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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:EPHA2-LSM14B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: EPHA2-LSM14B
FusionPDB ID: 26954
FusionGDB2.0 ID: 26954
HgeneTgene
Gene symbol

EPHA2

LSM14B

Gene ID

1969

149986

Gene nameEPH receptor A2LSM family member 14B
SynonymsARCC2|CTPA|CTPP1|CTRCT6|ECKC20orf40|FAM61B|FT005|LSM13|RAP55B|bA11M20.3
Cytomap

1p36.13

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECKprotein LSM14 homolog BLSM14 homolog BLSM14B, SCD6 homolog BRNA-associated protein 55Bfamily with sequence similarity 61, member BhRAP55B
Modification date2020031320200327
UniProtAcc

P29317

Q9BX40

Ensembl transtripts involved in fusion geneENST idsENST00000358432, ENST00000461614, 
ENST00000253001, ENST00000279068, 
ENST00000370915, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 4=1203 X 4 X 2=24
# samples 84
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: EPHA2 [Title/Abstract] AND LSM14B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)EPHA2(16474873)-LSM14B(60699673), # samples:3
Anticipated loss of major functional domain due to fusion event.EPHA2-LSM14B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHA2-LSM14B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHA2-LSM14B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
EPHA2-LSM14B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEPHA2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

18339848

HgeneEPHA2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

HgeneEPHA2

GO:0043491

protein kinase B signaling

19573808

HgeneEPHA2

GO:0048013

ephrin receptor signaling pathway

10655584|20861311

HgeneEPHA2

GO:0051898

negative regulation of protein kinase B signaling

19573808


check buttonFusion gene breakpoints across EPHA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LSM14B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-N9-A4PZ-01AEPHA2chr1

16474873

-LSM14Bchr20

60699673

+
ChimerDB4UCSTCGA-N9-A4PZEPHA2chr1

16474872

-LSM14Bchr20

60699672

+
ChimerDB4UCSTCGA-N9-A4PZEPHA2chr1

16474873

-LSM14Bchr20

60699673

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000358432EPHA2chr116474873-ENST00000370915LSM14Bchr2060699673+17249781551516453
ENST00000358432EPHA2chr116474873-ENST00000253001LSM14Bchr2060699673+32399781552008617
ENST00000358432EPHA2chr116474873-ENST00000279068LSM14Bchr2060699673+32399781552008617
ENST00000461614EPHA2chr116474873-ENST00000370915LSM14Bchr2060699673+1621875131413466
ENST00000461614EPHA2chr116474873-ENST00000253001LSM14Bchr2060699673+3136875131905630
ENST00000461614EPHA2chr116474873-ENST00000279068LSM14Bchr2060699673+3136875131905630
ENST00000358432EPHA2chr116474872-ENST00000370915LSM14Bchr2060699672+17249781551516453
ENST00000358432EPHA2chr116474872-ENST00000253001LSM14Bchr2060699672+32399781552008617
ENST00000358432EPHA2chr116474872-ENST00000279068LSM14Bchr2060699672+32399781552008617
ENST00000461614EPHA2chr116474872-ENST00000370915LSM14Bchr2060699672+1621875131413466
ENST00000461614EPHA2chr116474872-ENST00000253001LSM14Bchr2060699672+3136875131905630
ENST00000461614EPHA2chr116474872-ENST00000279068LSM14Bchr2060699672+3136875131905630

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358432ENST00000370915EPHA2chr116474873-LSM14Bchr2060699673+0.0096162440.99038374
ENST00000358432ENST00000253001EPHA2chr116474873-LSM14Bchr2060699673+0.0019539090.99804604
ENST00000358432ENST00000279068EPHA2chr116474873-LSM14Bchr2060699673+0.0015458630.9984541
ENST00000461614ENST00000370915EPHA2chr116474873-LSM14Bchr2060699673+0.0128152830.9871847
ENST00000461614ENST00000253001EPHA2chr116474873-LSM14Bchr2060699673+0.0027364840.99726355
ENST00000461614ENST00000279068EPHA2chr116474873-LSM14Bchr2060699673+0.0021549370.99784505
ENST00000358432ENST00000370915EPHA2chr116474872-LSM14Bchr2060699672+0.0096162440.99038374
ENST00000358432ENST00000253001EPHA2chr116474872-LSM14Bchr2060699672+0.0019539090.99804604
ENST00000358432ENST00000279068EPHA2chr116474872-LSM14Bchr2060699672+0.0015458630.9984541
ENST00000461614ENST00000370915EPHA2chr116474872-LSM14Bchr2060699672+0.0128152830.9871847
ENST00000461614ENST00000253001EPHA2chr116474872-LSM14Bchr2060699672+0.0027364840.99726355
ENST00000461614ENST00000279068EPHA2chr116474872-LSM14Bchr2060699672+0.0021549370.99784505

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26954_26954_1_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000358432_LSM14B_chr20_60699672_ENST00000253001_length(amino acids)=617AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP
CSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

--------------------------------------------------------------

>26954_26954_2_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000358432_LSM14B_chr20_60699672_ENST00000279068_length(amino acids)=617AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRR
PQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

--------------------------------------------------------------

>26954_26954_3_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000358432_LSM14B_chr20_60699672_ENST00000370915_length(amino acids)=453AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP

--------------------------------------------------------------

>26954_26954_4_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000461614_LSM14B_chr20_60699672_ENST00000253001_length(amino acids)=630AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAAD
RMTVAVADHLPSPCSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQ
SAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV

--------------------------------------------------------------

>26954_26954_5_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000461614_LSM14B_chr20_60699672_ENST00000279068_length(amino acids)=630AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAA
VQAQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQ
SAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV

--------------------------------------------------------------

>26954_26954_6_EPHA2-LSM14B_EPHA2_chr1_16474872_ENST00000461614_LSM14B_chr20_60699672_ENST00000370915_length(amino acids)=466AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAAD

--------------------------------------------------------------

>26954_26954_7_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000358432_LSM14B_chr20_60699673_ENST00000253001_length(amino acids)=617AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP
CSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

--------------------------------------------------------------

>26954_26954_8_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000358432_LSM14B_chr20_60699673_ENST00000279068_length(amino acids)=617AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAAVQAQGQVNDENRR
PQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQSAEAPAEEDLLGP

--------------------------------------------------------------

>26954_26954_9_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000358432_LSM14B_chr20_60699673_ENST00000370915_length(amino acids)=453AA_BP=274
MELQAARACFALLWGCALAAAAAAQGKEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSGDQDNWLRTNWVYRGE
AERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTRKGFYL
AFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPIGQCLCQAGYEKVE
DACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYSPFRGMAPYGPLAA
SSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAADRMTVAVADHLPSP

--------------------------------------------------------------

>26954_26954_10_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000461614_LSM14B_chr20_60699673_ENST00000253001_length(amino acids)=630AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAAD
RMTVAVADHLPSPCSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQ
SAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV

--------------------------------------------------------------

>26954_26954_11_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000461614_LSM14B_chr20_60699673_ENST00000279068_length(amino acids)=630AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLGAGFPSIPVGKSPMVEQAVQTGSADNLNAKKLLPGKGTTGTQLNGRQAQPSSKTASDVVQPAA
VQAQGQVNDENRRPQRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQ
SAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV

--------------------------------------------------------------

>26954_26954_12_EPHA2-LSM14B_EPHA2_chr1_16474873_ENST00000461614_LSM14B_chr20_60699673_ENST00000370915_length(amino acids)=466AA_BP=287
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAAD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16474873/chr20:60699673)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
EPHA2

P29317

LSM14B

Q9BX40

FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.FUNCTION: Required for oocyte meiotic maturation. May be involved in the storage of translationally inactive mRNAs and protect them from degradation (By similarity). Plays a role in control of mRNA translation (By similarity). {ECO:0000250|UniProtKB:Q68FI1, ECO:0000250|UniProtKB:Q8CGC4}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-31728_206274.3333333333333977.0DomainEph LBD
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-31728_206274.3333333333333977.0DomainEph LBD
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000025300109241_27742.333333333333336680.3333333333334DomainDFDF
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000027906809241_27742.333333333333336695.6666666666666DomainDFDF
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000037091504241_27742.333333333333336222.0DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000025300109241_27742.333333333333336680.3333333333334DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000027906809241_27742.333333333333336695.6666666666666DomainDFDF
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000037091504241_27742.333333333333336222.0DomainDFDF
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000025300109310_32642.333333333333336680.3333333333334MotifNote=FFD box
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000025300109330_35042.333333333333336680.3333333333334MotifNote=TFG box
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000027906809310_32642.333333333333336695.6666666666666MotifNote=FFD box
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000027906809330_35042.333333333333336695.6666666666666MotifNote=TFG box
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000037091504310_32642.333333333333336222.0MotifNote=FFD box
TgeneLSM14Bchr1:16474872chr20:60699672ENST0000037091504330_35042.333333333333336222.0MotifNote=TFG box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000025300109310_32642.333333333333336680.3333333333334MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000025300109330_35042.333333333333336680.3333333333334MotifNote=TFG box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000027906809310_32642.333333333333336695.6666666666666MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000027906809330_35042.333333333333336695.6666666666666MotifNote=TFG box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000037091504310_32642.333333333333336222.0MotifNote=FFD box
TgeneLSM14Bchr1:16474873chr20:60699673ENST0000037091504330_35042.333333333333336222.0MotifNote=TFG box

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317188_325274.3333333333333977.0Compositional biasNote=Cys-rich
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317188_325274.3333333333333977.0Compositional biasNote=Cys-rich
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317328_432274.3333333333333977.0DomainFibronectin type-III 1
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317438_529274.3333333333333977.0DomainFibronectin type-III 2
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317613_875274.3333333333333977.0DomainProtein kinase
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317904_968274.3333333333333977.0DomainSAM
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317328_432274.3333333333333977.0DomainFibronectin type-III 1
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317438_529274.3333333333333977.0DomainFibronectin type-III 2
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317613_875274.3333333333333977.0DomainProtein kinase
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317904_968274.3333333333333977.0DomainSAM
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317974_976274.3333333333333977.0MotifPDZ-binding
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317974_976274.3333333333333977.0MotifPDZ-binding
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317619_627274.3333333333333977.0Nucleotide bindingATP
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317619_627274.3333333333333977.0Nucleotide bindingATP
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-31724_537274.3333333333333977.0Topological domainExtracellular
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317559_976274.3333333333333977.0Topological domainCytoplasmic
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-31724_537274.3333333333333977.0Topological domainExtracellular
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317559_976274.3333333333333977.0Topological domainCytoplasmic
HgeneEPHA2chr1:16474872chr20:60699672ENST00000358432-317538_558274.3333333333333977.0TransmembraneHelical
HgeneEPHA2chr1:16474873chr20:60699673ENST00000358432-317538_558274.3333333333333977.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1326_EPHA2_16474873_LSM14B_60699673_1326_EPHA2_16474873_LSM14B_60699673_ranked_0.pdbEPHA21647487216474873ENST00000279068LSM14Bchr2060699673+
MRAGRRAGADTEAGVQACGCAGAGLGGIGPRARSAAWSSRQPAPASPCCGAVRWPRPRRRRARKWDLMQNIMNDMPIYMYSVCNVMSGDQ
DNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAESDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEE
RSVGPLTRKGFYLAFQDIGACVALLSVRVYYKKCPELLQGLAHFPETIAGSDAPSLATVAGTCVDHAVVPPGGEEPRMHCAVDGEWLVPI
GQCLCQAGYEKVEDACQVRSFGTEDRPTDRPAPPREEIYEYIIFRGSDIKDITVCEPPKAQHTLPQDPAIVQSSLGSASASPFQPHVPYS
PFRGMAPYGPLAASSLLSQQYAASLGLEKLVSPPASAAASSPSSSPSPQPVSELDLSSEPQQLTAKGNSSLGELHAVLQTILRARGKAAD
RMTVAVADHLPSPCSRRRSGNRRTRNRSRGQNRPTNVKENTIKFEGDFDFESANAQFNREELDKEFKKKLNFKDDKAEKGEEKDLAVVTQ
SAEAPAEEDLLGPNCYYDKSKSFFDNISSELKTSSRRTTWAEERKLNTETFGVSGRFLRGRSSRGGFRGGRGNGTTRRNPTSHRAGTGRV
630


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
EPHA2_pLDDT.png
all structure
all structure
LSM14B_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
EPHA2
LSM14B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to EPHA2-LSM14B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to EPHA2-LSM14B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource