UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ABCA5-C17orf67

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCA5-C17orf67
FusionPDB ID: 194
FusionGDB2.0 ID: 194
HgeneTgene
Gene symbol

ABCA5

C17orf67

Gene ID

23461

339210

Gene nameATP binding cassette subfamily A member 5chromosome 17 open reading frame 67
SynonymsABC13|EST90625|HTC3-
Cytomap

17q24.3

17q22

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family A member 5ATP-binding cassette A5ATP-binding cassette, sub-family A (ABC1), member 5uncharacterized protein C17orf67
Modification date2020031320200313
UniProtAcc

Q8WWZ7

Q0P5P2

Ensembl transtripts involved in fusion geneENST idsENST00000392676, ENST00000392677, 
ENST00000588877, ENST00000589609, 
ENST00000487705, ENST00000397862, 
ENST00000397861, ENST00000575658, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score7 X 8 X 6=3364 X 6 X 3=72
# samples 95
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCA5 [Title/Abstract] AND C17orf67 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCA5(67280094)-C17orf67(54872541), # samples:3
Anticipated loss of major functional domain due to fusion event.ABCA5-C17orf67 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA5-C17orf67 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA5-C17orf67 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA5-C17orf67 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCA5-C17orf67 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABCA5-C17orf67 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C17orf67 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-6A-AB49-01AABCA5chr17

67280094

-C17orf67chr17

54872541

-
ChimerDB4LUSCTCGA-6A-AB49ABCA5chr17

67280093

-C17orf67chr17

54872541

-
ChimerDB4LUSCTCGA-6A-AB49ABCA5chr17

67280094

-C17orf67chr17

54872541

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000392676ABCA5chr1767280094-ENST00000397861C17orf67chr1754872541-30342457652497810
ENST00000392676ABCA5chr1767280094-ENST00000575658C17orf67chr1754872541-30332457652497810
ENST00000392677ABCA5chr1767280094-ENST00000397861C17orf67chr1754872541-311525381462578810
ENST00000392677ABCA5chr1767280094-ENST00000575658C17orf67chr1754872541-311425381462578810
ENST00000588877ABCA5chr1767280094-ENST00000397861C17orf67chr1754872541-3979340210103442810
ENST00000588877ABCA5chr1767280094-ENST00000575658C17orf67chr1754872541-3978340210103442810
ENST00000392676ABCA5chr1767280093-ENST00000397861C17orf67chr1754872541-30342457652497810
ENST00000392676ABCA5chr1767280093-ENST00000575658C17orf67chr1754872541-30332457652497810
ENST00000392677ABCA5chr1767280093-ENST00000397861C17orf67chr1754872541-311525381462578810
ENST00000392677ABCA5chr1767280093-ENST00000575658C17orf67chr1754872541-311425381462578810
ENST00000588877ABCA5chr1767280093-ENST00000397861C17orf67chr1754872541-3979340210103442810
ENST00000588877ABCA5chr1767280093-ENST00000575658C17orf67chr1754872541-3978340210103442810

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000392676ENST00000397861ABCA5chr1767280094-C17orf67chr1754872541-0.0008338470.99916613
ENST00000392676ENST00000575658ABCA5chr1767280094-C17orf67chr1754872541-0.0008471480.9991529
ENST00000392677ENST00000397861ABCA5chr1767280094-C17orf67chr1754872541-0.0008314910.9991685
ENST00000392677ENST00000575658ABCA5chr1767280094-C17orf67chr1754872541-0.0008442990.99915576
ENST00000588877ENST00000397861ABCA5chr1767280094-C17orf67chr1754872541-0.0006579410.999342
ENST00000588877ENST00000575658ABCA5chr1767280094-C17orf67chr1754872541-0.0006617840.9993382
ENST00000392676ENST00000397861ABCA5chr1767280093-C17orf67chr1754872541-0.0008338470.99916613
ENST00000392676ENST00000575658ABCA5chr1767280093-C17orf67chr1754872541-0.0008471480.9991529
ENST00000392677ENST00000397861ABCA5chr1767280093-C17orf67chr1754872541-0.0008314910.9991685
ENST00000392677ENST00000575658ABCA5chr1767280093-C17orf67chr1754872541-0.0008442990.99915576
ENST00000588877ENST00000397861ABCA5chr1767280093-C17orf67chr1754872541-0.0006579410.999342
ENST00000588877ENST00000575658ABCA5chr1767280093-C17orf67chr1754872541-0.0006617840.9993382

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>194_194_1_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000392676_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_2_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000392676_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_3_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000392677_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_4_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000392677_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_5_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000588877_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_6_ABCA5-C17orf67_ABCA5_chr17_67280093_ENST00000588877_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_7_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000392676_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_8_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000392676_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_9_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000392677_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_10_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000392677_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_11_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000588877_C17orf67_chr17_54872541_ENST00000397861_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

>194_194_12_ABCA5-C17orf67_ABCA5_chr17_67280094_ENST00000588877_C17orf67_chr17_54872541_ENST00000575658_length(amino acids)=810AA_BP=
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:67280094/chr17:54872541)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCA5

Q8WWZ7

C17orf67

Q0P5P2

FUNCTION: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:25125465). May play a role in the processing of autolysosomes (By similarity). {ECO:0000250|UniProtKB:Q8K448, ECO:0000269|PubMed:25125465}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839478_713797.33333333333341643.0DomainABC transporter 1
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738478_713797.33333333333341643.0DomainABC transporter 1
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839478_713797.33333333333341643.0DomainABC transporter 1
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738478_713797.33333333333341643.0DomainABC transporter 1
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839514_521797.33333333333341643.0Nucleotide bindingATP 1
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738514_521797.33333333333341643.0Nucleotide bindingATP 1
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839514_521797.33333333333341643.0Nucleotide bindingATP 1
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738514_521797.33333333333341643.0Nucleotide bindingATP 1
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839220_240797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839264_284797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839297_317797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839328_348797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-183932_52797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839355_375797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839396_416797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738220_240797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738264_284797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738297_317797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738328_348797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-173832_52797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738355_375797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738396_416797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839220_240797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839264_284797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839297_317797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839328_348797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-183932_52797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839355_375797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839396_416797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738220_240797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738264_284797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738297_317797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738328_348797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-173832_52797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738355_375797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738396_416797.33333333333341643.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391290_1533797.33333333333341643.0DomainABC transporter 2
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381290_1533797.33333333333341643.0DomainABC transporter 2
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391290_1533797.33333333333341643.0DomainABC transporter 2
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381290_1533797.33333333333341643.0DomainABC transporter 2
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391333_1340797.33333333333341643.0Nucleotide bindingATP 2
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381333_1340797.33333333333341643.0Nucleotide bindingATP 2
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391333_1340797.33333333333341643.0Nucleotide bindingATP 2
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381333_1340797.33333333333341643.0Nucleotide bindingATP 2
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391021_1041797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391071_1091797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391102_1122797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391139_1159797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391169_1189797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-18391207_1227797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839866_886797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000392676-1839967_987797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381021_1041797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381071_1091797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381102_1122797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381139_1159797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381169_1189797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-17381207_1227797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738866_886797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280093chr17:54872541ENST00000588877-1738967_987797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391021_1041797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391071_1091797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391102_1122797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391139_1159797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391169_1189797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-18391207_1227797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839866_886797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000392676-1839967_987797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381021_1041797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381071_1091797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381102_1122797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381139_1159797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381169_1189797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-17381207_1227797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738866_886797.33333333333341643.0TransmembraneHelical
HgeneABCA5chr17:67280094chr17:54872541ENST00000588877-1738967_987797.33333333333341643.0TransmembraneHelical


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1587_ABCA5_67280094_C17orf67_54872541_ranked_0.pdbABCA56728009367280094ENST00000575658C17orf67chr1754872541-
MSTAIREVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILISMMHPNKKYEEVPNIELNPMDKFTLSNLILGYTPVTNITSS
IMQKVSTDHLPDVIITEEYTNEKEMLTSSLSKPSNFVGVVFKDSMSYELRFFPDMIPVSSIYMDSRAGCSKSCEAAQYWSSGFTVLQASI
DAAIIQLKTNVSLWKELESTKAVIMGETAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKIKEFLKIMGLHDTAFWLSWVLLY
TSLIFLMSLLMAVIATASLLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGIVEFFVTVAFGFIGLMIILIESFPKSLVWLFS
PFCHCTFVIGIAQVMHLEDFNEGASFSNLTAGPYPLIITIIMLTLNSIFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKSKRNYEEL
SEGNVNGNISFSEIIEPVSSEFVGKEAIRISGIQKTYRKKGENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASI
YGHRVSEIDEMFEARKMIGICPQLDIHFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQTIKDNQAKKLSGGQKRKLSLGIAVL
GNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSMFLKSKWGIGYRLSMYIDKYCAT
ESLSSLVKQHIPGATLLQQNDQQLVYSLPFKDMDKFSGLFSALDSHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQAGIHAPPARPGASR
810


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ABCA5_pLDDT.png
all structure
all structure
C17orf67_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCA5
C17orf67


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ABCA5-C17orf67


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ABCA5-C17orf67


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource