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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDK5RAP2-GRIN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDK5RAP2-GRIN1
FusionPDB ID: 15271
FusionGDB2.0 ID: 15271
HgeneTgene
Gene symbol

CDK5RAP2

GRIN1

Gene ID

55755

114787

Gene nameCDK5 regulatory subunit associated protein 2G protein regulated inducer of neurite outgrowth 1
SynonymsC48|Cep215|MCPH3GRIN1
Cytomap

9q33.2

5q35.2

Type of geneprotein-codingprotein-coding
DescriptionCDK5 regulatory subunit-associated protein 2CDK5 activator-binding protein C48centrosomal protein 215 kDacentrosominG protein-regulated inducer of neurite outgrowth 1
Modification date2020032820200313
UniProtAcc

Q96SN8

Q05586

Ensembl transtripts involved in fusion geneENST idsENST00000349780, ENST00000359309, 
ENST00000360190, ENST00000360822, 
ENST00000480467, 		ENST00000350902, 
ENST00000371546, ENST00000371550, 
ENST00000371553, ENST00000371555, 
ENST00000371559, ENST00000371560, 
ENST00000471122, ENST00000315048, 
ENST00000371561, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 5=7805 X 5 X 5=125
# samples 136
** MAII scorelog2(13/780*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDK5RAP2 [Title/Abstract] AND GRIN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDK5RAP2(123280705)-GRIN1(140036465), # samples:3
Anticipated loss of major functional domain due to fusion event.CDK5RAP2-GRIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK5RAP2-GRIN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK5RAP2-GRIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDK5RAP2-GRIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDK5RAP2

GO:0000226

microtubule cytoskeleton organization

17959831

HgeneCDK5RAP2

GO:0001578

microtubule bundle formation

19553473

HgeneCDK5RAP2

GO:0045893

positive regulation of transcription, DNA-templated

19282672

HgeneCDK5RAP2

GO:0090266

regulation of mitotic cell cycle spindle assembly checkpoint

19282672


check buttonFusion gene breakpoints across CDK5RAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7873-01BCDK5RAP2chr9

123280705

-GRIN1chr9

140036465

+
ChimerDB4LGGTCGA-HT-7873CDK5RAP2chr9

123280705

-GRIN1chr9

140036465

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360822CDK5RAP2chr9123280705-ENST00000371561GRIN1chr9140036465+5279149218140501289
ENST00000360822CDK5RAP2chr9123280705-ENST00000315048GRIN1chr9140036465+4916149218140021273
ENST00000359309CDK5RAP2chr9123280705-ENST00000371561GRIN1chr9140036465+5279149218140501289
ENST00000359309CDK5RAP2chr9123280705-ENST00000315048GRIN1chr9140036465+4916149218140021273
ENST00000349780CDK5RAP2chr9123280705-ENST00000371561GRIN1chr9140036465+5278149118040491289
ENST00000349780CDK5RAP2chr9123280705-ENST00000315048GRIN1chr9140036465+4915149118040011273
ENST00000360190CDK5RAP2chr9123280705-ENST00000371561GRIN1chr9140036465+5278149118040491289
ENST00000360190CDK5RAP2chr9123280705-ENST00000315048GRIN1chr9140036465+4915149118040011273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360822ENST00000371561CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0051517430.99484825
ENST00000360822ENST00000315048CDK5RAP2chr9123280705-GRIN1chr9140036465+0.004802650.99519736
ENST00000359309ENST00000371561CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0051517430.99484825
ENST00000359309ENST00000315048CDK5RAP2chr9123280705-GRIN1chr9140036465+0.004802650.99519736
ENST00000349780ENST00000371561CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0051509170.994849
ENST00000349780ENST00000315048CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0048040570.9951959
ENST00000360190ENST00000371561CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0051509170.994849
ENST00000360190ENST00000315048CDK5RAP2chr9123280705-GRIN1chr9140036465+0.0048040570.9951959

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15271_15271_1_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000349780_GRIN1_chr9_140036465_ENST00000315048_length(amino acids)=1273AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTQYHPTDITG

--------------------------------------------------------------

>15271_15271_2_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000349780_GRIN1_chr9_140036465_ENST00000371561_length(amino acids)=1289AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGAL

--------------------------------------------------------------

>15271_15271_3_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000359309_GRIN1_chr9_140036465_ENST00000315048_length(amino acids)=1273AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTQYHPTDITG

--------------------------------------------------------------

>15271_15271_4_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000359309_GRIN1_chr9_140036465_ENST00000371561_length(amino acids)=1289AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGAL

--------------------------------------------------------------

>15271_15271_5_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000360190_GRIN1_chr9_140036465_ENST00000315048_length(amino acids)=1273AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTQYHPTDITG

--------------------------------------------------------------

>15271_15271_6_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000360190_GRIN1_chr9_140036465_ENST00000371561_length(amino acids)=1289AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGAL

--------------------------------------------------------------

>15271_15271_7_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000360822_GRIN1_chr9_140036465_ENST00000315048_length(amino acids)=1273AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTQYHPTDITG

--------------------------------------------------------------

>15271_15271_8_CDK5RAP2-GRIN1_CDK5RAP2_chr9_123280705_ENST00000360822_GRIN1_chr9_140036465_ENST00000371561_length(amino acids)=1289AA_BP=437
MMDLVLEEDVTVPGTLSGCSGLVPSVPDDLDGINPNAGLGNGLLPNVSEETVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERMQQ
EFHGPTEHIYKTNIELKVEVESLKRELQEREQLLIKASKAVESLAEAGGSEIQRVKEDARKKVQQVEDLLTKRILLLEKDVTAAQAELEK
AFAGTETEKALRLRLESKLSEMKKMHEGDLAMALVLDEKDRLIEELKLSLKSKEALIQCLKEEKSQMACPDENVSSGELRGLCAAPREEK
ERETEAAQMEHQKERNSFEERIQALEEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKKVEELNSEIEKLSAAFAKAREALQKAQT
QEFQGSEDYETALSGKEALSAALRSQNLTKSTENHRLRRSIKKITQELSDLQQERERLEKDLEEAHREKSKGDCTIRVYAILVSHPPTPN
DHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEGRAAQKRLETLLEERES
KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISGNALRYAPDGILGLQLINGKNESA
HISDAVGVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDRKFANYSIMNLQNRKLVQVGIYNG
THVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFC
IDLLIKLARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKEIPRS
TLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGF
AMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDNKLHAF
IWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSNAPATLTFENMAGVFML
VAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEPDPKKKATFRAITSTLASSFKRRRSSKDTSTGGGRGAL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:123280705/chr9:140036465)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDK5RAP2

Q96SN8

GRIN1

Q05586

FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes (PubMed:26485573). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (PubMed:29162697). Required for the recruitment of AKAP9 to centrosomes (PubMed:29162697). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000269|PubMed:17959831, ECO:0000269|PubMed:18042621, ECO:0000269|PubMed:19282672, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697}.FUNCTION: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761). {ECO:0000269|PubMed:26875626, ECO:0000269|PubMed:26919761, ECO:0000269|PubMed:28105280, ECO:0000269|PubMed:28126851, ECO:0000269|PubMed:7685113}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020516_51886.0923.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020603_62486.0923.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021516_51886.0960.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021603_62486.0960.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019516_51886.0902.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019603_62486.0902.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021516_51886.0944.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021603_62486.0944.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019516_51886.0886.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019603_62486.0886.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020516_51886.0907.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020603_62486.0907.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020516_51886.0939.0RegionGlycine binding
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020603_62486.0939.0RegionPore-forming
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020581_60286.0923.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020625_63086.0923.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020648_81286.0923.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020834_93886.0923.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021581_60286.0960.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021625_63086.0960.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021648_81286.0960.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021834_93886.0960.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019581_60286.0902.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019625_63086.0902.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019648_81286.0902.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019834_93886.0902.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021581_60286.0944.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021625_63086.0944.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021648_81286.0944.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021834_93886.0944.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019581_60286.0886.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019625_63086.0886.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019648_81286.0886.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019834_93886.0886.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020581_60286.0907.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020625_63086.0907.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020648_81286.0907.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020834_93886.0907.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020581_60286.0939.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020625_63086.0939.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020648_81286.0939.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020834_93886.0939.0Topological domainCytoplasmic
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020560_58086.0923.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020631_64786.0923.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000315048020813_83386.0923.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021560_58086.0960.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021631_64786.0960.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371546021813_83386.0960.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019560_58086.0902.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019631_64786.0902.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371550019813_83386.0902.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021560_58086.0944.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021631_64786.0944.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371553021813_83386.0944.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019560_58086.0886.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019631_64786.0886.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371559019813_83386.0886.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020560_58086.0907.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020631_64786.0907.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371560020813_83386.0907.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020560_58086.0939.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020631_64786.0939.0TransmembraneHelical
TgeneGRIN1chr9:123280705chr9:140036465ENST00000371561020813_83386.0939.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIN1chr9:123280705chr9:140036465ENST0000031504802019_55986.0923.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037154602119_55986.0960.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037155001919_55986.0902.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037155302119_55986.0944.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037155901919_55986.0886.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037156002019_55986.0907.0Topological domainExtracellular
TgeneGRIN1chr9:123280705chr9:140036465ENST0000037156102019_55986.0939.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CDK5RAP2_pLDDT.png
all structure
all structure
GRIN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDK5RAP2
GRIN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000349780-12381726_1768437.01894.0CDK5R1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000359309-12371726_1768437.01853.0CDK5R1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360190-12371726_1768437.01815.0CDK5R1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360822-12371726_1768437.01862.0CDK5R1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000349780-1238926_1208437.01894.0MAPRE1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000359309-1237926_1208437.01853.0MAPRE1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360190-1237926_1208437.01815.0MAPRE1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360822-1237926_1208437.01862.0MAPRE1
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000349780-12381726_1893437.01894.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000359309-12371726_1893437.01853.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360190-12371726_1893437.01815.0PCNT and AKAP9
HgeneCDK5RAP2chr9:123280705chr9:140036465ENST00000360822-12371726_1893437.01862.0PCNT and AKAP9


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Related Drugs to CDK5RAP2-GRIN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDK5RAP2-GRIN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource