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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MAP4K3-EML4

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP4K3-EML4
FusionPDB ID: 51390
FusionGDB2.0 ID: 51390
HgeneTgene
Gene symbol

MAP4K3

EML4

Gene ID

8491

27436

Gene namemitogen-activated protein kinase kinase kinase kinase 3EMAP like 4
SynonymsGLK|MAPKKKK3|MEKKK 3|MEKKK3|RAB8IPL1C2orf2|ELP120|EMAP-4|EMAPL4|ROPP120
Cytomap

2p22.1

2p21

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinaseechinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120
Modification date2020031320200313
UniProtAcc

Q8IVH8

Main function of 5'-partner protein: FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269|PubMed:9275185}.

Q9HC35

Main function of 5'-partner protein: FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269|PubMed:16890222, ECO:0000269|PubMed:25789526, ECO:0000269|PubMed:31409757}.
Ensembl transtripts involved in fusion geneENST idsENST00000263881, ENST00000341681, 
ENST00000484274, ENST00000437545, 
ENST00000474502, ENST00000536018, 
ENST00000401738, ENST00000453191, 
ENST00000482660, ENST00000318522, 
ENST00000402711, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 6 X 7=3789 X 10 X 6=540
# samples 1010
** MAII scorelog2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/540*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MAP4K3 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MAP4K3 [Title/Abstract] AND EML4 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP4K3(39605207)-EML4(42507990), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP4K3-EML4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP4K3-EML4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP4K3

GO:0006468

protein phosphorylation

9275185

HgeneMAP4K3

GO:0009411

response to UV

9275185

HgeneMAP4K3

GO:0034612

response to tumor necrosis factor

9275185

HgeneMAP4K3

GO:0035556

intracellular signal transduction

9275185



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39605207/chr2:42507990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MAP4K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EML4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000263881MAP4K3chr239605207-ENST00000318522EML4chr242507990+50994793132757814
ENST00000263881MAP4K3chr239605207-ENST00000402711EML4chr242507990+32954793132757814
ENST00000341681MAP4K3chr239605207-ENST00000318522EML4chr242507990+50884683022746814
ENST00000341681MAP4K3chr239605207-ENST00000402711EML4chr242507990+32844683022746814
ENST00000484274MAP4K3chr239605207-ENST00000318522EML4chr242507990+4852232662510814
ENST00000484274MAP4K3chr239605207-ENST00000402711EML4chr242507990+3048232662510814

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263881ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.0002464820.99975353
ENST00000263881ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005804060.99941957
ENST00000341681ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.000250240.9997497
ENST00000341681ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005846490.9994154
ENST00000484274ENST00000318522MAP4K3chr239605207-EML4chr242507990+0.0002347490.9997652
ENST00000484274ENST00000402711MAP4K3chr239605207-EML4chr242507990+0.0005941760.99940586

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MAP4K3-EML4

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MAP4K3chr239605207EML4chr24250799023255GELAAIKVIKLEPEGEYIKMFMRGRP
MAP4K3chr239605207EML4chr24250799046855GELAAIKVIKLEPEGEYIKMFMRGRP
MAP4K3chr239605207EML4chr24250799047955GELAAIKVIKLEPEGEYIKMFMRGRP

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Potential FusionNeoAntigen Information of MAP4K3-EML4 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MAP4K3-EML4_39605207_42507990.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MAP4K3-EML4chr239605207chr242507990479HLA-B35:08EPEGEYIKM0.9840.88061120
MAP4K3-EML4chr239605207chr242507990479HLA-B35:01EPEGEYIKM0.97970.9361120
MAP4K3-EML4chr239605207chr242507990479HLA-B44:03PEGEYIKMF0.95950.9051221
MAP4K3-EML4chr239605207chr242507990479HLA-A02:60KLEPEGEYI0.95850.8753918
MAP4K3-EML4chr239605207chr242507990479HLA-A02:27KLEPEGEYI0.90420.8342918
MAP4K3-EML4chr239605207chr242507990479HLA-A02:16KLEPEGEYI0.86970.8208918
MAP4K3-EML4chr239605207chr242507990479HLA-B35:03EPEGEYIKM0.86730.9331120
MAP4K3-EML4chr239605207chr242507990479HLA-B35:04EPEGEYIKM0.62990.92471120
MAP4K3-EML4chr239605207chr242507990479HLA-B35:02EPEGEYIKM0.62990.92471120
MAP4K3-EML4chr239605207chr242507990479HLA-A02:19KLEPEGEYI0.62820.6458918
MAP4K3-EML4chr239605207chr242507990479HLA-B15:18IKLEPEGEY0.19840.8497817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:03IKLEPEGEY0.12530.8785817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:01VIKLEPEGEY0.99970.9364717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:25VIKLEPEGEY0.99610.9158717
MAP4K3-EML4chr239605207chr242507990479HLA-B44:03EPEGEYIKMF0.75390.91491121
MAP4K3-EML4chr239605207chr242507990479HLA-B15:01KVIKLEPEGEY0.99980.9312617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:25KVIKLEPEGEY0.99950.9052617
MAP4K3-EML4chr239605207chr242507990479HLA-C05:09KLEPEGEYI0.99910.9737918
MAP4K3-EML4chr239605207chr242507990479HLA-A02:02KLEPEGEYI0.93790.5201918
MAP4K3-EML4chr239605207chr242507990479HLA-B35:12EPEGEYIKM0.62990.92471120
MAP4K3-EML4chr239605207chr242507990479HLA-B39:10EPEGEYIKM0.14120.89641120
MAP4K3-EML4chr239605207chr242507990479HLA-B15:07VIKLEPEGEY0.99940.8188717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:07KVIKLEPEGEY0.99980.8375617
MAP4K3-EML4chr239605207chr242507990479HLA-C05:01KLEPEGEYI0.99910.9737918
MAP4K3-EML4chr239605207chr242507990479HLA-C04:03KLEPEGEYI0.9990.8989918
MAP4K3-EML4chr239605207chr242507990479HLA-B35:77EPEGEYIKM0.97970.9361120
MAP4K3-EML4chr239605207chr242507990479HLA-B35:23EPEGEYIKM0.97710.91761120
MAP4K3-EML4chr239605207chr242507990479HLA-B44:13PEGEYIKMF0.95950.9051221
MAP4K3-EML4chr239605207chr242507990479HLA-B44:07PEGEYIKMF0.95950.9051221
MAP4K3-EML4chr239605207chr242507990479HLA-B44:26PEGEYIKMF0.95950.9051221
MAP4K3-EML4chr239605207chr242507990479HLA-B35:24EPEGEYIKM0.95570.96531120
MAP4K3-EML4chr239605207chr242507990479HLA-B35:09EPEGEYIKM0.62990.92471120
MAP4K3-EML4chr239605207chr242507990479HLA-B18:07EPEGEYIKM0.24150.95711120
MAP4K3-EML4chr239605207chr242507990479HLA-B67:01EPEGEYIKM0.21980.62831120
MAP4K3-EML4chr239605207chr242507990479HLA-B48:02IKLEPEGEY0.18360.9801817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:53IKLEPEGEY0.18270.9545817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:54IKLEPEGEY0.02790.9479817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:68IKLEPEGEY0.00730.8332817
MAP4K3-EML4chr239605207chr242507990479HLA-B15:34VIKLEPEGEY0.99970.9364717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:33VIKLEPEGEY0.99970.9364717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:27VIKLEPEGEY0.99970.9362717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:125VIKLEPEGEY0.99970.9364717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:135VIKLEPEGEY0.99970.9354717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:50VIKLEPEGEY0.99950.9617717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:35VIKLEPEGEY0.99930.931717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:12VIKLEPEGEY0.99750.9348717
MAP4K3-EML4chr239605207chr242507990479HLA-B15:39VIKLEPEGEY0.99560.84717
MAP4K3-EML4chr239605207chr242507990479HLA-B44:07EPEGEYIKMF0.75390.91491121
MAP4K3-EML4chr239605207chr242507990479HLA-B44:26EPEGEYIKMF0.75390.91491121
MAP4K3-EML4chr239605207chr242507990479HLA-B44:13EPEGEYIKMF0.75390.91491121
MAP4K3-EML4chr239605207chr242507990479HLA-B15:125KVIKLEPEGEY0.99980.9312617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:50KVIKLEPEGEY0.99980.9317617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:34KVIKLEPEGEY0.99980.9312617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:33KVIKLEPEGEY0.99980.9312617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:135KVIKLEPEGEY0.99980.9197617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:35KVIKLEPEGEY0.99970.9185617
MAP4K3-EML4chr239605207chr242507990479HLA-B15:39KVIKLEPEGEY0.99960.8598617

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Potential FusionNeoAntigen Information of MAP4K3-EML4 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MAP4K3-EML4_39605207_42507990.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MAP4K3-EML4chr239605207chr242507990479DRB1-1201AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1203AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1205AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1206AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1207AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1210AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1211AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1212AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1212IKVIKLEPEGEYIKM520
MAP4K3-EML4chr239605207chr242507990479DRB1-1214AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1217AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1219AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1220AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1220IKVIKLEPEGEYIKM520
MAP4K3-EML4chr239605207chr242507990479DRB1-1220AAIKVIKLEPEGEYI318
MAP4K3-EML4chr239605207chr242507990479DRB1-1220GELAAIKVIKLEPEG015
MAP4K3-EML4chr239605207chr242507990479DRB1-1220LAAIKVIKLEPEGEY217
MAP4K3-EML4chr239605207chr242507990479DRB1-1221GELAAIKVIKLEPEG015
MAP4K3-EML4chr239605207chr242507990479DRB1-1221AIKVIKLEPEGEYIK419
MAP4K3-EML4chr239605207chr242507990479DRB1-1221IKVIKLEPEGEYIKM520

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Fusion breakpoint peptide structures of MAP4K3-EML4

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
4673KVIKLEPEGEYIKMMAP4K3EML4chr239605207chr242507990479

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MAP4K3-EML4

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN4673KVIKLEPEGEYIKM-7.9962-8.1096
HLA-B14:023BVN4673KVIKLEPEGEYIKM-5.70842-6.74372
HLA-B52:013W394673KVIKLEPEGEYIKM-6.83737-6.95077
HLA-B52:013W394673KVIKLEPEGEYIKM-4.4836-5.5189
HLA-A11:014UQ24673KVIKLEPEGEYIKM-10.0067-10.1201
HLA-A11:014UQ24673KVIKLEPEGEYIKM-9.03915-10.0745
HLA-A24:025HGA4673KVIKLEPEGEYIKM-6.56204-6.67544
HLA-A24:025HGA4673KVIKLEPEGEYIKM-5.42271-6.45801
HLA-B44:053DX84673KVIKLEPEGEYIKM-7.85648-8.89178
HLA-B44:053DX84673KVIKLEPEGEYIKM-5.3978-5.5112
HLA-A02:016TDR4673KVIKLEPEGEYIKM-3.37154-4.40684

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Vaccine Design for the FusionNeoAntigens of MAP4K3-EML4

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MAP4K3-EML4chr239605207chr2425079901120EPEGEYIKMAACCAGAAGGAGAATATATTAAAATGT
MAP4K3-EML4chr239605207chr2425079901121EPEGEYIKMFAACCAGAAGGAGAATATATTAAAATGTTTA
MAP4K3-EML4chr239605207chr2425079901221PEGEYIKMFCAGAAGGAGAATATATTAAAATGTTTA
MAP4K3-EML4chr239605207chr242507990617KVIKLEPEGEYAAGTAATAAAATTGGAACCAGAAGGAGAATATA
MAP4K3-EML4chr239605207chr242507990717VIKLEPEGEYTAATAAAATTGGAACCAGAAGGAGAATATA
MAP4K3-EML4chr239605207chr242507990817IKLEPEGEYTAAAATTGGAACCAGAAGGAGAATATA
MAP4K3-EML4chr239605207chr242507990918KLEPEGEYIAATTGGAACCAGAAGGAGAATATATTA

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MAP4K3-EML4chr239605207chr242507990015GELAAIKVIKLEPEGGTGAATTAGCAGCAATTAAAGTAATAAAATTGGAACCAGAAGGAG
MAP4K3-EML4chr239605207chr242507990217LAAIKVIKLEPEGEYTAGCAGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATA
MAP4K3-EML4chr239605207chr242507990318AAIKVIKLEPEGEYICAGCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTA
MAP4K3-EML4chr239605207chr242507990419AIKVIKLEPEGEYIKCAATTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAA
MAP4K3-EML4chr239605207chr242507990520IKVIKLEPEGEYIKMTTAAAGTAATAAAATTGGAACCAGAAGGAGAATATATTAAAATGT

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Information of the samples that have these potential fusion neoantigens of MAP4K3-EML4

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
HNSCMAP4K3-EML4chr239605207ENST00000263881chr242507990ENST00000318522TCGA-QK-A8ZB-01A

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Potential target of CAR-T therapy development for MAP4K3-EML4

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MAP4K3-EML4

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAP4K3-EML4

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneEML4C0007131Non-Small Cell Lung Carcinoma6CTD_human
TgeneEML4C0027627Neoplasm Metastasis2CTD_human
TgeneEML4C0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneEML4C0006118Brain Neoplasms1CTD_human
TgeneEML4C0153633Malignant neoplasm of brain1CTD_human
TgeneEML4C0496899Benign neoplasm of brain, unspecified1CTD_human
TgeneEML4C0750974Brain Tumor, Primary1CTD_human
TgeneEML4C0750977Recurrent Brain Neoplasm1CTD_human
TgeneEML4C0750979Primary malignant neoplasm of brain1CTD_human
TgeneEML4C1527390Neoplasms, Intracranial1CTD_human