Home

Download

Statistics

Examples

Help

Contact

Fusion Protein:ORMDL3-PPP1R1B

Fusion Gene and Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ORMDL3-PPP1R1B
	FusionPDB ID: 61712
	FusionGDB2.0 ID: 61712
		Hgene	Tgene
	Gene symbol	ORMDL3	PPP1R1B
	Gene ID	94103	84152
	Gene name	ORMDL sphingolipid biosynthesis regulator 3	protein phosphatase 1 regulatory inhibitor subunit 1B
	Synonyms	-	DARPP-32\|DARPP32
	Cytomap	17q21.1	17q12
	Type of gene	protein-coding	protein-coding
	Description	ORM1-like protein 3	protein phosphatase 1 regulatory subunit 1Bdopamine and cAMP-regulated neuronal phosphoprotein 32
	Modification date	20200329	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000304046, ENST00000394169, ENST00000579695, ENST00000582052, ENST00000584220,	ENST00000394265, ENST00000394267, ENST00000254079, ENST00000579000, ENST00000580825,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	17 X 10 X 9=1530
	# samples	7	26
	** MAII score	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(26/1530*10)=-2.55694812455156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Fusion gene context	PubMed: ORMDL3 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND fusion [Title/Abstract]
Fusion neoantigen context	PubMed: ORMDL3 [Title/Abstract] AND PPP1R1B [Title/Abstract] AND neoantigen [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ORMDL3(38080283)-PPP1R1B(37785423), # samples:2
Anticipated loss of major functional domain due to fusion event.	ORMDL3-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ORMDL3-PPP1R1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ORMDL3-PPP1R1B seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPP1R1B	GO:0032515	negative regulation of phosphoprotein phosphatase activity	10807923

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:38080283/chr17:37785423)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Retention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

Fusion gene breakpoints across ORMDL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R1B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Amino Acid Sequences

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000580825	PPP1R1B	chr17	37785423	+	983	314	41	847	268
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000254079	PPP1R1B	chr17	37785423	+	1609	314	41	847	268
ENST00000304046	ORMDL3	chr17	38080283	-	ENST00000579000	PPP1R1B	chr17	37785423	+	1506	314	41	748	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000580825	PPP1R1B	chr17	37785423	+	2338	1669	1495	2202	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000254079	PPP1R1B	chr17	37785423	+	2964	1669	1495	2202	235
ENST00000394169	ORMDL3	chr17	38080283	-	ENST00000579000	PPP1R1B	chr17	37785423	+	2861	1669	1495	2103	202

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000304046	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.010393483	0.98960644
ENST00000304046	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.007576624	0.9924233
ENST00000304046	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.007406845	0.9925931
ENST00000394169	ENST00000580825	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.008073447	0.99192655
ENST00000394169	ENST00000254079	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.005531914	0.9944681
ENST00000394169	ENST00000579000	ORMDL3	chr17	38080283	-	PPP1R1B	chr17	37785423	+	0.005726485	0.9942735

Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for ORMDL3-PPP1R1B

+/-13 AA sequence from the breakpoints of the fusion protein sequences.

Hgene	Hchr	Hbp	Tgene	Tchr	Tbp	Length(fusion protein)	BP in fusion protein	Peptide
ORMDL3	chr17	38080283	PPP1R1B	chr17	37785423	1669	58	PVVWTLTNLIHNMIRRRRPTPAMLFR
ORMDL3	chr17	38080283	PPP1R1B	chr17	37785423	314	91	PVVWTLTNLIHNMIRRRRPTPAMLFR

Top

Potential FusionNeoAntigen Information of ORMDL3-PPP1R1B in HLA I

Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)

Fusion gene

Hchr

Hbp

Tgene

Tchr

Tbp

HLA I

FusionNeoAntigen peptide

Binding score

Immunogenic score

Neoantigen start (at BP 13)

Neoantigen end (at BP 13)

Top

Potential FusionNeoAntigen Information of ORMDL3-PPP1R1B in HLA II

ORMDL3-PPP1R1B_38080283_37785423.msa

Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).

Fusion gene	Hchr	Hbp	Tgene	Tchr	Tbp	HLA II	FusionNeoAntigen peptide	Neoantigen start (at BP 13)	Neoantigen end (at BP 13)
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-0303	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1102	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1102	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1102	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1102	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1103	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1103	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1103	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1111	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1114	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1114	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1116	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1116	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1116	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1116	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1120	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1120	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1121	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1121	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1121	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1121	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1136	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1136	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1136	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1136	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1141	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1148	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1148	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1148	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1155	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1155	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1157	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1159	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1159	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1159	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1163	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1163	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1163	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1165	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1165	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1165	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1165	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1168	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1168	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1170	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1170	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1170	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1170	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1176	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1176	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1176	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1185	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1185	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1185	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1186	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1186	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1186	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1186	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1192	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1192	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1301	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1301	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1301	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1301	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1302	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1302	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1304	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1308	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1308	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1308	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1309	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1315	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1315	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1315	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1315	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1316	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1316	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1316	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1316	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1317	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1317	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1317	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1317	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1319	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1319	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1319	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1319	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1320	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1320	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1320	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1320	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1322	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1322	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1322	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1322	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1323	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1323	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1324	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1324	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1324	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1327	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1327	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1327	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1327	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1329	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1329	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1334	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1334	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1335	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1335	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1335	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1335	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1336	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1339	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1339	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1341	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1341	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1343	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1351	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1351	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1351	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1351	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1352	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1352	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1352	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1352	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1353	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1353	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1353	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1353	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1357	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1357	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1357	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1357	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1359	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1359	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1359	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1359	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1361	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1361	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1361	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1361	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1363	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1364	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1364	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1364	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1364	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1368	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1368	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1368	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1368	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1369	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1369	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1369	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1369	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1370	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1370	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1370	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1371	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1371	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1371	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1371	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1372	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1372	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1372	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1373	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1373	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1374	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1374	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1376	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1376	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1378	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1378	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1378	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1378	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1379	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1379	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1379	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1379	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1380	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1380	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1380	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1380	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1383	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1383	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1383	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1383	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1384	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1384	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1384	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1387	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1387	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1387	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1387	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1391	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1391	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1391	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1391	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1392	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1392	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1392	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1392	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1393	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1396	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1396	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1397	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1397	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1398	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1398	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1398	TLTNLIHNMIRRRRP	4	19
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1398	NLIHNMIRRRRPTPA	7	22
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1399	TNLIHNMIRRRRPTP	6	21
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1399	LTNLIHNMIRRRRPT	5	20
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	314	DRB1-1412	TNLIHNMIRRRRPTP	6	21

Top

Fusion breakpoint peptide structures of ORMDL3-PPP1R1B

3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of ORMDL3-PPP1R1B

Virtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.

HLA allele

PDB ID

File name

BPseq

Docking score

Glide score

Top

Vaccine Design for the FusionNeoAntigens of ORMDL3-PPP1R1B

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.

Fusion gene

Hchr

Hbp

Tchr

Tbp

Start in +/-13AA

End in +/-13AA

FusionNeoAntigen peptide sequence

FusionNeoAntigen RNA sequence

mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.

Fusion gene	Hchr	Hbp	Tchr	Tbp	Start in +/-13AA	End in +/-13AA	FusionNeoAntigen peptide	FusionNEoAntigen RNA sequence
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	4	19	TLTNLIHNMIRRRRP	ACCCTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCA
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	5	20	LTNLIHNMIRRRRPT	CTCACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACG
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	6	21	TNLIHNMIRRRRPTP	ACCAACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCT
ORMDL3-PPP1R1B	chr17	38080283	chr17	37785423	7	22	NLIHNMIRRRRPTPA	AACCTCATTCACAACATGATCCGGCGCAGGAGACCAACGCCTGCC

Top

Information of the samples that have these potential fusion neoantigens of ORMDL3-PPP1R1B

These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.

Cancer type

Fusion gene

Hchr

Hbp

Henst

Tchr

Tbp

Tenst

Sample

Top

Potential target of CAR-T therapy development for ORMDL3-PPP1R1B

Predicted 3D structure. We used RoseTTAFold.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features

* Minus value of BPloci means that the break point is located before the CDS.

- In-frame and retained 'Transmembrane'.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000304046

22_42

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000394169

22_42

154.0

Transmembrane

Helical

Hgene

ORMDL3

chr17:38080283

chr17:37785423

ENST00000579695

22_42

154.0

Transmembrane

Helical

Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.

Hgene

Hchr

Hbp

Henst

Tgene

Tchr

Tbp

Tenst

DeepLoc result

Top

Related Drugs to ORMDL3-PPP1R1B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ORMDL3-PPP1R1B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source

	Fusion Gene and Fusion Protein Summary
	Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)
	Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)
	Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)
	Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)
	Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)
	Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)
	Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)
	Potential target of CAR-T therapy development
	Information on the samples that have these potential fusion neoantigens
	Fusion Protein Targeting Drugs - (Manual Curation)
	Fusion Protein Related diseases - (Manual Curation)