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Fusion Protein:KDM4B-CHAF1A

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KDM4B-CHAF1A
	FusionPDB ID: 41799
	FusionGDB2.0 ID: 41799
		Hgene	Tgene
	Gene symbol	KDM4B	CHAF1A
	Gene ID	23030	10036
	Gene name	lysine demethylase 4B	chromatin assembly factor 1 subunit A
	Synonyms	JMJD2B\|TDRD14B	CAF-1\|CAF1\|CAF1B\|CAF1P150\|P150
	Cytomap	19p13.3	19p13.3
	Type of gene	protein-coding	protein-coding
	Description	lysine-specific demethylase 4BjmjC domain-containing histone demethylation protein 3Bjumonji domain containing 2Bjumonji domain-containing protein 2Blysine (K)-specific demethylase 4Btudor domain containing 14B	chromatin assembly factor 1 subunit ACAF-1 subunit ACAF-I 150 kDa subunitCAF-I p150CTB-50L17.7chromatin assembly factor I (150 kDa)chromatin assembly factor I p150 subunithp150
	Modification date	20200313	20200313
	UniProtAcc	O94953 Main function of 5'-partner protein: FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000269\|PubMed:16603238, ECO:0000269\|PubMed:28262558}.	Q13111 Main function of 5'-partner protein: FUNCTION: Core component of the CAF-1 complex, a complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250\|UniProtKB:Q5R1T0}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000159111, ENST00000381759, ENST00000536461, ENST00000592175,	ENST00000587368, ENST00000301280,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	30 X 16 X 14=6720	5 X 6 X 6=180
	# samples	38	7
	** MAII score	log2(38/6720*10)=-4.14438990933518 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/180*10)=-1.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: KDM4B [Title/Abstract] AND CHAF1A [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: KDM4B [Title/Abstract] AND CHAF1A [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KDM4B(5082515)-CHAF1A(4418017), # samples:2
Anticipated loss of major functional domain due to fusion event.	KDM4B-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM4B-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KDM4B-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KDM4B-CHAF1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	KDM4B	GO:0033169	histone H3-K9 demethylation	21914792
Hgene	KDM4B	GO:0070544	histone H3-K36 demethylation	21914792
Tgene	CHAF1A	GO:0006335	DNA replication-dependent nucleosome assembly	14718166
Tgene	CHAF1A	GO:0031497	chromatin assembly	8858152

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:5082515/chr19:4418017)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across KDM4B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CHAF1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000159111

KDM4B

chr19

5082515

ENST00000301280

CHAF1A

chr19

4418017

3414

1136

218

3046

942

ENST00000381759

KDM4B

chr19

5082515

ENST00000301280

CHAF1A

chr19

4418017

3403

1125

207

3035

942

ENST00000536461

KDM4B

chr19

5082515

ENST00000301280

CHAF1A

chr19

4418017

3236

958

2868

942

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000159111	ENST00000301280	KDM4B	chr19	5082515	+	CHAF1A	chr19	4418017	+	0.001380299	0.9986197
ENST00000381759	ENST00000301280	KDM4B	chr19	5082515	+	CHAF1A	chr19	4418017	+	0.001337451	0.9986626
ENST00000536461	ENST00000301280	KDM4B	chr19	5082515	+	CHAF1A	chr19	4418017	+	0.00129263	0.9987074

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for KDM4B-CHAF1A

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
KDM4B	chr19	5082515	CHAF1A	chr19	4418017	1125	305	ATLRWIDYGKVATQITKKFVKGSTEK
KDM4B	chr19	5082515	CHAF1A	chr19	4418017	1136	305	ATLRWIDYGKVATQITKKFVKGSTEK
KDM4B	chr19	5082515	CHAF1A	chr19	4418017	958	305	ATLRWIDYGKVATQITKKFVKGSTEK

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Potential FusionNeoAntigen Information of KDM4B-CHAF1A in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

KDM4B-CHAF1A_5082515_4418017.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A30:08	KVATQITKK	0.9977	0.5571	9	18
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:01	VATQITKKF	0.9972	0.9211	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A24:25	DYGKVATQI	0.9951	0.5026	6	15
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A24:20	DYGKVATQI	0.9947	0.5014	6	15
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B58:02	VATQITKKF	0.9935	0.8795	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B15:17	VATQITKKF	0.9927	0.8136	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B15:16	VATQITKKF	0.9885	0.7254	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:03	VATQITKKF	0.9874	0.9254	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B58:01	VATQITKKF	0.982	0.8328	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:01	KVATQITKKF	0.9995	0.9268	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:03	KVATQITKKF	0.9928	0.9477	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A32:13	KVATQITKKF	0.9746	0.9229	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A24:02	DYGKVATQI	0.9947	0.5014	6	15
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:08	VATQITKKF	0.9945	0.8349	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:19	VATQITKKF	0.9933	0.9722	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C15:04	VATQITKKF	0.9787	0.8543	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:07	VATQITKKF	0.9718	0.9685	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C15:06	VATQITKKF	0.9101	0.8878	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C07:95	VATQITKKF	0.7694	0.5697	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:14	VATQITKKF	0.6853	0.9507	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C12:12	VATQITKKF	0.6147	0.9217	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C12:04	VATQITKKF	0.5076	0.9862	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C06:03	VATQITKKF	0.5066	0.9883	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C02:06	VATQITKKF	0.2708	0.951	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:02	VATQITKKF	0.9981	0.9513	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A30:01	KVATQITKK	0.9976	0.7097	9	18
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:10	VATQITKKF	0.9972	0.9211	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:03	VATQITKKF	0.9967	0.9736	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:04	VATQITKKF	0.9967	0.9736	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:67	VATQITKKF	0.9955	0.9631	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B58:06	VATQITKKF	0.9949	0.8267	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:04	VATQITKKF	0.9911	0.6159	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A30:01	TQITKKFVK	0.9845	0.6246	12	21
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:17	VATQITKKF	0.9804	0.9564	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C15:09	VATQITKKF	0.9787	0.8543	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B15:13	VATQITKKF	0.9735	0.6433	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C03:05	VATQITKKF	0.9715	0.8547	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:02	VATQITKKF	0.9675	0.8899	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B15:24	VATQITKKF	0.835	0.7757	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B35:43	VATQITKKF	0.8319	0.7733	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C16:04	VATQITKKF	0.8271	0.9655	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C12:02	VATQITKKF	0.8209	0.9484	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C12:03	VATQITKKF	0.6735	0.9689	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C16:01	VATQITKKF	0.6254	0.967	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C16:02	VATQITKKF	0.5814	0.9842	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C06:02	VATQITKKF	0.5566	0.9859	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C06:17	VATQITKKF	0.5566	0.9859	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C06:08	VATQITKKF	0.3884	0.99	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C02:10	VATQITKKF	0.3878	0.9731	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-C02:02	VATQITKKF	0.3878	0.9731	10	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B57:10	KVATQITKKF	0.9995	0.9268	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B58:06	KVATQITKKF	0.9987	0.7053	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-B15:24	KVATQITKKF	0.9981	0.7526	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A32:01	KVATQITKKF	0.9959	0.8612	9	19
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	HLA-A30:01	ATQITKKFVK	0.9883	0.6872	11	21

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Potential FusionNeoAntigen Information of KDM4B-CHAF1A in HLA II

KDM4B-CHAF1A_5082515_4418017.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	DRB1-1220	YGKVATQITKKFVKG	7	22
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	1136	DRB1-1221	YGKVATQITKKFVKG	7	22

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Fusion breakpoint peptide structures of KDM4B-CHAF1A

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
1491	DYGKVATQITKKFV	KDM4B	CHAF1A	chr19	5082515	chr19	4418017	1136

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of KDM4B-CHAF1A

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	1491	DYGKVATQITKKFV	-7.15543	-7.26883
HLA-B14:02	3BVN	1491	DYGKVATQITKKFV	-4.77435	-5.80965
HLA-B52:01	3W39	1491	DYGKVATQITKKFV	-6.80875	-6.92215
HLA-B52:01	3W39	1491	DYGKVATQITKKFV	-4.20386	-5.23916
HLA-A11:01	4UQ2	1491	DYGKVATQITKKFV	-7.5194	-8.5547
HLA-A11:01	4UQ2	1491	DYGKVATQITKKFV	-6.9601	-7.0735
HLA-A24:02	5HGA	1491	DYGKVATQITKKFV	-7.52403	-7.63743
HLA-A24:02	5HGA	1491	DYGKVATQITKKFV	-5.82433	-6.85963
HLA-B27:05	6PYJ	1491	DYGKVATQITKKFV	-3.28285	-4.31815
HLA-B44:05	3DX8	1491	DYGKVATQITKKFV	-5.91172	-6.94702
HLA-B44:05	3DX8	1491	DYGKVATQITKKFV	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of KDM4B-CHAF1A

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	10	19	VATQITKKF	GCCACTCAGATAACTAAGAAATTCGTC
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	11	21	ATQITKKFVK	ACTCAGATAACTAAGAAATTCGTCAAAGGC
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	12	21	TQITKKFVK	CAGATAACTAAGAAATTCGTCAAAGGC
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	6	15	DYGKVATQI	TACGGCAAAGTGGCCACTCAGATAACT
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	9	18	KVATQITKK	GTGGCCACTCAGATAACTAAGAAATTC
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	9	19	KVATQITKKF	GTGGCCACTCAGATAACTAAGAAATTCGTC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
KDM4B-CHAF1A	chr19	5082515	chr19	4418017	7	22	YGKVATQITKKFVKG	GGCAAAGTGGCCACTCAGATAACTAAGAAATTCGTCAAAGGCTCT

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Information of the samples that have these potential fusion neoantigens of KDM4B-CHAF1A

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
LGG	KDM4B-CHAF1A	chr19	5082515	ENST00000159111	chr19	4418017	ENST00000301280	TCGA-DU-8163-01A

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Potential target of CAR-T therapy development for KDM4B-CHAF1A

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to KDM4B-CHAF1A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KDM4B-CHAF1A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)