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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:CYTH3-MAD1L1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CYTH3-MAD1L1
FusionPDB ID: 21162
FusionGDB2.0 ID: 21162
HgeneTgene
Gene symbol

CYTH3

MAD1L1

Gene ID

9265

8379

Gene namecytohesin 3mitotic arrest deficient 1 like 1
SynonymsARNO3|GRP1|PSCD3|cytohesin-3MAD1|PIG9|TP53I9|TXBP181
Cytomap

7p22.1

7p22.3

Type of geneprotein-codingprotein-coding
Descriptioncytohesin-3ARF nucleotide-binding site opener 3PH, SEC7 and coiled-coil domain-containing protein 3general receptor of phosphoinositides 1pleckstrin homology, Sec7 and coiled-coil domains 3mitotic spindle assembly checkpoint protein MAD1MAD1 mitotic arrest deficient like 1MAD1-like protein 1mitotic arrest deficient 1-like protein 1mitotic checkpoint MAD1 protein homologmitotic-arrest deficient 1, yeast, homolog-like 1tax-binding prote
Modification date2020031320200313
UniProtAcc

O43739

Main function of 5'-partner protein: FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Plays a role in the epithelial polarization (By similarity). {ECO:0000250|UniProtKB:O08967, ECO:0000269|PubMed:23940353, ECO:0000269|PubMed:9707577}.

Q9Y6D9

Main function of 5'-partner protein: FUNCTION: Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate (PubMed:10049595, PubMed:20133940, PubMed:29162720). Forms a heterotetrameric complex with the closed conformation form of MAD2L1 (C-MAD2) at unattached kinetochores during prometaphase, recruits an open conformation of MAD2L1 (O-MAD2) and promotes the conversion of O-MAD2 to C-MAD2, which ensures mitotic checkpoint signaling (PubMed:29162720). {ECO:0000269|PubMed:10049595, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:29162720}.
Ensembl transtripts involved in fusion geneENST idsENST00000350796, ENST00000396741, 
ENST00000488964, 		ENST00000486340, 
ENST00000265854, ENST00000399654, 
ENST00000402746, ENST00000406869, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 10 X 8=96023 X 16 X 12=4416
# samples 1437
** MAII scorelog2(14/960*10)=-2.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(37/4416*10)=-3.57714299626186
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: CYTH3 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: CYTH3 [Title/Abstract] AND MAD1L1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CYTH3(6210833)-MAD1L1(1938026), # samples:3
Anticipated loss of major functional domain due to fusion event.CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CYTH3-MAD1L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAD1L1

GO:0007094

mitotic spindle assembly checkpoint

18981471

TgeneMAD1L1

GO:0090235

regulation of metaphase plate congression

20133940



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:6210833/chr7:1938026)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across CYTH3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAD1L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000350796CYTH3chr76210833-ENST00000402746MAD1L1chr71938026-1325699321048338
ENST00000350796CYTH3chr76210833-ENST00000399654MAD1L1chr71938026-1325699321048338
ENST00000350796CYTH3chr76210833-ENST00000406869MAD1L1chr71938026-1325699321048338
ENST00000350796CYTH3chr76210833-ENST00000265854MAD1L1chr71938026-1308699321048338
ENST00000396741CYTH3chr76210833-ENST00000402746MAD1L1chr71938026-1084458145807220
ENST00000396741CYTH3chr76210833-ENST00000399654MAD1L1chr71938026-1084458145807220
ENST00000396741CYTH3chr76210833-ENST00000406869MAD1L1chr71938026-1084458145807220
ENST00000396741CYTH3chr76210833-ENST00000265854MAD1L1chr71938026-1067458145807220
ENST00000350796CYTH3chr76210165-ENST00000402746MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210165-ENST00000399654MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210165-ENST00000406869MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210165-ENST00000265854MAD1L1chr71938026-1569960321309425
ENST00000396741CYTH3chr76210165-ENST00000402746MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210165-ENST00000399654MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210165-ENST00000406869MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210165-ENST00000265854MAD1L1chr71938026-13287191451068307
ENST00000350796CYTH3chr76210166-ENST00000402746MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210166-ENST00000399654MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210166-ENST00000406869MAD1L1chr71938026-1586960321309425
ENST00000350796CYTH3chr76210166-ENST00000265854MAD1L1chr71938026-1569960321309425
ENST00000396741CYTH3chr76210166-ENST00000402746MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210166-ENST00000399654MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210166-ENST00000406869MAD1L1chr71938026-13457191451068307
ENST00000396741CYTH3chr76210166-ENST00000265854MAD1L1chr71938026-13287191451068307

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000350796ENST00000402746CYTH3chr76210833-MAD1L1chr71938026-0.0089438410.9910562
ENST00000350796ENST00000399654CYTH3chr76210833-MAD1L1chr71938026-0.0089438410.9910562
ENST00000350796ENST00000406869CYTH3chr76210833-MAD1L1chr71938026-0.0089438410.9910562
ENST00000350796ENST00000265854CYTH3chr76210833-MAD1L1chr71938026-0.0087647590.99123526
ENST00000396741ENST00000402746CYTH3chr76210833-MAD1L1chr71938026-0.0280594450.9719406
ENST00000396741ENST00000399654CYTH3chr76210833-MAD1L1chr71938026-0.0280594450.9719406
ENST00000396741ENST00000406869CYTH3chr76210833-MAD1L1chr71938026-0.0280594450.9719406
ENST00000396741ENST00000265854CYTH3chr76210833-MAD1L1chr71938026-0.0261651760.9738348
ENST00000350796ENST00000402746CYTH3chr76210165-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000399654CYTH3chr76210165-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000406869CYTH3chr76210165-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000265854CYTH3chr76210165-MAD1L1chr71938026-0.0115138130.9884862
ENST00000396741ENST00000402746CYTH3chr76210165-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000399654CYTH3chr76210165-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000406869CYTH3chr76210165-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000265854CYTH3chr76210165-MAD1L1chr71938026-0.017785330.9822146
ENST00000350796ENST00000402746CYTH3chr76210166-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000399654CYTH3chr76210166-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000406869CYTH3chr76210166-MAD1L1chr71938026-0.0117664050.98823357
ENST00000350796ENST00000265854CYTH3chr76210166-MAD1L1chr71938026-0.0115138130.9884862
ENST00000396741ENST00000402746CYTH3chr76210166-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000399654CYTH3chr76210166-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000406869CYTH3chr76210166-MAD1L1chr71938026-0.018612740.98138726
ENST00000396741ENST00000265854CYTH3chr76210166-MAD1L1chr71938026-0.017785330.9822146

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for CYTH3-MAD1L1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
CYTH3chr76210165MAD1L1chr71938026719191FFNPDREGWLLKLELKKQVESAELKN
CYTH3chr76210165MAD1L1chr71938026960309FFNPDREGWLLKLELKKQVESAELKN
CYTH3chr76210166MAD1L1chr71938026719191FFNPDREGWLLKLELKKQVESAELKN
CYTH3chr76210166MAD1L1chr71938026960309FFNPDREGWLLKLELKKQVESAELKN
CYTH3chr76210833MAD1L1chr71938026458104RYCLCNPGVFQSTELKKQVESAELKN
CYTH3chr76210833MAD1L1chr71938026699222RYCLCNPGVFQSTELKKQVESAELKN

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Potential FusionNeoAntigen Information of CYTH3-MAD1L1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
CYTH3-MAD1L1_6210165_1938026.msa
CYTH3-MAD1L1_6210833_1938026.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
CYTH3-MAD1L1chr76210165chr71938026960HLA-B40:06LELKKQVESA0.99060.86211222
CYTH3-MAD1L1chr76210165chr71938026960HLA-B40:03REGWLLKLEL0.9490.5374515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B45:01TELKKQVES0.9810.89481221
CYTH3-MAD1L1chr76210833chr71938026699HLA-B50:02TELKKQVES0.94930.66231221
CYTH3-MAD1L1chr76210833chr71938026699HLA-A30:08GVFQSTELK0.92230.7587716
CYTH3-MAD1L1chr76210833chr71938026699HLA-B41:01TELKKQVES0.58210.85761221
CYTH3-MAD1L1chr76210833chr71938026699HLA-B45:01TELKKQVESA0.99330.9531222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B50:02TELKKQVESA0.97960.75071222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B35:03NPGVFQSTEL0.83350.8164515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B41:01TELKKQVESA0.820.89951222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B50:01TELKKQVESA0.80030.77581222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B35:02NPGVFQSTEL0.64280.9105515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B35:04NPGVFQSTEL0.64280.9105515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B40:06TELKKQVES0.94890.62771221
CYTH3-MAD1L1chr76210833chr71938026699HLA-B40:06TELKKQVESA0.99110.80171222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B39:10NPGVFQSTEL0.680.8721515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B35:12NPGVFQSTEL0.64280.9105515
CYTH3-MAD1L1chr76210833chr71938026699HLA-A30:01GVFQSTELK0.92110.9184716
CYTH3-MAD1L1chr76210833chr71938026699HLA-B50:05TELKKQVESA0.80030.77581222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B50:04TELKKQVESA0.80030.77581222
CYTH3-MAD1L1chr76210833chr71938026699HLA-B67:01NPGVFQSTEL0.68310.6973515
CYTH3-MAD1L1chr76210833chr71938026699HLA-B35:09NPGVFQSTEL0.64280.9105515

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Potential FusionNeoAntigen Information of CYTH3-MAD1L1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of CYTH3-MAD1L1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1764EGWLLKLELKKQVECYTH3MAD1L1chr76210165chr71938026960
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
6679PGVFQSTELKKQVECYTH3MAD1L1chr76210833chr71938026699

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of CYTH3-MAD1L1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN1764EGWLLKLELKKQVE-7.15543-7.26883
HLA-B14:023BVN1764EGWLLKLELKKQVE-4.77435-5.80965
HLA-B52:013W391764EGWLLKLELKKQVE-6.80875-6.92215
HLA-B52:013W391764EGWLLKLELKKQVE-4.20386-5.23916
HLA-A11:014UQ21764EGWLLKLELKKQVE-7.5194-8.5547
HLA-A11:014UQ21764EGWLLKLELKKQVE-6.9601-7.0735
HLA-A24:025HGA1764EGWLLKLELKKQVE-7.52403-7.63743
HLA-A24:025HGA1764EGWLLKLELKKQVE-5.82433-6.85963
HLA-B27:056PYJ1764EGWLLKLELKKQVE-3.28285-4.31815
HLA-B44:053DX81764EGWLLKLELKKQVE-5.91172-6.94702
HLA-B44:053DX81764EGWLLKLELKKQVE-4.24346-4.35686
HLA-B14:023BVN6679PGVFQSTELKKQVE-7.9962-8.1096
HLA-B14:023BVN6679PGVFQSTELKKQVE-5.70842-6.74372
HLA-B52:013W396679PGVFQSTELKKQVE-6.83737-6.95077
HLA-B52:013W396679PGVFQSTELKKQVE-4.4836-5.5189
HLA-A11:014UQ26679PGVFQSTELKKQVE-10.0067-10.1201
HLA-A11:014UQ26679PGVFQSTELKKQVE-9.03915-10.0745
HLA-A24:025HGA6679PGVFQSTELKKQVE-6.56204-6.67544
HLA-A24:025HGA6679PGVFQSTELKKQVE-5.42271-6.45801
HLA-B44:053DX86679PGVFQSTELKKQVE-7.85648-8.89178
HLA-B44:053DX86679PGVFQSTELKKQVE-5.3978-5.5112
HLA-A02:016TDR6679PGVFQSTELKKQVE-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of CYTH3-MAD1L1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
CYTH3-MAD1L1chr76210165chr719380261222LELKKQVESATGGAGCTGAAGAAGCAGGTGGAGAGTGCCG
CYTH3-MAD1L1chr76210165chr71938026515REGWLLKLELGCGAGGGCTGGCTCCTGAAGCTGGAGCTGA
CYTH3-MAD1L1chr76210833chr719380261221TELKKQVESCAGAGCTGAAGAAGCAGGTGGAGAGTG
CYTH3-MAD1L1chr76210833chr719380261222TELKKQVESACAGAGCTGAAGAAGCAGGTGGAGAGTGCCG
CYTH3-MAD1L1chr76210833chr71938026515NPGVFQSTELACCCCGGGGTCTTCCAGTCCACAGAGCTGA
CYTH3-MAD1L1chr76210833chr71938026716GVFQSTELKGGGTCTTCCAGTCCACAGAGCTGAAGA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of CYTH3-MAD1L1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
BRCACYTH3-MAD1L1chr76210833ENST00000350796chr71938026ENST00000265854TCGA-A8-A09Q-01A
BRCACYTH3-MAD1L1chr76210165ENST00000350796chr71938026ENST00000265854TCGA-A8-A09Q

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Potential target of CAR-T therapy development for CYTH3-MAD1L1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to CYTH3-MAD1L1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CYTH3-MAD1L1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource