Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Sample | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp |
| CCLE | SNU-C5 | CBL | chr11 | 119142591 | MST1R | chr3 | 49928083 |
Top |
Kinase Fusion ORF Analysis |
| Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Seq length (transcript) | Seq length (amino acids) |
Top |
Kinase Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq |
Multiple Sequence Alignment of All Fusion Protein Isoforms |
Top |
Kinase Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:/chr3:) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CBL | MST1R |
| FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity). Targets CDH1 for endocytosis and degradation (By similarity). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Its function in the WMM complex is unknown (PubMed:29507755). {ECO:0000250|UniProtKB:Q9JIY2, ECO:0000269|PubMed:29507755}. | FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand. {ECO:0000269|PubMed:18836480, ECO:0000269|PubMed:7939629, ECO:0000269|PubMed:9764835}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
| - Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt). |
| Partner | Hgeneene | Hbp | Tgeneene | Tbp | ENST | BPexon | TotalExon | Protein feature loci | BPloci | TotalLen | Feature | Note |
Top |
Kinase-Substrate Information of CBL_MST1R |
| Phosphorylation target of the kinase (phosphosite, 03-17-2024) |
| Kinase | Kinase UniProt Acc | Kinase species | Substrate | Substrate UniProt Acc | Substrate phosphorylated residues | Substrate phosphorylated sites (+/-7AA) | Domain |
| MST1R | Q04912 | human | ABL1 | P00519 | Y393 | RLMtGDtytAHAGAk | PK_Tyr_Ser-Thr |
| MST1R | Q04912 | human | MET | P08581 | Y1349 | stFIGEHyVHVNAty | |
| MST1R | Q04912 | human | ABL1 | P00519 | Y226 | KRNKPtVyGVsPNyD | |
| MST1R | Q04912 | human | GJB1 | P08034 | Y243 | GHRLsPEyKQNEINk | |
| MST1R | Q04912 | human | MET | P08581 | Y1356 | yVHVNAtyVNVKCVA | |
| MST1R | Q04912 | human | MET | P08581 | Y1234 | RDMyDkEyysVHNkt | PK_Tyr_Ser-Thr |
| MST1R | Q04912 | human | MET | P08581 | Y1235 | DMyDkEyysVHNktG | PK_Tyr_Ser-Thr |
| Biological Network Integration of This Kinase and Substrates (GeneMANIA website) |
| Enriched GO biological processes of the phosphorylation target genes of the kinase |
| Kinase | GOID | GO term | P.adjust |
| MST1R | ID | Description | 0.00e+00 |
| MST1R | GO:0031113 | regulation of microtubule polymerization | 5.42e-03 |
| MST1R | GO:0035023 | regulation of Rho protein signal transduction | 5.42e-03 |
| MST1R | GO:0046785 | microtubule polymerization | 5.42e-03 |
| MST1R | GO:0051492 | regulation of stress fiber assembly | 5.42e-03 |
| MST1R | GO:0031110 | regulation of microtubule polymerization or depolymerization | 5.42e-03 |
| MST1R | GO:0110020 | regulation of actomyosin structure organization | 5.42e-03 |
| MST1R | GO:0032231 | regulation of actin filament bundle assembly | 5.42e-03 |
| MST1R | GO:0030038 | contractile actin filament bundle assembly | 5.42e-03 |
| MST1R | GO:0043149 | stress fiber assembly | 5.42e-03 |
| MST1R | GO:0051099 | positive regulation of binding | 5.83e-03 |
| MST1R | GO:0010595 | positive regulation of endothelial cell migration | 5.83e-03 |
| MST1R | GO:0031109 | microtubule polymerization or depolymerization | 5.83e-03 |
| MST1R | GO:0007266 | Rho protein signal transduction | 5.83e-03 |
| MST1R | GO:0034614 | cellular response to reactive oxygen species | 6.11e-03 |
| MST1R | GO:0048754 | branching morphogenesis of an epithelial tube | 6.11e-03 |
| MST1R | GO:0051017 | actin filament bundle assembly | 6.11e-03 |
| MST1R | GO:0070507 | regulation of microtubule cytoskeleton organization | 6.11e-03 |
| MST1R | GO:0061572 | actin filament bundle organization | 6.11e-03 |
| MST1R | GO:1902905 | positive regulation of supramolecular fiber organization | 6.14e-03 |
| MST1R | GO:0010634 | positive regulation of epithelial cell migration | 6.14e-03 |
| MST1R | GO:0046578 | regulation of Ras protein signal transduction | 6.14e-03 |
| MST1R | GO:0051495 | positive regulation of cytoskeleton organization | 6.14e-03 |
| MST1R | GO:0061138 | morphogenesis of a branching epithelium | 6.14e-03 |
| MST1R | GO:0001763 | morphogenesis of a branching structure | 6.47e-03 |
| MST1R | GO:0032271 | regulation of protein polymerization | 6.47e-03 |
| MST1R | GO:0000302 | response to reactive oxygen species | 6.47e-03 |
| MST1R | GO:0031032 | actomyosin structure organization | 6.47e-03 |
| MST1R | GO:0010594 | regulation of endothelial cell migration | 7.69e-03 |
| MST1R | GO:0006909 | phagocytosis | 7.82e-03 |
| MST1R | GO:0034599 | cellular response to oxidative stress | 8.65e-03 |
| MST1R | GO:0032886 | regulation of microtubule-based process | 8.65e-03 |
| MST1R | GO:0051098 | regulation of binding | 8.65e-03 |
| MST1R | GO:0110053 | regulation of actin filament organization | 9.11e-03 |
| MST1R | GO:0043542 | endothelial cell migration | 9.42e-03 |
| MST1R | GO:0051258 | protein polymerization | 9.42e-03 |
| MST1R | GO:0010632 | regulation of epithelial cell migration | 9.48e-03 |
| MST1R | GO:0051056 | regulation of small GTPase mediated signal transduction | 9.48e-03 |
| MST1R | GO:0062197 | cellular response to chemical stress | 1.07e-02 |
| MST1R | GO:0060562 | epithelial tube morphogenesis | 1.11e-02 |
| MST1R | GO:0032956 | regulation of actin cytoskeleton organization | 1.11e-02 |
| MST1R | GO:0033674 | positive regulation of kinase activity | 1.11e-02 |
| MST1R | GO:0007265 | Ras protein signal transduction | 1.11e-02 |
| MST1R | GO:0010506 | regulation of autophagy | 1.18e-02 |
| MST1R | GO:0010631 | epithelial cell migration | 1.24e-02 |
| MST1R | GO:0090132 | epithelium migration | 1.24e-02 |
| MST1R | GO:0032970 | regulation of actin filament-based process | 1.24e-02 |
| MST1R | GO:0090130 | tissue migration | 1.24e-02 |
| MST1R | GO:1902903 | regulation of supramolecular fiber organization | 1.27e-02 |
| MST1R | GO:0006979 | response to oxidative stress | 1.31e-02 |
Top |
Related Drugs to CBL_MST1R |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
| Distribution of the number of studies mentioning CBL-MST1R and kinase inhibitors the PubMed Abstract (04-01-2024) |
| Fusion gene - drug pair 1 | Fusion gene - drug pair 2 | PMID | Publication date | DOI | Study title |
Top |
Related Diseases to CBL_MST1R |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Related diseases from the literature mentioned this fusion gene and drug. (PubMed, 04-01-2024) |
| MeSH ID | MeSH term |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CBL | C3150803 | NOONAN SYNDROME-LIKE DISORDER WITH OR WITHOUT JUVENILE MYELOMONOCYTIC LEUKEMIA | 8 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
| Hgene | CBL | C0349639 | Juvenile Myelomonocytic Leukemia | 5 | CTD_human;GENOMICS_ENGLAND;ORPHANET |
Top |
Clinical Trials of the Found Drugs/Small Molecules |
| Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024) |
| Clinical Trials from clinicaltrials.gov (06-17-2024) |
| Fusion Gene | Kinase Inhibitor | NCT ID | Study Status | Phases | Disease | # Enrolment | Date |
Copyright 2024-Present -The University of Texas Health Science Center at Houston
Web File Viewing | Emergency Information |Campus Carry|Site Policies |