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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ELMSAN1-ANO1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ELMSAN1-ANO1
FusionPDB ID: 26265
FusionGDB2.0 ID: 26265
HgeneTgene
Gene symbol

ELMSAN1

ANO1

Gene ID

91748

55107

Gene namemitotic deacetylase associated SANT domain proteinanoctamin 1
SynonymsC14orf117|C14orf43|ELMSAN1|LSR68|c14_5541DOG1|ORAOV2|TAOS2|TMEM16A
Cytomap

14q24.3

11q13.3

Type of geneprotein-codingprotein-coding
DescriptionELM2 and SANT domain-containing protein 1ELM2 and Myb/SANT domain containing 1ELM2 and Myb/SANT-like domain containing 1anoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spannin
Modification date2020031320200313
UniProtAcc.

Q9NW15

Ensembl transtripts involved in fusion geneENST idsENST00000286523, ENST00000394071, 
ENST00000486739, 		ENST00000525494, 
ENST00000316296, ENST00000355303, 
ENST00000398543, ENST00000530676, 
ENST00000531349, ENST00000538023, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 9 X 9=113419 X 28 X 10=5320
# samples 1536
** MAII scorelog2(15/1134*10)=-2.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(36/5320*10)=-3.88535743405888
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ELMSAN1 [Title/Abstract] AND ANO1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ELMSAN1(74194161)-ANO1(69957813), # samples:2
Anticipated loss of major functional domain due to fusion event.ELMSAN1-ANO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ELMSAN1-ANO1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneANO1

GO:0006812

cation transport

22946059


check buttonFusion gene breakpoints across ELMSAN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ANO1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4742-01AELMSAN1chr14

74194161

-ANO1chr11

69957813

+
ChimerDB4HNSCTCGA-CN-4742ELMSAN1chr14

74194161

-ANO1chr11

69957813

+
ChimerDB4HNSCTCGA-CN-4742ELMSAN1chr14

74196343

-ANO1chr11

69957813

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394071ELMSAN1chr1474194161-ENST00000355303ANO1chr1169957813+625225664042638744
ENST00000394071ELMSAN1chr1474194161-ENST00000398543ANO1chr1169957813+616125664042638744
ENST00000394071ELMSAN1chr1474194161-ENST00000538023ANO1chr1169957813+625125664042638744
ENST00000394071ELMSAN1chr1474194161-ENST00000316296ANO1chr1169957813+386425664042638744
ENST00000394071ELMSAN1chr1474194161-ENST00000530676ANO1chr1169957813+491525664042638744
ENST00000394071ELMSAN1chr1474194161-ENST00000531349ANO1chr1169957813+589825664042638744
ENST00000286523ELMSAN1chr1474194161-ENST00000355303ANO1chr1169957813+663129457833017744
ENST00000286523ELMSAN1chr1474194161-ENST00000398543ANO1chr1169957813+654029457833017744
ENST00000286523ELMSAN1chr1474194161-ENST00000538023ANO1chr1169957813+663029457833017744
ENST00000286523ELMSAN1chr1474194161-ENST00000316296ANO1chr1169957813+424329457833017744
ENST00000286523ELMSAN1chr1474194161-ENST00000530676ANO1chr1169957813+529429457833017744
ENST00000286523ELMSAN1chr1474194161-ENST00000531349ANO1chr1169957813+627729457833017744

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394071ENST00000355303ELMSAN1chr1474194161-ANO1chr1169957813+0.0174431470.9825569
ENST00000394071ENST00000398543ELMSAN1chr1474194161-ANO1chr1169957813+0.0171699170.98283005
ENST00000394071ENST00000538023ELMSAN1chr1474194161-ANO1chr1169957813+0.017449270.9825507
ENST00000394071ENST00000316296ELMSAN1chr1474194161-ANO1chr1169957813+0.0390624480.96093756
ENST00000394071ENST00000530676ELMSAN1chr1474194161-ANO1chr1169957813+0.0399801540.9600198
ENST00000394071ENST00000531349ELMSAN1chr1474194161-ANO1chr1169957813+0.0239864550.97601354
ENST00000286523ENST00000355303ELMSAN1chr1474194161-ANO1chr1169957813+0.0176764130.9823235
ENST00000286523ENST00000398543ELMSAN1chr1474194161-ANO1chr1169957813+0.0174957330.9825043
ENST00000286523ENST00000538023ELMSAN1chr1474194161-ANO1chr1169957813+0.0176800790.9823199
ENST00000286523ENST00000316296ELMSAN1chr1474194161-ANO1chr1169957813+0.0366232730.96337676
ENST00000286523ENST00000530676ELMSAN1chr1474194161-ANO1chr1169957813+0.039241330.9607587
ENST00000286523ENST00000531349ELMSAN1chr1474194161-ANO1chr1169957813+0.0238615960.97613835

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26265_26265_1_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000316296_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_2_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000355303_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_3_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000398543_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_4_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000530676_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_5_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000531349_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_6_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000286523_ANO1_chr11_69957813_ENST00000538023_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_7_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000316296_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_8_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000355303_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_9_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000398543_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_10_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000530676_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_11_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000531349_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

>26265_26265_12_ELMSAN1-ANO1_ELMSAN1_chr14_74194161_ENST00000394071_ANO1_chr11_69957813_ENST00000538023_length(amino acids)=744AA_BP=242
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:74194161/chr11:69957813)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ANO1

Q9NW15

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512111_115720.66666666666661046.0Compositional biasNote=Poly-Gly
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512210_291720.66666666666661046.0Compositional biasNote=Gln-rich
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512234_395720.66666666666661046.0Compositional biasNote=Pro-rich
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512455_459720.66666666666661046.0Compositional biasNote=Poly-Arg
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512111_115720.66666666666661046.0Compositional biasNote=Poly-Gly
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512210_291720.66666666666661046.0Compositional biasNote=Gln-rich
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512234_395720.66666666666661046.0Compositional biasNote=Pro-rich
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512455_459720.66666666666661046.0Compositional biasNote=Poly-Arg
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517355_406238.33333333333334643.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517428_519238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517541_568238.33333333333334643.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517590_607238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517629_657238.33333333333334643.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517679_725238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517768_784238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517806_892238.33333333333334643.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517914_986238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526355_406266.3333333333333987.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526428_519266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526541_568266.3333333333333987.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526590_607266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526629_657266.3333333333333987.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526679_725266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526768_784266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526806_892266.3333333333333987.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526914_986266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524355_406150.33333333333334841.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524428_519150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524541_568150.33333333333334841.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524590_607150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524629_657150.33333333333334841.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524679_725150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524768_784150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524806_892150.33333333333334841.0Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524914_986150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525355_406150.33333333333334819.3333333333334Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525428_519150.33333333333334819.3333333333334Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525541_568150.33333333333334819.3333333333334Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525590_607150.33333333333334819.3333333333334Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525629_657150.33333333333334819.3333333333334Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525679_725150.33333333333334819.3333333333334Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525768_784150.33333333333334819.3333333333334Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525806_892150.33333333333334819.3333333333334Topological domainExtracellular
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525914_986150.33333333333334819.3333333333334Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517334_354238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517407_427238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517520_540238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517569_589238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517608_628238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517658_678238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517726_746238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517747_767238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517785_805238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000316296517893_913238.33333333333334643.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526334_354266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526407_427266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526520_540266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526569_589266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526608_628266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526658_678266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526726_746266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526747_767266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526785_805266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000355303526893_913266.3333333333333987.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524334_354150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524407_427150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524520_540150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524569_589150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524608_628150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524658_678150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524726_746150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524747_767150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524785_805150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000398543524893_913150.33333333333334841.0TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525334_354150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525407_427150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525520_540150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525569_589150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525608_628150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525658_678150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525726_746150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525747_767150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525785_805150.33333333333334819.3333333333334TransmembraneHelical
TgeneANO1chr14:74194161chr11:69957813ENST00000530676525893_913150.33333333333334819.3333333333334TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-5121021_1024720.66666666666661046.0Compositional biasNote=Poly-Lys
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-5121021_1024720.66666666666661046.0Compositional biasNote=Poly-Lys
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512721_813720.66666666666661046.0DomainELM2
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000286523-512828_879720.66666666666661046.0DomainSANT
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512721_813720.66666666666661046.0DomainELM2
HgeneELMSAN1chr14:74194161chr11:69957813ENST00000394071-512828_879720.66666666666661046.0DomainSANT
TgeneANO1chr14:74194161chr11:69957813ENST000003162965171_333238.33333333333334643.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST000003553035261_333266.3333333333333987.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST000003985435241_333150.33333333333334841.0Topological domainCytoplasmic
TgeneANO1chr14:74194161chr11:69957813ENST000005306765251_333150.33333333333334819.3333333333334Topological domainCytoplasmic


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1501_ELMSAN1_74194161_ANO1_69957813_ranked_0.pdbELMSAN17419416174194161ENST00000531349ANO1chr1169957813+
MNLQAQPKAQNKRKRCLFGGQEPAPKEQPPPLQPPQQSIRVKEEQYLGHEGPGGAVSTSQPVELPPPSSLALLNSVVYGPERTSAAMLSQ
QVASVKWPNSVMAPGRGPERGGGGGVSDSSWQQQPGQPPPHSTWNCHSLSLYSATKGSPHPGVGVPTYYNHPEALKREKAGGPQLDRYVR
PMMPQKVQLEVGRPQAPLNSFHAAKKPPNQSLPLQPFQLAFGHQVNRQVFRQGPPPPNPVAAFPPQKQQQQQQPQQQQQQQQAALPQMPL
FENFYSMPQQPSQQPQDFGLQPAGPLGQSHLAHHSMAPYPFPPNPDMNPELRKALLQDSAPQPALPQVQIPFPRRSRRLSKEGILPPSAL
DGAGTQPGQEATGNLFLHHWPLQQPPPGSLGQPHPEALGFPLELRESQLLPDGERLAPNGREREAPAMGSEEGMRAVSTGDCGQVLRGGV
IQSTRRRRRASQEANLLTLAQKAVELASLQNAKDGSGSEEKRKSVLASTTKCGVEFSEPSLATKRAREDSGMVPLIIPVSVPVRTVDPTE
AAQAGGLDEDGKGPEQNPAEHKPSVIVTRRRSTRIPGTDAQAQAEDMNVKLEGEPSVRKPKQRPRPEPLIIPTKAGTFIAPPVYSNITPY
QSHLRSPVRLADHPSERSFELPPYTPPPILSPVREGSGLYFNAIISTSTIPAPPPITPKSAHRTLLRTNSAEVTPPVLSVMGEATPVSIE
744


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
ANO1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ELMSAN1
ANO1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ELMSAN1-ANO1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ELMSAN1-ANO1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource