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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:CDKN2A-SRGAP2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: CDKN2A-SRGAP2
FusionPDB ID: 15413
FusionGDB2.0 ID: 15413
HgeneTgene
Gene symbol

CDKN2A

SRGAP2

Gene ID

1029

23380

Gene namecyclin dependent kinase inhibitor 2ASLIT-ROBO Rho GTPase activating protein 2
SynonymsARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16ARHGAP34|FNBP2|SRGAP2A|SRGAP3
Cytomap

9p21.3

1q32.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-dependent kinase inhibitor 2ACDK4 inhibitor p16-INK4alternative reading framecell cycle negative regulator betacyclin-dependent kinase 4 inhibitor Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)multiple tumor suppressor 1SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34
Modification date2020032920200313
UniProtAcc

Q96HQ2

.
Ensembl transtripts involved in fusion geneENST idsENST00000304494, ENST00000361570, 
ENST00000446177, ENST00000498124, 
ENST00000530628, ENST00000579122, 
ENST00000579755, ENST00000470819, 
ENST00000479692, ENST00000494262, 
ENST00000497750, ENST00000498628, 
ENST00000578845, 		ENST00000419187, 
ENST00000471256, ENST00000414007, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 9 X 11=138615 X 15 X 7=1575
# samples 1716
** MAII scorelog2(17/1386*10)=-3.02732060599951
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1575*10)=-3.29920801838728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: CDKN2A [Title/Abstract] AND SRGAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)CDKN2A(21994138)-SRGAP2(206634382), # samples:3
Anticipated loss of major functional domain due to fusion event.CDKN2A-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2A-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2A-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDKN2A-SRGAP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDKN2A

GO:0000082

G1/S transition of mitotic cell cycle

10208428

HgeneCDKN2A

GO:0007050

cell cycle arrest

15149599

HgeneCDKN2A

GO:0008285

negative regulation of cell proliferation

15149599

HgeneCDKN2A

GO:0030308

negative regulation of cell growth

10208428

HgeneCDKN2A

GO:0032088

negative regulation of NF-kappaB transcription factor activity

10353611

HgeneCDKN2A

GO:0042326

negative regulation of phosphorylation

8259215|10208428

HgeneCDKN2A

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

7739547|8259215

TgeneSRGAP2

GO:0043547

positive regulation of GTPase activity

21148482

TgeneSRGAP2

GO:0046847

filopodium assembly

22559944

TgeneSRGAP2

GO:0051014

actin filament severing

21148482

TgeneSRGAP2

GO:0060996

dendritic spine development

22559944

TgeneSRGAP2

GO:2001223

negative regulation of neuron migration

22559944


check buttonFusion gene breakpoints across CDKN2A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SRGAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-60-2715-01ACDKN2Achr9

21994138

-SRGAP2chr1

206634382

+
ChimerDB4LUSCTCGA-60-2715CDKN2Achr9

21974676

-SRGAP2chr1

206634381

+
ChimerDB4LUSCTCGA-60-2715CDKN2Achr9

21974677

-SRGAP2chr1

206634382

+
ChimerDB4LUSCTCGA-60-2715CDKN2Achr9

21994138

-SRGAP2chr1

206634382

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361570CDKN2Achr921994138-ENST00000414007SRGAP2chr1206634382+3755353720322132
ENST00000579755CDKN2Achr921994138-ENST00000414007SRGAP2chr1206634382+3888486853455132
ENST00000530628CDKN2Achr921994138-ENST00000414007SRGAP2chr1206634382+3675273640242132
ENST00000304494CDKN2Achr921974676-ENST00000414007SRGAP2chr1206634381+3823421124804226
ENST00000579122CDKN2Achr921974676-ENST00000414007SRGAP2chr1206634381+358318131564177
ENST00000498124CDKN2Achr921974676-ENST00000414007SRGAP2chr1206634381+359118939572177
ENST00000446177CDKN2Achr921974676-ENST00000414007SRGAP2chr1206634381+376436265745226
ENST00000304494CDKN2Achr921974677-ENST00000414007SRGAP2chr1206634382+3823421124804226
ENST00000579122CDKN2Achr921974677-ENST00000414007SRGAP2chr1206634382+358318131564177
ENST00000498124CDKN2Achr921974677-ENST00000414007SRGAP2chr1206634382+359118939572177
ENST00000446177CDKN2Achr921974677-ENST00000414007SRGAP2chr1206634382+376436265745226

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361570ENST00000414007CDKN2Achr921994138-SRGAP2chr1206634382+0.07940190.92059815
ENST00000579755ENST00000414007CDKN2Achr921994138-SRGAP2chr1206634382+0.088299380.91170055
ENST00000530628ENST00000414007CDKN2Achr921994138-SRGAP2chr1206634382+0.0796662640.9203337
ENST00000304494ENST00000414007CDKN2Achr921974676-SRGAP2chr1206634381+0.0112135840.98878646
ENST00000579122ENST00000414007CDKN2Achr921974676-SRGAP2chr1206634381+0.0092234870.9907766
ENST00000498124ENST00000414007CDKN2Achr921974676-SRGAP2chr1206634381+0.0094019870.990598
ENST00000446177ENST00000414007CDKN2Achr921974676-SRGAP2chr1206634381+0.010642390.98935765
ENST00000304494ENST00000414007CDKN2Achr921974677-SRGAP2chr1206634382+0.0112135840.98878646
ENST00000579122ENST00000414007CDKN2Achr921974677-SRGAP2chr1206634382+0.0092234870.9907766
ENST00000498124ENST00000414007CDKN2Achr921974677-SRGAP2chr1206634382+0.0094019870.990598
ENST00000446177ENST00000414007CDKN2Achr921974677-SRGAP2chr1206634382+0.010642390.98935765

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15413_15413_1_CDKN2A-SRGAP2_CDKN2A_chr9_21974676_ENST00000304494_SRGAP2_chr1_206634381_ENST00000414007_length(amino acids)=226AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP
NSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPV

--------------------------------------------------------------

>15413_15413_2_CDKN2A-SRGAP2_CDKN2A_chr9_21974676_ENST00000446177_SRGAP2_chr1_206634381_ENST00000414007_length(amino acids)=226AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP
NSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPV

--------------------------------------------------------------

>15413_15413_3_CDKN2A-SRGAP2_CDKN2A_chr9_21974676_ENST00000498124_SRGAP2_chr1_206634381_ENST00000414007_length(amino acids)=177AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP

--------------------------------------------------------------

>15413_15413_4_CDKN2A-SRGAP2_CDKN2A_chr9_21974676_ENST00000579122_SRGAP2_chr1_206634381_ENST00000414007_length(amino acids)=177AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP

--------------------------------------------------------------

>15413_15413_5_CDKN2A-SRGAP2_CDKN2A_chr9_21974677_ENST00000304494_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=226AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP
NSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPV

--------------------------------------------------------------

>15413_15413_6_CDKN2A-SRGAP2_CDKN2A_chr9_21974677_ENST00000446177_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=226AA_BP=98
MRDRVGGGSSASTGGRKRRGWLVTRGWGGPRALGGCGEGESRQRAAGSSMEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAP
NSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPV

--------------------------------------------------------------

>15413_15413_7_CDKN2A-SRGAP2_CDKN2A_chr9_21974677_ENST00000498124_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=177AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP

--------------------------------------------------------------

>15413_15413_8_CDKN2A-SRGAP2_CDKN2A_chr9_21974677_ENST00000579122_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=177AA_BP=49
MEPAAGSSMEPSADWLATAAARGRVEEVRALLEAGALPNAPNSYGRRPIQDIEATMNSALNELRELERQSSVKHTPDVVLDTLEPLKTSP

--------------------------------------------------------------

>15413_15413_9_CDKN2A-SRGAP2_CDKN2A_chr9_21994138_ENST00000361570_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=132AA_BP=1
MSVDCGEVDELTPGLVAFVLGKTVGLGRVAGGLTGAAILTDLTGRKAQAMSPAVLALRWKAGSGSLRSWVCRGLEGSDVGATTGEVLRGS

--------------------------------------------------------------

>15413_15413_10_CDKN2A-SRGAP2_CDKN2A_chr9_21994138_ENST00000530628_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=132AA_BP=1
MSVDCGEVDELTPGLVAFVLGKTVGLGRVAGGLTGAAILTDLTGRKAQAMSPAVLALRWKAGSGSLRSWVCRGLEGSDVGATTGEVLRGS

--------------------------------------------------------------

>15413_15413_11_CDKN2A-SRGAP2_CDKN2A_chr9_21994138_ENST00000579755_SRGAP2_chr1_206634382_ENST00000414007_length(amino acids)=132AA_BP=1
MSVDCGEVDELTPGLVAFVLGKTVGLGRVAGGLTGAAILTDLTGRKAQAMSPAVLALRWKAGSGSLRSWVCRGLEGSDVGATTGEVLRGS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:21994138/chr1:206634382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDKN2A

Q96HQ2

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000304494-1311_4050.0157.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000446177-1311_4050.0168.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498124-1411_4050.0130.66666666666666RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000304494-1311_4050.0157.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000446177-1311_4050.0168.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498124-1411_4050.0130.66666666666666RepeatNote=ANK 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000304494-13110_13950.0157.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000304494-1344_7250.0157.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000304494-1377_10650.0157.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000446177-13110_13950.0168.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000446177-1344_7250.0168.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000446177-1377_10650.0168.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000494262-14110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000494262-1411_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000494262-1444_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000494262-1477_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498124-14110_13950.0130.66666666666666RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498124-1444_7250.0130.66666666666666RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498124-1477_10650.0130.66666666666666RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498628-13110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498628-1311_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498628-1344_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000498628-1377_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000578845-12110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000578845-1211_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000578845-1244_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000578845-1277_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000304494-13110_13950.0157.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000304494-1344_7250.0157.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000304494-1377_10650.0157.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000446177-13110_13950.0168.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000446177-1344_7250.0168.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000446177-1377_10650.0168.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000494262-14110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000494262-1411_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000494262-1444_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000494262-1477_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498124-14110_13950.0130.66666666666666RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498124-1444_7250.0130.66666666666666RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498124-1477_10650.0130.66666666666666RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498628-13110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498628-1311_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498628-1344_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000498628-1377_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000578845-12110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000578845-1211_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000578845-1244_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000578845-1277_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000304494-13110_1390157.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000304494-1311_400157.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000304494-1344_720157.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000304494-1377_1060157.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000446177-13110_1390168.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000446177-1311_400168.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000446177-1344_720168.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000446177-1377_1060168.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000494262-14110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000494262-1411_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000494262-1444_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000494262-1477_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498124-14110_1390130.66666666666666RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498124-1411_400130.66666666666666RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498124-1444_720130.66666666666666RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498124-1477_1060130.66666666666666RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498628-13110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498628-1311_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498628-1344_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000498628-1377_1060106.0RepeatNote=ANK 3
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000578845-12110_1390106.0RepeatNote=ANK 4
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000578845-1211_400106.0RepeatNote=ANK 1
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000578845-1244_720106.0RepeatNote=ANK 2
HgeneCDKN2Achr9:21994138chr1:206634382ENST00000578845-1277_1060106.0RepeatNote=ANK 3


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>71_CDKN2A_21994138_SRGAP2_206634382_ranked_0.pdbCDKN2A2197467721994138ENST00000414007SRGAP2chr1206634382+
MSVDCGEVDELTPGLVAFVLGKTVGLGRVAGGLTGAAILTDLTGRKAQAMSPAVLALRWKAGSGSLRSWVCRGLEGSDVGATTGEVLRGS
132


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
CDKN2A_pLDDT.png
all structure
all structure
SRGAP2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
CDKN2A
SRGAP2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000361570-131_640220.0CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000530628-131_640122.66666666666667CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974676chr1:206634381ENST00000579755-131_640134.33333333333334CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000361570-131_640220.0CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000530628-131_640122.66666666666667CDK5RAP3 and MDM2
HgeneCDKN2Achr9:21974677chr1:206634382ENST00000579755-131_640134.33333333333334CDK5RAP3 and MDM2


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Related Drugs to CDKN2A-SRGAP2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to CDKN2A-SRGAP2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource