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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EGFR-ERP44

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EGFR-ERP44
FusionPDB ID: 25453
FusionGDB2.0 ID: 25453
HgeneTgene
Gene symbol

EGFR

ERP44

Gene ID

1956

23071

Gene nameepidermal growth factor receptorendoplasmic reticulum protein 44
SynonymsERBB|ERBB1|HER1|NISBD2|PIG61|mENAPDIA10|TXNDC4
Cytomap

7p11.2

9q31.1

Type of geneprotein-codingprotein-coding
Descriptionepidermal growth factor receptoravian erythroblastic leukemia viral (v-erb-b) oncogene homologcell growth inhibiting protein 40cell proliferation-inducing protein 61epidermal growth factor receptor tyrosine kinase domainerb-b2 receptor tyrosine kinasendoplasmic reticulum resident protein 44ER protein 44endoplasmic reticulum resident protein 44 kDaepididymis secretory sperm binding proteinprotein disulfide isomerase family A, member 10thioredoxin domain containing 4 (endoplasmic reticulum)thiore
Modification date2020032920200313
UniProtAcc

P00533

Q9BS26

Ensembl transtripts involved in fusion geneENST idsENST00000463948, ENST00000275493, 
ENST00000342916, ENST00000344576, 
ENST00000420316, ENST00000442591, 
ENST00000455089, ENST00000454757, 
ENST00000262455, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score41 X 25 X 14=143507 X 5 X 5=175
# samples 537
** MAII scorelog2(53/14350*10)=-4.75891456699985
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EGFR [Title/Abstract] AND ERP44 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EGFR(55087058)-ERP44(102784508), # samples:2
Anticipated loss of major functional domain due to fusion event.EGFR-ERP44 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-ERP44 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-ERP44 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EGFR-ERP44 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEGFR

GO:0001934

positive regulation of protein phosphorylation

20551055

HgeneEGFR

GO:0007165

signal transduction

10572067

HgeneEGFR

GO:0007166

cell surface receptor signaling pathway

7736574

HgeneEGFR

GO:0007173

epidermal growth factor receptor signaling pathway

7736574|12435727

HgeneEGFR

GO:0008283

cell proliferation

17115032

HgeneEGFR

GO:0008284

positive regulation of cell proliferation

7736574

HgeneEGFR

GO:0010750

positive regulation of nitric oxide mediated signal transduction

12828935

HgeneEGFR

GO:0018108

peptidyl-tyrosine phosphorylation

22732145

HgeneEGFR

GO:0030307

positive regulation of cell growth

15467833

HgeneEGFR

GO:0042177

negative regulation of protein catabolic process

17115032

HgeneEGFR

GO:0042327

positive regulation of phosphorylation

15082764

HgeneEGFR

GO:0043406

positive regulation of MAP kinase activity

10572067

HgeneEGFR

GO:0045739

positive regulation of DNA repair

17115032

HgeneEGFR

GO:0045740

positive regulation of DNA replication

17115032

HgeneEGFR

GO:0045944

positive regulation of transcription by RNA polymerase II

20551055

HgeneEGFR

GO:0050679

positive regulation of epithelial cell proliferation

10572067

HgeneEGFR

GO:0050999

regulation of nitric-oxide synthase activity

12828935

HgeneEGFR

GO:0070141

response to UV-A

18483258

HgeneEGFR

GO:0070374

positive regulation of ERK1 and ERK2 cascade

20551055

HgeneEGFR

GO:0071392

cellular response to estradiol stimulus

20551055

HgeneEGFR

GO:1900020

positive regulation of protein kinase C activity

22732145

HgeneEGFR

GO:1903078

positive regulation of protein localization to plasma membrane

22732145

TgeneERP44

GO:0006457

protein folding

11847130

TgeneERP44

GO:0006986

response to unfolded protein

11847130

TgeneERP44

GO:0009100

glycoprotein metabolic process

11847130

TgeneERP44

GO:0034976

response to endoplasmic reticulum stress

11847130


check buttonFusion gene breakpoints across EGFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERP44 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0744-01AEGFRchr7

55087058

-ERP44chr9

102784508

-
ChimerDB4GBMTCGA-06-0744EGFRchr7

55087058

+ERP44chr9

102784508

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000455089EGFRchr755087058+ENST00000262455ERP44chr9102784508-47133452571279340
ENST00000342916EGFRchr755087058+ENST00000262455ERP44chr9102784508-47023342461268340
ENST00000344576EGFRchr755087058+ENST00000262455ERP44chr9102784508-47013332451267340
ENST00000420316EGFRchr755087058+ENST00000262455ERP44chr9102784508-47003322441266340
ENST00000275493EGFRchr755087058+ENST00000262455ERP44chr9102784508-46332651771199340
ENST00000442591EGFRchr755087058+ENST00000262455ERP44chr9102784508-46162481601182340

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000455089ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.62E-050.99995387
ENST00000342916ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.60E-050.999954
ENST00000344576ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.59E-050.9999541
ENST00000420316ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.60E-050.999954
ENST00000275493ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.39E-050.99995613
ENST00000442591ENST00000262455EGFRchr755087058+ERP44chr9102784508-4.29E-050.9999571

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>25453_25453_1_EGFR-ERP44_EGFR_chr7_55087058_ENST00000275493_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

>25453_25453_2_EGFR-ERP44_EGFR_chr7_55087058_ENST00000342916_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

>25453_25453_3_EGFR-ERP44_EGFR_chr7_55087058_ENST00000344576_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

>25453_25453_4_EGFR-ERP44_EGFR_chr7_55087058_ENST00000420316_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

>25453_25453_5_EGFR-ERP44_EGFR_chr7_55087058_ENST00000442591_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

>25453_25453_6_EGFR-ERP44_EGFR_chr7_55087058_ENST00000455089_ERP44_chr9_102784508_ENST00000262455_length(amino acids)=340AA_BP=29
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:55087058/chr9:102784508)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EGFR

P00533

ERP44

Q9BS26

FUNCTION: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704, PubMed:17909029). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling (PubMed:11602604). Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin (PubMed:11483589). Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration (PubMed:20462955). Plays a role in enhancing learning and memory performance (By similarity). {ECO:0000250|UniProtKB:Q01279, ECO:0000269|PubMed:10805725, ECO:0000269|PubMed:11116146, ECO:0000269|PubMed:11483589, ECO:0000269|PubMed:11602604, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12873986, ECO:0000269|PubMed:15374980, ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:15611079, ECO:0000269|PubMed:17115032, ECO:0000269|PubMed:17909029, ECO:0000269|PubMed:19560417, ECO:0000269|PubMed:20462955, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:27153536, ECO:0000269|PubMed:2790960, ECO:0000269|PubMed:7679104, ECO:0000269|PubMed:8144591, ECO:0000269|PubMed:9419975}.; FUNCTION: Isoform 2 may act as an antagonist of EGF action.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.FUNCTION: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneERP44chr7:55087058chr9:102784508ENST00000262455312403_40695.33333333333333407.0MotifPrevents secretion from ER

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128712_97929.3333333333333321211.0DomainProtein kinase
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116712_97929.333333333333332629.0DomainProtein kinase
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116712_97929.333333333333332706.0DomainProtein kinase
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110712_97929.333333333333332406.0DomainProtein kinase
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128718_72629.3333333333333321211.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128790_79129.3333333333333321211.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116718_72629.333333333333332629.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116790_79129.333333333333332629.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116718_72629.333333333333332706.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116790_79129.333333333333332706.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110718_72629.333333333333332406.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110790_79129.333333333333332406.0Nucleotide bindingATP
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128688_70429.3333333333333321211.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116688_70429.333333333333332629.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116688_70429.333333333333332706.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110688_70429.333333333333332406.0RegionNote=Important for dimerization%2C phosphorylation and activation
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128390_60029.3333333333333321211.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+12875_30029.3333333333333321211.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116390_60029.333333333333332629.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+11675_30029.333333333333332629.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116390_60029.333333333333332706.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+11675_30029.333333333333332706.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110390_60029.333333333333332406.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+11075_30029.333333333333332406.0RepeatNote=Approximate
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+12825_64529.3333333333333321211.0Topological domainExtracellular
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128669_121029.3333333333333321211.0Topological domainCytoplasmic
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+11625_64529.333333333333332629.0Topological domainExtracellular
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116669_121029.333333333333332629.0Topological domainCytoplasmic
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+11625_64529.333333333333332706.0Topological domainExtracellular
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116669_121029.333333333333332706.0Topological domainCytoplasmic
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+11025_64529.333333333333332406.0Topological domainExtracellular
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110669_121029.333333333333332406.0Topological domainCytoplasmic
HgeneEGFRchr7:55087058chr9:102784508ENST00000275493+128646_66829.3333333333333321211.0TransmembraneHelical
HgeneEGFRchr7:55087058chr9:102784508ENST00000342916+116646_66829.333333333333332629.0TransmembraneHelical
HgeneEGFRchr7:55087058chr9:102784508ENST00000344576+116646_66829.333333333333332706.0TransmembraneHelical
HgeneEGFRchr7:55087058chr9:102784508ENST00000420316+110646_66829.333333333333332406.0TransmembraneHelical
TgeneERP44chr7:55087058chr9:102784508ENST0000026245531230_13895.33333333333333407.0DomainThioredoxin


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>644_EGFR_55087058_ERP44_102784508_ranked_0.pdbEGFR5508705855087058ENST00000262455ERP44chr9102784508-
MRPSGTAGAALLALLAALCPASRALEEKKADIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTL
DRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVR
EITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFK
340


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EGFR_pLDDT.png
all structure
all structure
ERP44_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EGFR
ERP44


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EGFR-ERP44


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EGFR-ERP44


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource