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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CHD2-HOMER2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CHD2-HOMER2
	FusionPDB ID: 16301
	FusionGDB2.0 ID: 16301
		Hgene	Tgene
	Gene symbol	CHD2	HOMER2
	Gene ID	1826	9455
	Gene name	DS cell adhesion molecule	homer scaffold protein 2
	Synonyms	CHD2\|CHD2-42\|CHD2-52	ACPD\|CPD\|DFNA68\|HOMER-2\|VESL-2
	Cytomap	21q22.2	15q25.2
	Type of gene	protein-coding	protein-coding
	Description	Down syndrome cell adhesion molecule	homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2
	Modification date	20200313	20200313
	UniProtAcc	O14647	Q9NSB8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000394196, ENST00000557381, ENST00000420239, ENST00000536619, ENST00000554122,	ENST00000500334, ENST00000304231, ENST00000399166, ENST00000426485, ENST00000450735,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 13 X 11=3146	8 X 6 X 3=144
	# samples	23	8
	** MAII score	log2(23/3146*10)=-3.77381290447131 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/144*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CHD2 [Title/Abstract] AND HOMER2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CHD2(93496803)-HOMER2(83533011), # samples:4
Anticipated loss of major functional domain due to fusion event.	CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CHD2-HOMER2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CHD2	GO:0042327	positive regulation of phosphorylation	19196994
Hgene	CHD2	GO:0048842	positive regulation of axon extension involved in axon guidance	18585357

Fusion gene breakpoints across CHD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HOMER2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A06U-01A	CHD2	chr15	93496803	-	HOMER2	chr15	83533011	-
ChimerDB4	BRCA	TCGA-A8-A06U-01A	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-
ChimerDB4	BRCA	TCGA-A8-A06U	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394196	CHD2	chr15	93496803	+	ENST00000450735	HOMER2	chr15	83533011	-	4257	2787	1068	3524	818
ENST00000394196	CHD2	chr15	93496803	+	ENST00000304231	HOMER2	chr15	83533011	-	4290	2787	1068	3557	829
ENST00000394196	CHD2	chr15	93496803	+	ENST00000399166	HOMER2	chr15	83533011	-	4089	2787	1068	3359	763
ENST00000394196	CHD2	chr15	93496803	+	ENST00000426485	HOMER2	chr15	83533011	-	4122	2787	1068	3392	774
ENST00000557381	CHD2	chr15	93496803	+	ENST00000450735	HOMER2	chr15	83533011	-	3896	2426	707	3163	818
ENST00000557381	CHD2	chr15	93496803	+	ENST00000304231	HOMER2	chr15	83533011	-	3929	2426	707	3196	829
ENST00000557381	CHD2	chr15	93496803	+	ENST00000399166	HOMER2	chr15	83533011	-	3728	2426	707	2998	763
ENST00000557381	CHD2	chr15	93496803	+	ENST00000426485	HOMER2	chr15	83533011	-	3761	2426	707	3031	774

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394196	ENST00000450735	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.002503394	0.99749655
ENST00000394196	ENST00000304231	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.00227896	0.997721
ENST00000394196	ENST00000399166	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.002594551	0.99740547
ENST00000394196	ENST00000426485	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.002255485	0.99774456
ENST00000557381	ENST00000450735	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.003520848	0.9964792
ENST00000557381	ENST00000304231	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.003184755	0.99681526
ENST00000557381	ENST00000399166	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.003572797	0.99642724
ENST00000557381	ENST00000426485	CHD2	chr15	93496803	+	HOMER2	chr15	83533011	-	0.003096406	0.9969036

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>16301_16301_1_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000304231_length(amino acids)=829AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK
NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG

--------------------------------------------------------------

>16301_16301_2_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000399166_length(amino acids)=763AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD

--------------------------------------------------------------

>16301_16301_3_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000426485_length(amino acids)=774AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN

--------------------------------------------------------------

>16301_16301_4_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000394196_HOMER2_chr15_83533011_ENST00000450735_length(amino acids)=818AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL
EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRG

--------------------------------------------------------------

>16301_16301_5_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000304231_length(amino acids)=829AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK
NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG

--------------------------------------------------------------

>16301_16301_6_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000399166_length(amino acids)=763AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTD

--------------------------------------------------------------

>16301_16301_7_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000426485_length(amino acids)=774AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA
GPANTHLKSENDKLKIALTQSAANVKNEINREKEKNTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQN

--------------------------------------------------------------

>16301_16301_8_CHD2-HOMER2_CHD2_chr15_93496803_ENST00000557381_HOMER2_chr15_83533011_ENST00000450735_length(amino acids)=818AA_BP=573
MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK
ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP
VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR
LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV
EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS
KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV
PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQASSVNGTDDEKASHAGPANTHLKSEN
DKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEKNTQLKRRIEEL
EAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDGKIDDLHDFRRG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:93496803/chr15:83533011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CHD2 O14647	HOMER2 Q9NSB8
FUNCTION: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). {ECO:0000250}.	FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000269\|PubMed:18218901, ECO:0000269\|PubMed:25816005, ECO:0000269\|PubMed:9808459}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

121_139

573.0

1829.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

13_74

573.0

1829.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

121_139

573.0

1740.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

13_74

573.0

1740.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

261_353

573.0

1829.0

Domain

Chromo 1

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

378_456

573.0

1829.0

Domain

Chromo 2

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

261_353

573.0

1740.0

Domain

Chromo 1

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

378_456

573.0

1740.0

Domain

Chromo 2

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

509_516

573.0

1829.0

Nucleotide binding

ATP

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

509_516

573.0

1740.0

Nucleotide binding

ATP

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000304231

160_329

98.0

355.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000450735

160_329

98.0

344.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

966_1066

573.0

1829.0

Compositional bias

Note=Glu-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

121_139

502.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

13_74

502.0

Compositional bias

Note=Ser-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

966_1066

502.0

Compositional bias

Note=Glu-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

966_1066

573.0

1740.0

Compositional bias

Note=Glu-rich

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

496_666

573.0

1829.0

Domain

Helicase ATP-binding

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

795_946

573.0

1829.0

Domain

Helicase C-terminal

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

261_353

502.0

Domain

Chromo 1

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

378_456

502.0

Domain

Chromo 2

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

496_666

502.0

Domain

Helicase ATP-binding

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

795_946

502.0

Domain

Helicase C-terminal

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

496_666

573.0

1740.0

Domain

Helicase ATP-binding

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

795_946

573.0

1740.0

Domain

Helicase C-terminal

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000394196

617_620

573.0

1829.0

Motif

Note=DEAH box

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

617_620

502.0

Motif

Note=DEAH box

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000557381

617_620

573.0

1740.0

Motif

Note=DEAH box

Hgene

CHD2

chr15:93496803

chr15:83533011

ENST00000420239

509_516

502.0

Nucleotide binding

ATP

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000304231

92_122

98.0

355.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000450735

92_122

98.0

344.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000304231

1_110

98.0

355.0

Domain

WH1

Tgene

HOMER2

chr15:93496803

chr15:83533011

ENST00000450735

1_110

98.0

344.0

Domain

WH1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1612_CHD2_93496803_HOMER2_83533011_ranked_0.pdb	CHD2	93496803	93496803	ENST00000426485	HOMER2	chr15	83533011	-	MMRNKDKSQEEDSSLHSNASSHSASEEASGSDSGSQSESEQGSDPGSGHGSESNSSSESSESQSESESESAGSKSQPVLPEAKEKPASKK ERIADVKKMWEEYPDVYGVRRSNRSRQEPSRFNIKEEASSGSESGSPKRRGQRQLKKQEKWKQEPSEDEQEQGTSAESEPEQKKVKARRP VPRRTVPKPRVKKQPKTQRGKRKKQDSSDEDDDDDEAPKRQTRRRAAKNVSYKEDDDFETDSDDLIEMTGEGVDEQQDNSETIEKVLDSR LGKKGATGASTTVYAIEANGDPSGDFDTEKDEGEIQYLIKWKGWSYIHSTWESEESLQQQKVKGLKKLENFKKKEDEIKQWLGKVSPEDV EYFNCQQELASELNKQYQIVERVIAVKTSKSTLGQTDFPAHSRKPAPSNEPEYLCKWMGLPYSECSWEDEALIGKKFQNCIDSFHSRNNS KTIPTRECKALKQRPRFVALKKQPAYLGGENLELRDYQLEGLNWLAHSWCKNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPFLIVV PLSTLTSWQREFEIWAPEINVVVYIGDLMSRNTFAEKFQEVKEAAKIAKDKTQEKIETSSNHSQESGRETPSSTQASSVNGTDDEKASHA GPANTHLKSENDKLKIALTQSAANVKKWEIELQTLRESNARLTTALQESAASVEQWKRQFSICRDENDRLRNKIDELEEQCSEINREKEK NTQLKRRIEELEAELREKETELKDLRKQSEIIPQLMSECEYVSEKLEAAERDNQNLEDKVRSLKTDIEESKYRQRHLKVELKSFLEVLDG	829

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CHD2_pLDDT.png

HOMER2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CHD2
HOMER2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to CHD2-HOMER2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CHD2-HOMER2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source