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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:BRD9-STARD3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: BRD9-STARD3
FusionPDB ID: 10228
FusionGDB2.0 ID: 10228
HgeneTgene
Gene symbol

BRD9

STARD3

Gene ID

65980

10948

Gene namebromodomain containing 9StAR related lipid transfer domain containing 3
SynonymsLAVS3040|PRO9856CAB1|MLN64|es64
Cytomap

5p15.33

17q12

Type of geneprotein-codingprotein-coding
Descriptionbromodomain-containing protein 9rhabdomyosarcoma antigen MU-RMS-40.8sarcoma antigen NY-SAR-29stAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein related
Modification date2020031520200313
UniProtAcc

Q9H8M2

STARD3NL

Ensembl transtripts involved in fusion geneENST idsENST00000323510, ENST00000388890, 
ENST00000467963, ENST00000483173, 
ENST00000435709, ENST00000494422, 
ENST00000394250, ENST00000544210, 
ENST00000578232, ENST00000580611, 
ENST00000336308, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 15 X 7=105015 X 10 X 10=1500
# samples 1224
** MAII scorelog2(12/1050*10)=-3.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/1500*10)=-2.64385618977472
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: BRD9 [Title/Abstract] AND STARD3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)BRD9(876216)-STARD3(37813261), # samples:3
Anticipated loss of major functional domain due to fusion event.BRD9-STARD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD9-STARD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD9-STARD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
BRD9-STARD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSTARD3

GO:0030301

cholesterol transport

28377464

TgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464


check buttonFusion gene breakpoints across BRD9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across STARD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A8W5-01BBRD9chr5

876216

-STARD3chr17

37813261

+
ChimerDB4ESCATCGA-R6-A8W5BRD9chr5

876215

-STARD3chr17

37813260

+
ChimerDB4ESCATCGA-R6-A8W5BRD9chr5

876215

-STARD3chr17

37814027

+
ChimerDB4ESCATCGA-R6-A8W5BRD9chr5

876216

-STARD3chr17

37813261

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000388890BRD9chr5876216-ENST00000336308STARD3chr1737813261+2730103502153717
ENST00000323510BRD9chr5876216-ENST00000336308STARD3chr1737813261+2790109502213737
ENST00000483173BRD9chr5876216-ENST00000336308STARD3chr1737813261+305913641042482792
ENST00000467963BRD9chr5876216-ENST00000336308STARD3chr1737813261+324515501672668833
ENST00000388890BRD9chr5876215-ENST00000336308STARD3chr1737813260+2730103502153717
ENST00000323510BRD9chr5876215-ENST00000336308STARD3chr1737813260+2790109502213737
ENST00000483173BRD9chr5876215-ENST00000336308STARD3chr1737813260+305913641042482792
ENST00000467963BRD9chr5876215-ENST00000336308STARD3chr1737813260+324515501672668833
ENST00000388890BRD9chr5876215-ENST00000336308STARD3chr1737814027+2652103502075691
ENST00000323510BRD9chr5876215-ENST00000336308STARD3chr1737814027+2712109502135711
ENST00000483173BRD9chr5876215-ENST00000336308STARD3chr1737814027+298113641042404766
ENST00000467963BRD9chr5876215-ENST00000336308STARD3chr1737814027+316715501672590807

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000388890ENST00000336308BRD9chr5876216-STARD3chr1737813261+0.0026518410.9973482
ENST00000323510ENST00000336308BRD9chr5876216-STARD3chr1737813261+0.0031815910.9968184
ENST00000483173ENST00000336308BRD9chr5876216-STARD3chr1737813261+0.0051183890.99488163
ENST00000467963ENST00000336308BRD9chr5876216-STARD3chr1737813261+0.0028030810.9971969
ENST00000388890ENST00000336308BRD9chr5876215-STARD3chr1737813260+0.0026518410.9973482
ENST00000323510ENST00000336308BRD9chr5876215-STARD3chr1737813260+0.0031815910.9968184
ENST00000483173ENST00000336308BRD9chr5876215-STARD3chr1737813260+0.0051183890.99488163
ENST00000467963ENST00000336308BRD9chr5876215-STARD3chr1737813260+0.0028030810.9971969
ENST00000388890ENST00000336308BRD9chr5876215-STARD3chr1737814027+0.0029349330.9970651
ENST00000323510ENST00000336308BRD9chr5876215-STARD3chr1737814027+0.0029625720.9970374
ENST00000483173ENST00000336308BRD9chr5876215-STARD3chr1737814027+0.004183080.9958169
ENST00000467963ENST00000336308BRD9chr5876215-STARD3chr1737814027+0.0033574340.9966426

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>10228_10228_1_BRD9-STARD3_BRD9_chr5_876215_ENST00000323510_STARD3_chr17_37813260_ENST00000336308_length(amino acids)=737AA_BP=362
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVS
FVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAV
VDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAA
GGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMF

--------------------------------------------------------------

>10228_10228_2_BRD9-STARD3_BRD9_chr5_876215_ENST00000323510_STARD3_chr17_37814027_ENST00000336308_length(amino acids)=711AA_BP=364
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWY
LAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTI
EVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSG

--------------------------------------------------------------

>10228_10228_3_BRD9-STARD3_BRD9_chr5_876215_ENST00000388890_STARD3_chr17_37813260_ENST00000336308_length(amino acids)=717AA_BP=342
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQTNTGIRKNLEQEIIQ
YNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEA
EEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYG
DTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRD

--------------------------------------------------------------

>10228_10228_4_BRD9-STARD3_BRD9_chr5_876215_ENST00000388890_STARD3_chr17_37814027_ENST00000336308_length(amino acids)=691AA_BP=344
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQVLAFFRFSGLLLGYA
VLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSE
GQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAE
LVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENG

--------------------------------------------------------------

>10228_10228_5_BRD9-STARD3_BRD9_chr5_876215_ENST00000467963_STARD3_chr17_37813260_ENST00000336308_length(amino acids)=833AA_BP=458
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGY
LLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQG
KEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYD
VSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQS

--------------------------------------------------------------

>10228_10228_6_BRD9-STARD3_BRD9_chr5_876215_ENST00000467963_STARD3_chr17_37814027_ENST00000336308_length(amino acids)=807AA_BP=460
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEA
EEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYG
DTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRD

--------------------------------------------------------------

>10228_10228_7_BRD9-STARD3_BRD9_chr5_876215_ENST00000483173_STARD3_chr17_37813260_ENST00000336308_length(amino acids)=792AA_BP=417
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAF
FRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVAR
GPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTF
ILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKP

--------------------------------------------------------------

>10228_10228_8_BRD9-STARD3_BRD9_chr5_876215_ENST00000483173_STARD3_chr17_37814027_ENST00000336308_length(amino acids)=766AA_BP=419
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQVLAFFRFSGLLLGYAVLRLRHWWVIAVTTL
VSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDN
ESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVL
WNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRV

--------------------------------------------------------------

>10228_10228_9_BRD9-STARD3_BRD9_chr5_876216_ENST00000323510_STARD3_chr17_37813261_ENST00000336308_length(amino acids)=737AA_BP=362
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKERLLALKRSMSFMQDMDFSQQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREV
ISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPG
FTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTL
FQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVS
FVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAV
VDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAA
GGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQSLAATMF

--------------------------------------------------------------

>10228_10228_10_BRD9-STARD3_BRD9_chr5_876216_ENST00000388890_STARD3_chr17_37813261_ENST00000336308_length(amino acids)=717AA_BP=342
MKGYQSLVFNFFFLKLSAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFK
LMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAE
EHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSA
TTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQTNTGIRKNLEQEIIQ
YNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEA
EEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYG
DTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRD

--------------------------------------------------------------

>10228_10228_11_BRD9-STARD3_BRD9_chr5_876216_ENST00000467963_STARD3_chr17_37813261_ENST00000336308_length(amino acids)=833AA_BP=458
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGY
LLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQG
KEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYD
VSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQS

--------------------------------------------------------------

>10228_10228_12_BRD9-STARD3_BRD9_chr5_876216_ENST00000483173_STARD3_chr17_37813261_ENST00000336308_length(amino acids)=792AA_BP=417
MNSQDPATTPVTMMTGQTMSERGTKKRKRRRRRSPRRRSIWTMRKEGSERKRRSGSERGSTVTRRERLTTLILGRRWRWSRPQIGQSERA
GHSQPKMRAHLFSNSWNTSSASFRDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTV
YYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEAR
DRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDL
KSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGGDHSRTLFQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAF
FRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVAR
GPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTF
ILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:876216/chr17:37813261)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRD9

Q9H8M2

STARD3

STARD3NL

FUNCTION: Plays a role in chromatin remodeling and regulation of transcription (PubMed:22464331, PubMed:26365797). Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797). Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:29374058). Orchestrates also the RAD51-RAD54 complex formation and thereby plays a role in homologous recombination (HR) (PubMed:32457312). {ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:26365797, ECO:0000269|PubMed:29374058, ECO:0000269|PubMed:32457312}.234

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRD9chr5:876215chr17:37813260ENST00000323510-91364_95365.0502.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37813260ENST00000388890-91364_95345.0482.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37813260ENST00000467963-121664_95461.0598.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37813260ENST00000483173-121664_95408.0545.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37814027ENST00000323510-91364_95365.0502.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37814027ENST00000388890-91364_95345.0482.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37814027ENST00000467963-121664_95461.0598.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37814027ENST00000483173-121664_95408.0545.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876216chr17:37813261ENST00000323510-91364_95365.0502.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876216chr17:37813261ENST00000388890-91364_95345.0482.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876216chr17:37813261ENST00000467963-121664_95461.0598.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876216chr17:37813261ENST00000483173-121664_95408.0545.0Compositional biasNote=Lys-rich
HgeneBRD9chr5:876215chr17:37813260ENST00000323510-913153_223365.0502.0DomainBromo
HgeneBRD9chr5:876215chr17:37813260ENST00000388890-913153_223345.0482.0DomainBromo
HgeneBRD9chr5:876215chr17:37813260ENST00000467963-1216153_223461.0598.0DomainBromo
HgeneBRD9chr5:876215chr17:37813260ENST00000483173-1216153_223408.0545.0DomainBromo
HgeneBRD9chr5:876215chr17:37814027ENST00000323510-913153_223365.0502.0DomainBromo
HgeneBRD9chr5:876215chr17:37814027ENST00000388890-913153_223345.0482.0DomainBromo
HgeneBRD9chr5:876215chr17:37814027ENST00000467963-1216153_223461.0598.0DomainBromo
HgeneBRD9chr5:876215chr17:37814027ENST00000483173-1216153_223408.0545.0DomainBromo
HgeneBRD9chr5:876216chr17:37813261ENST00000323510-913153_223365.0502.0DomainBromo
HgeneBRD9chr5:876216chr17:37813261ENST00000388890-913153_223345.0482.0DomainBromo
HgeneBRD9chr5:876216chr17:37813261ENST00000467963-1216153_223461.0598.0DomainBromo
HgeneBRD9chr5:876216chr17:37813261ENST00000483173-1216153_223408.0545.0DomainBromo
HgeneBRD9chr5:876215chr17:37813260ENST00000323510-913214_216365.0502.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37813260ENST00000388890-913214_216345.0482.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37813260ENST00000467963-1216214_216461.0598.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37813260ENST00000483173-1216214_216408.0545.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37814027ENST00000323510-913214_216365.0502.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37814027ENST00000388890-913214_216345.0482.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37814027ENST00000467963-1216214_216461.0598.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876215chr17:37814027ENST00000483173-1216214_216408.0545.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876216chr17:37813261ENST00000323510-913214_216365.0502.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876216chr17:37813261ENST00000388890-913214_216345.0482.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876216chr17:37813261ENST00000467963-1216214_216461.0598.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
HgeneBRD9chr5:876216chr17:37813261ENST00000483173-1216214_216408.0545.0RegionHistone H4K5ac H4K8ac and histone H4K5bu H4K8bu binding
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115230_44373.0446.0DomainSTART
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114230_44373.0428.0DomainSTART
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115230_44373.0446.0DomainSTART
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215230_44399.0446.0DomainSTART
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214230_44399.0428.0DomainSTART
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215230_44399.0446.0DomainSTART
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115230_44373.0446.0DomainSTART
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114230_44373.0428.0DomainSTART
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115230_44373.0446.0DomainSTART
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115207_21273.0446.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114207_21273.0428.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115207_21273.0446.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215207_21299.0446.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214207_21299.0428.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215207_21299.0446.0MotifFFAT
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115207_21273.0446.0MotifFFAT
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114207_21273.0428.0MotifFFAT
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115207_21273.0446.0MotifFFAT
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115116_12073.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115142_14873.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115170_44573.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST0000033630811573_9473.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114116_12073.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114142_14873.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114170_44573.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST0000039425011473_9473.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115116_12073.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115142_14873.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115170_44573.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST0000054421011573_9473.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215116_12099.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215142_14899.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215170_44599.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214116_12099.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214142_14899.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214170_44599.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215116_12099.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215142_14899.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215170_44599.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115116_12073.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115142_14873.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115170_44573.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST0000033630811573_9473.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114116_12073.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114142_14873.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114170_44573.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST0000039425011473_9473.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115116_12073.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115142_14873.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115170_44573.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST0000054421011573_9473.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115121_14173.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST00000336308115149_16973.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST0000033630811595_11573.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114121_14173.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST00000394250114149_16973.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST0000039425011495_11573.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115121_14173.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST00000544210115149_16973.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST0000054421011595_11573.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215121_14199.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000336308215149_16999.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214121_14199.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000394250214149_16999.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215121_14199.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST00000544210215149_16999.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115121_14173.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000336308115149_16973.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000033630811595_11573.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114121_14173.0428.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000394250114149_16973.0428.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000039425011495_11573.0428.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115121_14173.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST00000544210115149_16973.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000054421011595_11573.0446.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTARD3chr5:876215chr17:37813260ENST0000033630811546_21773.0446.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37813260ENST0000039425011446_21773.0428.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37813260ENST0000054421011546_21773.0446.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37814027ENST0000033630821546_21799.0446.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37814027ENST0000039425021446_21799.0428.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37814027ENST0000054421021546_21799.0446.0DomainMENTAL
TgeneSTARD3chr5:876216chr17:37813261ENST0000033630811546_21773.0446.0DomainMENTAL
TgeneSTARD3chr5:876216chr17:37813261ENST0000039425011446_21773.0428.0DomainMENTAL
TgeneSTARD3chr5:876216chr17:37813261ENST0000054421011546_21773.0446.0DomainMENTAL
TgeneSTARD3chr5:876215chr17:37813260ENST000003363081151_5173.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST000003942501141_5173.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST000005442101151_5173.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST000003363082151_5199.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST0000033630821573_9499.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST000003942502141_5199.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST0000039425021473_9499.0428.0Topological domainExtracellular
TgeneSTARD3chr5:876215chr17:37814027ENST000005442102151_5199.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37814027ENST0000054421021573_9499.0446.0Topological domainExtracellular
TgeneSTARD3chr5:876216chr17:37813261ENST000003363081151_5173.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST000003942501141_5173.0428.0Topological domainCytoplasmic
TgeneSTARD3chr5:876216chr17:37813261ENST000005442101151_5173.0446.0Topological domainCytoplasmic
TgeneSTARD3chr5:876215chr17:37813260ENST0000033630811552_7273.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST0000039425011452_7273.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37813260ENST0000054421011552_7273.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000033630821552_7299.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000033630821595_11599.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000039425021452_7299.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000039425021495_11599.0428.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000054421021552_7299.0446.0TransmembraneHelical
TgeneSTARD3chr5:876215chr17:37814027ENST0000054421021595_11599.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000033630811552_7273.0446.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000039425011452_7273.0428.0TransmembraneHelical
TgeneSTARD3chr5:876216chr17:37813261ENST0000054421011552_7273.0446.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1620_BRD9_876216_STARD3_37813261_ranked_0.pdbBRD9876215876216ENST00000336308STARD3chr1737813261+
MGKKHKKHKAEWRSSYEDYADKPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHKEKKKKKKKKSEKEKHLDDEERRKRKE
EKKRKREREHCDTEGEADDFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQQLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHP
MDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKQAALLGNEDTAVEEPVPEVVPVQVETAKKSK
KPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKRNGDGSLLYSVVNTAEPDADEEETHPVDLSSLS
SKLLPGFTTLGFKDERRNKVTFLSSATTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKVVDDLLDQITGG
DHSRTLFQLKQTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRHWWVIAVTTLVSSAFLIVKVILSELLSKGAFGY
LLPIVSFVLAWLETWFLDFKVLPQEAEEERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIRQG
KEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEVILQPERMVLWNKTVTACQILQRVEDNTLISYD
VSAGAAGGVVSPRDFVNVRRIERRRDRYLSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIHQS
833


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
BRD9_pLDDT.png
all structure
all structure
STARD3_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
BRD9BRD4, WHSC1L1, CATIP, SS18, SMARCD1, MUS81, NFE2L1, CXXC4, BCL7C, BCL7A, SMARCC2, TRIM25, UBE2A, RUNX1, DPF2, INO80, INO80E, THAP3, WDR5, MED8, TRRAP, GEMIN5, ACTL6A, MCM2, CNOT1, CENPA, MED14, PSME3, ATG16L1, NR2C2, GLTSCR1, SMARCA4, GLTSCR1L, ESR1, CHMP4B, ECT2, PRC1, BRD2, BRD3, SMARCC1, SMARCA2, NOLC1, CKAP4, RCN2, SLC25A13, PGAM5, SLC25A11, TCOF1, MSH6, SLC25A12, DNAJA2, SLC16A1, LBR, TUFM, CSNK2A1, RIN3, DPF1, SMARCD3, BRD7, ARID1A, ARID2, ARID1B, DPF3, STK11IP, SMARCD2, SMARCB1, SS18L1, PBRM1, PHF10, SMARCE1, ACTC1, RAD51, ATRX, ZCCHC10, SS18L2, RNPS1, MAPKAPK2, PPARG, HSPBP1, SRRM2, JMJD6, AP3B1, PNN, RDH13, EPB41L2, CWC22, NAF1, RANBP6, TUBA1B, JMY,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
BRD9all structure
STARD3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to BRD9-STARD3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to BRD9-STARD3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRD9C0036920Sezary Syndrome1CTD_human