FusionNeoAntigen Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use

Center for Computational Systems Medicine
leaf

Fusion Gene and Fusion Protein Summary

leaf

Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

leaf

Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

leaf

Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

leaf

Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

leaf

Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

leaf

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

leaf

Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

leaf

Potential target of CAR-T therapy development

leaf

Information on the samples that have these potential fusion neoantigens

leaf

Fusion Protein Targeting Drugs - (Manual Curation)

leaf

Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:BAZ1A-NKX2-1

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BAZ1A-NKX2-1
FusionPDB ID: 9015
FusionGDB2.0 ID: 9015
HgeneTgene
Gene symbol

BAZ1A

NKX2-1

Gene ID

11177

7080

Gene namebromodomain adjacent to zinc finger domain 1ANK2 homeobox 1
SynonymsACF1|WALp1|WCRF180|hACF1BCH|BHC|NK-2|NKX2.1|NKX2A|NMTC1|T/EBP|TEBP|TITF1|TTF-1|TTF1
Cytomap

14q13.1-q13.2

14q13.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain adjacent to zinc finger domain protein 1AATP-dependent chromatin remodeling proteinATP-utilizing chromatin assembly and remodeling factor 1CHRAC subunit ACF1hWALp1williams syndrome transcription factor-related chromatin-remodeling factor homeobox protein Nkx-2.1NK-2 homolog Ahomeobox protein NK-2 homolog Athyroid nuclear factor 1thyroid transcription factor 1thyroid-specific enhancer-binding protein
Modification date2020031320200313
UniProtAcc

Q9NRL2

Main function of 5'-partner protein: FUNCTION: Component of the ACF complex, an ATP-dependent chromatin remodeling complex, that regulates spacing of nucleosomes using ATP to generate evenly spaced nucleosomes along the chromatin. The ATPase activity of the complex is regulated by the length of flanking DNA. Also involved in facilitating the DNA replication process. BAZ1A is the accessory, non-catalytic subunit of the complex which can enhance and direct the process provided by the ATPase subunit, SMARCA5, probably through targeting pericentromeric heterochromatin in late S phase. Moves end-positioned nucleosomes to a predominantly central position. May have a role in nuclear receptor-mediated transcription repression.; FUNCTION: Component of the histone-fold protein complex CHRAC complex which facilitates nucleosome sliding by the ACF complex and enhances ACF-mediated chromatin assembly. The C-terminal regions of both CHRAC1 and POLE1 are required for these functions.

P43699

Main function of 5'-partner protein: FUNCTION: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (By similarity). {ECO:0000250|UniProtKB:P23441, ECO:0000250|UniProtKB:P50220}.
Ensembl transtripts involved in fusion geneENST idsENST00000358716, ENST00000360310, 
ENST00000382422, ENST00000553853, 
ENST00000498187, ENST00000518149, 
ENST00000522719, ENST00000354822, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 9 X 5=5401 X 1 X 1=1
# samples 121
** MAII scorelog2(12/540*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Fusion gene context

PubMed: BAZ1A [Title/Abstract] AND NKX2-1 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: BAZ1A [Title/Abstract] AND NKX2-1 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BAZ1A(35331250)-NKX2-1(36988575), # samples:1
Anticipated loss of major functional domain due to fusion event.BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
BAZ1A-NKX2-1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAZ1A

GO:0006261

DNA-dependent DNA replication

12434153

TgeneNKX2-1

GO:0000122

negative regulation of transcription by RNA polymerase II

23143308

TgeneNKX2-1

GO:0010628

positive regulation of gene expression

16960125

TgeneNKX2-1

GO:0010719

negative regulation of epithelial to mesenchymal transition

19293183

TgeneNKX2-1

GO:0030336

negative regulation of cell migration

19293183

TgeneNKX2-1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

19293183

TgeneNKX2-1

GO:0045893

positive regulation of transcription, DNA-templated

14960358

TgeneNKX2-1

GO:0045944

positive regulation of transcription by RNA polymerase II

7559607|7713914|16960125



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:35331250/chr14:36988575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across BAZ1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NKX2-1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000382422BAZ1Achr1435331250-ENST00000354822NKX2-1chr1436988575-2730720281848606

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000382422ENST00000354822BAZ1Achr1435331250-NKX2-1chr1436988575-0.015189990.98481005

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

Top

Fusion Protein Breakpoint Sequences for BAZ1A-NKX2-1

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
BAZ1Achr1435331250NKX2chr1436988575720230VEETVEVIRNNGASRRRIMSMSPKHT

Top

Potential FusionNeoAntigen Information of BAZ1A-NKX2-1 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
BAZ1A-NKX2-1_35331250_36988575.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A30:08ASRRRIMSM0.96920.77571221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-B14:02ASRRRIMSM0.81380.69741221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-B14:01ASRRRIMSM0.81380.69741221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A31:02VIRNNGASR0.77740.7436615
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:24EVIRNNGASR0.9990.5797515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:03EVIRNNGASR0.99860.5572515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A66:01EVIRNNGASR0.99850.8209515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A26:03EVIRNNGASR0.98890.8177515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:05EVIRNNGASR0.98380.5705515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A33:05EVIRNNGASR0.95750.6141515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A33:01EVIRNNGASR0.95750.6141515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A34:01EVIRNNGASR0.94110.6236515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A34:05EVIRNNGASR0.94110.6236515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:08EVIRNNGASR0.90120.5047515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A66:01EVIRNNGASRR0.9990.8469516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:24EVIRNNGASRR0.99890.7595516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:03EVIRNNGASRR0.99850.746516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A26:03EVIRNNGASRR0.99480.8512516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:05EVIRNNGASRR0.99170.7532516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A34:05EVIRNNGASRR0.98630.7545516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A34:01EVIRNNGASRR0.98630.7545516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A66:03EVIRNNGASRR0.95990.5516516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C15:04ASRRRIMSM0.98420.89571221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C12:12ASRRRIMSM0.97740.9361221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C15:06ASRRRIMSM0.92780.87791221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C06:03ASRRRIMSM0.91760.99421221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C12:04ASRRRIMSM0.9140.99441221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:01EVIRNNGASR0.9990.5797515
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A68:01EVIRNNGASRR0.99890.7595516
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C15:09ASRRRIMSM0.98420.89571221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A30:01ASRRRIMSM0.97410.91041221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C12:03ASRRRIMSM0.96220.98121221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-B58:06ASRRRIMSM0.9110.78391221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C15:02ASRRRIMSM0.89850.85441221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C16:04ASRRRIMSM0.86550.97241221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C16:01ASRRRIMSM0.66050.98011221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-C16:02ASRRRIMSM0.56030.99311221
BAZ1A-NKX2-1chr1435331250chr1436988575720HLA-A66:02EVIRNNGASRR0.96970.5815516

Top

Potential FusionNeoAntigen Information of BAZ1A-NKX2-1 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
BAZ1A-NKX2-1_35331250_36988575.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0102EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0123EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0303TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0303ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0303VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0303EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0303EVIRNNGASRRRIMS520
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0307TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0324TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0324ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0324VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0401EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0401VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0401ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0403EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0403VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0403ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0407EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0407VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0411EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0411VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0413EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0413VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0413ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0415EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0415VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0415ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0419EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0419VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0419ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0422EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0422VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0427EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0427VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0427ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0431EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0431VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0431ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0433EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0433VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0433ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0434EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0434VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0435EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0435VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0435ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0436EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0436VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0436ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0437EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0437VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0437ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0438EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0438VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0438ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0439EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0439VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0439ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0440EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0440VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0440ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0441EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0441VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0441ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0442EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0442VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0442ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0443EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0443VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0443ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0444EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0444VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0444ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0446EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0446VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0446ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0447EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0447VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0449EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0449VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0449ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0450EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0450VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0450ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0451EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0451VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0451ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0452EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0452VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0452ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0453EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0453VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0453ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0454EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0454VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0455EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0455VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0455ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0456EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0456VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0456ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0458EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0458VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0458ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0459EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0459VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0459ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0460EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0460VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0460ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0461EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0461VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0461ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0462EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0462VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0463EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0463VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0463ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0464EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0464VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0465EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0465VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0465ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0467EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0467VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0468EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0468VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0468ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0470EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0470VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0470ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0471EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0471VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0471ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0472EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0472VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0473EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0473VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0473ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0474EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0474VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0475EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0475VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0475ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0476EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0476VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0476ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0478EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0478VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0478ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0479EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0479VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0479ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0480EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0482EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0482VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0485EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0485VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0485ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0488EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0488VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0488ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0491EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0491VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0804EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0812EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0813EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0815EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0830EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0831EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-0831VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1002EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1002VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1107TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1130EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1134EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1182EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1183EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1186EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1186ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1186TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1204EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1209EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1220EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1309EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1316EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1316ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1316TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1344EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1367EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1386EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1396TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1396ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1396VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1402EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1402ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1406EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1406ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1406VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1409EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1410EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1410VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1410ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1412EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1415EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1417EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1419TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1419ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1419VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1419EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1420EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1420ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1420VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1421EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1424EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1424ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1424TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1429EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1429ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1429TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1429VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1437EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1437VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1441EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1441ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1446EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1446VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1446ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1447TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1447ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1447VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1447EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1448EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1452EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1452VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1452ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1457EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1457VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1457ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1480EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1480VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1481EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1483EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1483ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1483VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1484EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1489EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1489ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1489TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1494EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1494ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1498TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1498ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1501EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1503EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1504EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1504VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1505EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1505VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1506EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1507EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1507VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1509EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1510EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1511EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1512EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1513EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1515EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1516EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1518EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1520EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1521EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1521VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1522EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1523EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1523VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1524EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1525EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1525VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1525ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1527EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1528EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1531EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1532EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1533EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1534EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1534VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1535EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1535VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1536EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1537EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1540EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1541EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1542EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1543EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1545EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1546EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1548EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1548VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1549EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1549VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1601EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1602EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1603EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1604EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1605EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1607EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1608EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1611EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1612EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1614EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1615EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1615VEETVEVIRNNGASR015
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1615ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB1-1616EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0201ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0201EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0201TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0201VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0204TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0204ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0204EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0204VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0205TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0205ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0214TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0214ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0219TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0222TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0224ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0224EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0224TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB3-0224VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0106ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0106TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0106EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0106VEVIRNNGASRRRIM419
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0111TVEVIRNNGASRRRI318
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0111ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0204EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0204ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0205EETVEVIRNNGASRR116
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0205ETVEVIRNNGASRRR217
BAZ1A-NKX2-1chr1435331250chr1436988575720DRB5-0205TVEVIRNNGASRRRI318

Top

Fusion breakpoint peptide structures of BAZ1A-NKX2-1

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.

Top

Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of BAZ1A-NKX2-1

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score

Top

Vaccine Design for the FusionNeoAntigens of BAZ1A-NKX2-1

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

Top

Information of the samples that have these potential fusion neoantigens of BAZ1A-NKX2-1

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
LUADBAZ1A-NKX2-1chr1435331250ENST00000382422chr1436988575ENST00000354822TCGA-L9-A444-01A

Top

Potential target of CAR-T therapy development for BAZ1A-NKX2-1

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

Top

Related Drugs to BAZ1A-NKX2-1

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to BAZ1A-NKX2-1

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource