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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:DNAJC19-ADK

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: DNAJC19-ADK
FusionPDB ID: 23478
FusionGDB2.0 ID: 23478
HgeneTgene
Gene symbol

DNAJC19

ADK

Gene ID

131118

132

Gene nameDnaJ heat shock protein family (Hsp40) member C19adenosine kinase
SynonymsPAM18|TIM14|TIMM14AK
Cytomap

3q26.33

10q22.2|10q11-q24

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit TIM14DnaJ (Hsp40) homolog, subfamily C, member 19DnaJ-like protein subfamily C member 19homolog of yeast TIM14adenosine kinaseadenosine 5'-phosphotransferasetesticular tissue protein Li 14
Modification date2020031320200313
UniProtAcc

Q96DA6

Main function of 5'-partner protein: FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}.

P55263

Main function of 5'-partner protein: FUNCTION: ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Ensembl transtripts involved in fusion geneENST idsENST00000382564, ENST00000479269, 
ENST00000486355, ENST00000491873, 
ENST00000286621, ENST00000372734, 
ENST00000467840, ENST00000539909, 
ENST00000541550, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 3 X 2=1230 X 17 X 14=7140
# samples 364
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(64/7140*10)=-3.4797802640291
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: DNAJC19 [Title/Abstract] AND ADK [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: DNAJC19 [Title/Abstract] AND ADK [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)DNAJC19(180705811)-ADK(76285014), # samples:2
DNAJC19(180705810)-ADK(76285013), # samples:2
DNAJC19(180705810)-ADK(76349039), # samples:2
Anticipated loss of major functional domain due to fusion event.DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
DNAJC19-ADK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:180705811/chr10:76285014)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across DNAJC19 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000382564DNAJC19chr3180705810-ENST00000539909ADKchr1076349039+91730072662196
ENST00000382564DNAJC19chr3180705810-ENST00000286621ADKchr1076349039+69330072662196
ENST00000382564DNAJC19chr3180705810-ENST00000372734ADKchr1076349039+152130072662196
ENST00000382564DNAJC19chr3180705810-ENST00000541550ADKchr1076349039+75630072662196
ENST00000491873DNAJC19chr3180705810-ENST00000539909ADKchr1076349039+802185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000286621ADKchr1076349039+578185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000372734ADKchr1076349039+1406185122547141
ENST00000491873DNAJC19chr3180705810-ENST00000541550ADKchr1076349039+641185122547141

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382564ENST00000539909DNAJC19chr3180705810-ADKchr1076349039+0.0012744710.9987255
ENST00000382564ENST00000286621DNAJC19chr3180705810-ADKchr1076349039+0.0012025380.9987974
ENST00000382564ENST00000372734DNAJC19chr3180705810-ADKchr1076349039+0.0012507310.99874926
ENST00000382564ENST00000541550DNAJC19chr3180705810-ADKchr1076349039+0.0013487290.9986513
ENST00000491873ENST00000539909DNAJC19chr3180705810-ADKchr1076349039+0.0053700820.99462986
ENST00000491873ENST00000286621DNAJC19chr3180705810-ADKchr1076349039+0.0050239420.99497604
ENST00000491873ENST00000372734DNAJC19chr3180705810-ADKchr1076349039+0.0057868520.99421316
ENST00000491873ENST00000541550DNAJC19chr3180705810-ADKchr1076349039+0.0065342260.9934657

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for DNAJC19-ADK

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
DNAJC19chr3180705810ADKchr107634903918521PQVKQVFQSLPKSEAATFAREQGFET
DNAJC19chr3180705810ADKchr107634903930076PQVKQVFQSLPKSEAATFAREQGFET

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Potential FusionNeoAntigen Information of DNAJC19-ADK in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DNAJC19-ADK_180705810_76349039.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:01LPKSEAATF0.98410.848918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:08LPKSEAATF0.9760.852918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B39:06FQSLPKSEA0.95940.8413615
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:02LPKSEAATF0.95490.9516918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:05LPKSEAATF0.9510.5594918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:03LPKSEAATF0.9240.8735918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B08:01LPKSEAATF0.74820.7947918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:02LPKSEAATF0.60490.9681918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:04LPKSEAATF0.60490.9681918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B82:01LPKSEAATF0.03350.5588918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B81:01LPKSEAATF0.00860.5103918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:01SLPKSEAATF0.99880.9283818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:25SLPKSEAATF0.92480.9506818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:08SLPKSEAATF0.89370.8225818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:05SLPKSEAATF0.88740.6944818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B82:01SLPKSEAATF0.30140.5066818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B57:01QSLPKSEAATF0.99970.9881718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B58:02QSLPKSEAATF0.99880.9809718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B57:03QSLPKSEAATF0.99790.995718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:17QSLPKSEAATF0.99720.9484718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B58:01QSLPKSEAATF0.99550.9824718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:31LPKSEAATF0.98850.8191918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:21LPKSEAATF0.95260.9365918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B07:12LPKSEAATF0.79980.5175918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B42:02LPKSEAATF0.7760.8106918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B42:01LPKSEAATF0.70690.8057918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:12LPKSEAATF0.60490.9681918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B51:07LPKSEAATF0.60120.9801918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B78:01LPKSEAATF0.58330.7384918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B56:04LPKSEAATF0.57810.5297918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B51:08LPKSEAATF0.43950.5246918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B39:10LPKSEAATF0.11420.9646918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:07SLPKSEAATF0.9980.7129818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B42:02SLPKSEAATF0.89440.6264818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B42:01SLPKSEAATF0.85180.6198818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B07:12SLPKSEAATF0.79770.5495818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:23LPKSEAATF0.98630.8974918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:77LPKSEAATF0.98410.848918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:20LPKSEAATF0.98350.8781918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:24LPKSEAATF0.96120.864918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:11LPKSEAATF0.96110.9274918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:17LPKSEAATF0.94940.7315918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:30LPKSEAATF0.94940.7315918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:13LPKSEAATF0.89650.8814918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:13LPKSEAATF0.83310.8936918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B08:18LPKSEAATF0.74820.7947918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:22LPKSEAATF0.7470.5036918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B55:04LPKSEAATF0.65140.6152918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B18:04LPKSEAATF0.61710.893918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:09LPKSEAATF0.60490.9681918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B78:02LPKSEAATF0.59720.7802918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B51:06LPKSEAATF0.57950.5194918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B56:02LPKSEAATF0.57810.5297918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B51:14LPKSEAATF0.520.5112918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B08:12LPKSEAATF0.43590.8835918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B51:21LPKSEAATF0.30620.5706918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:43LPKSEAATF0.28710.8592918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:08LPKSEAATF0.27690.8595918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:11LPKSEAATF0.26670.8568918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B18:07LPKSEAATF0.24190.8524918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B18:03LPKSEAATF0.18560.8718918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B67:01LPKSEAATF0.17080.9274918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B82:02LPKSEAATF0.03350.5588918
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:27SLPKSEAATF0.99890.9402818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:135SLPKSEAATF0.99880.9233818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:11SLPKSEAATF0.99880.9151818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:125SLPKSEAATF0.99880.9283818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:08SLPKSEAATF0.99880.9063818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:33SLPKSEAATF0.99880.9283818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:34SLPKSEAATF0.99880.9283818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:24SLPKSEAATF0.99850.9685818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:50SLPKSEAATF0.99840.9714818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:43SLPKSEAATF0.99830.9074818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:35SLPKSEAATF0.99810.9107818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:12SLPKSEAATF0.99360.9476818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:30SLPKSEAATF0.9750.8279818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:11SLPKSEAATF0.95940.9329818
DNAJC19-ADKchr3180705810chr1076349039300HLA-C01:02SLPKSEAATF0.9270.9712818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B15:39SLPKSEAATF0.92230.9132818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:30SLPKSEAATF0.89130.8364818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B35:17SLPKSEAATF0.89130.8364818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B82:02SLPKSEAATF0.30140.5066818
DNAJC19-ADKchr3180705810chr1076349039300HLA-B57:10QSLPKSEAATF0.99970.9881718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B57:04QSLPKSEAATF0.99960.7809718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B58:06QSLPKSEAATF0.99910.9582718
DNAJC19-ADKchr3180705810chr1076349039300HLA-B57:02QSLPKSEAATF0.99820.958718

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Potential FusionNeoAntigen Information of DNAJC19-ADK in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
DNAJC19-ADK_180705810_76349039.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0466VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0466KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0466QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0801VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0801KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0801QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0802VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0802KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0802QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0803VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0803KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0805VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0805KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0805QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0807VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0807KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0807QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0808VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0808KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0808QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0809VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0809KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0809QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0811VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0811KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0811QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0813VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0813KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0813QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0814VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0814KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0815VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0815KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0815QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0816VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0816KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0816QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0818VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0818KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0818QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0821VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0821KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0821QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0823VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0823KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0824VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0824KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0824QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0824QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0825VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0825KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0825QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0826VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0826KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0826QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0827VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0827KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0829VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0829KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0830VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0830KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0830QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0832VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0832KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0832QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0833VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0833KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0834VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0835VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0835KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0836VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0836KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0837VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0837KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0838VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0838KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0839VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0839KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0839QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0840VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0840KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-0840QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1101VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1101KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1101QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1101QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1105VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1105KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1105QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1105QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1108VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1108KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1108QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1108QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1109VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1109KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1109QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1109QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1110VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1110KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1110QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1110QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1111VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1111KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1112VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1112KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1112QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1112QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1115VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1115KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1115QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1115QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1119VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1119KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1119QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1124VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1124KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1124QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1124QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1127VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1127KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1127QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1127QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1128VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1128KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1128QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1128QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1129VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1129KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1129QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1129QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1130VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1130KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1130QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1131VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1131KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1131QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1132VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1132KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1132QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1133VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1133KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1133QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1133QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1137VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1137KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1137QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1137QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1139VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1139KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1139QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1139QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1145VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1145KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1145QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1149VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1149KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1149QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1149QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1151VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1151KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1151QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1151QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1153VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1153KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1161VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1161KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1161QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1161QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1162VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1162KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1162QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1162QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1164VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1164KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1164QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1166VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1166KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1166QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1166QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1169VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1169KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1169QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1172KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1172VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1172QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1172QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1173VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1173KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1173QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1174VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1174KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1174QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1174QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1175VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1175KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1175QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1175QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1179KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1179VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1180VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1180KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1180QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1180QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1181VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1181KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1181QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1181QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1182VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1182KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1183VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1183KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1187VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1187KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1187QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1187QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1190VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1190KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1190QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1190QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1191VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1191KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1191QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1191QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1193VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1193KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1193QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1194VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1194KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1194QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1194QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1195VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1195KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1195QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1195QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1196VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1196KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1196QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1196QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1216VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1216KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1303VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1305VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1305KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1305QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1305QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1307VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1307KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1307QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1307QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-13100VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-13100KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-13100QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-13101VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-13101KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1310VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1310KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1312VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1312KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1313VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1313KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1314VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1314KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1314QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1314QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1321VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1321KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1321QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1326VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1326KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1326QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1326QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1330VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1330KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1330QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1336VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1337VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1337KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1337QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1346VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1346KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1346QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1347VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1347KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1347QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1349VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1349KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1349QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1350VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1350KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1350QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1350QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1355VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1355KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1355QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1356VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1356KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1356QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1356QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1360VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1360KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1360QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1360QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1362VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1362KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1362QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1362QVFQSLPKSEAATFA419
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1363VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1363KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1366VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1382VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1382KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1382QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1385KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1385VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1385QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1386KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1386VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1386QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1388VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1388KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1390VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1395VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1402VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1402KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1402QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1403VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1403KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1403QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1409VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1409KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1409QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1413VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1413KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1413QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1414VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1414KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1419VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1419KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1419QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1422VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1422KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1422QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1424KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1424VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1425VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1425KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1425QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1427KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1427VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1427QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1430VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1430KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1430QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1436VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1436KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1440VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1440KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1440QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1441VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1441KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1441QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1444VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1444KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1446VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1446KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1446QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1447KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1447VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1449VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1449KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1449QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1451VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1451KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1451QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1453VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1453KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1453QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1463VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1463KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1467KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1467VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1467QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1469VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1469KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1469QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1477VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1477KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1477QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1485VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1485KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1489VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1489KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1489QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1494VKQVFQSLPKSEAAT217
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1494KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1494QVKQVFQSLPKSEAA116
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1498KQVFQSLPKSEAATF318
DNAJC19-ADKchr3180705810chr1076349039300DRB1-1498VKQVFQSLPKSEAAT217

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Fusion breakpoint peptide structures of DNAJC19-ADK

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
2531FQSLPKSEAATFARDNAJC19ADKchr3180705810chr1076349039300

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of DNAJC19-ADK

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN2531FQSLPKSEAATFAR-7.15543-7.26883
HLA-B14:023BVN2531FQSLPKSEAATFAR-4.77435-5.80965
HLA-B52:013W392531FQSLPKSEAATFAR-6.80875-6.92215
HLA-B52:013W392531FQSLPKSEAATFAR-4.20386-5.23916
HLA-A11:014UQ22531FQSLPKSEAATFAR-7.5194-8.5547
HLA-A11:014UQ22531FQSLPKSEAATFAR-6.9601-7.0735
HLA-A24:025HGA2531FQSLPKSEAATFAR-7.52403-7.63743
HLA-A24:025HGA2531FQSLPKSEAATFAR-5.82433-6.85963
HLA-B27:056PYJ2531FQSLPKSEAATFAR-3.28285-4.31815
HLA-B44:053DX82531FQSLPKSEAATFAR-5.91172-6.94702
HLA-B44:053DX82531FQSLPKSEAATFAR-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of DNAJC19-ADK

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
DNAJC19-ADKchr3180705810chr1076349039615FQSLPKSEATTTCAAAGCCTACCAAAATCTGAAGCT
DNAJC19-ADKchr3180705810chr1076349039718QSLPKSEAATFCAAAGCCTACCAAAATCTGAAGCTGCCACTTTT
DNAJC19-ADKchr3180705810chr1076349039818SLPKSEAATFAGCCTACCAAAATCTGAAGCTGCCACTTTT
DNAJC19-ADKchr3180705810chr1076349039918LPKSEAATFCTACCAAAATCTGAAGCTGCCACTTTT

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
DNAJC19-ADKchr3180705810chr1076349039116QVKQVFQSLPKSEAACAAGTAAAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCC
DNAJC19-ADKchr3180705810chr1076349039217VKQVFQSLPKSEAATGTAAAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACT
DNAJC19-ADKchr3180705810chr1076349039318KQVFQSLPKSEAATFAAACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTT
DNAJC19-ADKchr3180705810chr1076349039419QVFQSLPKSEAATFACAAGTTTTTCAAAGCCTACCAAAATCTGAAGCTGCCACTTTTGCT

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Information of the samples that have these potential fusion neoantigens of DNAJC19-ADK

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
HNSCDNAJC19-ADKchr3180705810ENST00000382564chr1076349039ENST00000286621TCGA-CV-7103

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Potential target of CAR-T therapy development for DNAJC19-ADK

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDNAJC19chr3:180705810chr10:76349039ENST00000382564-364_2443117.0TransmembraneHelical

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to DNAJC19-ADK

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to DNAJC19-ADK

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource