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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CASZ1-SLC9A1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CASZ1-SLC9A1
FusionPDB ID: 13293
FusionGDB2.0 ID: 13293
HgeneTgene
Gene symbol

CASZ1

SLC9A1

Gene ID

54897

6548

Gene namecastor zinc finger 1solute carrier family 9 member A1
SynonymsCAS11|CST|SRG|ZNF693|dJ734G22.1APNH|LIKNS|NHE-1|NHE1|PPP1R143
Cytomap

1p36.22

1p36.11

Type of geneprotein-codingprotein-coding
Descriptionzinc finger protein castor homolog 1castor homolog 1, zinc fingercastor-related proteinsurvival-relatedzinc finger protein 693sodium/hydrogen exchanger 1Na(+)/H(+) exchanger 1Na-Li countertransporterprotein phosphatase 1, regulatory subunit 143solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive)solute carrier family 9 (sod
Modification date2020031320200313
UniProtAcc

Q86V15

.
Ensembl transtripts involved in fusion geneENST idsENST00000344008, ENST00000377022, 
ENST00000478728, 		ENST00000374086, 
ENST00000545949, ENST00000490329, 
ENST00000263980, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 19 X 12=52449 X 7 X 7=441
# samples 3011
** MAII scorelog2(30/5244*10)=-4.12763327972587
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/441*10)=-2.00327513203286
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CASZ1 [Title/Abstract] AND SLC9A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CASZ1(10753931)-SLC9A1(27440777), # samples:2
Anticipated loss of major functional domain due to fusion event.CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
CASZ1-SLC9A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCASZ1

GO:0045893

positive regulation of transcription, DNA-templated

27693370

TgeneSLC9A1

GO:0006883

cellular sodium ion homeostasis

24840010

TgeneSLC9A1

GO:0006885

regulation of pH

8901634

TgeneSLC9A1

GO:0010447

response to acidic pH

8901634

TgeneSLC9A1

GO:0045944

positive regulation of transcription by RNA polymerase II

22688515

TgeneSLC9A1

GO:0051453

regulation of intracellular pH

15035633|24840010

TgeneSLC9A1

GO:0070886

positive regulation of calcineurin-NFAT signaling cascade

22688515

TgeneSLC9A1

GO:0071468

cellular response to acidic pH

24840010

TgeneSLC9A1

GO:0098719

sodium ion import across plasma membrane

24840010

TgeneSLC9A1

GO:1902600

proton transmembrane transport

24840010


check buttonFusion gene breakpoints across CASZ1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC9A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-3A-A9J0-01ACASZ1chr1

10753931

-SLC9A1chr1

27436268

-
ChimerDB4PAADTCGA-3A-A9J0-01ACASZ1chr1

10753931

-SLC9A1chr1

27440777

-
ChimerDB4PAADTCGA-3A-A9J0CASZ1chr1

10753930

-SLC9A1chr1

27440777

-
ChimerDB4PAADTCGA-3A-A9J0CASZ1chr1

10753931

-SLC9A1chr1

27440777

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377022CASZ1chr110753930-ENST00000263980SLC9A1chr127440777-39223342852429714
ENST00000344008CASZ1chr110753930-ENST00000263980SLC9A1chr127440777-39243362872431714
ENST00000377022CASZ1chr110753931-ENST00000263980SLC9A1chr127440777-39223342852429714
ENST00000344008CASZ1chr110753931-ENST00000263980SLC9A1chr127440777-39243362872431714

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377022ENST00000263980CASZ1chr110753930-SLC9A1chr127440777-0.0035744950.99642545
ENST00000344008ENST00000263980CASZ1chr110753930-SLC9A1chr127440777-0.0036369870.996363
ENST00000377022ENST00000263980CASZ1chr110753931-SLC9A1chr127440777-0.0035744950.99642545
ENST00000344008ENST00000263980CASZ1chr110753931-SLC9A1chr127440777-0.0036369870.996363

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>13293_13293_1_CASZ1-SLC9A1_CASZ1_chr1_10753930_ENST00000344008_SLC9A1_chr1_27440777_ENST00000263980_length(amino acids)=714AA_BP=16
MLREFGTKEKRMDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILI
FAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFA
NYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANI
SHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAI
AFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLN
RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQK
TRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVD

--------------------------------------------------------------

>13293_13293_2_CASZ1-SLC9A1_CASZ1_chr1_10753930_ENST00000377022_SLC9A1_chr1_27440777_ENST00000263980_length(amino acids)=714AA_BP=16
MLREFGTKEKRMDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILI
FAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFA
NYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANI
SHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAI
AFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLN
RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQK
TRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVD

--------------------------------------------------------------

>13293_13293_3_CASZ1-SLC9A1_CASZ1_chr1_10753931_ENST00000344008_SLC9A1_chr1_27440777_ENST00000263980_length(amino acids)=714AA_BP=16
MLREFGTKEKRMDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILI
FAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFA
NYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANI
SHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAI
AFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLN
RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQK
TRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVD

--------------------------------------------------------------

>13293_13293_4_CASZ1-SLC9A1_CASZ1_chr1_10753931_ENST00000377022_SLC9A1_chr1_27440777_ENST00000263980_length(amino acids)=714AA_BP=16
MLREFGTKEKRMDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILI
FAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFA
NYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANI
SHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAI
AFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLN
RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQK
TRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:10753931/chr1:27440777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CASZ1

Q86V15

.
FUNCTION: Transcriptional activator (PubMed:23639441, PubMed:27693370). Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7 (PubMed:23639441). {ECO:0000269|PubMed:23639441, ECO:0000269|PubMed:27693370}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012382_402117.33333333333333816.0IntramembraneName%3DH10
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605382_402117.33333333333333556.0IntramembraneName%3DH10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012382_402117.33333333333333816.0IntramembraneName%3DH10
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605382_402117.33333333333333556.0IntramembraneName%3DH10
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012128_129117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012150_154117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012175_191117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012212_227117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012248_256117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012277_294117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012316_338117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012359_381117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012403_410117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012431_448117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012471_479117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012500_815117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605128_129117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605150_154117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605175_191117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605212_227117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605248_256117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605277_294117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605316_338117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605359_381117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605403_410117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605431_448117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605471_479117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605500_815117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012128_129117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012150_154117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012175_191117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012212_227117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012248_256117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012277_294117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012316_338117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012359_381117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012403_410117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012431_448117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012471_479117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012500_815117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605128_129117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605150_154117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605175_191117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605212_227117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605248_256117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605277_294117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605316_338117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605359_381117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605403_410117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605431_448117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605471_479117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605500_815117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012130_149117.33333333333333816.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012155_174117.33333333333333816.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012192_211117.33333333333333816.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012228_247117.33333333333333816.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012257_276117.33333333333333816.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012295_315117.33333333333333816.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012339_358117.33333333333333816.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012411_430117.33333333333333816.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012449_470117.33333333333333816.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012480_499117.33333333333333816.0TransmembraneHelical%3B Name%3DM12
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605130_149117.33333333333333556.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605155_174117.33333333333333556.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605192_211117.33333333333333556.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605228_247117.33333333333333556.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605257_276117.33333333333333556.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605295_315117.33333333333333556.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605339_358117.33333333333333556.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605411_430117.33333333333333556.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605449_470117.33333333333333556.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605480_499117.33333333333333556.0TransmembraneHelical%3B Name%3DM12
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012130_149117.33333333333333816.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012155_174117.33333333333333816.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012192_211117.33333333333333816.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012228_247117.33333333333333816.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012257_276117.33333333333333816.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012295_315117.33333333333333816.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012339_358117.33333333333333816.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012411_430117.33333333333333816.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012449_470117.33333333333333816.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012480_499117.33333333333333816.0TransmembraneHelical%3B Name%3DM12
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605130_149117.33333333333333556.0TransmembraneHelical%3B Name%3DM3
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605155_174117.33333333333333556.0TransmembraneHelical%3B Name%3DM4
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605192_211117.33333333333333556.0TransmembraneHelical%3B Name%3DM5
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605228_247117.33333333333333556.0TransmembraneHelical%3B Name%3DM6
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605257_276117.33333333333333556.0TransmembraneHelical%3B Name%3DM7
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605295_315117.33333333333333556.0TransmembraneHelical%3B Name%3DM8
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605339_358117.33333333333333556.0TransmembraneHelical%3B Name%3DM9
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605411_430117.33333333333333556.0TransmembraneHelical%3B Name%3DM10
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605449_470117.33333333333333556.0TransmembraneHelical%3B Name%3DM11
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605480_499117.33333333333333556.0TransmembraneHelical%3B Name%3DM12

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161080_11435.3333333333333331167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161635_16705.3333333333333331167.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161672_17295.3333333333333331167.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161691_17185.3333333333333331167.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-416384_4175.3333333333333331167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211080_11435.3333333333333331760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211635_16705.3333333333333331760.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211672_17295.3333333333333331760.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211691_17185.3333333333333331760.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-421384_4175.3333333333333331760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161080_11435.3333333333333331167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161635_16705.3333333333333331167.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161672_17295.3333333333333331167.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161691_17185.3333333333333331167.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416384_4175.3333333333333331167.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211080_11435.3333333333333331760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211635_16705.3333333333333331760.0Compositional biasNote=Ala-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211672_17295.3333333333333331760.0Compositional biasNote=Glu-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211691_17185.3333333333333331760.0Compositional biasNote=Asp-rich
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421384_4175.3333333333333331760.0Compositional biasNote=Pro-rich
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161031_10555.3333333333333331167.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161300_13245.3333333333333331167.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161457_14815.3333333333333331167.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161515_15375.3333333333333331167.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-4161571_15955.3333333333333331167.0Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-416551_5755.3333333333333331167.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-416610_6345.3333333333333331167.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753930chr1:27440777ENST00000344008-416668_6925.3333333333333331167.0Zinc fingerC2H2-type 3
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211031_10555.3333333333333331760.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211300_13245.3333333333333331760.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211457_14815.3333333333333331760.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211515_15375.3333333333333331760.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-4211571_15955.3333333333333331760.0Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-421551_5755.3333333333333331760.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-421610_6345.3333333333333331760.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753930chr1:27440777ENST00000377022-421668_6925.3333333333333331760.0Zinc fingerC2H2-type 3
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161031_10555.3333333333333331167.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161300_13245.3333333333333331167.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161457_14815.3333333333333331167.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161515_15375.3333333333333331167.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-4161571_15955.3333333333333331167.0Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416551_5755.3333333333333331167.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416610_6345.3333333333333331167.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753931chr1:27440777ENST00000344008-416668_6925.3333333333333331167.0Zinc fingerC2H2-type 3
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211031_10555.3333333333333331760.0Zinc fingerC2H2-type 4
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211300_13245.3333333333333331760.0Zinc fingerC2H2-type 5
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211457_14815.3333333333333331760.0Zinc fingerC2H2-type 6
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211515_15375.3333333333333331760.0Zinc fingerC2H2-type 7
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-4211571_15955.3333333333333331760.0Zinc fingerC2H2-type 8
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421551_5755.3333333333333331760.0Zinc fingerC2H2-type 1
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421610_6345.3333333333333331760.0Zinc fingerC2H2-type 2
HgeneCASZ1chr1:10753931chr1:27440777ENST00000377022-421668_6925.3333333333333331760.0Zinc fingerC2H2-type 3
TgeneSLC9A1chr1:10753930chr1:27440777ENST000002639800121_12117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000026398001234_105117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000374086051_12117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753930chr1:27440777ENST000003740860534_105117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST000002639800121_12117.33333333333333816.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000026398001234_105117.33333333333333816.0Topological domainExtracellular
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000374086051_12117.33333333333333556.0Topological domainCytoplasmic
TgeneSLC9A1chr1:10753931chr1:27440777ENST000003740860534_105117.33333333333333556.0Topological domainExtracellular
TgeneSLC9A1chr1:10753930chr1:27440777ENST00000263980012106_127117.33333333333333816.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000026398001213_33117.33333333333333816.0TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr1:10753930chr1:27440777ENST0000037408605106_127117.33333333333333556.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753930chr1:27440777ENST000003740860513_33117.33333333333333556.0TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr1:10753931chr1:27440777ENST00000263980012106_127117.33333333333333816.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000026398001213_33117.33333333333333816.0TransmembraneHelical%3B Name%3DM1
TgeneSLC9A1chr1:10753931chr1:27440777ENST0000037408605106_127117.33333333333333556.0TransmembraneHelical%3B Name%3DM2
TgeneSLC9A1chr1:10753931chr1:27440777ENST000003740860513_33117.33333333333333556.0TransmembraneHelical%3B Name%3DM1


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1456_CASZ1_10753931_SLC9A1_27440777_ranked_0.pdbCASZ11075393110753931ENST00000263980SLC9A1chr127440777-
MLREFGTKEKRMDLGTGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILI
FAVVGTLWNAFFLGGLMYAVCLVGGEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFA
NYEHVGIVDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANI
SHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAI
AFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLN
RFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSLPSERILPALSKDKEEEIRKILRNNLQK
TRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKINNYLTVPAHKLDSPTMSRARIGSDPLAYEPKEDLPVITIDPASPQSPESVD
714


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CASZ1_pLDDT.png
all structure
all structure
SLC9A1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CASZ1
SLC9A1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CASZ1-SLC9A1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CASZ1-SLC9A1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource