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	Kinase Fusion Gene Summary
	Kinase Fusion Gene Sample Information
	Kinase Fusion ORF Analysis
	Kinase Fusion Amino Acid Sequences
	Multiple Sequence Alignment of All Fusion Protein Isoforms
	Kinase Fusion Protein Functional Features
	Kinase Fusion Protein Structures
	Comparison of Fusion Protein Isoforms
	Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB
	pLDDT Scores and Difference Analysis of pLDDT Scores Between the Active Sites (Best) and Non-Active Sites.
	Ramachandran Plot of Kinase Fusion Protein Structure
	Potential Active Site Information
	Virtual Screening Results
	Kinase-Substrate Information
	Related Drugs with This Kinase Fusion Protein
	Related Disease with This Kinase Fusion Protein
	Clinical Trials of the Found Drugs/Small Molecules

Kinase Fusion Gene:ABR_SLC43A2

Kinase Fusion Protein Summary

Kinase Fusion gene summary

Kinase Fusion partner gene information	Kinase Fusion gene name: ABR_SLC43A2
	KinaseFusionDB ID: KFG95
	FusionGDB2.0 ID: KFG95
		Hgene	Tgene
	Gene symbol	ABR	SLC43A2
	Gene ID	29	124935
	Gene name	ABR activator of RhoGEF and GTPase	solute carrier family 43 member 2
	Synonyms	MDB	LAT4
	Cytomap	17p13.3	17p13.3
	Type of gene	protein-coding	protein-coding
	Description	active breakpoint cluster region-related proteinABR, RhoGEF and GTPase activating proteinactive BCR-related	large neutral amino acids transporter small subunit 4L-type amino acid transporter 4solute carrier family 43 (amino acid system L transporter), member 2
	Modification date	20240302	20240411
	UniProtAcc	Q9P1F3	Q8N370
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000302538, ENST00000544583, ENST00000572441, ENST00000574437, ENST00000291107, ENST00000543210, ENST00000536794, ENST00000573895,	ENST00000301335, ENST00000571650, ENST00000382147, ENST00000412517, ENST00000574274,
Context (manual curation of fusion genes in KinaseFusionDB)	PubMed: ABR [Title/Abstract] AND SLC43A2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABR	GO:0090630	activation of GTPase activity	7479768
Tgene	SLC43A2	GO:0015818	isoleucine transport	15659399
Tgene	SLC43A2	GO:0015820	L-leucine transport	15659399
Tgene	SLC43A2	GO:0015821	methionine transport	15659399
Tgene	SLC43A2	GO:0015823	phenylalanine transport	30379325
Tgene	SLC43A2	GO:0051956	negative regulation of amino acid transport	26305885
Tgene	SLC43A2	GO:1905533	negative regulation of L-leucine import across plasma membrane	26305885

Kinase Fusion gene breakpoints across ABR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Kinase Fusion gene breakpoints across SLC43A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Kinase Fusion Gene Sample Information

Kinase Fusion gene information.

Kinase Fusion gene information from four resources (ChiTars 5.0, ChimerDB 4.0, COSMIC, and CCLE)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Sample	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp
CCLE	Daoy	ABR	chr17	970317	SLC43A2	chr17	1489345
CCLE	Daoy	ABR	chr17	960238	SLC43A2	chr17	1489345
CCLE	Daoy	ABR	chr17	970317	SLC43A2	chr17	1486630

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Kinase Fusion ORF Analysis

Kinase Fusion information from ORFfinder translation from full-length transcript sequence from KinaseFusionDB.

Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Seq length (transcript)	Seq length (amino acids)
ENST00000544583	ENST00000301335	ABR	chr17	970317	SLC43A2	chr17	1489345	8613	497
ENST00000302538	ENST00000301335	ABR	chr17	960238	SLC43A2	chr17	1489345	8602	705

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Kinase Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from KinaseFusionDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>Henst_Tenst_Hgene_Hchr_Hbp_Tgene_Tchr_Tbp_length(fusion AA)_AAseq

>ENST00000544583_ENST00000301335_ABR_chr17_970317_SLC43A2_chr17_1489345_length(amino acids)=497
MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS
AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL
QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV
QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE
DGGVEANSFWISLLRAEIFIFMSSSSWSGKGCTWGLASDSSGDGNTRSARGMYHLQSYCWCFPAEVFFSLAHSRTSVKRKTCRSFRELSD

--------------------------------------------------------------

>ENST00000302538_ENST00000301335_ABR_chr17_960238_SLC43A2_chr17_1489345_length(amino acids)=705
MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE
MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ
LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA
LRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP
EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW
REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDA
NQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISAL

--------------------------------------------------------------

Multiple Sequence Alignment of All Fusion Protein Isoforms

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Kinase Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:/chr17:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABR Q9P1F3	SLC43A2 Q8N370
	FUNCTION: Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine (PubMed:30379325, PubMed:15659399). The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent (PubMed:15659399). {ECO:0000269\|PubMed:15659399, ECO:0000269\|PubMed:30379325}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained domain in the 5'-partner of fusion protein (protein functional feature from UniProt).

449458449495348394348357458495

Partner	Hgeneene	Hbp	Tgeneene	Tbp	ENST	BPexon	TotalExon	Protein feature loci	BPloci	TotalLen	Feature	Note
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	12	22	91_284	1	814	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	12	22	91_284	1	823	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	13	23	91_284	1	814	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	13	23	91_284	1	860	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	970317	SLC43A2	1489345	ENST00000544583	10	23	91_284	1	814	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	970317	SLC43A2	1489345	ENST00000544583	10	23	91_284	1	860	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	970317	SLC43A2	1489345	ENST00000544583	9	22	91_284	1	814	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	970317	SLC43A2	1489345	ENST00000544583	9	22	91_284	1	823	Domain	Note=DH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00062
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	12	22	301_459	1	823	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00145
Hgene	ABR	960238	SLC43A2	1489345	ENST00000302538	13	23	301_459	1	860	Domain	Note=PH;Ontology_term=ECO:0000255;evidence=ECO:0000255\|PROSITE-ProRule:PRU00145

- Retained domain in the 3'-partner of fusion protein (protein functional feature from UniProt).

Partner

Hgeneene

Hbp

Tgeneene

Tbp

ENST

BPexon

TotalExon

Protein feature loci

BPloci

TotalLen

Feature

Note

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Kinase Fusion Protein Structures

CIF files of the predicted kinase fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Kinase Fusion protein CIF link (fusion AA seq ID in KinaseFusionDB)	Henst	Tenst	Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	AA seq	Len(AA seq)
PDB file >>>14_ABR_SLC43A2	ENST00000302538	ENST00000301335	ABR	chr17	960238	SLC43A2	chr17	1489345	MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA LRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDA NQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISAL	705
3D view using mol* of 14_ABR_SLC43A2

PDB file >>>HKFP_16_ABR_SLC43A2	ENST00000544583	ENST00000301335	ABR	chr17	970317	SLC43A2	chr17	1489345	MAGEGVGARRGRDSASLCPQAGTAVGMQPRGRWQAGDGSPLCFGKRQNPDTGGRAPACRAFLAPAAGTTETPGPGSPGGGRAKSGQPLRS AGENARVRGPLPSFHHRAPRQGPGRERERWHGDGEGPGGAWGTLEGQDRGQSLKHRQETAVPRRQPLHEGLLVGRAVDFEEEFVILLPLL QLPLQLAPVADQVEREAEAQQAEKEQPHVHPQRVSLERTHHGQKQRLLQKGEERADQRLQSREAAELGGGVHGSVQAPDSGVDESSHDCV QDEGEDLERQVGNEAGHPKAHEQQVGEGEGPHGISDLLDLPVPLLLFLLALVGVFLLGLLGGVFTLLQPPVHDVANDGGRQQAQQLEHAE DGGVEANSFWISLLRAEIFIFMSSSSWSGKGCTWGLASDSSGDGNTRSARGMYHLQSYCWCFPAEVFFSLAHSRTSVKRKTCRSFRELSD	497_ABR_SLC43A2
PDB file >>>HKFP_17_ABR_SLC43A2	ENST00000302538	ENST00000301335	ABR	chr17	960238	SLC43A2	chr17	1489345	MEPLSHRGLPRLSWIDTLYSNFSYGTDEYDGEGNEEQKGPPEGSETMPYIDESPTMSPQLSARSQGGGDGVSPTPPEGLAPGVEAGKGLE MRKLVLSGFLASEEIYINQLEALLLPMKPLKATATTSQPVLTIQQIETIFYKIQDIYEIHKEFYDNLCPKVQQWDSQVTMGHLFQKLASQ LGVYKAFVDNYKVALETAEKCSQSNNQFQKISEELKVKGPKDSKDSHTSVTMEALLYKPIDRVTRSTLVLHDLLKHTPVDHPDYPLLQDA LRISQNFLSSINEDIDPRRTAVTTPKGETRQLVKDGFLVEVSESSRKLRHVFLFTDVLLCAKLKKTSAGKHQQYDCKWYIPLADLVFPSP EESEASPQVHPFPDHELEDMKMKISALKSEIQKEKANKGQSRAIERLKKKMFENEFLLLLNSPTIPFRIHNRNGKSYLFLLSSDYERSEW REAIQKLQKKDLQAFVLSSVELQVLTGSCFKLRTVHNIPVTSNKDVGLYTSIFGVLQLLCLLTAPVIGYIMDWRLKECEDASEEPEEKDA NQGEKKKKKRDRQIQKITNAMRAFAFTNLLLVGFGVTCLIPNLPLQILSFILHTIVRGFIHSAVGGLYAAVYPSTQFGSLTGLQSLISAL	705_ABR_SLC43A2
3D view using mol* of HKFP_17_ABR_SLC43A2

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Comparison of Fusion Protein Isoforms

Superimpose the 3D Structures Among All Fusion Protein Isoforms
* Download the pdb file and open it from the molstar online viewer.

3D view using mol* of viewer/superimpose_isoforms/HKFP_16_ABR_SLC43A2_vs_HKFP_17_ABR_SLC43A2_superimposed.pdb.html

Comparison of the Secondary Structures of Fusion Protein Isoforms

./secondary_str/HKFP_16_ABR_SLC43A2_vs_HKFP_17_ABR_SLC43A2.png

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Comparison of Fusion Protein Sequences/Structures with Known Sequences/Structures from PDB

ABR_SLC43A2 does not have any known PDB structures.

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pLDDT score distribution

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
* The blue color at the bottom marks the best active site residues.

14_ABR_SLC43A2.png

HKFP_17_ABR_SLC43A2.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Kinase Fusion AA seq ID in KinaseFusionDB	Site score	Size	Dscore	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
HKFP_17_ABR_SLC43A2	1.04	970	1.077	3327.1	0.578	0.716	0.891	0.729	0.897	0.813	0.885	Chain A: 5,6,7,8,9,10,11,12,13,14,15,16,17,18,49,5 1,53,54,55,56,57,58,59,60,87,90,91,94,95,98,99,188 ,189,191,192,233,234,237,238,240,244,249,252,255,2 56,278,281,282,284,285,286,287,288,289,290,292,293 ,301,302,304,306,307,308,309,316,358,359,360,363,3 66,367,368,369,371,381,384,418,419,422,423,424,425 ,426,427,428,440,441,442,443,444,445,446,447,448,4 51,452,455,456,459,478,480,481,482,483,484,485,486 ,487,489,490,491,492,493,494,495,496,499,500,503,5 71,574,575,577,578,579,580,581,582,583,584,585,586 ,587,588,589,590,591,593,596,597,600,635,638,639,6 42,643,647,648,649,650,651,653,654,657,658,661

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Ramachandran Plot of Kinase Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

14_ABR_SLC43A2_ramachandran.png

HKFP_17_ABR_SLC43A2_ramachandran.png

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Virtual Screening Results

Distribution of the average docking score across all approved kinase inhibitors.
Distribution of the number of occurrence across all approved kinase inhibitors.

5'-kinase fusion protein case

3'-kinase fusion protein case

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Drug information from DrugBank of the top 20 interacting small molecules.
* The detailed information of individual kinase inhibitors are available in the download page.

Fusion gene name info	Drug	Docking score	Glide g score	Glide energy
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Tepotinib	-5.99054	-5.99164	-45.8184
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Upadacitinib	-5.9785900000000005	-5.97959	-36.4806
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Ripretinib	-5.71479	-5.72179	-44.312
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Ripretinib	-5.71479	-5.72179	-44.312
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Pralsetinib	-5.62488	-5.71638	-50.2363
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Regorafenib	-5.56277	-5.56277	-41.8974
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Temsirolimus	-5.56153	-5.5629300000000015	-46.4171
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Tepotinib	-5.49934	-5.50044	-52.1698
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Larotrectinib	-5.48227	-5.48227	-42.71100000000001
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Larotrectinib	-5.46199	-5.46199	-42.9962
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Brigatinib	-5.43014	-5.44364	-42.8214
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Brigatinib	-5.43014	-5.44364	-42.8214
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Pacritinib	-5.4294400000000005	-5.43454	-38.4831
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Dacomitinib	-5.4235	-5.5318	-37.5757
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Dacomitinib	-5.4235	-5.5318	-37.5757
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Infigratinib	-5.41835	-5.98515	-43.7316
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Infigratinib	-5.41835	-5.98515	-43.7316
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Infigratinib	-5.41835	-5.98515	-43.7316
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Temsirolimus	-5.38215	-5.38355	-58.3003
HKFP_17_ABR_SLC43A2_vsw_2-DOCK_HTVS_1-001	Upadacitinib	-5.342969999999998	-5.34397	-33.8786
14_ABR_SLC43A2-DOCK_HTVS_1-001	Nilotinib	-7.920789999999999	-8.84559	-53.6685
14_ABR_SLC43A2-DOCK_HTVS_1-001	Nilotinib	-7.920789999999999	-8.84559	-53.6685
14_ABR_SLC43A2-DOCK_HTVS_1-001	Lapatinib	-7.760039999999999	-7.848839999999999	-57.7263
14_ABR_SLC43A2-DOCK_HTVS_1-001	Lapatinib	-7.7583899999999995	-7.847189999999999	-57.7029
14_ABR_SLC43A2-DOCK_HTVS_1-001	Ripretinib	-7.53718	-7.54418	-50.3616
14_ABR_SLC43A2-DOCK_HTVS_1-001	Ripretinib	-7.53718	-7.54418	-50.3616
14_ABR_SLC43A2-DOCK_HTVS_1-001	Tucatinib	-7.52908	-7.90428	-49.2521
14_ABR_SLC43A2-DOCK_HTVS_1-001	Capmatinib	-7.52425	-7.52985	-48.1218
14_ABR_SLC43A2-DOCK_HTVS_1-001	Belumosudil	-7.46897	-7.4766699999999995	-51.2583
14_ABR_SLC43A2-DOCK_HTVS_1-001	Netarsudil	-7.418889999999999	-7.429989999999999	-50.4288
14_ABR_SLC43A2-DOCK_HTVS_1-001	Netarsudil	-7.418889999999999	-7.429989999999999	-50.4288
14_ABR_SLC43A2-DOCK_HTVS_1-001	Midostaurin	-7.265560000000001	-7.265560000000001	-43.8565
14_ABR_SLC43A2-DOCK_HTVS_1-001	Midostaurin	-7.247539999999999	-7.247539999999999	-44.8447
14_ABR_SLC43A2-DOCK_HTVS_1-001	Netarsudil	-7.16781	-7.178910000000001	-50.5071
14_ABR_SLC43A2-DOCK_HTVS_1-001	Netarsudil	-7.16781	-7.178910000000001	-50.5071
14_ABR_SLC43A2-DOCK_HTVS_1-001	Ponatinib	-7.090210000000001	-7.296810000000001	-47.6717
14_ABR_SLC43A2-DOCK_HTVS_1-001	Ponatinib	-7.090210000000001	-7.296810000000001	-47.6717
14_ABR_SLC43A2-DOCK_HTVS_1-001	Ponatinib	-7.090210000000001	-7.296810000000001	-47.6717
14_ABR_SLC43A2-DOCK_HTVS_1-001	Erdafitinib	-7.064489999999999	-7.06469	-49.8213
14_ABR_SLC43A2-DOCK_HTVS_1-001	Avapritinib	-7.0624899999999995	-7.393789999999999	-49.891999999999996

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Kinase-Substrate Information of ABR_SLC43A2

Phosphorylation target of the kinase
(phosphosite, 03-17-2024)

Kinase

Kinase UniProt Acc

Kinase species

Substrate

Substrate UniProt Acc

Substrate phosphorylated residues

Substrate phosphorylated sites (+/-7AA)

Domain

Biological Network Integration of This Kinase and Substrates
(GeneMANIA website)

Enriched GO biological processes of the phosphorylation target genes of the kinase

Kinase

GOID

GO term

P.adjust

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Related Drugs to ABR_SLC43A2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Distribution of the number of studies mentioning ABR-SLC43A2 and kinase inhibitors the PubMed Abstract (04-01-2024)

Fusion gene - drug pair 1

Fusion gene - drug pair 2

PMID

Publication date

DOI

Study title

Top

Related Diseases to ABR_SLC43A2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Related diseases from the literature mentioned this fusion gene and drug.
(PubMed, 04-01-2024)

MeSH ID

MeSH term

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

Top

Clinical Trials of the Found Drugs/Small Molecules

Statistics of the Clinical Trials of the Found Kinase Inibitors from clinicaltrials.gov (06-17-2024)

Clinical Trials from clinicaltrials.gov (06-17-2024)

Fusion Gene

Kinase Inhibitor

NCT ID

Study Status

Phases

Disease

# Enrolment

Date