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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDH17-ERLIN2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDH17-ERLIN2
FusionPDB ID: 15013
FusionGDB2.0 ID: 15013
HgeneTgene
Gene symbol

CDH17

ERLIN2

Gene ID

1015

11160

Gene namecadherin 17ER lipid raft associated 2
SynonymsCDH16|HPT-1|HPT1C8orf2|Erlin-2|NET32|SPFH2|SPG18
Cytomap

8q22.1

8p11.23

Type of geneprotein-codingprotein-coding
Descriptioncadherin-17HPT-1 cadherinLI cadherincadherin 17, LI cadherin (liver-intestine)cadherin-16human intestinal peptide-associated transporter HPT-1human peptide transporter 1intestinal peptide-associated transporter HPT-1liver-intestine cadherinerlin-2SPFH domain family, member 2endoplasmic reticulum lipid raft-associated protein 2epididymis secretory sperm binding proteinspastic paraplegia 18 (autosomal dominant)stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2
Modification date2020031320200327
UniProtAcc

Q12864

O94905

Ensembl transtripts involved in fusion geneENST idsENST00000027335, ENST00000441892, 
ENST00000450165, 		ENST00000276461, 
ENST00000335171, ENST00000397228, 
ENST00000518586, ENST00000519638, 
ENST00000523107, ENST00000523887, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=1444 X 6 X 3=72
# samples 76
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDH17 [Title/Abstract] AND ERLIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDH17(95206863)-ERLIN2(37597883), # samples:4
Anticipated loss of major functional domain due to fusion event.CDH17-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH17-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH17-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH17-ERLIN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERLIN2

GO:0030433

ubiquitin-dependent ERAD pathway

19240031


check buttonFusion gene breakpoints across CDH17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERLIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-A6-2677-01ACDH17chr8

95206863

-ERLIN2chr8

37597883

+
ChimerDB4COADTCGA-A6-2677-01BCDH17chr8

95206863

-ERLIN2chr8

37597883

+
ChimerDB4COADTCGA-A6-2677-01BCDH17chr8

95206863

-ERLIN2chr8

37601873

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000027335CDH17chr895206863-ENST00000397228ERLIN2chr837597883+1447176186527113
ENST00000027335CDH17chr895206863-ENST00000523887ERLIN2chr837597883+2347176186689167
ENST00000027335CDH17chr895206863-ENST00000276461ERLIN2chr837597883+60751761861088300
ENST00000027335CDH17chr895206863-ENST00000518586ERLIN2chr837597883+2350176186689167
ENST00000027335CDH17chr895206863-ENST00000335171ERLIN2chr837597883+1473176186527113
ENST00000027335CDH17chr895206863-ENST00000523107ERLIN2chr837597883+718176186689167
ENST00000027335CDH17chr895206863-ENST00000519638ERLIN2chr837597883+14301761861088300
ENST00000441892CDH17chr895206863-ENST00000397228ERLIN2chr837597883+1415144154495113
ENST00000441892CDH17chr895206863-ENST00000523887ERLIN2chr837597883+2315144154657167
ENST00000441892CDH17chr895206863-ENST00000276461ERLIN2chr837597883+60431441541056300
ENST00000441892CDH17chr895206863-ENST00000518586ERLIN2chr837597883+2318144154657167
ENST00000441892CDH17chr895206863-ENST00000335171ERLIN2chr837597883+1441144154495113
ENST00000441892CDH17chr895206863-ENST00000523107ERLIN2chr837597883+686144154657167
ENST00000441892CDH17chr895206863-ENST00000519638ERLIN2chr837597883+13981441541056300
ENST00000450165CDH17chr895206863-ENST00000397228ERLIN2chr837597883+1448177187528113
ENST00000450165CDH17chr895206863-ENST00000523887ERLIN2chr837597883+2348177187690167
ENST00000450165CDH17chr895206863-ENST00000276461ERLIN2chr837597883+60761771871089300
ENST00000450165CDH17chr895206863-ENST00000518586ERLIN2chr837597883+2351177187690167
ENST00000450165CDH17chr895206863-ENST00000335171ERLIN2chr837597883+1474177187528113
ENST00000450165CDH17chr895206863-ENST00000523107ERLIN2chr837597883+719177187690167
ENST00000450165CDH17chr895206863-ENST00000519638ERLIN2chr837597883+14311771871089300
ENST00000027335CDH17chr895206863-ENST00000397228ERLIN2chr837601873+1318176854115098
ENST00000027335CDH17chr895206863-ENST00000523887ERLIN2chr837601873+2218176186560124
ENST00000027335CDH17chr895206863-ENST00000276461ERLIN2chr837601873+5946176186959257
ENST00000027335CDH17chr895206863-ENST00000518586ERLIN2chr837601873+2221176186560124
ENST00000027335CDH17chr895206863-ENST00000335171ERLIN2chr837601873+1344176854115098
ENST00000027335CDH17chr895206863-ENST00000523107ERLIN2chr837601873+589176186560124
ENST00000027335CDH17chr895206863-ENST00000519638ERLIN2chr837601873+1301176186959257
ENST00000441892CDH17chr895206863-ENST00000397228ERLIN2chr837601873+1286144822111898
ENST00000441892CDH17chr895206863-ENST00000523887ERLIN2chr837601873+2186144154528124
ENST00000441892CDH17chr895206863-ENST00000276461ERLIN2chr837601873+5914144154927257
ENST00000441892CDH17chr895206863-ENST00000518586ERLIN2chr837601873+2189144154528124
ENST00000441892CDH17chr895206863-ENST00000335171ERLIN2chr837601873+1312144822111898
ENST00000441892CDH17chr895206863-ENST00000523107ERLIN2chr837601873+557144154528124
ENST00000441892CDH17chr895206863-ENST00000519638ERLIN2chr837601873+1269144154927257
ENST00000450165CDH17chr895206863-ENST00000397228ERLIN2chr837601873+1319177855115198
ENST00000450165CDH17chr895206863-ENST00000523887ERLIN2chr837601873+2219177187561124
ENST00000450165CDH17chr895206863-ENST00000276461ERLIN2chr837601873+5947177187960257
ENST00000450165CDH17chr895206863-ENST00000518586ERLIN2chr837601873+2222177187561124
ENST00000450165CDH17chr895206863-ENST00000335171ERLIN2chr837601873+1345177855115198
ENST00000450165CDH17chr895206863-ENST00000523107ERLIN2chr837601873+590177187561124
ENST00000450165CDH17chr895206863-ENST00000519638ERLIN2chr837601873+1302177187960257

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000027335ENST00000397228CDH17chr895206863-ERLIN2chr837597883+0.0301208850.96987915
ENST00000027335ENST00000523887CDH17chr895206863-ERLIN2chr837597883+0.0108501430.98914987
ENST00000027335ENST00000276461CDH17chr895206863-ERLIN2chr837597883+0.0003011460.9996989
ENST00000027335ENST00000518586CDH17chr895206863-ERLIN2chr837597883+0.0109364460.98906356
ENST00000027335ENST00000335171CDH17chr895206863-ERLIN2chr837597883+0.0341107140.9658892
ENST00000027335ENST00000523107CDH17chr895206863-ERLIN2chr837597883+0.0067039240.9932961
ENST00000027335ENST00000519638CDH17chr895206863-ERLIN2chr837597883+0.0006402950.99935967
ENST00000441892ENST00000397228CDH17chr895206863-ERLIN2chr837597883+0.0255658550.97443414
ENST00000441892ENST00000523887CDH17chr895206863-ERLIN2chr837597883+0.0062038580.9937961
ENST00000441892ENST00000276461CDH17chr895206863-ERLIN2chr837597883+0.0003003710.9996997
ENST00000441892ENST00000518586CDH17chr895206863-ERLIN2chr837597883+0.0062700120.99372995
ENST00000441892ENST00000335171CDH17chr895206863-ERLIN2chr837597883+0.0254372340.9745627
ENST00000441892ENST00000523107CDH17chr895206863-ERLIN2chr837597883+0.0072663020.9927337
ENST00000441892ENST00000519638CDH17chr895206863-ERLIN2chr837597883+0.0006263250.99937373
ENST00000450165ENST00000397228CDH17chr895206863-ERLIN2chr837597883+0.0281026080.9718974
ENST00000450165ENST00000523887CDH17chr895206863-ERLIN2chr837597883+0.0080853380.99191463
ENST00000450165ENST00000276461CDH17chr895206863-ERLIN2chr837597883+0.0003024120.99969757
ENST00000450165ENST00000518586CDH17chr895206863-ERLIN2chr837597883+0.0081444680.9918555
ENST00000450165ENST00000335171CDH17chr895206863-ERLIN2chr837597883+0.0317866840.9682133
ENST00000450165ENST00000523107CDH17chr895206863-ERLIN2chr837597883+0.0077117150.9922883
ENST00000450165ENST00000519638CDH17chr895206863-ERLIN2chr837597883+0.0006670090.99933296
ENST00000027335ENST00000397228CDH17chr895206863-ERLIN2chr837601873+0.1171826650.8828173
ENST00000027335ENST00000523887CDH17chr895206863-ERLIN2chr837601873+0.0786595340.92134047
ENST00000027335ENST00000276461CDH17chr895206863-ERLIN2chr837601873+0.0004630570.999537
ENST00000027335ENST00000518586CDH17chr895206863-ERLIN2chr837601873+0.076232430.9237676
ENST00000027335ENST00000335171CDH17chr895206863-ERLIN2chr837601873+0.137323230.8626768
ENST00000027335ENST00000523107CDH17chr895206863-ERLIN2chr837601873+0.0238133130.97618663
ENST00000027335ENST00000519638CDH17chr895206863-ERLIN2chr837601873+0.0007937180.99920636
ENST00000441892ENST00000397228CDH17chr895206863-ERLIN2chr837601873+0.137831720.8621683
ENST00000441892ENST00000523887CDH17chr895206863-ERLIN2chr837601873+0.074761530.9252385
ENST00000441892ENST00000276461CDH17chr895206863-ERLIN2chr837601873+0.0004611640.9995389
ENST00000441892ENST00000518586CDH17chr895206863-ERLIN2chr837601873+0.072973560.9270265
ENST00000441892ENST00000335171CDH17chr895206863-ERLIN2chr837601873+0.144092460.85590756
ENST00000441892ENST00000523107CDH17chr895206863-ERLIN2chr837601873+0.026029610.97397035
ENST00000441892ENST00000519638CDH17chr895206863-ERLIN2chr837601873+0.0008278610.9991722
ENST00000450165ENST00000397228CDH17chr895206863-ERLIN2chr837601873+0.0897298160.9102702
ENST00000450165ENST00000523887CDH17chr895206863-ERLIN2chr837601873+0.065386520.93461347
ENST00000450165ENST00000276461CDH17chr895206863-ERLIN2chr837601873+0.0004678420.9995322
ENST00000450165ENST00000518586CDH17chr895206863-ERLIN2chr837601873+0.06466440.93533564
ENST00000450165ENST00000335171CDH17chr895206863-ERLIN2chr837601873+0.102842190.89715785
ENST00000450165ENST00000523107CDH17chr895206863-ERLIN2chr837601873+0.033779920.9662201
ENST00000450165ENST00000519638CDH17chr895206863-ERLIN2chr837601873+0.0008172070.99918276

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15013_15013_1_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000276461_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_2_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000335171_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_3_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000397228_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_4_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000518586_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_5_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000519638_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_6_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000523107_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_7_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37597883_ENST00000523887_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_8_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000276461_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_9_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000335171_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_10_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000397228_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_11_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000518586_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_12_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000519638_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_13_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000523107_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_14_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000027335_ERLIN2_chr8_37601873_ENST00000523887_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_15_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000276461_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_16_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000335171_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_17_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000397228_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_18_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000518586_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_19_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000519638_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_20_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000523107_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_21_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37597883_ENST00000523887_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_22_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000276461_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_23_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000335171_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_24_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000397228_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_25_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000518586_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_26_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000519638_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_27_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000523107_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_28_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000441892_ERLIN2_chr8_37601873_ENST00000523887_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_29_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000276461_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_30_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000335171_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_31_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000397228_length(amino acids)=113AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_32_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000518586_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_33_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000519638_length(amino acids)=300AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA

--------------------------------------------------------------

>15013_15013_34_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000523107_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_35_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37597883_ENST00000523887_length(amino acids)=167AA_BP=
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS

--------------------------------------------------------------

>15013_15013_36_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000276461_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_37_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000335171_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_38_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000397228_length(amino acids)=98AA_BP=
MLVWRSWGNIFALKLFYFYISVLLASTTWLRICHIHKGGAHVSSPGPSTQKVLLYFPSLRTLIAQTLNMKLHNFHHFLLCRILFAHVIKV

--------------------------------------------------------------

>15013_15013_39_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000518586_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_40_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000519638_length(amino acids)=257AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTK
PNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAEKVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAEC

--------------------------------------------------------------

>15013_15013_41_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000523107_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

>15013_15013_42_CDH17-ERLIN2_CDH17_chr8_95206863_ENST00000450165_ERLIN2_chr8_37601873_ENST00000523887_length(amino acids)=124AA_BP=
MIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCSVHTLQEVYIELFGKKVSPEHAVLKQGSWNPASLHCLKPGCLQG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:95206863/chr8:37597883)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDH17

Q12864

ERLIN2

O94905

FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. {ECO:0000269|PubMed:8153632}.FUNCTION: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1 (PubMed:19240031, PubMed:17502376). Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex (PubMed:21343306). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (PubMed:24217618). {ECO:0000269|PubMed:17502376, ECO:0000269|PubMed:19240031, ECO:0000269|PubMed:21343306, ECO:0000269|PubMed:24217618}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218129_24417.0833.0DomainCadherin 2
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218245_34017.0833.0DomainCadherin 3
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-21830_12817.0833.0DomainCadherin 1
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218341_44917.0833.0DomainCadherin 4
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218450_56617.0833.0DomainCadherin 5
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218567_66717.0833.0DomainCadherin 6
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218668_77717.0833.0DomainCadherin 7
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218129_24417.0833.0DomainCadherin 2
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218245_34017.0833.0DomainCadherin 3
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-21830_12817.0833.0DomainCadherin 1
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218341_44917.0833.0DomainCadherin 4
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218450_56617.0833.0DomainCadherin 5
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218567_66717.0833.0DomainCadherin 6
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218668_77717.0833.0DomainCadherin 7
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218129_24417.0833.0DomainCadherin 2
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218245_34017.0833.0DomainCadherin 3
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-21830_12817.0833.0DomainCadherin 1
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218341_44917.0833.0DomainCadherin 4
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218450_56617.0833.0DomainCadherin 5
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218567_66717.0833.0DomainCadherin 6
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218668_77717.0833.0DomainCadherin 7
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218129_24417.0833.0DomainCadherin 2
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218245_34017.0833.0DomainCadherin 3
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-21830_12817.0833.0DomainCadherin 1
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218341_44917.0833.0DomainCadherin 4
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218450_56617.0833.0DomainCadherin 5
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218567_66717.0833.0DomainCadherin 6
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218668_77717.0833.0DomainCadherin 7
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-21823_78717.0833.0Topological domainExtracellular
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218809_83217.0833.0Topological domainCytoplasmic
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-21823_78717.0833.0Topological domainExtracellular
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218809_83217.0833.0Topological domainCytoplasmic
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-21823_78717.0833.0Topological domainExtracellular
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218809_83217.0833.0Topological domainCytoplasmic
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-21823_78717.0833.0Topological domainExtracellular
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218809_83217.0833.0Topological domainCytoplasmic
HgeneCDH17chr8:95206863chr8:37597883ENST00000027335-218788_80817.0833.0TransmembraneHelical
HgeneCDH17chr8:95206863chr8:37597883ENST00000450165-218788_80817.0833.0TransmembraneHelical
HgeneCDH17chr8:95206863chr8:37601873ENST00000027335-218788_80817.0833.0TransmembraneHelical
HgeneCDH17chr8:95206863chr8:37601873ENST00000450165-218788_80817.0833.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST000002764611121_335.666666666666664340.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST0000027646111225_33935.666666666666664340.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST00000335171171_335.666666666666664153.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST000003351711725_33935.666666666666664153.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST00000397228171_335.666666666666664153.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST000003972281725_33935.666666666666664153.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST00000518586161_335.666666666666664207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST000005185861625_33935.666666666666664207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST000005196380111_335.666666666666664340.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST0000051963801125_33935.666666666666664340.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST00000523107161_335.666666666666664207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST000005231071625_33935.666666666666664207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST00000523887161_335.666666666666664207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37597883ENST000005238871625_33935.666666666666664207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST000002764613121_378.66666666666667340.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST0000027646131225_33978.66666666666667340.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST00000335171371_378.66666666666667153.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST000003351713725_33978.66666666666667153.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST00000397228371_378.66666666666667153.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST000003972283725_33978.66666666666667153.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST00000518586361_378.66666666666667207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST000005185863625_33978.66666666666667207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST000005196382111_378.66666666666667340.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST0000051963821125_33978.66666666666667340.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST00000523107361_378.66666666666667207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST000005231073625_33978.66666666666667207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37601873ENST00000523887361_378.66666666666667207.0Topological domainCytoplasmic
TgeneERLIN2chr8:95206863chr8:37601873ENST000005238873625_33978.66666666666667207.0Topological domainLumenal
TgeneERLIN2chr8:95206863chr8:37597883ENST000002764611124_2435.666666666666664340.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST00000335171174_2435.666666666666664153.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST00000397228174_2435.666666666666664153.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST00000518586164_2435.666666666666664207.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST000005196380114_2435.666666666666664340.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST00000523107164_2435.666666666666664207.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37597883ENST00000523887164_2435.666666666666664207.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST000002764613124_2478.66666666666667340.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST00000335171374_2478.66666666666667153.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST00000397228374_2478.66666666666667153.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST00000518586364_2478.66666666666667207.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST000005196382114_2478.66666666666667340.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST00000523107364_2478.66666666666667207.0TransmembraneHelical
TgeneERLIN2chr8:95206863chr8:37601873ENST00000523887364_2478.66666666666667207.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>539_CDH17_95206863_ERLIN2_37597883_ranked_0.pdbCDH179520686395206863ENST00000519638ERLIN2chr837597883+
MLTSTSGPGFHLMLPFITSYKSVQTTLQTDEVKNVPCGTSGGVMIYFDRIEVVNFLVPNAVYDIVKNYTADYDKALIFNKIHHELNQFCS
VHTLQEVYIELFDQIDENLKLALQQDLTSMAPGLVIQAVRVTKPNIPEAIRRNYELMESEKTKLLIAAQKQKVVEKEAETERKKALIEAE
KVAQVAEITYGQKVMEKETEKKISEIEDAAFLAREKAKADAECYTAMKIAEANKLKLTPEYLQLMKYKAIASNSKIYFGKDIPNMFMDSA
300


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CDH17_pLDDT.png
all structure
all structure
ERLIN2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDH17
ERLIN2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to CDH17-ERLIN2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDH17-ERLIN2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource