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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:SSR1-HADH

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: SSR1-HADH
FusionPDB ID: 86825
FusionGDB2.0 ID: 86825
HgeneTgene
Gene symbol

SSR1

HADH

Gene ID

6745

3033

Gene namesignal sequence receptor subunit 1hydroxyacyl-CoA dehydrogenase
SynonymsTRAPAHAD|HADH1|HADHSC|HCDH|HHF4|MSCHAD|SCHAD
Cytomap

6p24.3

4q25

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit alphaSSR alpha subunitSSR-alphaTRAP alphasignal sequence receptor subunit alphasignal sequence receptor, alphatranslocon-associated protein alpha subunithydroxyacyl-coenzyme A dehydrogenase, mitochondrialL-3-hydroxyacyl-Coenzyme A dehydrogenase, short chainmedium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenaseshort-chain 3-hydroxyacyl-CoA dehydrogenasetestis secretory sperm-binding protein Li
Modification date2020031320200320
UniProtAcc.

P55084

Main function of 5'-partner protein: FUNCTION: Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway (PubMed:8135828, PubMed:29915090, PubMed:30850536). The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA (PubMed:29915090). Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids (PubMed:30850536). Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity (PubMed:8135828, PubMed:29915090, PubMed:30850536). {ECO:0000269|PubMed:29915090, ECO:0000269|PubMed:30850536, ECO:0000269|PubMed:8135828, ECO:0000303|PubMed:29915090, ECO:0000303|PubMed:30850536}.
Ensembl transtripts involved in fusion geneENST idsENST00000244763, ENST00000397511, 
ENST00000462112, ENST00000474597, 
ENST00000479365, ENST00000489567, 
ENST00000534851, ENST00000488834, 
ENST00000510728, ENST00000309522, 
ENST00000403312, ENST00000454409, 
ENST00000505878, ENST00000603302, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 18 X 8=21605 X 7 X 3=105
# samples 185
** MAII scorelog2(18/2160*10)=-3.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/105*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: SSR1 [Title/Abstract] AND HADH [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: SSR1 [Title/Abstract] AND HADH [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)SSR1(7310149)-HADH(108944629), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:7310149/chr4:108944629)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across SSR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HADH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000474597SSR1chr67310149-ENST00000603302HADHchr4108944629+154627987728213
ENST00000474597SSR1chr67310149-ENST00000403312HADHchr4108944629+154727987728213
ENST00000474597SSR1chr67310149-ENST00000309522HADHchr4108944629+149627987677196
ENST00000474597SSR1chr67310149-ENST00000505878HADHchr4108944629+149227987677196
ENST00000474597SSR1chr67310149-ENST00000454409HADHchr4108944629+149227987677196
ENST00000244763SSR1chr67310149-ENST00000603302HADHchr4108944629+154627987728213
ENST00000244763SSR1chr67310149-ENST00000403312HADHchr4108944629+154727987728213
ENST00000244763SSR1chr67310149-ENST00000309522HADHchr4108944629+149627987677196
ENST00000244763SSR1chr67310149-ENST00000505878HADHchr4108944629+149227987677196
ENST00000244763SSR1chr67310149-ENST00000454409HADHchr4108944629+149227987677196
ENST00000397511SSR1chr67310149-ENST00000603302HADHchr4108944629+153727078719213
ENST00000397511SSR1chr67310149-ENST00000403312HADHchr4108944629+153827078719213
ENST00000397511SSR1chr67310149-ENST00000309522HADHchr4108944629+148727078668196
ENST00000397511SSR1chr67310149-ENST00000505878HADHchr4108944629+148327078668196
ENST00000397511SSR1chr67310149-ENST00000454409HADHchr4108944629+148327078668196
ENST00000534851SSR1chr67310149-ENST00000603302HADHchr4108944629+154127482723213
ENST00000534851SSR1chr67310149-ENST00000403312HADHchr4108944629+154227482723213
ENST00000534851SSR1chr67310149-ENST00000309522HADHchr4108944629+149127482672196
ENST00000534851SSR1chr67310149-ENST00000505878HADHchr4108944629+148727482672196
ENST00000534851SSR1chr67310149-ENST00000454409HADHchr4108944629+148727482672196
ENST00000489567SSR1chr67310149-ENST00000603302HADHchr4108944629+151324654695213
ENST00000489567SSR1chr67310149-ENST00000403312HADHchr4108944629+151424654695213
ENST00000489567SSR1chr67310149-ENST00000309522HADHchr4108944629+146324654644196
ENST00000489567SSR1chr67310149-ENST00000505878HADHchr4108944629+145924654644196
ENST00000489567SSR1chr67310149-ENST00000454409HADHchr4108944629+145924654644196
ENST00000479365SSR1chr67310149-ENST00000603302HADHchr4108944629+152125462703213
ENST00000479365SSR1chr67310149-ENST00000403312HADHchr4108944629+152225462703213
ENST00000479365SSR1chr67310149-ENST00000309522HADHchr4108944629+147125462652196
ENST00000479365SSR1chr67310149-ENST00000505878HADHchr4108944629+146725462652196
ENST00000479365SSR1chr67310149-ENST00000454409HADHchr4108944629+146725462652196
ENST00000462112SSR1chr67310149-ENST00000603302HADHchr4108944629+152726068709213
ENST00000462112SSR1chr67310149-ENST00000403312HADHchr4108944629+152826068709213
ENST00000462112SSR1chr67310149-ENST00000309522HADHchr4108944629+147726068658196
ENST00000462112SSR1chr67310149-ENST00000505878HADHchr4108944629+147326068658196
ENST00000462112SSR1chr67310149-ENST00000454409HADHchr4108944629+147326068658196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000474597ENST00000603302SSR1chr67310149-HADHchr4108944629+0.000276210.99972373
ENST00000474597ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002804180.99971956
ENST00000474597ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0002343010.9997657
ENST00000474597ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0002255450.9997745
ENST00000474597ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0002255450.9997745
ENST00000244763ENST00000603302SSR1chr67310149-HADHchr4108944629+0.000276210.99972373
ENST00000244763ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002804180.99971956
ENST00000244763ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0002343010.9997657
ENST00000244763ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0002255450.9997745
ENST00000244763ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0002255450.9997745
ENST00000397511ENST00000603302SSR1chr67310149-HADHchr4108944629+0.0002476060.99975234
ENST00000397511ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002521860.9997478
ENST00000397511ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0001926160.9998074
ENST00000397511ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0001858140.9998142
ENST00000397511ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0001858140.9998142
ENST00000534851ENST00000603302SSR1chr67310149-HADHchr4108944629+0.0002295620.99977046
ENST00000534851ENST00000403312SSR1chr67310149-HADHchr4108944629+0.000232430.9997676
ENST00000534851ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0001859880.9998141
ENST00000534851ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0001814930.9998185
ENST00000534851ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0001814930.9998185
ENST00000489567ENST00000603302SSR1chr67310149-HADHchr4108944629+0.0002755280.99972445
ENST00000489567ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002782650.9997217
ENST00000489567ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0002518140.9997482
ENST00000489567ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0002470830.99975294
ENST00000489567ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0002470830.99975294
ENST00000479365ENST00000603302SSR1chr67310149-HADHchr4108944629+0.0002367530.9997632
ENST00000479365ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002395140.99976045
ENST00000479365ENST00000309522SSR1chr67310149-HADHchr4108944629+0.0001966110.99980336
ENST00000479365ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0001893510.99981064
ENST00000479365ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0001893510.99981064
ENST00000462112ENST00000603302SSR1chr67310149-HADHchr4108944629+0.0002555970.99974436
ENST00000462112ENST00000403312SSR1chr67310149-HADHchr4108944629+0.0002575110.99974245
ENST00000462112ENST00000309522SSR1chr67310149-HADHchr4108944629+0.00021530.99978477
ENST00000462112ENST00000505878SSR1chr67310149-HADHchr4108944629+0.0002034320.99979657
ENST00000462112ENST00000454409SSR1chr67310149-HADHchr4108944629+0.0002034320.99979657

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for SSR1-HADH

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
SSR1chr67310149HADHchr410894462924664DEAEVEEDEPTDLVIKTPMTSQKTFE
SSR1chr67310149HADHchr410894462925464DEAEVEEDEPTDLVIKTPMTSQKTFE
SSR1chr67310149HADHchr410894462926064DEAEVEEDEPTDLVIKTPMTSQKTFE
SSR1chr67310149HADHchr410894462927064DEAEVEEDEPTDLVIKTPMTSQKTFE
SSR1chr67310149HADHchr410894462927464DEAEVEEDEPTDLVIKTPMTSQKTFE
SSR1chr67310149HADHchr410894462927964DEAEVEEDEPTDLVIKTPMTSQKTFE

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Potential FusionNeoAntigen Information of SSR1-HADH in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SSR1-HADH_7310149_108944629.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SSR1-HADHchr67310149chr4108944629279HLA-B45:01EEDEPTDLV0.93840.8295514
SSR1-HADHchr67310149chr4108944629279HLA-B50:02EEDEPTDLV0.85860.5527514
SSR1-HADHchr67310149chr4108944629279HLA-B41:01EEDEPTDLV0.13940.8859514
SSR1-HADHchr67310149chr4108944629279HLA-B44:10EEDEPTDLV0.68550.5325514
SSR1-HADHchr67310149chr4108944629279HLA-B39:08EEDEPTDLV0.18320.8305514
SSR1-HADHchr67310149chr4108944629279HLA-B39:11EEDEPTDLV0.14690.7702514

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Potential FusionNeoAntigen Information of SSR1-HADH in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
SSR1-HADH_7310149_108944629.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
SSR1-HADHchr67310149chr4108944629279DRB1-0804PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-0804EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-0820PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-0820EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-0828PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-0828EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1125PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1167PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1167EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1318PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1367PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1403PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1403EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1412PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1412EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1415PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1415EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1427PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1427EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1440PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1440EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1467PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1467EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1477PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1477EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1484PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1484EPTDLVIKTPMTSQK823
SSR1-HADHchr67310149chr4108944629279DRB1-1489PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1498PTDLVIKTPMTSQKT924
SSR1-HADHchr67310149chr4108944629279DRB1-1498EPTDLVIKTPMTSQK823

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Fusion breakpoint peptide structures of SSR1-HADH

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
1582EDEPTDLVIKTPMTSSR1HADHchr67310149chr4108944629279

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of SSR1-HADH

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B52:013W391582EDEPTDLVIKTPMT-6.4768-6.4768
HLA-B44:053DX81582EDEPTDLVIKTPMT-4.90229-4.90229
HLA-A02:016TDR1582EDEPTDLVIKTPMT-7.52444-7.52444

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Vaccine Design for the FusionNeoAntigens of SSR1-HADH

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
SSR1-HADHchr67310149chr4108944629514EEDEPTDLVGAAGAAGATGAACCCACAGATTTGGTC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence
SSR1-HADHchr67310149chr4108944629823EPTDLVIKTPMTSQKGAACCCACAGATTTGGTCATTAAAACACCAATGACCAGCCAGAAG
SSR1-HADHchr67310149chr4108944629924PTDLVIKTPMTSQKTCCCACAGATTTGGTCATTAAAACACCAATGACCAGCCAGAAGACA

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Information of the samples that have these potential fusion neoantigens of SSR1-HADH

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
Non-CancerSSR1-HADHchr67310149ENST00000244763chr4108944629ENST00000309522123Nd

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Potential target of CAR-T therapy development for SSR1-HADH

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to SSR1-HADH

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to SSR1-HADH

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource