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Fusion Protein:LIN7A-NUP107

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LIN7A-NUP107
	FusionPDB ID: 44775
	FusionGDB2.0 ID: 44775
		Hgene	Tgene
	Gene symbol	LIN7A	NUP107
	Gene ID	8825	57122
	Gene name	lin-7 homolog A, crumbs cell polarity complex component	nucleoporin 107
	Synonyms	LIN-7A\|LIN7\|MALS-1\|MALS1\|TIP-33\|VELI1	NPHS11\|NUP84\|ODG6\|ODG6; GAMOS7
	Cytomap	12q21.31	12q15
	Type of gene	protein-coding	protein-coding
	Description	protein lin-7 homolog Amammalian lin-seven protein 1tax interaction protein 33vertebrate LIN7 homolog 1	nuclear pore complex protein Nup107nucleoporin 107kDa
	Modification date	20200313	20200313
	UniProtAcc	O14910 Main function of 5'-partner protein: FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250\|UniProtKB:Q8JZS0, ECO:0000269\|PubMed:12967566}.	P57740 Main function of 5'-partner protein: FUNCTION: Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:12552102, PubMed:15229283, PubMed:30179222). Required for the assembly of peripheral proteins into the NPC (PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC (PubMed:15229283). Involved in nephrogenesis (PubMed:30179222). {ECO:0000269\|PubMed:12552102, ECO:0000269\|PubMed:15229283, ECO:0000269\|PubMed:30179222}.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000552864,	ENST00000401003, ENST00000229179, ENST00000378905, ENST00000539906,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 4 X 3=108	27 X 22 X 9=5346
	# samples	8	37
	** MAII score	log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(37/5346*10)=-3.85286266172677 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: LIN7A [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: LIN7A [Title/Abstract] AND NUP107 [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LIN7A(81283030)-NUP107(69135593), # samples:1
Anticipated loss of major functional domain due to fusion event.	LIN7A-NUP107 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIN7A-NUP107 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIN7A-NUP107 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIN7A-NUP107 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NUP107	GO:0006406	mRNA export from nucleus	11684705

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:81283030/chr12:69135593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across LIN7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NUP107 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000552864	LIN7A	chr12	81283030	-	ENST00000229179	NUP107	chr12	69135593	+	1223	404	53	679	208
ENST00000552864	LIN7A	chr12	81283030	-	ENST00000378905	NUP107	chr12	69135593	+	901	404	53	679	208
ENST00000552864	LIN7A	chr12	81283030	-	ENST00000539906	NUP107	chr12	69135593	+	749	404	53	679	208

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000552864	ENST00000229179	LIN7A	chr12	81283030	-	NUP107	chr12	69135593	+	0.002053325	0.9979467
ENST00000552864	ENST00000378905	LIN7A	chr12	81283030	-	NUP107	chr12	69135593	+	0.003388239	0.9966118
ENST00000552864	ENST00000539906	LIN7A	chr12	81283030	-	NUP107	chr12	69135593	+	0.005922304	0.9940777

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for LIN7A-NUP107

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
LIN7A	chr12	81283030	NUP107	chr12	69135593	404	98	LEKLQESGEVPVHKLQSLKKVLQSEF

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Potential FusionNeoAntigen Information of LIN7A-NUP107 in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

LIN7A-NUP107_81283030_69135593.msa

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA I	FusionNeoAntigen peptide	Binding score	Immunogenic score	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:03	GEVPVHKL	0.9992	0.9844	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B47:01	GEVPVHKL	0.998	0.6877	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:01	GEVPVHKL	0.9778	0.9595	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:13	GEVPVHKL	0.9245	0.9818	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B41:01	GEVPVHKL	0.872	0.9828	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B07:10	VPVHKLQSL	0.9996	0.5116	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:01	VPVHKLQSL	0.996	0.6286	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:09	VPVHKLQSL	0.9922	0.6799	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B14:01	VPVHKLQSL	0.9703	0.7067	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B14:02	VPVHKLQSL	0.9703	0.7067	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:03	VPVHKLQSL	0.9352	0.8011	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:01	VPVHKLQSL	0.9263	0.772	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:08	VPVHKLQSL	0.8936	0.7355	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:04	VPVHKLQSL	0.7748	0.889	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:02	VPVHKLQSL	0.7748	0.889	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:01	EVPVHKLQSL	0.958	0.6338	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:03	QESGEVPVHKL	0.9997	0.9806	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B48:01	GEVPVHKLQSL	0.9996	0.5966	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:03	GEVPVHKLQSL	0.9977	0.9427	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:13	GEVPVHKLQSL	0.9775	0.9617	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B40:06	GEVPVHKL	0.9998	0.7068	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B40:03	GEVPVHKL	0.9993	0.5894	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:08	GEVPVHKL	0.9733	0.9737	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C05:09	SGEVPVHKL	0.9998	0.9674	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:15	SGEVPVHKL	0.9997	0.9808	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B42:02	VPVHKLQSL	0.997	0.6316	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B42:01	VPVHKLQSL	0.9964	0.6238	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B07:12	VPVHKLQSL	0.9592	0.6146	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:13	SGEVPVHKL	0.9316	0.9746	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:04	SGEVPVHKL	0.9316	0.9746	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B14:03	VPVHKLQSL	0.851	0.7948	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B51:07	VPVHKLQSL	0.8392	0.5592	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:09	VPVHKLQSL	0.7976	0.5797	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:12	VPVHKLQSL	0.7748	0.889	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:10	VPVHKLQSL	0.7713	0.8764	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:03	SGEVPVHKL	0.7544	0.9944	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:12	VPVHKLQSL	0.7348	0.898	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C01:30	VPVHKLQSL	0.4339	0.9582	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B42:02	EVPVHKLQSL	0.9793	0.6415	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B42:01	EVPVHKLQSL	0.9696	0.6326	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C01:30	EVPVHKLQSL	0.9205	0.9586	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:09	QESGEVPVHKL	0.9997	0.5295	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:10	GEVPVHKLQSL	0.9978	0.6158	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B40:04	GEVPVHKL	0.9997	0.7759	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:26	GEVPVHKL	0.9992	0.9844	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:07	GEVPVHKL	0.9992	0.9844	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:13	GEVPVHKL	0.9992	0.9844	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:11	GEVPVHKL	0.9894	0.9547	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:05	GEVPVHKL	0.9778	0.9595	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:03	GEVPVHKL	0.976	0.9566	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B41:03	GEVPVHKL	0.9749	0.7914	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:06	GEVPVHKL	0.9707	0.9663	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:02	GEVPVHKL	0.93	0.9818	7	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C04:03	SGEVPVHKL	0.9998	0.9011	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C18:01	SGEVPVHKL	0.9998	0.8842	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C05:01	SGEVPVHKL	0.9998	0.9674	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C01:03	SGEVPVHKL	0.9997	0.9348	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:02	SGEVPVHKL	0.9997	0.9808	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B07:13	VPVHKLQSL	0.9996	0.8683	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:18	VPVHKLQSL	0.996	0.6286	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C03:17	VPVHKLQSL	0.9892	0.957	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C03:05	VPVHKLQSL	0.9874	0.8678	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C03:67	VPVHKLQSL	0.9796	0.9467	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:23	VPVHKLQSL	0.9347	0.7673	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:13	VPVHKLQSL	0.9297	0.81	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:77	VPVHKLQSL	0.9263	0.772	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:24	VPVHKLQSL	0.8813	0.7731	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:12	VPVHKLQSL	0.856	0.7835	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:17	VPVHKLQSL	0.7867	0.5902	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:30	VPVHKLQSL	0.7867	0.5902	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:09	VPVHKLQSL	0.7748	0.889	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C08:01	SGEVPVHKL	0.7544	0.9944	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:11	VPVHKLQSL	0.7494	0.7698	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B67:01	VPVHKLQSL	0.7435	0.7705	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-C04:04	VPVHKLQSL	0.6255	0.8626	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B18:07	VPVHKLQSL	0.0507	0.723	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B15:08	VPVHKLQSL	0.0242	0.6989	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B35:43	VPVHKLQSL	0.0238	0.7069	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B15:11	VPVHKLQSL	0.023	0.7007	9	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B07:13	SGEVPVHKL	0.0039	0.8438	6	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-A25:01	EVPVHKLQSL	0.9682	0.8403	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:18	EVPVHKLQSL	0.958	0.6338	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B08:12	EVPVHKLQSL	0.8461	0.7924	8	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:13	QESGEVPVHKL	0.9997	0.9806	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B40:04	GEVPVHKLQSL	0.9997	0.7268	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:26	QESGEVPVHKL	0.9997	0.9806	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:07	QESGEVPVHKL	0.9997	0.9806	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B40:04	QESGEVPVHKL	0.9991	0.7593	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:13	GEVPVHKLQSL	0.9977	0.9427	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:07	GEVPVHKLQSL	0.9977	0.9427	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B44:26	GEVPVHKLQSL	0.9977	0.9427	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B39:02	GEVPVHKLQSL	0.9899	0.9622	7	18
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B41:03	QESGEVPVHKL	0.9892	0.8431	4	15
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	HLA-B41:03	GEVPVHKLQSL	0.9859	0.7357	7	18

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Potential FusionNeoAntigen Information of LIN7A-NUP107 in HLA II

LIN7A-NUP107_81283030_69135593.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0802	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0802	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0804	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0804	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0804	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0806	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0806	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0809	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0809	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0810	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0812	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0812	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0820	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0820	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0820	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0821	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0821	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0822	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0822	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0824	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0824	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0828	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0828	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0828	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0831	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0831	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-0831	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1101	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1101	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1103	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1103	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1104	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1104	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1104	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1105	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1105	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1106	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1106	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1106	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1108	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1108	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1109	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1109	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1110	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1110	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1112	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1112	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1113	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1113	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1115	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1115	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1118	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1118	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1118	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1119	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1119	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1124	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1124	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1125	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1125	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1125	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1127	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1127	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1128	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1128	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1129	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1129	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1131	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1131	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1132	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1132	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1133	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1133	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1134	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1134	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1135	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1135	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1135	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1137	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1137	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1138	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1138	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1138	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1139	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1139	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1141	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1141	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1142	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1142	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1142	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1143	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1143	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1143	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1144	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1144	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1144	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1145	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1146	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1146	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1146	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1147	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1147	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1147	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1149	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1149	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1150	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1150	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1150	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1151	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1151	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1154	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1154	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1154	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1156	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1156	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1156	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1157	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1157	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1157	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1158	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1158	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1158	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1159	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1160	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1160	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1160	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1161	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1161	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1162	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1162	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1163	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1163	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1166	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1166	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1167	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1167	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1167	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1172	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1172	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1172	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1174	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1174	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1175	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1175	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1176	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1176	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1177	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1177	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1177	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1178	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1178	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1178	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1180	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1180	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1181	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1181	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1183	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1183	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1184	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1184	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1184	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1185	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1185	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1187	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1187	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1188	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1188	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1188	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1189	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1189	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1190	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1190	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1191	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1191	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1192	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1192	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1192	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1193	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1194	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1194	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1195	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1195	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1196	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1196	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1204	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1204	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1204	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1209	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1209	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1209	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1305	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1305	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1306	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1306	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1306	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1307	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1307	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1311	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1311	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1311	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1314	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1314	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1318	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1318	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1318	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1324	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1324	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1326	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1326	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1342	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1342	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1342	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1344	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1344	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1347	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1350	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1350	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1356	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1356	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1358	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1358	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1360	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1360	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1362	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1362	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1377	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1382	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1382	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1406	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1406	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1412	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1412	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1415	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1415	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1415	VPVHKLQSLKKVLQS	9	24
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1417	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1417	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1420	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1420	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1421	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1421	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1427	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1427	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1429	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1429	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1433	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1433	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1434	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1434	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1452	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1452	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1453	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1465	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1473	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1473	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1474	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1474	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1478	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1478	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1480	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1480	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1481	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1481	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1483	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1483	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1484	PVHKLQSLKKVLQSE	10	25
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB1-1484	VHKLQSLKKVLQSEF	11	26
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB5-0204	EVPVHKLQSLKKVLQ	8	23
LIN7A-NUP107	chr12	81283030	chr12	69135593	404	DRB5-0205	EVPVHKLQSLKKVLQ	8	23

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Fusion breakpoint peptide structures of LIN7A-NUP107

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

File name	BPseq	Hgene	Tgene	Hchr	Hbp	Tchr	Tbp	AAlen
8584	SGEVPVHKLQSLKK	LIN7A	NUP107	chr12	81283030	chr12	69135593	404

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of LIN7A-NUP107

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele	PDB ID	File name	BPseq	Docking score	Glide score
HLA-B14:02	3BVN	8584	SGEVPVHKLQSLKK	-7.15543	-7.26883
HLA-B14:02	3BVN	8584	SGEVPVHKLQSLKK	-4.77435	-5.80965
HLA-B52:01	3W39	8584	SGEVPVHKLQSLKK	-6.80875	-6.92215
HLA-B52:01	3W39	8584	SGEVPVHKLQSLKK	-4.20386	-5.23916
HLA-A11:01	4UQ2	8584	SGEVPVHKLQSLKK	-7.5194	-8.5547
HLA-A11:01	4UQ2	8584	SGEVPVHKLQSLKK	-6.9601	-7.0735
HLA-A24:02	5HGA	8584	SGEVPVHKLQSLKK	-7.52403	-7.63743
HLA-A24:02	5HGA	8584	SGEVPVHKLQSLKK	-5.82433	-6.85963
HLA-B27:05	6PYJ	8584	SGEVPVHKLQSLKK	-3.28285	-4.31815
HLA-B44:05	3DX8	8584	SGEVPVHKLQSLKK	-5.91172	-6.94702
HLA-B44:05	3DX8	8584	SGEVPVHKLQSLKK	-4.24346	-4.35686

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Vaccine Design for the FusionNeoAntigens of LIN7A-NUP107

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide sequence	FusionNeoAntigen RNA sequence
LIN7A-NUP107	chr12	81283030	chr12	69135593	4	15	QESGEVPVHKL	AGTGAGTTTTGTACAGCTATTCGAGAGGATGCC
LIN7A-NUP107	chr12	81283030	chr12	69135593	6	15	SGEVPVHKL	TTTTGTACAGCTATTCGAGAGGATGCC
LIN7A-NUP107	chr12	81283030	chr12	69135593	7	15	GEVPVHKL	TGTACAGCTATTCGAGAGGATGCC
LIN7A-NUP107	chr12	81283030	chr12	69135593	7	18	GEVPVHKLQSL	TGTACAGCTATTCGAGAGGATGCCAAAGAAGAC
LIN7A-NUP107	chr12	81283030	chr12	69135593	8	18	EVPVHKLQSL	ACAGCTATTCGAGAGGATGCCAAAGAAGAC
LIN7A-NUP107	chr12	81283030	chr12	69135593	9	18	VPVHKLQSL	GCTATTCGAGAGGATGCCAAAGAAGAC

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
LIN7A-NUP107	chr12	81283030	chr12	69135593	10	25	PVHKLQSLKKVLQSE	ATTCGAGAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATG
LIN7A-NUP107	chr12	81283030	chr12	69135593	11	26	VHKLQSLKKVLQSEF	CGAGAGGATGCCAAAGAAGACCATGAAAGAACACATCAAATGGTC
LIN7A-NUP107	chr12	81283030	chr12	69135593	8	23	EVPVHKLQSLKKVLQ	ACAGCTATTCGAGAGGATGCCAAAGAAGACCATGAAAGAACACAT
LIN7A-NUP107	chr12	81283030	chr12	69135593	9	24	VPVHKLQSLKKVLQS	GCTATTCGAGAGGATGCCAAAGAAGACCATGAAAGAACACATCAA

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Information of the samples that have these potential fusion neoantigens of LIN7A-NUP107

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type	Fusion gene	Hchr	Hbp	Henst	Tchr	Tbp	Tenst	Sample
SARC	LIN7A-NUP107	chr12	81283030	ENST00000552864	chr12	69135593	ENST00000229179	TCGA-3B-A9HO-01A

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Potential target of CAR-T therapy development for LIN7A-NUP107

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

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Related Drugs to LIN7A-NUP107

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to LIN7A-NUP107

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NUP107	C4225228	NEPHROTIC SYNDROME, TYPE 11	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NUP107	C0018051	Gonadal Dysgenesis	1	GENOMICS_ENGLAND
Tgene	NUP107	C0685837	Pure Gonadal Dysgenesis, 46, XX	1	ORPHANET
Tgene	NUP107	C0795949	Galloway Mowat syndrome	1	ORPHANET
Tgene	NUP107	C0949595	Gonadal Dysgenesis, 46,XX	1	ORPHANET
Tgene	NUP107	C1868672	NEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVE	1	ORPHANET
Tgene	NUP107	C4748084	OVARIAN DYSGENESIS 6	1	UNIPROT

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)