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Fusion Protein:MTMR2-CLNS1A |
Fusion Gene and Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: MTMR2-CLNS1A | FusionPDB ID: 55748 | FusionGDB2.0 ID: 55748 | Hgene | Tgene | Gene symbol | MTMR2 | CLNS1A | Gene ID | 8898 | 1207 |
Gene name | myotubularin related protein 2 | chloride nucleotide-sensitive channel 1A | |
Synonyms | CMT4B|CMT4B1 | CLCI|CLNS1B|ICln | |
Cytomap | 11q21 | 11q14.1 | |
Type of gene | protein-coding | protein-coding | |
Description | myotubularin-related protein 2phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphatasephosphatidylinositol-3-phosphate phosphatasephosphoinositide-3-phosphatase | methylosome subunit pIClnchloride channel regulatory proteinchloride channel, nucleotide sensitive 1Achloride conductance regulatory protein IClnchloride ion current inducer proteini(Cln)reticulocyte pIClnreticulocyte protein ICln | |
Modification date | 20200328 | 20200313 | |
UniProtAcc | Q13614 Main function of 5'-partner protein: FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11733541, PubMed:12668758, PubMed:21372139, PubMed:14690594). Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate (By similarity). Stabilizes SBF2/MTMR13 at the membranes (By similarity). Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein (By similarity). {ECO:0000250|UniProtKB:Q9Z2D1, ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:14690594, ECO:0000269|PubMed:21372139}. | P54105 Main function of 5'-partner protein: FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway. {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000346299, ENST00000352297, ENST00000393223, ENST00000409459, ENST00000484818, | ENST00000533957, ENST00000263309, ENST00000525064, ENST00000525428, ENST00000528364, ENST00000532069, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 9 X 7=504 | 10 X 8 X 6=480 |
# samples | 13 | 13 | |
** MAII score | log2(13/504*10)=-1.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/480*10)=-1.88452278258006 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Fusion gene context | PubMed: MTMR2 [Title/Abstract] AND CLNS1A [Title/Abstract] AND fusion [Title/Abstract] | ||
Fusion neoantigen context | PubMed: MTMR2 [Title/Abstract] AND CLNS1A [Title/Abstract] AND neoantigen [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | MTMR2(95647406)-CLNS1A(77340944), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. | MTMR2-CLNS1A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MTMR2-CLNS1A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | MTMR2 | GO:0046856 | phosphatidylinositol dephosphorylation | 12668758 |
Hgene | MTMR2 | GO:0060304 | regulation of phosphatidylinositol dephosphorylation | 16787938 |
Tgene | CLNS1A | GO:0000387 | spliceosomal snRNP assembly | 18984161 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:95647406/chr11:77340944) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Amino Acid Sequences |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000346299 | MTMR2 | chr11 | 95657039 | - | ENST00000525428 | CLNS1A | chr11 | 77340944 | - | 3198 | 421 | 245 | 1009 | 254 |
ENST00000346299 | MTMR2 | chr11 | 95657039 | - | ENST00000263309 | CLNS1A | chr11 | 77340944 | - | 1431 | 421 | 245 | 907 | 220 |
ENST00000346299 | MTMR2 | chr11 | 95657039 | - | ENST00000525064 | CLNS1A | chr11 | 77340944 | - | 1359 | 421 | 245 | 835 | 196 |
ENST00000346299 | MTMR2 | chr11 | 95657039 | - | ENST00000532069 | CLNS1A | chr11 | 77340944 | - | 1114 | 421 | 245 | 799 | 184 |
ENST00000346299 | MTMR2 | chr11 | 95657039 | - | ENST00000528364 | CLNS1A | chr11 | 77340944 | - | 1187 | 421 | 245 | 1009 | 254 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000346299 | ENST00000525428 | MTMR2 | chr11 | 95657039 | - | CLNS1A | chr11 | 77340944 | - | 0.00042552 | 0.9995745 |
ENST00000346299 | ENST00000263309 | MTMR2 | chr11 | 95657039 | - | CLNS1A | chr11 | 77340944 | - | 0.002075356 | 0.99792457 |
ENST00000346299 | ENST00000525064 | MTMR2 | chr11 | 95657039 | - | CLNS1A | chr11 | 77340944 | - | 0.026085163 | 0.97391486 |
ENST00000346299 | ENST00000532069 | MTMR2 | chr11 | 95657039 | - | CLNS1A | chr11 | 77340944 | - | 0.009004667 | 0.99099535 |
ENST00000346299 | ENST00000528364 | MTMR2 | chr11 | 95657039 | - | CLNS1A | chr11 | 77340944 | - | 0.001270025 | 0.99873 |
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Get the fusion protein sequences from here. |
Fusion protein sequence information is available in the fasta format. >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP |
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Fusion Protein Breakpoint Sequences for MTMR2-CLNS1A |
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Hgene | Hchr | Hbp | Tgene | Tchr | Tbp | Length(fusion protein) | BP in fusion protein | Peptide |
MTMR2 | chr11 | 95657039 | CLNS1A | chr11 | 77340944 | 421 | 58 | PAAARPPSVDSLSSRLSWLDGSGLGF |
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Potential FusionNeoAntigen Information of MTMR2-CLNS1A in HLA I |
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MTMR2-CLNS1A_95657039_77340944.msa |
![]() * We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5) |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA I | FusionNeoAntigen peptide | Binding score | Immunogenic score | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:01 | SLSSRLSW | 0.9988 | 0.9741 | 10 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:01 | DSLSSRLSW | 0.9981 | 0.9505 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:01 | DSLSSRLSW | 0.9947 | 0.8856 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:02 | DSLSSRLSW | 0.9945 | 0.8741 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A02:22 | SLSSRLSWL | 0.9922 | 0.5363 | 10 | 19 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A02:13 | SLSSRLSWL | 0.9807 | 0.7283 | 10 | 19 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A02:27 | SLSSRLSWL | 0.9725 | 0.673 | 10 | 19 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:17 | DSLSSRLSW | 0.9723 | 0.85 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A02:38 | SLSSRLSWL | 0.9646 | 0.7715 | 10 | 19 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:03 | DSLSSRLSW | 0.8838 | 0.9567 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A32:13 | DSLSSRLSW | 0.7874 | 0.94 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:01 | VDSLSSRLSW | 0.9998 | 0.9454 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:02 | VDSLSSRLSW | 0.9985 | 0.85 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:01 | VDSLSSRLSW | 0.9975 | 0.8675 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:03 | VDSLSSRLSW | 0.9925 | 0.9562 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:17 | VDSLSSRLSW | 0.9806 | 0.7753 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:16 | VDSLSSRLSW | 0.9775 | 0.555 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:01 | SVDSLSSRLSW | 1 | 0.9642 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:02 | SVDSLSSRLSW | 0.9998 | 0.9002 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:01 | SVDSLSSRLSW | 0.9995 | 0.9112 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:03 | SVDSLSSRLSW | 0.9991 | 0.9756 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:16 | SVDSLSSRLSW | 0.999 | 0.6166 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:17 | SVDSLSSRLSW | 0.9985 | 0.8405 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A32:13 | SVDSLSSRLSW | 0.9954 | 0.951 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A74:11 | RPPSVDSLSSR | 0.9905 | 0.5061 | 4 | 15 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A74:03 | RPPSVDSLSSR | 0.9905 | 0.5061 | 4 | 15 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A74:09 | RPPSVDSLSSR | 0.9905 | 0.5061 | 4 | 15 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:10 | SVDSLSSRL | 0.9999 | 0.6719 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C05:09 | SVDSLSSRL | 0.9999 | 0.8599 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:15 | SVDSLSSRL | 0.9999 | 0.9434 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:07 | SVDSLSSRL | 0.9999 | 0.6923 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C01:17 | SVDSLSSRL | 0.9998 | 0.9223 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C03:07 | SVDSLSSRL | 0.9986 | 0.9339 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C15:06 | SVDSLSSRL | 0.9982 | 0.8978 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C01:30 | SVDSLSSRL | 0.9959 | 0.9508 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:06 | SVDSLSSRL | 0.9958 | 0.6812 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:04 | SVDSLSSRL | 0.9903 | 0.9205 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:13 | SVDSLSSRL | 0.9903 | 0.9205 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:14 | SVDSLSSRL | 0.9779 | 0.7152 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:03 | SVDSLSSRL | 0.8744 | 0.9828 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C02:06 | SVDSLSSRL | 0.8662 | 0.9064 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:10 | SLSSRLSW | 0.9988 | 0.9741 | 10 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C01:03 | SVDSLSSRL | 0.9999 | 0.869 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C18:01 | SVDSLSSRL | 0.9999 | 0.6958 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C05:01 | SVDSLSSRL | 0.9999 | 0.8599 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:02 | SVDSLSSRL | 0.9999 | 0.9434 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:01 | SVDSLSSRL | 0.9999 | 0.6923 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:03 | SVDSLSSRL | 0.9999 | 0.7268 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C01:02 | SVDSLSSRL | 0.9998 | 0.9228 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:10 | DSLSSRLSW | 0.9981 | 0.9505 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C15:05 | SVDSLSSRL | 0.9974 | 0.8549 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:04 | DSLSSRLSW | 0.9938 | 0.7518 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C04:04 | SVDSLSSRL | 0.9936 | 0.6334 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A02:03 | SLSSRLSWL | 0.9914 | 0.7258 | 10 | 19 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:06 | DSLSSRLSW | 0.9819 | 0.7533 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:02 | DSLSSRLSW | 0.9693 | 0.9313 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C03:06 | SVDSLSSRL | 0.963 | 0.979 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A25:01 | DSLSSRLSW | 0.913 | 0.6795 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B15:13 | DSLSSRLSW | 0.8801 | 0.6404 | 9 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C08:01 | SVDSLSSRL | 0.8744 | 0.9828 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C07:04 | SVDSLSSRL | 0.8171 | 0.8847 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-C17:01 | SVDSLSSRL | 0.7768 | 0.814 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B07:13 | SVDSLSSRL | 0.4754 | 0.6309 | 7 | 16 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:10 | VDSLSSRLSW | 0.9998 | 0.9454 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:04 | VDSLSSRLSW | 0.999 | 0.7568 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:02 | VDSLSSRLSW | 0.9953 | 0.9082 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:06 | VDSLSSRLSW | 0.9948 | 0.7158 | 8 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:10 | SVDSLSSRLSW | 1 | 0.9642 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:04 | SVDSLSSRLSW | 0.9999 | 0.7606 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B57:02 | SVDSLSSRLSW | 0.9998 | 0.8825 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-B58:06 | SVDSLSSRLSW | 0.9996 | 0.7812 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A32:01 | SVDSLSSRLSW | 0.9939 | 0.9095 | 7 | 18 |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 | HLA-A74:01 | RPPSVDSLSSR | 0.9905 | 0.5061 | 4 | 15 |
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Potential FusionNeoAntigen Information of MTMR2-CLNS1A in HLA II |
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![]() * We used NetMHCIIpan v4.1 (%rank<0.5). |
Fusion gene | Hchr | Hbp | Tgene | Tchr | Tbp | HLA II | FusionNeoAntigen peptide | Neoantigen start (at BP 13) | Neoantigen end (at BP 13) |
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Fusion breakpoint peptide structures of MTMR2-CLNS1A |
![]() * The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA. |
File name | BPseq | Hgene | Tgene | Hchr | Hbp | Tchr | Tbp | AAlen |
7025 | PSVDSLSSRLSWLD | MTMR2 | CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 421 |
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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MTMR2-CLNS1A |
![]() * We used Glide to predict the interaction between HLAs and neoantigens. |
HLA allele | PDB ID | File name | BPseq | Docking score | Glide score |
HLA-B14:02 | 3BVN | 7025 | PSVDSLSSRLSWLD | -6.44495 | -6.55835 |
HLA-B14:02 | 3BVN | 7025 | PSVDSLSSRLSWLD | -4.99634 | -6.03164 |
HLA-B52:01 | 3W39 | 7025 | PSVDSLSSRLSWLD | -4.20701 | -5.24231 |
HLA-B52:01 | 3W39 | 7025 | PSVDSLSSRLSWLD | -3.71661 | -3.83001 |
HLA-A24:02 | 5HGA | 7025 | PSVDSLSSRLSWLD | -6.53818 | -6.65158 |
HLA-A24:02 | 5HGA | 7025 | PSVDSLSSRLSWLD | -4.37882 | -5.41412 |
HLA-B44:05 | 3DX8 | 7025 | PSVDSLSSRLSWLD | -4.88113 | -4.99453 |
HLA-B44:05 | 3DX8 | 7025 | PSVDSLSSRLSWLD | -3.29255 | -4.32785 |
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Vaccine Design for the FusionNeoAntigens of MTMR2-CLNS1A |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide sequence | FusionNeoAntigen RNA sequence |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 10 | 18 | SLSSRLSW | CTTGTCCAGCCGCCTGTCTTGGTT |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 10 | 19 | SLSSRLSWL | CTTGTCCAGCCGCCTGTCTTGGTTAGA |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 4 | 15 | RPPSVDSLSSR | GCCGCCCAGCGTGGACTCCTTGTCCAGCCGCCT |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 7 | 16 | SVDSLSSRL | CGTGGACTCCTTGTCCAGCCGCCTGTC |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 7 | 18 | SVDSLSSRLSW | CGTGGACTCCTTGTCCAGCCGCCTGTCTTGGTT |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 8 | 18 | VDSLSSRLSW | GGACTCCTTGTCCAGCCGCCTGTCTTGGTT |
MTMR2-CLNS1A | chr11 | 95657039 | chr11 | 77340944 | 9 | 18 | DSLSSRLSW | CTCCTTGTCCAGCCGCCTGTCTTGGTT |
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Fusion gene | Hchr | Hbp | Tchr | Tbp | Start in +/-13AA | End in +/-13AA | FusionNeoAntigen peptide | FusionNEoAntigen RNA sequence |
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Information of the samples that have these potential fusion neoantigens of MTMR2-CLNS1A |
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Cancer type | Fusion gene | Hchr | Hbp | Henst | Tchr | Tbp | Tenst | Sample |
STAD | MTMR2-CLNS1A | chr11 | 95657039 | ENST00000346299 | chr11 | 77340944 | ENST00000263309 | TCGA-BR-6456-01A |
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Potential target of CAR-T therapy development for MTMR2-CLNS1A |
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![]() * Minus value of BPloci means that the break point is located before the CDS. |
- In-frame and retained 'Transmembrane'. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
![]() * We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image. |
Hgene | Hchr | Hbp | Henst | Tgene | Tchr | Tbp | Tenst | DeepLoc result |
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Related Drugs to MTMR2-CLNS1A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to MTMR2-CLNS1A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |