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Fusion Protein:ADCY9-CREBBP |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ADCY9-CREBBP | FusionPDB ID: 2253 | FusionGDB2.0 ID: 2253 | Hgene | Tgene | Gene symbol | ADCY9 | CREBBP | Gene ID | 115 | 1387 |
| Gene name | adenylate cyclase 9 | CREB binding protein | |
| Synonyms | AC9|ACIX | CBP|KAT3A|MKHK1|RSTS|RSTS1 | |
| Cytomap | 16p13.3 | 16p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 9ATP pyrophosphate-lyase 9adenylate cyclase type IXadenylyl cyclase 9type IX ATP pyrophosphate-lyase | CREB-binding proteinhistone lysine acetyltransferase CREBBPprotein-lysine acetyltransferase CREBBP | |
| Modification date | 20200313 | 20200329 | |
| UniProtAcc | O60503 | Q92793 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000294016, ENST00000571889, | ENST00000262367, ENST00000382070, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 27 X 12 X 11=3564 | 18 X 30 X 8=4320 |
| # samples | 27 | 28 | |
| ** MAII score | log2(27/3564*10)=-3.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(28/4320*10)=-3.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ADCY9 [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | CREBBP(3929833)-ADCY9(4016967), # samples:2 ADCY9(4163751)-CREBBP(3901010), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ADCY9-CREBBP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CREBBP-ADCY9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ADCY9 | GO:0006171 | cAMP biosynthetic process | 9628827|10987815 |
| Hgene | ADCY9 | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway | 9628827 |
| Tgene | CREBBP | GO:0000122 | negative regulation of transcription by RNA polymerase II | 21539536 |
| Tgene | CREBBP | GO:0006355 | regulation of transcription, DNA-templated | 12169688 |
| Tgene | CREBBP | GO:0006473 | protein acetylation | 15273251|24207024|24939902|28790157|30540930 |
| Tgene | CREBBP | GO:0016573 | histone acetylation | 11742995 |
| Tgene | CREBBP | GO:0018076 | N-terminal peptidyl-lysine acetylation | 12435739 |
| Tgene | CREBBP | GO:0034644 | cellular response to UV | 24939902 |
| Tgene | CREBBP | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995 |
| Tgene | CREBBP | GO:1990258 | histone glutamine methylation | 30540930 |
| Fusion gene breakpoints across ADCY9 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CREBBP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | BRCA | TCGA-A7-A26I-01A | ADCY9 | chr16 | 4163751 | - | CREBBP | chr16 | 3901010 | - |
| ChimerDB4 | BRCA | TCGA-A7-A26I-01B | ADCY9 | chr16 | 4163751 | - | CREBBP | chr16 | 3901010 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000294016 | ADCY9 | chr16 | 4163751 | - | ENST00000262367 | CREBBP | chr16 | 3901010 | - | 12140 | 2232 | 539 | 9475 | 2978 |
| ENST00000294016 | ADCY9 | chr16 | 4163751 | - | ENST00000382070 | CREBBP | chr16 | 3901010 | - | 9541 | 2232 | 539 | 9361 | 2940 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000294016 | ENST00000262367 | ADCY9 | chr16 | 4163751 | - | CREBBP | chr16 | 3901010 | - | 0.004074513 | 0.99592555 |
| ENST00000294016 | ENST00000382070 | ADCY9 | chr16 | 4163751 | - | CREBBP | chr16 | 3901010 | - | 0.010757808 | 0.98924226 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >2253_2253_1_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000262367_length(amino acids)=2978AA_BP=0 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD DRYEMEDGKVIERLGQSVVADQLKDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSP VQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQT HPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTS PFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHA HKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWKNCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQ NTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPN LISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAK KVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSF NPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPP AQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPG SVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPV LEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKI FKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRV YKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISK DQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEA GEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRC LRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSA KELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYAT MEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHV ETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQH TKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPT QQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPG RTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTL KSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGL NPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHL PLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVR SPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHLGNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDT -------------------------------------------------------------- >2253_2253_2_ADCY9-CREBBP_ADCY9_chr16_4163751_ENST00000294016_CREBBP_chr16_3901010_ENST00000382070_length(amino acids)=2940AA_BP=0 MASPPHQQLLHHHSTEVSCDSSGDSNSVRVKINPKQLSSNSHPKHCKYSISSSCSSSGDSGGVPRRVGGGGRLRRQKKLPQLFERASSRW WDPKFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFLLVCVGFFLFTFTKLYARHYAWTSLALT LLVFALTLAAQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFP SPGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKR HATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLD DRYEMEDGKVIERLGQSVVADQLKDFGSLFDLENDLPDELIPNGGELGLLNSGNLVPDAASKHKQLSELLRGGSGSSINPGIGNVSASSP VQQGLGGQAQGQPNSANMASLSAMGKSPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNANFNQT HPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLAETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTS PFGQPFSQAGGQPMGATGVNPQLASKQSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVLLLHA HKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQAILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSSMQRAYAALGLPY MNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQQPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAP PSSTGVRKGWHEHVTQDLRSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYKIQKELEEKRRSR LHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQGMNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGM AISPSRMPQPPNMMGAHTNNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQASQLPCPPVTQSP LHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPTPTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATP QSSQQQPTPVHAQPPGTPLSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSEMMEEDLQGASQV KEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQPRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGI PDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLC CYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIW PSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVDSGEMSESFPYR TKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDY IFHCHPPDQKIPKPKRLQEWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKKEESTAAS ETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMD GRDAFLTLARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAHKMVKWGLGLDDE GSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPF CLNIKHKLRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAGFPSVARTQPPTT VSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNSMPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQ QAPLPQQQPMPGLPRPVISMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAFIKQRTAKYVANQ PGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQAMGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQ QQQQQQQQQQQQQQGSAGMAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLGADSTPNIQQALQ QRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLSNQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:3929833/chr16:4016967) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY9 | CREBBP |
| FUNCTION: Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827). {ECO:0000269|PubMed:10987815, ECO:0000269|PubMed:12972952, ECO:0000269|PubMed:15879435, ECO:0000269|PubMed:9628827}. | FUNCTION: Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510). Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930). Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157). Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000269|PubMed:10490106, ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:24616510, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:28790157, ECO:0000269|PubMed:30540930, ECO:0000269|PubMed:9707565}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 394_521 | 564.3333333333334 | 1354.0 | Domain | Guanylate cyclase 1 |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 399_404 | 564.3333333333334 | 1354.0 | Nucleotide binding | ATP |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 441_443 | 564.3333333333334 | 1354.0 | Nucleotide binding | ATP |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 139_141 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 163_171 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 193_215 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 1_117 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 236_241 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 260_280 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 118_138 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 142_162 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 172_192 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 216_235 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 242_259 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 281_301 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1061_1064 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1199_1487 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Cys/His-rich | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1555_1562 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1943_1948 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1967_1970 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 2081_2085 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 2199_2216 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 2245_2248 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 2297_2300 | 28.333333333333332 | 2443.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1061_1064 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1199_1487 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Cys/His-rich | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1555_1562 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1943_1948 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Pro | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1967_1970 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 2081_2085 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 2199_2216 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 2245_2248 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 2297_2300 | 28.333333333333332 | 2405.0 | Compositional bias | Note=Poly-Gln | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1103_1175 | 28.333333333333332 | 2443.0 | Domain | Bromo | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1323_1700 | 28.333333333333332 | 2443.0 | Domain | CBP/p300-type HAT | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 587_666 | 28.333333333333332 | 2443.0 | Domain | KIX | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1103_1175 | 28.333333333333332 | 2405.0 | Domain | Bromo | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1323_1700 | 28.333333333333332 | 2405.0 | Domain | CBP/p300-type HAT | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 587_666 | 28.333333333333332 | 2405.0 | Domain | KIX | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1434_1436 | 28.333333333333332 | 2443.0 | Region | Acetyl-CoA binding | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1446_1447 | 28.333333333333332 | 2443.0 | Region | Acetyl-CoA binding | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1434_1436 | 28.333333333333332 | 2405.0 | Region | Acetyl-CoA binding | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1446_1447 | 28.333333333333332 | 2405.0 | Region | Acetyl-CoA binding | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1701_1744 | 28.333333333333332 | 2443.0 | Zinc finger | ZZ-type | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 1765_1846 | 28.333333333333332 | 2443.0 | Zinc finger | TAZ-type 2 | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000262367 | 0 | 31 | 347_433 | 28.333333333333332 | 2443.0 | Zinc finger | TAZ-type 1 | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1701_1744 | 28.333333333333332 | 2405.0 | Zinc finger | ZZ-type | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 1765_1846 | 28.333333333333332 | 2405.0 | Zinc finger | TAZ-type 2 | |
| Tgene | CREBBP | chr16:4163751 | chr16:3901010 | ENST00000382070 | 0 | 30 | 347_433 | 28.333333333333332 | 2405.0 | Zinc finger | TAZ-type 1 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 1058_1198 | 564.3333333333334 | 1354.0 | Domain | Guanylate cyclase 2 |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 1185_1187 | 564.3333333333334 | 1354.0 | Nucleotide binding | ATP |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 1192_1196 | 564.3333333333334 | 1354.0 | Nucleotide binding | ATP |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 302_786 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 808_818 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 840_867 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 889_891 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 913_920 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 942_975 | 564.3333333333334 | 1354.0 | Topological domain | Extracellular |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 997_1353 | 564.3333333333334 | 1354.0 | Topological domain | Cytoplasmic |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 787_807 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 819_839 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 868_888 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 892_912 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 921_941 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
| Hgene | ADCY9 | chr16:4163751 | chr16:3901010 | ENST00000294016 | - | 2 | 11 | 976_996 | 564.3333333333334 | 1354.0 | Transmembrane | Helical |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
ADCY9_pLDDT.png  |
CREBBP_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| CREBBP | EGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, tat, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, K8, MTDH, MEIS1, LDLR, vIRF-1, vIRF-3, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, Ctnnb1, Cebpb, EID3, POU2F3, Spi1, Nfic, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, HCVgp1, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, HHV8GK18_gp81, Ar, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, E7, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, E6, SUMO1, NFATC1, CPSF4, USP7, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25, HNRNPL, DUX4, HLF, EGLN3, FGF2, TH, FBXL19, USP14, BBC3, RBBP5, GATA3, BYRF1, TP53BP1, KIAA1429, ATF7IP, ATRX, CASP8AP2, CBX4, CHAF1A, CHD3, EIF3D, GATAD2A, HIPK3, HMGXB4, FBXO38, PIAS2, PPP1R8, PPP2R2A, PTPRF, RNF111, RPL3, RPL35, SETDB1, SP100, TOPORS, UIMC1, ZCCHC7, ZMYM2, ZNF451, ZNF106, HIPK1, PIAS1, FAF1, KISS1, ZHX1, ZMYM5, ZNFX1, WDR77, PPP1CC, BRIP1, CCAR2, HSPB1, MAPT, PNKP, PPP1CA, POLR1E, DDX3X, TSPYL2, PYCR1, TRIM24, SMG7, AFP, BRD4, KDM2B, ACSS1, ACTB, ANKS1A, ANKS1B, ANXA7, APP, BAG5, TUBB, CNTRL, CEP290, CHRDL1, CLASP2, EEF1A1, EEF2, EIF4G2, FUS, GAA, GPR161, GRIA3, GSTO2, HEXA, HIVEP1, HIVEP2, HMG20A, HUWE1, IQGAP1, KDM6B, KDM2A, CAMSAP2, EPG5, KIF5A, MAP1B, MYO1E, OGT, PAPPA, PAX6, PHLDA1, RAD50, RBM24, RBM5, RFK, RNF7, RPS20, EXOC5, SEMA3B, SEPT3, SLC1A4, SNAPC5, SNRNP200, SOS2, SPTAN1, SYT1, TIAL1, TIAM1, TP53BP2, KDM6A, VAT1L, WAS, YTHDF2, BCAT2, CDC25A, TERF2IP, TGM1, BAG2, GMEB2, HIST1H2AB, LATS1, RXRA, NEUROD1, CIITA, FOXH1, T, ERG, ETV4, FEV, FOXI1, FOXQ1, GATA2, HNF1B, KLF15, LHX3, NFIA, NFIB, PAX7, PAX8, SOX9, SP7, TAL1, TEAD1, TLX1, SNAI2, |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ADCY9 | |
| CREBBP |  |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ADCY9-CREBBP |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ADCY9-CREBBP |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CREBBP | C4551859 | RUBINSTEIN-TAYBI SYNDROME 1 | 12 | CLINGEN;GENOMICS_ENGLAND;UNIPROT |
| Tgene | CREBBP | C0035934 | Rubinstein-Taybi Syndrome | 6 | CLINGEN;CTD_human |
| Tgene | CREBBP | C0033578 | Prostatic Neoplasms | 2 | CTD_human |
| Tgene | CREBBP | C0376358 | Malignant neoplasm of prostate | 2 | CTD_human |
| Tgene | CREBBP | C4511003 | Acute myeloid leukemia with t(8;16)(p11;p13) translocation | 2 | ORPHANET |
| Tgene | CREBBP | C0005684 | Malignant neoplasm of urinary bladder | 1 | CTD_human |
| Tgene | CREBBP | C0005695 | Bladder Neoplasm | 1 | CTD_human |
| Tgene | CREBBP | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0007138 | Carcinoma, Transitional Cell | 1 | CTD_human |
| Tgene | CREBBP | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | CREBBP | C0011573 | Endogenous depression | 1 | PSYGENET |
| Tgene | CREBBP | C0024301 | Lymphoma, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | CREBBP | C0079745 | Lymphoma, Large-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0079758 | Lymphoma, Mixed-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0079765 | Lymphoma, Small Cleaved-Cell, Follicular | 1 | CTD_human |
| Tgene | CREBBP | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
| Tgene | CREBBP | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
| Tgene | CREBBP | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
| Tgene | CREBBP | C1862939 | AMYOTROPHIC LATERAL SCLEROSIS 1 | 1 | CTD_human |
| Tgene | CREBBP | C1862941 | Amyotrophic Lateral Sclerosis, Sporadic | 1 | CTD_human |
| Tgene | CREBBP | C1956130 | Lymphoma, Follicular, Grade 1 | 1 | CTD_human |
| Tgene | CREBBP | C1956131 | Lymphoma, Follicular, Grade 3 | 1 | CTD_human |
| Tgene | CREBBP | C1956132 | Lymphoma, Follicular, Grade 2 | 1 | CTD_human |
| Tgene | CREBBP | C4551993 | Amyotrophic Lateral Sclerosis, Familial | 1 | CTD_human |
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