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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MIPEP-GATAD2A

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MIPEP-GATAD2A
FusionPDB ID: 53743
FusionGDB2.0 ID: 53743
HgeneTgene
Gene symbol

MIPEP

GATAD2A

Gene ID

4285

54815

Gene namemitochondrial intermediate peptidaseGATA zinc finger domain containing 2A
SynonymsCOXPD31|HMIP|MIPp66alpha
Cytomap

13q12.12

19p13.11

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial intermediate peptidasetranscriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A
Modification date2020031320200313
UniProtAcc

Q99797

Main function of 5'-partner protein: FUNCTION: Cleaves proteins, imported into the mitochondrion, to their mature size.

Q86YP4

Main function of 5'-partner protein: FUNCTION: Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.
Ensembl transtripts involved in fusion geneENST idsENST00000382172, ENST00000469167, 
ENST00000473184, ENST00000358713, 
ENST00000404158, ENST00000429563, 
ENST00000537887, ENST00000252577, 
ENST00000360315, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 7 X 6=29411 X 10 X 9=990
# samples 714
** MAII scorelog2(7/294*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/990*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MIPEP [Title/Abstract] AND GATAD2A [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MIPEP [Title/Abstract] AND GATAD2A [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MIPEP(24432999)-GATAD2A(19603115), # samples:1
Anticipated loss of major functional domain due to fusion event.MIPEP-GATAD2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MIPEP-GATAD2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:24432999/chr19:19603115)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MIPEP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GATAD2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000382172MIPEPchr1324432999-ENST00000252577GATAD2Achr1919603115+6220120592762917
ENST00000382172MIPEPchr1324432999-ENST00000360315GATAD2Achr1919603115+6295120592837942

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382172ENST00000252577MIPEPchr1324432999-GATAD2Achr1919603115+0.0030477670.9969522
ENST00000382172ENST00000360315MIPEPchr1324432999-GATAD2Achr1919603115+0.002374290.99762577

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MIPEP-GATAD2A

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MIPEPchr1324432999GATAD2Achr19196031151205398WDPPYYSGVIRAESDMKSERRPPSPD

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Potential FusionNeoAntigen Information of MIPEP-GATAD2A in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MIPEP-GATAD2A_24432999_19603115.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MIPEP-GATAD2Achr1324432999chr19196031151205HLA-B45:01AESDMKSERRP0.99940.83371122

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Potential FusionNeoAntigen Information of MIPEP-GATAD2A in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MIPEP-GATAD2A_24432999_19603115.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0401SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0401YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0401GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0401YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0403SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0403YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0403YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0407SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0413SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0413YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0413GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0413YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0415SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0415YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0419SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0419YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0422SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0422YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0422GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0422YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0427SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0427YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0427YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0431SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0431YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0433SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0433YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0433GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0433YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0434SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0434YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0435SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0435YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0435GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0435YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0436SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0436YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0437SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0437YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0437GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0438SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0438YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0438GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0438YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0439SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0439YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0439YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0440SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0440YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0440GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0440YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0441SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0441YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0441YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0442SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0442YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0442GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0442YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0443SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0443YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0444SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0444YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0444GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0444YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0446SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0446YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0446YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0449SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0449YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0449YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0450SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0450YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0450YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0451SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0451YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0451YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0451GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0452SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0452YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0452YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0453SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0453YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0455SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0455YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0455GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0455YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0456SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0456YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0456GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0456YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0458SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0458YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0459SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0459YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0460SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0460YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0460YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0461SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0461YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0462SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0463SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0463YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0463GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0463YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0464SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0464YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0465SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0465YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0467SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0467YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0468SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0468YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0468GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0468YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0470SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0470YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0470GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0470YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0471SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0471YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0471YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0472SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0472YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0472GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0473SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0473YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0473GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0473YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0474SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0474YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0475SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0475YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0476SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0476YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0476GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0476YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0478SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0478YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0479SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0479YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0479GVIRAESDMKSERRP722
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0479YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0485SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0485YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0485YYSGVIRAESDMKSE419
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0488SGVIRAESDMKSERR621
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0488YSGVIRAESDMKSER520
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0801PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0801DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0801WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0802PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0802DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0802WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0803PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0803DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0805PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0805DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0805WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0807PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0808PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0808DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0808WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0809PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0809DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0809WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0811PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0811DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0811WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0813PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0813DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0814PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0814DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0815PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0815DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0816PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0816DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0816WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0818PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0821PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0821DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0821WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0823PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0823DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0824PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0824DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0824WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0826PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0826DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0826WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0827PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0827DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0829PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0830PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0830DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0833PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0833DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0835PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0835DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0836PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0836DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0837PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0838PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0838DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0839PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0839DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0839WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0908WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-0908DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1101PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1101DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1101WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1105PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1105DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1105WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1108PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1108DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1108WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1109PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1109DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1109WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1110PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1110DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1110WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1111PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1112PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1112DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1112WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1115PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1115DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1115WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1119PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1119DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1119WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1124PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1124DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1124WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1127PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1127DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1127WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1128PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1128DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1128WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1129PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1129DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1129WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1130PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1131PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1131DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1131WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1132PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1132DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1132WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1133PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1133DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1133WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1137PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1137DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1137WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1139PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1139DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1139WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1145PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1145DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1149PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1149DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1149WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1151PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1151DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1151WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1153PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1153DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1153WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1161PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1161DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1161WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1162PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1162DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1162WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1164PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1164DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1164WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1166PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1166DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1166WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1169PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1169DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1172PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1173PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1173DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1174PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1174DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1174WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1175PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1175DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1175WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1180PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1180DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1180WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1181PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1181DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1181WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1181PYYSGVIRAESDMKS318
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1182PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1187PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1187DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1187WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1190PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1190DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1190WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1191PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1191DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1191WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1193PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1193DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1193WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1194PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1194DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1194WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1195PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1195DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1195WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1196PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1196DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1196WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1305PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1305DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1305WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1307PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1307DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1307WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-13100PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-13101PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1310PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1312PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1313PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1313DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1313WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1314PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1314DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1314WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1321PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1321DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1321WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1326PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1326DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1326WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1330PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1337PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1337DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1346PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1347PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1347DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1347WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1347PYYSGVIRAESDMKS318
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1349PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1349DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1349WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1350PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1350DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1350WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1355PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1355DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1355WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1356PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1356DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1356WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1360PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1360DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1360WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1362PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1362DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1362WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1363PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1366PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1382PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1382DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1382WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1385PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1386PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1402PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1403PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1403DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1409PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1414PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1414DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1422PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1422DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1422WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1425PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1425DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1425WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1427PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1427DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1427WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1430PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1436PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1436DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1440PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1440DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1441PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1442PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1442DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1444PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1444DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1451PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1451DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1453PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1453DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1453WDPPYYSGVIRAESD015
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1463PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1463DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1467PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1469PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1477PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1477DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1485PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1485DPPYYSGVIRAESDM116
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1494PPYYSGVIRAESDMK217
MIPEP-GATAD2Achr1324432999chr19196031151205DRB1-1525SGVIRAESDMKSERR621

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Fusion breakpoint peptide structures of MIPEP-GATAD2A

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
8615SGVIRAESDMKSERMIPEPGATAD2Achr1324432999chr19196031151205

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MIPEP-GATAD2A

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN8615SGVIRAESDMKSER-8.85616-8.96956
HLA-B14:023BVN8615SGVIRAESDMKSER-5.66423-6.69953
HLA-B52:013W398615SGVIRAESDMKSER-6.49489-6.60829
HLA-B52:013W398615SGVIRAESDMKSER-3.99785-5.03315
HLA-A11:014UQ28615SGVIRAESDMKSER-4.90759-5.94289
HLA-A24:025HGA8615SGVIRAESDMKSER-7.27887-7.39227
HLA-A24:025HGA8615SGVIRAESDMKSER-7.11524-8.15054
HLA-B27:056PYJ8615SGVIRAESDMKSER-6.11615-6.22955
HLA-B27:056PYJ8615SGVIRAESDMKSER-4.78818-5.82348
HLA-B44:053DX88615SGVIRAESDMKSER-7.22602-7.33942
HLA-B44:053DX88615SGVIRAESDMKSER-4.86671-5.90201

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Vaccine Design for the FusionNeoAntigens of MIPEP-GATAD2A

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MIPEP-GATAD2Achr1324432999chr19196031151122AESDMKSERRPAGAAAGTGACATGAAGTCCGAGAGGAGACCCCC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
MIPEP-GATAD2Achr1324432999chr1919603115015WDPPYYSGVIRAESDGGACCCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGTGACAT
MIPEP-GATAD2Achr1324432999chr1919603115116DPPYYSGVIRAESDMCCCCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGTGACATGAA
MIPEP-GATAD2Achr1324432999chr1919603115217PPYYSGVIRAESDMKCCCTTACTACAGTGGTGTGATTCGTGCAGAAAGTGACATGAAGTC
MIPEP-GATAD2Achr1324432999chr1919603115318PYYSGVIRAESDMKSTTACTACAGTGGTGTGATTCGTGCAGAAAGTGACATGAAGTCCGA
MIPEP-GATAD2Achr1324432999chr1919603115419YYSGVIRAESDMKSECTACAGTGGTGTGATTCGTGCAGAAAGTGACATGAAGTCCGAGAG
MIPEP-GATAD2Achr1324432999chr1919603115520YSGVIRAESDMKSERCAGTGGTGTGATTCGTGCAGAAAGTGACATGAAGTCCGAGAGGAG
MIPEP-GATAD2Achr1324432999chr1919603115621SGVIRAESDMKSERRTGGTGTGATTCGTGCAGAAAGTGACATGAAGTCCGAGAGGAGACC
MIPEP-GATAD2Achr1324432999chr1919603115722GVIRAESDMKSERRPTGTGATTCGTGCAGAAAGTGACATGAAGTCCGAGAGGAGACCCCC

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Information of the samples that have these potential fusion neoantigens of MIPEP-GATAD2A

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LGGMIPEP-GATAD2Achr1324432999ENST00000382172chr1919603115ENST00000252577TCGA-TM-A84B-01A

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Potential target of CAR-T therapy development for MIPEP-GATAD2A

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MIPEP-GATAD2A

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MIPEP-GATAD2A

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource