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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EPHB2-NTRK1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EPHB2-NTRK1
	FusionPDB ID: 26993
	FusionGDB2.0 ID: 26993
		Hgene	Tgene
	Gene symbol	EPHB2	NTRK1
	Gene ID	2048	4914
	Gene name	EPH receptor B2	neurotrophic receptor tyrosine kinase 1
	Synonyms	BDPLT22\|CAPB\|DRT\|EK5\|EPHT3\|ERK\|Hek5\|PCBC\|Tyro5	MTC\|TRK\|TRK1\|TRKA\|Trk-A\|p140-TrkA
	Cytomap	1p36.12	1q23.1
	Type of gene	protein-coding	protein-coding
	Description	ephrin type-B receptor 2EPH-like kinase 5developmentally-regulated Eph-related tyrosine kinaseelk-related tyrosine kinaseeph tyrosine kinase 3protein-tyrosine kinase HEK5renal carcinoma antigen NY-REN-47tyrosine-protein kinase TYRO5tyrosine-protei	high affinity nerve growth factor receptorOncogene TRKTRK1-transforming tyrosine kinase proteingp140trkneurotrophic tyrosine kinase, receptor, type 1tropomyosin-related kinase Atyrosine kinase receptor A
	Modification date	20200313	20200313
	UniProtAcc	P29323	P04629
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000374627, ENST00000374630, ENST00000374632, ENST00000400191, ENST00000544305, ENST00000465676,	ENST00000531606, ENST00000358660, ENST00000368196, ENST00000392302, ENST00000524377,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 6 X 7=378	25 X 24 X 13=7800
	# samples	13	33
	** MAII score	log2(13/378*10)=-1.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(33/7800*10)=-4.56293619439116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EPHB2 [Title/Abstract] AND NTRK1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EPHB2(23111569)-NTRK1(156843425), # samples:3
Anticipated loss of major functional domain due to fusion event.	EPHB2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPHB2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EPHB2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EPHB2-NTRK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	NTRK1	GO:0006468	protein phosphorylation	15488758
Tgene	NTRK1	GO:0008285	negative regulation of cell proliferation	15488758
Tgene	NTRK1	GO:0010976	positive regulation of neuron projection development	15488758
Tgene	NTRK1	GO:0018108	peptidyl-tyrosine phosphorylation	2927393
Tgene	NTRK1	GO:0043547	positive regulation of GTPase activity	15488758
Tgene	NTRK1	GO:0046579	positive regulation of Ras protein signal transduction	15488758
Tgene	NTRK1	GO:0046777	protein autophosphorylation	15488758
Tgene	NTRK1	GO:0048011	neurotrophin TRK receptor signaling pathway	15488758
Tgene	NTRK1	GO:0051092	positive regulation of NF-kappaB transcription factor activity	15488758
Tgene	NTRK1	GO:0070374	positive regulation of ERK1 and ERK2 cascade	15488758
Tgene	NTRK1	GO:1904646	cellular response to amyloid-beta	11927634

Fusion gene breakpoints across EPHB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NTRK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-TM-A84J-01A	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+
ChimerDB4	LGG	TCGA-TM-A84J-01A	EPHB2	chr1	23111569	-	NTRK1	chr1	156843425	+
ChimerDB4	LGG	TCGA-TM-A84J-01A	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+
ChimerDB4	LGG	TCGA-TM-A84J	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+
ChimerDB4	LGG	TCGA-TM-A84J	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843425	+	2630	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843425	+	2686	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843425	+	2496	955	3	2495	830
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843425	+	2556	955	3	2486	827
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843425	+	2504	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843425	+	2560	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843425	+	2370	829	18	2369	783
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843425	+	2430	829	18	2360	780
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843425	+	2504	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843425	+	2560	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843425	+	2370	829	18	2369	783
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843425	+	2430	829	18	2360	780
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843425	+	2499	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843425	+	2555	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843425	+	2365	824	13	2364	784
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843425	+	2425	824	13	2355	780
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843425	+	2492	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843425	+	2548	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843425	+	2358	817	24	2357	777
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843425	+	2418	817	24	2348	774
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843424	+	2630	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843424	+	2686	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843424	+	2496	955	3	2495	830
ENST00000544305	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843424	+	2556	955	3	2486	827
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843424	+	2504	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843424	+	2560	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843424	+	2370	829	18	2369	783
ENST00000374630	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843424	+	2430	829	18	2360	780
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843424	+	2504	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843424	+	2560	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843424	+	2370	829	18	2369	783
ENST00000400191	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843424	+	2430	829	18	2360	780
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843424	+	2499	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843424	+	2555	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843424	+	2365	824	13	2364	784
ENST00000374632	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843424	+	2425	824	13	2355	780
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000392302	NTRK1	chr1	156843424	+	2492	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000368196	NTRK1	chr1	156843424	+	2548	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000524377	NTRK1	chr1	156843424	+	2358	817	24	2357	777
ENST00000374627	EPHB2	chr1	23111569	+	ENST00000358660	NTRK1	chr1	156843424	+	2418	817	24	2348	774
ENST00000544305	EPHB2	chr1	23111568	+	ENST00000392302	NTRK1	chr1	156843424	+	2630	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111568	+	ENST00000368196	NTRK1	chr1	156843424	+	2686	955	3	2477	824
ENST00000544305	EPHB2	chr1	23111568	+	ENST00000524377	NTRK1	chr1	156843424	+	2496	955	3	2495	830
ENST00000544305	EPHB2	chr1	23111568	+	ENST00000358660	NTRK1	chr1	156843424	+	2556	955	3	2486	827
ENST00000374630	EPHB2	chr1	23111568	+	ENST00000392302	NTRK1	chr1	156843424	+	2504	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111568	+	ENST00000368196	NTRK1	chr1	156843424	+	2560	829	18	2351	777
ENST00000374630	EPHB2	chr1	23111568	+	ENST00000524377	NTRK1	chr1	156843424	+	2370	829	18	2369	783
ENST00000374630	EPHB2	chr1	23111568	+	ENST00000358660	NTRK1	chr1	156843424	+	2430	829	18	2360	780
ENST00000400191	EPHB2	chr1	23111568	+	ENST00000392302	NTRK1	chr1	156843424	+	2504	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111568	+	ENST00000368196	NTRK1	chr1	156843424	+	2560	829	18	2351	777
ENST00000400191	EPHB2	chr1	23111568	+	ENST00000524377	NTRK1	chr1	156843424	+	2370	829	18	2369	783
ENST00000400191	EPHB2	chr1	23111568	+	ENST00000358660	NTRK1	chr1	156843424	+	2430	829	18	2360	780
ENST00000374632	EPHB2	chr1	23111568	+	ENST00000392302	NTRK1	chr1	156843424	+	2499	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111568	+	ENST00000368196	NTRK1	chr1	156843424	+	2555	824	13	2346	777
ENST00000374632	EPHB2	chr1	23111568	+	ENST00000524377	NTRK1	chr1	156843424	+	2365	824	13	2364	784
ENST00000374632	EPHB2	chr1	23111568	+	ENST00000358660	NTRK1	chr1	156843424	+	2425	824	13	2355	780
ENST00000374627	EPHB2	chr1	23111568	+	ENST00000392302	NTRK1	chr1	156843424	+	2492	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111568	+	ENST00000368196	NTRK1	chr1	156843424	+	2548	817	24	2339	771
ENST00000374627	EPHB2	chr1	23111568	+	ENST00000524377	NTRK1	chr1	156843424	+	2358	817	24	2357	777
ENST00000374627	EPHB2	chr1	23111568	+	ENST00000358660	NTRK1	chr1	156843424	+	2418	817	24	2348	774

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000544305	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.011121076	0.98887897
ENST00000544305	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.010294411	0.98970556
ENST00000544305	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.011264661	0.9887354
ENST00000544305	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.011288713	0.98871124
ENST00000374630	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.013038058	0.98696196
ENST00000374630	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.011991832	0.98800814
ENST00000374630	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.01317983	0.98682016
ENST00000374630	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.01329265	0.9867073
ENST00000400191	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.013038058	0.98696196
ENST00000400191	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.011991832	0.98800814
ENST00000400191	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.01317983	0.98682016
ENST00000400191	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.01329265	0.9867073
ENST00000374632	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.013153109	0.98684686
ENST00000374632	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.012064186	0.9879358
ENST00000374632	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.013275875	0.9867242
ENST00000374632	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.013410459	0.98658955
ENST00000374627	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.01047554	0.98952454
ENST00000374627	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.009655287	0.9903447
ENST00000374627	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.010354955	0.989645
ENST00000374627	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843425	+	0.010709321	0.98929065
ENST00000544305	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.011121076	0.98887897
ENST00000544305	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.010294411	0.98970556
ENST00000544305	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.011264661	0.9887354
ENST00000544305	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.011288713	0.98871124
ENST00000374630	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.013038058	0.98696196
ENST00000374630	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.011991832	0.98800814
ENST00000374630	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.01317983	0.98682016
ENST00000374630	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.01329265	0.9867073
ENST00000400191	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.013038058	0.98696196
ENST00000400191	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.011991832	0.98800814
ENST00000400191	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.01317983	0.98682016
ENST00000400191	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.01329265	0.9867073
ENST00000374632	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.013153109	0.98684686
ENST00000374632	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.012064186	0.9879358
ENST00000374632	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.013275875	0.9867242
ENST00000374632	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.013410459	0.98658955
ENST00000374627	ENST00000392302	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.01047554	0.98952454
ENST00000374627	ENST00000368196	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.009655287	0.9903447
ENST00000374627	ENST00000524377	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.010354955	0.989645
ENST00000374627	ENST00000358660	EPHB2	chr1	23111569	+	NTRK1	chr1	156843424	+	0.010709321	0.98929065
ENST00000544305	ENST00000392302	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.011121076	0.98887897
ENST00000544305	ENST00000368196	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.010294411	0.98970556
ENST00000544305	ENST00000524377	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.011264661	0.9887354
ENST00000544305	ENST00000358660	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.011288713	0.98871124
ENST00000374630	ENST00000392302	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.013038058	0.98696196
ENST00000374630	ENST00000368196	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.011991832	0.98800814
ENST00000374630	ENST00000524377	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.01317983	0.98682016
ENST00000374630	ENST00000358660	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.01329265	0.9867073
ENST00000400191	ENST00000392302	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.013038058	0.98696196
ENST00000400191	ENST00000368196	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.011991832	0.98800814
ENST00000400191	ENST00000524377	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.01317983	0.98682016
ENST00000400191	ENST00000358660	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.01329265	0.9867073
ENST00000374632	ENST00000392302	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.013153109	0.98684686
ENST00000374632	ENST00000368196	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.012064186	0.9879358
ENST00000374632	ENST00000524377	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.013275875	0.9867242
ENST00000374632	ENST00000358660	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.013410459	0.98658955
ENST00000374627	ENST00000392302	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.01047554	0.98952454
ENST00000374627	ENST00000368196	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.009655287	0.9903447
ENST00000374627	ENST00000524377	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.010354955	0.989645
ENST00000374627	ENST00000358660	EPHB2	chr1	23111568	+	NTRK1	chr1	156843424	+	0.010709321	0.98929065

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>26993_26993_1_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374627_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=774AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>26993_26993_2_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374627_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_3_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374627_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_4_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374627_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=777AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_5_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374630_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_6_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374630_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_7_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374630_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_8_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374630_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_9_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374632_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_10_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374632_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_11_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374632_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_12_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000374632_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=784AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_13_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000400191_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_14_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000400191_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_15_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000400191_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_16_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000400191_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_17_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000544305_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=827AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRD
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNR
FLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML
PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA

--------------------------------------------------------------

>26993_26993_18_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000544305_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_19_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000544305_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_20_EPHB2-NTRK1_EPHB2_chr1_23111568_ENST00000544305_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=830AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK
RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR
TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD

--------------------------------------------------------------

>26993_26993_21_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=774AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>26993_26993_22_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_23_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_24_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=777AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_25_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843425_ENST00000358660_length(amino acids)=774AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAE
LLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLA
TRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQ

--------------------------------------------------------------

>26993_26993_26_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843425_ENST00000368196_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_27_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843425_ENST00000392302_length(amino acids)=771AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSS
LSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLT
MLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRN
CLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRE

--------------------------------------------------------------

>26993_26993_28_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374627_NTRK1_chr1_156843425_ENST00000524377_length(amino acids)=777AA_BP=264
MWVPVLALPVCTYAETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRD
CSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMS
LIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQ
LHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFM
DNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_29_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_30_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_31_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_32_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_33_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843425_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_34_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843425_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_35_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843425_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_36_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374630_NTRK1_chr1_156843425_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_37_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_38_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_39_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_40_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=784AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_41_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843425_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_42_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843425_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_43_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843425_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_44_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000374632_NTRK1_chr1_156843425_ENST00000524377_length(amino acids)=784AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_45_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_46_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_47_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_48_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_49_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843425_ENST00000358660_length(amino acids)=780AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQD
FQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHF
VHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEA

--------------------------------------------------------------

>26993_26993_50_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843425_ENST00000368196_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_51_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843425_ENST00000392302_length(amino acids)=777AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFM
TLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQR
EAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHR
DLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDC

--------------------------------------------------------------

>26993_26993_52_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000400191_NTRK1_chr1_156843425_ENST00000524377_length(amino acids)=783AA_BP=270
MALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEM
KFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQD
YGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCR
VPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASAS
IMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLA
MSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA
RQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAG
LHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSN

--------------------------------------------------------------

>26993_26993_53_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843424_ENST00000358660_length(amino acids)=827AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRD
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNR
FLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML
PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA

--------------------------------------------------------------

>26993_26993_54_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843424_ENST00000368196_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_55_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843424_ENST00000392302_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_56_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843424_ENST00000524377_length(amino acids)=830AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK
RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR
TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD

--------------------------------------------------------------

>26993_26993_57_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843425_ENST00000358660_length(amino acids)=827AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDASPSGVHHIKRRD
IVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNR
FLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTML
PIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHA

--------------------------------------------------------------

>26993_26993_58_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843425_ENST00000368196_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_59_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843425_ENST00000392302_length(amino acids)=824AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPDTNSTSGDPVEKKDETPFGVSVAV
GLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVL
KWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLR
SHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR
WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQ

--------------------------------------------------------------

>26993_26993_60_EPHB2-NTRK1_EPHB2_chr1_23111569_ENST00000544305_NTRK1_chr1_156843425_ENST00000524377_length(amino acids)=830AA_BP=317
MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW
EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN
PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR
GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS
FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPF
GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK
RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD
LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR
TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD

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Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:23111569/chr1:156843425)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EPHB2 P29323	NTRK1 P04629
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874). {ECO:0000269\|PubMed:15300251, ECO:0000269\|PubMed:30213874}.	FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:22649032, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. {ECO:0000250\|UniProtKB:P35739, ECO:0000250\|UniProtKB:Q3UFB7, ECO:0000269\|PubMed:11244088, ECO:0000269\|PubMed:1281417, ECO:0000269\|PubMed:15488758, ECO:0000269\|PubMed:17196528, ECO:0000269\|PubMed:1849459, ECO:0000269\|PubMed:1850821, ECO:0000269\|PubMed:22649032, ECO:0000269\|PubMed:27445338, ECO:0000269\|PubMed:27676246, ECO:0000269\|PubMed:8155326, ECO:0000269\|PubMed:8325889}.; FUNCTION: [Isoform TrkA-III]: Resistant to NGF, it constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed. {ECO:0000269\|PubMed:15488758}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

20_202

270.3333333333333

987.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

20_202

270.3333333333333

988.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

20_202

270.3333333333333

1056.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

20_202

270.3333333333333

987.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

20_202

270.3333333333333

988.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

20_202

270.3333333333333

1056.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

20_202

270.3333333333333

987.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

20_202

270.3333333333333

988.0

Domain

Eph LBD

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

20_202

270.3333333333333

1056.0

Domain

Eph LBD

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

299_365

283.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

510_781

283.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

299_365

253.33333333333334

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

510_781

253.33333333333334

761.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

299_365

283.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

510_781

283.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

299_365

283.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

510_781

283.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

299_365

253.33333333333334

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

510_781

253.33333333333334

761.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

299_365

283.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

510_781

283.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

299_365

283.3333333333333

791.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

510_781

283.3333333333333

791.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

299_365

253.33333333333334

761.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

510_781

253.33333333333334

761.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

299_365

283.3333333333333

797.0

Domain

Ig-like C2-type 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

510_781

283.3333333333333

797.0

Domain

Protein kinase

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

537_541

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

607_611

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

537_541

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

607_611

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

537_541

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

607_611

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

537_541

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

607_611

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

537_541

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

607_611

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

537_541

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

607_611

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

537_541

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

607_611

283.3333333333333

791.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

537_541

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

607_611

253.33333333333334

761.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

537_541

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

607_611

283.3333333333333

797.0

Motif

DXXLL

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

516_524

283.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

516_524

253.33333333333334

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

516_524

283.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

516_524

283.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

516_524

253.33333333333334

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

516_524

283.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

516_524

283.3333333333333

791.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

516_524

253.33333333333334

761.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

516_524

283.3333333333333

797.0

Nucleotide binding

ATP

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

440_796

283.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

440_796

253.33333333333334

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

440_796

283.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

440_796

283.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

440_796

253.33333333333334

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

440_796

283.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

440_796

283.3333333333333

791.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

440_796

253.33333333333334

761.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

440_796

283.3333333333333

797.0

Topological domain

Cytoplasmic

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

424_439

283.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

424_439

253.33333333333334

761.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

424_439

283.3333333333333

797.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

424_439

283.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

424_439

253.33333333333334

761.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

424_439

283.3333333333333

797.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

424_439

283.3333333333333

791.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

424_439

253.33333333333334

761.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

424_439

283.3333333333333

797.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

184_324

270.3333333333333

987.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

184_324

270.3333333333333

988.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

184_324

270.3333333333333

1056.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

184_324

270.3333333333333

987.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

184_324

270.3333333333333

988.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

184_324

270.3333333333333

1056.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

184_324

270.3333333333333

987.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

184_324

270.3333333333333

988.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

184_324

270.3333333333333

1056.0

Compositional bias

Note=Cys-rich

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

324_434

270.3333333333333

987.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

435_530

270.3333333333333

987.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

621_884

270.3333333333333

987.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

913_977

270.3333333333333

987.0

Domain

SAM

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

324_434

270.3333333333333

988.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

435_530

270.3333333333333

988.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

621_884

270.3333333333333

988.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

913_977

270.3333333333333

988.0

Domain

SAM

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

324_434

270.3333333333333

1056.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

435_530

270.3333333333333

1056.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

621_884

270.3333333333333

1056.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

913_977

270.3333333333333

1056.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

324_434

270.3333333333333

987.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

435_530

270.3333333333333

987.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

621_884

270.3333333333333

987.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

913_977

270.3333333333333

987.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

324_434

270.3333333333333

988.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

435_530

270.3333333333333

988.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

621_884

270.3333333333333

988.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

913_977

270.3333333333333

988.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

324_434

270.3333333333333

1056.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

435_530

270.3333333333333

1056.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

621_884

270.3333333333333

1056.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

913_977

270.3333333333333

1056.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

324_434

270.3333333333333

987.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

435_530

270.3333333333333

987.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

621_884

270.3333333333333

987.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

913_977

270.3333333333333

987.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

324_434

270.3333333333333

988.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

435_530

270.3333333333333

988.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

621_884

270.3333333333333

988.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

913_977

270.3333333333333

988.0

Domain

SAM

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

324_434

270.3333333333333

1056.0

Domain

Fibronectin type-III 1

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

435_530

270.3333333333333

1056.0

Domain

Fibronectin type-III 2

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

621_884

270.3333333333333

1056.0

Domain

Protein kinase

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

913_977

270.3333333333333

1056.0

Domain

SAM

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

984_986

270.3333333333333

987.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

984_986

270.3333333333333

988.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

984_986

270.3333333333333

1056.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

984_986

270.3333333333333

987.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

984_986

270.3333333333333

988.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

984_986

270.3333333333333

1056.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

984_986

270.3333333333333

987.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

984_986

270.3333333333333

988.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

984_986

270.3333333333333

1056.0

Motif

PDZ-binding (in isoform 2)

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

627_635

270.3333333333333

987.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

627_635

270.3333333333333

988.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

627_635

270.3333333333333

1056.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

627_635

270.3333333333333

987.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

627_635

270.3333333333333

988.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

627_635

270.3333333333333

1056.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

627_635

270.3333333333333

987.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

627_635

270.3333333333333

988.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

627_635

270.3333333333333

1056.0

Nucleotide binding

ATP

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

19_543

270.3333333333333

987.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

565_1055

270.3333333333333

987.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

19_543

270.3333333333333

988.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

565_1055

270.3333333333333

988.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

19_543

270.3333333333333

1056.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

565_1055

270.3333333333333

1056.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

19_543

270.3333333333333

987.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

565_1055

270.3333333333333

987.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

19_543

270.3333333333333

988.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

565_1055

270.3333333333333

988.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

19_543

270.3333333333333

1056.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

565_1055

270.3333333333333

1056.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

19_543

270.3333333333333

987.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

565_1055

270.3333333333333

987.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

19_543

270.3333333333333

988.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

565_1055

270.3333333333333

988.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

19_543

270.3333333333333

1056.0

Topological domain

Extracellular

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

565_1055

270.3333333333333

1056.0

Topological domain

Cytoplasmic

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374630

544_564

270.3333333333333

987.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000374632

544_564

270.3333333333333

988.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111568

chr1:156843424

ENST00000400191

544_564

270.3333333333333

1056.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374630

544_564

270.3333333333333

987.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000374632

544_564

270.3333333333333

988.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843424

ENST00000400191

544_564

270.3333333333333

1056.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374630

544_564

270.3333333333333

987.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000374632

544_564

270.3333333333333

988.0

Transmembrane

Helical

Hgene

EPHB2

chr1:23111569

chr1:156843425

ENST00000400191

544_564

270.3333333333333

1056.0

Transmembrane

Helical

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

148_193

283.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

194_283

283.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

148_193

253.33333333333334

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

194_283

253.33333333333334

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

148_193

283.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

194_283

283.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

148_193

283.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

194_283

283.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

148_193

253.33333333333334

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

194_283

253.33333333333334

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

148_193

283.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

194_283

283.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

148_193

283.3333333333333

791.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

194_283

283.3333333333333

791.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

148_193

253.33333333333334

761.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

194_283

253.33333333333334

761.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

148_193

283.3333333333333

797.0

Domain

Note=LRRCT

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

194_283

283.3333333333333

797.0

Domain

Ig-like C2-type 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

116_137

283.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

90_113

283.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

116_137

253.33333333333334

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

90_113

253.33333333333334

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

116_137

283.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

90_113

283.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

116_137

283.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

90_113

283.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

116_137

253.33333333333334

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

90_113

253.33333333333334

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

116_137

283.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

90_113

283.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

116_137

283.3333333333333

791.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

90_113

283.3333333333333

791.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

116_137

253.33333333333334

761.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

90_113

253.33333333333334

761.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

116_137

283.3333333333333

797.0

Repeat

Note=LRR 2

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

90_113

283.3333333333333

797.0

Repeat

Note=LRR 1

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000368196

33_423

283.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000392302

33_423

253.33333333333334

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111568

chr1:156843424

ENST00000524377

33_423

283.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000368196

33_423

283.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000392302

33_423

253.33333333333334

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843424

ENST00000524377

33_423

283.3333333333333

797.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000368196

33_423

283.3333333333333

791.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000392302

33_423

253.33333333333334

761.0

Topological domain

Extracellular

Tgene

NTRK1

chr1:23111569

chr1:156843425

ENST00000524377

33_423

283.3333333333333

797.0

Topological domain

Extracellular

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1616_EPHB2_23111569_NTRK1_156843425_ranked_0.pdb	EPHB2	23111568	23111569	ENST00000358660	NTRK1	chr1	156843425	+	MLAARWRRLCVRRALPPPLAPRARGARSRPGRPGPAAPRPEAPGSAAMALRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGW EEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDSATKTFPNWMEN PWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRSGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAAR GSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRVPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETS FIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPF GVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIK RRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGD LNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGR TMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKD	830

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EPHB2_pLDDT.png

NTRK1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

NTRK1

ABL1, NGF, MATK, PLCG1, GRB2, CAV1, NTF3, SQSTM1, SH2B1, SHC1, SH2B2, ARHGAP32, FRS2, NTRK1, RAP1A, SHC3, GIPC1, RGS19, PTPN1, TRAF6, NEDD4, CBL, HSP90AA1, HSPA4, CDC37, NEDD4L, MYC, SGSM3, SORBS1, TNK2, SNX17, SNX27, GAREML, SOS2, PIK3CA, GAREM, PIK3C2B, ARHGEF40, PIK3R1, PIK3R2, SOS1, PIK3CB, PML, UBC, AMFR, CBLB, GAB1, EPN1, PIK3C2A, ANKRD13A, DOCK4, TRIO, LGR5, WRNIP1, RABEP1, PDGFRA, KANK2, RABGEF1, VAV2, TBC1D15, PTPN11, GAK, IRS2, PCDHGC3, EPS15, LRRN3, HUWE1, ACVR1B, MIB1, OFD1, PIBF1, ZNF497, TXN, CAT, FABP3, JUP, DSG1, TGM1, CFL1, LCN1, HIST2H4A, DSP, PFN1, LGALS3BP, HIST1H2BL, LTF, S100A9, IGLL5, TGM3, DSC1, LYZ, DCD, LEKR1, ENO2, PPIA, BTN1A1, XRCC5, XRCC6, HLA-A, GSTP1, ABCB7, PA2G4, PRDX1, HDGF, HSPA4L, TBC1D10B, HP1BP3, KIF26B, SYT4, RHOBTB3, NOTCH3, GAB2, ATAD3A, RBM15B, KCNH2, USP15, PDCD11, RBFOX2, RBM14, RNF31, ADNP, ZC3HAV1, MAP7D1, USP4, JAK1, PTPRS, PDGFRB, HIST1H1C, USP11, PPFIBP1, INTS6, VGF, ARHGEF11, SMPD4, SYNPO2, HNRNPM, SLC27A4, DDX41, EGFR, H1FX, ASAP1, HIST1H1B, RRBP1, EPHA2, KIDINS220, CPT1A, UNC5B, IGF1R, DDR2, AUP1, XPR1, RP9, MARK2, REPS1, EMD, SMARCA4, DDX21, DAB2IP, C7, MSTO1, CDC27, ZNF629, ASAP2, NCAPH2, SRBD1, ATAD3B, TCF12, PLEKHA6, INPPL1, PRPF4B, DPM1, SMARCA1, FIP1L1, DLGAP5, PLEKHH3, TRA2A, ACIN1, DDX10, TAX1BP1, SMARCA5, RABEP2, DDX5, MYO1C, SRSF10, DNAJA2, RET, TRA2B, MYEF2, PNPLA6, SLC12A2, TAF6L, RSL1D1, ARAP3, DDX18, ABL2, KHDRBS1, CERK, SRSF7, SPTLC2, PBXIP1, DNAJA1, IQGAP3, DDX31, ZC3H11A, PLRG1, CNP, FMR1, HIP1R, KIAA1429, CDC5L, ARAP1, ZNF316, SMARCC2, EML5, VANGL2, SLC25A1, UNC5C, SLC16A1, RFC1, ZKSCAN1, CHD1, PTK7, SMARCD2, AP3B1, YTHDC2, AKAP8L, RPL15, CTNND1, PHLDB1, ZNF574, DDX27, TOM1, RASA1, MORC2, MTCH2, IMMT, SMARCC1, ROR2, CAPN2, DNAJC11, SYT11, AP2A1, LBR, MEPCE, NCAPD3, CEP97, QKI, LRRC41, LPCAT2, EPS15L1, LAS1L, TMEM131, CWF19L2, NCAPG2, MAP4K5, CCP110, ARHGEF2, ITGAV, ZC3H18, CWC22, VIM, FAM171A1, TMEM132A, SRSF9, SOGA1, NKRF, RBL1, FMNL3, TOP1, PIGT, RBM15, GBAS, EDC3, WDR5, NOP2, GNL2, SLC25A11, RRP1B, FAM115A, INTS5, SLC25A5, AAK1, HERC5, CCNT1, FERMT2, CDC42BPA, MRPL28, UBAP2, WWP2, SEC24B, HNRNPU, GPD2, FXR2, DHX15, SLC25A22, SSR1, PLXNB2, PROX1, TEX10, USP19, FTSJ3, TMEM59, GTF3C2, PGAM5, CPSF1, KLHL22, TMX3, SIN3A, NOP58, PTCD3, RPRD2, DHX9, PICALM, FARP1, SLC25A6, ERLIN2, SMARCD1, RHOT1, ALDH1B1, SGPL1, USP9X, HNRNPF, KIAA1211, MAPK7, DDX17, GSE1, DVL3, MRPL44, DNAJB6, GTPBP4, HNRNPA0, PLXNA4, SFXN3, NAT10, DDX28, SNW1, MYO6, MRPL24, PRRT4, FAM98A, PURA, DHX29, C1QBP, TRIP4, TBK1, RBM28, ZNF609, POLRMT, PCDHB3, XRN1, HSD17B11, DKC1, DHX30, CDK13, SENP3, LPHN2, GPATCH4, NDUFA9, RASA4, MCCC1, DDX24, RPL14, RPS8, ATG2B, MYO1B, PTPN12, CEBPZ, ILVBL, RALY, KIF14, ZC3H7A, MOV10, MAP4K4, DHX57, RBMX, FXR1, MRPS35, SART1, MARK3, DECR1, CCDC88A, ANKLE2, PRPF31, LARP7, RPL10, PACS1, RPL13, FAM120A, SLC25A13, ADAR, CDK1, HNRNPR, CSNK1E, DLG1, LEMD3, NOL9, IFT122, NCLN, STK11IP, GATAD2B, CHERP, LARP4, MAP3K1, HNRNPUL2, PPIL2, ESYT2, MYH10, RPL8, UQCRC2, NDUFA10, HAX1, HELLS, MED14, RBM42, CHCHD3, RPL7, ABCD3, TUBGCP6, MRPS9, SNRNP200, IGF2BP3, LRCH3, MRPL3, RSBN1L, SAFB, TUBG1, ALDH16A1, ARHGEF12, EPB41L5, AP2A2, SRSF6, HLTF, PTPLAD1, TMPO, AGO2, POP1, RPS9, HDAC6, ILF3, VWA8, ABCB1, SCRIB, GTF3C5, YBX1, RBM4, PTPN9, PRPF8, BRD3, TRIM24, CLASP2, MADD, TCF4, MAP4K3, TSC2, DDX23, RPL7A, RRP12, PRKD2, TRMT1L, EDC4, CSTF3, RPS2, NDUFS2, RPL13A, PTPRR, ATP7A, EXD2, IK, HIP1, MATR3, IGSF3, PTPRF, SPATA5L1, EFTUD2, RPS3A, TUBGCP5, TTN, GIT1, PATL1, NUP160, PDE4B, SUN2, PTPN23, RPS6, DCP1A, CDC73, MEX3A, EIF2AK2, RPL3, PPP1R10, SRP72, ELAVL3, NOM1, RPL18, CEP170, THRAP3, MED17, MRPS7, DDX20, PDPR, SH3PXD2A, DBN1, DAP3, OAS3, STT3B, COPE, MED12, AP3D1, CAPRIN1, PHB2, U2SURP, BSG, TECR, FARSA, HSD17B12, RPL4, HNRNPUL1, PPFIA1, MRPS22, TBL3, GNL3, MTA2, CPSF2, ATP2B1, AP3B2, PPIP5K2, DDX56, ASCC3, FMNL2, SMCHD1, MYBBP1A, SRPK2, RHOT2, SRP68, PUM1, SLC25A3, SRPK1, RPL19, BEND3, SEC61A1, LSG1, NOC3L, TNKS1BP1, GTF3C3, TUBGCP3, PRPF40A, TRMT10C, URGCP, XRN2, MSH3, XRCC1, GEMIN4, DIS3L2, BCLAF1, SBF2, DHTKD1, ATXN2, ARID4B, TOR1AIP1, RPL29, NAA16, PRPF6, KIFAP3, TMEM33, WASF2, NACAD, LIG3, POLE, CKAP4, TCEB3, MTA1, GNA13, DHX38, PHF6, ELAVL4, DDX3X, CTR9, PRPF19, CAMSAP2, PRMT3, SH3PXD2B, SCAF8, MAGED1, ILF2, TONSL, PPP1R12A, SRSF5, KIAA0020, PTBP1, CAD, ACSL3, CHD1L, STAU1, MRPL38, DVL2, GNAI3, RPL10A, RPL6, MRPS5, CDK11B, MRPS34, PES1, ATP5C1, STXBP3, HNRNPLL, CHTF18, VPS39, SART3, COPA, PRPF3, UBE2O, ABCF2, HNRNPH3, EARS2, DHX40, ARHGEF7, EMC1, CASK, PTK2, SORT1, OGT, ATP12A, LMNB1, SLC4A7, PFKP, VDAC2, RBM25, ATL3, DHX36, TFIP11, EXOSC10, GTF3C1, SRSF1, PPP6C, TRAPPC9, RAD21, DNAJC13, ACOT1, ZC3H4, SRRM1, NDUFS3, DYRK1A, INTS1, SF3B2, EHHADH, MYO9B, ASCC2, WDR11, RPN1, EHD4, WDR91, SMARCAL1, NBAS, PI4KA, PAF1, EIF2B4, NUP107, EMC2, SYNE1, KLHL13, TBL1XR1, DNAJC10, SEC16A, METTL13, C7orf50, CDC42BPB, CLCN5, PGM3, DOCK7, ALYREF, POLR3A, TOP3A, WDR48, WDR81, DOCK1, CSNK2A2, CYC1, TLE3, THOC2, EIF2S3, MYO5A, SNX9, TARDBP, NAP1L4, CRKL, YTHDF2, PYGB, PABPC1, LTV1, PSMD4, KTN1, UBTF, WDR6, FUBP3, UBXN7, PHB, PDXP, CNOT3, TBL2, LLGL1, PLOD1, AHSA1, AAAS, ERGIC1, LARP4B, CYFIP1, DNM1, TARS2, ACSL1, ATXN1L, WDR59, SUCLA2, MLH1, CSNK2B, SYNCRIP, WDR36, FAM91A1, MTDH, UBE3C, CAPN1, BRIX1, DNAJB11, EDEM3, PLOD3, CLASP1, DPYSL3, MED16, NONO, EPM2AIP1, NT5DC2, ADRBK2, RPTOR, TELO2, MRPL37, PRKACB, ELMO1, TRAPPC8, ANAPC1, NIPSNAP1, EWSR1, PIK3R4, POLD1, IQGAP1, PRRC2A, COG1, ANKRD44, TFRC, DIEXF, FHOD1, SERPINH1, SPATA5, MED1, ABCF3, ZSWIM8, LMNA, HAT1, PABPC4, SMC4, HADH, RNGTT, TUBGCP2, ZNF598, SKIV2L2, GNB2L1, LARP1, DIP2B, BCR, IDH3B, LSM14A, FBL, NDUFS1, APPL2, USP39, SMC2, HCFC1, LANCL1, POLR2B, UPF2, CCBL2, MRPL15, MAGED2, AGK, GNPAT, AIMP1, GTF3C4, KDM1A, SCAMP3, RDH11, SRGAP2, CRNKL1, RFC5, PFKL, SPTBN1, PHOX2A, VDAC3, HNRNPA1, WDR26, DNM2, HAUS5, LCMT2, MCM7, CLINT1, UGDH, ACO1, TRIM46, PHKB, USP10, PCF11, YTHDF3, AARS2, FIGNL1, SFPQ, ATP5A1, NUP133, CPSF3, ANKRD28, PNN, C9orf64, ABCF1, ATL1, NAP1L1, HSPA9, MCCC2, FKBP5, CNOT1, TAF6, NEMF, UHRF1, SDHA, PELP1, HADHB, OAT, NEK9, AP3M1, PRKCA, LPCAT1, MRPL39, AFG3L2, WASF1, HNRNPL, RALGAPB, HK1, GBA, PLD3, CPSF7, HADHA, PDE12, DCX, LIMA1, HNRNPA2B1, POLR2A, MYH9, ZNF207, DDX55, ELP3, EIF2B5, MICAL1, TTI1, NES, HSDL1, GPSM1, PPM1F, C4orf27, SRRM2, OSBPL9, STAT3, IRF2BPL, KLC2, P3H1, STAT5B, UQCRC1, PCK2, CCAR2, TBC1D5, SACM1L, QARS, XPO4, CHD4, KIF2A, TACC3, NCL, BTAF1, RARS2, NCKAP1, EIF3D, RPS3, YME1L1, EIF4A3, HAUS6, HNRNPDL, MON2, G3BP2, WDHD1, CSNK1A1, SDAD1, RPS25, LSM14B, AP1M1, CCDC47, HNRNPK, DNMT1, NUP85, CUL5, TANC1, STAT1, COG5, STOML2, CDC45, OSBPL11, CIC, ABCD2, ARFGEF1, TROVE2, GBF1, SRPRB, UBE3A, GTPBP1, SCCPDH, RPS4X, PRPF4, ACTL6A, CCAR1, KIAA1033, TRAPPC12, HNRNPA3, FASTKD5, LYN, VPS18, PGRMC2, NUP214, AIFM1, TSG101, PPP6R3, OCRL, GANAB, IARS, SARS2, ATP2A2, EXOC1, NCAPH, TTC27, GNE, SRC, MIOS, ZCCHC8, GOLGA2, CARM1, ABCC1, PRMT5, LEO1, LMNB2, USP8, DARS, GYS1, APEH, ZYG11B, AKAP1, ELAVL1, MCM5, LRWD1, PSMC1, MOGS, TRIM28, EXOC6, LUC7L3, ANKFY1, NSUN2, HDAC2, G3BP1, QRICH1, INTS3, UBR1, XAB2, DYNC1LI1, TUFM, GAA, EXOC8, DHX8, LIMCH1, CLTC, SRPR, RNH1, ABI2, AQR, PREP, PPM1E, COG2, SEPT9, IDH2, MFN2, EXOC4, VPS33B, INTS4, GNB1, MSH6, HNRNPC, ERLIN1, EPRS, LRRC49, RPAP1, MCM3, PSMC4, PSMD3, GNL1, TRIP13, CUX1, PFAS, MAP1S, LRCH1, MRPL19, ABCD1, EIF3F, PDS5B, SMC3, KIF4A, FANCD2, IRF2BP1, SMC1A, RNF20, CLPX, NOC2L, DLAT, CTBP1, APPL1, NAA35, VPS45, PUM2, RELA, NUP210, RANBP9, DNAJC9, WRN, PRKAA1, AIMP2, VPS8, MAD1L1, MRE11A, ATP13A1, ATG7, CEP131, TRIM33, SLC25A10, HERC4, LRRFIP1, POLR1C, IPO9, GEMIN5, METAP2, SMG8, WASL, PPP1CB, SCFD1, RANBP3, RB1, CLTA, RNF40, SNRNP70, NCSTN, MGEA5, NARS, EIF4E, INPP4A, TFB2M, SEL1L, ARGLU1, PPP4R1, ANKRD17, TTK, RAD50, KIF2C, GOLGA3, TRAPPC11, GIGYF2, MSI2, CYFIP2, CDK5, HBS1L, IFT81, UFL1, PFKM, SMARCAD1, WDR35, PRIM2, NAMPT, PSMD2, MSH2, SOGA3, HEATR6, SFXN1, ARCN1, OGDH, FDPS, PSMC5, INSR, IRF2BP2, DDOST, ATXN2L, CSNK2A1, EIF2S2, MAP4, LTN1, COPB1, BRAT1, SMC6, SNRPN, RIC8A, SKIV2L, EIF4A1, KIF15, CLPTM1L, KPNA1, VPS16, VPS26B, RNPEP, RBM39, PMS1, FAM129B, RFC3, NUP155, RBM26, KIF21A, GAPVD1, C2CD5, WAPAL, RPS13, ARHGEF1, ACTR1A, KLC4, ISLR2, DCK, LRRC8A, STT3A, BOP1, RPN2, AFTPH, ORC3, FOXK1, CD2BP2, PDHA1, PPP6R1, PANK4, KIAA0196, WDR77, CHUK, DDX1, COLGALT1, VAPA, PPME1, CAMSAP1, RABL6, RTCB, SRRT, PIK3C3, NUMA1, STXBP1, OTUB1, UBAP2L, EXOC5, LRRC59, EXOC3, RQCD1, FLII, COPG2, USP5, XPOT, TIMM44, ATP1A1, SBF1, ARPC1B, PLK1, OSBPL8, BAG6, PPP6R2, FAM98B, VPS52, FADS2, EIF4G2, EIF4G3, HSPA8, POLR1B, PSMC6, SFSWAP, VPS33A, MCM10, AVL9, RINT1, PPIB, FBXL18, MFAP1, KIF13B, ATP2C1, ERCC2, CTTNBP2NL, WDR82, VARS, KPNA6, MIA3, HEATR1, SEC23B, AASDHPPT, POLR3B, ALDH18A1, PIKFYVE, MPP6, MRI1, CAPN7, RAB3GAP2, NCAPD2, UGGT1, IKBKAP, KDM3B, CLNS1A, FEN1, ECH1, AP2B1, HNRNPH1, RARS, AGPS, FANCI, PYCR2, EHD1, BUB3, KIF5B, SYMPK, PC, ACAA2, NDC80, PRRC2C, MTHFD1L, FASN, RANBP6, VPS11, NUP93, STRN, SCYL1, DDX19A, GTF2I, SEC23A, CTNNB1, STAM, VPRBP, VCL, PDHB, SEC24D, ERCC4, GRN, ACADM, HSPA6, ERCC6L, RPL5, ARHGAP17, DDX6, MAPK8IP3, TJP1, RIOK1, ERP29, PARG, NUP205, PALLD, COG4, TPP2, EPB41, VAC14, FUS, ZW10, KIF11, GET4, MCM6, EIF2S1, CSDE1, DHX16, GFM1, RABGAP1, TTC28, XPO1, EXOC2, DCTN1, ACBD3, RFC4, PARP1, COPG1, GPRIN1, EIF3C, CUL1, C14orf166, RTL1, STRIP1, MRPS2, PPP2R5D, EIF4G1, EXOSC4, MCM4, SEC63, WDR1, CUL4B, CRMP1, NSF, RNMT, BLVRA, UBE4A, PCBP1, MLLT4, RNF214, ARVCF, CKAP5, NUP188, SMCR8, CTNNA1, SYT1, PCM1, KNTC1, GFPT1, THYN1, SARM1, LPIN1, TIA1, NUP54, PKN1, SUMO4, DICER1, KIF3A, IPO8, CLIC4, PSMD14, GLG1, ABCE1, SMEK1, NCAPG, PPP5C, RTF1, IARS2, PDS5A, PHGDH, RPS6KA3, LONP1, ROCK1, CDK6, LARS, KPNA3, HNRNPAB, MCM2, PPP2R2A, HSP90AB2P, VCPIP1, PCBP2, RPA1, SEC24A, HECTD3, RCC2, DIS3, SMS, KHSRP, CLGN, GNAS, FOCAD, SEC23IP, ACOT7, HK2, CCDC6, MFN1, WDR7, CNN3, KIAA1524, RAB3GAP1, OXCT1, SBNO1, PRPSAP2, ACTR3, CTPS2, TMEM43, FAM21A, LRRC47, VAPB, SCYL2, STRN4, NAE1, SREK1, TFG, SF3A1, CDK2, GPKOW, GPHN, PDCD4, U2AF2, UNC45A, VPS35, NAA15, ASNS, TOP2B, ACO2, AGAP3, ROCK2, NUDT21, NPEPPS, ADD1, AP1G1, CPSF6, DNAJC2, RPS5, CTPS1, IDH1, SEC24C, KIF3B, ACTR2, CPD, EEF1D, SAMHD1, ETFB, DNM1L, LRPPRC, MCMBP, RBM12, OPA1, FARSB, UPF1, PCMT1, USO1, COG3, CLPTM1, TLK2, PRUNE, ASPSCR1, MARS, PYCR1, TCERG1, MED23, PITPNB, ARPC2, UBE4B, DBR1, ETFA, BICD1, KLC1, WDR70, PXDN, DPYSL4, USP7, CLUH, TBRG4, OGFR, SV2A, PDCD6IP, PDLIM5, PSMC2, TRAP1, DRG1, SMEK2, TCP1, TNPO2, CALD1, ARIH2, POR, FKBP3, DCTN2, NPM1, USP48, IPO13, NUP88, NNT, TAOK1, PPWD1, PSPC1, PABPN1, POLA1, MTR, BCCIP, RUVBL2, C16orf62, SORD, PPP2CA, STRN3, RUVBL1, PPP1CA, CACTIN, RPAP3, VPS51, TUBB3, PRKDC, HSPA5, CCDC132, MRPS27, RBBP4, CAPZA1, SLC4A1AP, THUMPD3, FAF1, CDK4, GSTO1, NCBP1, CAPZB, SNRPA, TXLNG, NELFE, MUT, DYNC1LI2, CTTN, DYNC1I2, TIMELESS, CBS, TTLL12, ESYT1, LAMB1, KARS, PPIL4, LRRC40, TXLNA, RAD23B, TBCE, ACAD9, THADA, GCN1L1, SLK, PNKP, ACLY, ATP6V0A1, VTA1, TXNDC5, OXSR1, ACACA, TNPO3, CCDC93, TIPRL, RAN, HOOK3, PSME4, YWHAQ, PPM1G, PSMC3, SCARB2, EXOC7, DFNA5, TRMT6, CPNE3, SLC3A2, G6PD, EIF2B1, SF3B1, EXOC6B, HGS, DYNC1H1, DNAJC7, CANX, TSR1, TTC37, DARS2, ZPR1, SERBP1, HSP90AB1, TBCB, UCHL5, IMPDH2, PUF60, RANGAP1, PDXDC1, YWHAH, LARS2, ZC3H15, GMPS, YWHAG, SUPV3L1, SPAG9, IMPDH1, HSD17B10, GTF2F1, EXOSC9, CUL3, ARHGAP35, TUBB4B, EIF5B, KIF5C, PDIA6, LDHA, ATL2, SNX1, SF3B3, SRM, MAP2, DIAPH1, DBH, NHLRC2, ELP2, GRPEL1, TWF1, WBP11, ERP44, SERPINB6, VCP, HSPH1, CMTR1, KIF1A, USP47, EML4, PRMT1, ATP6V1B2, GPS1, CAND1, CLPB, PCNA, RPLP0, CORO7, TUBB, ANXA2, API5, SUPT16H, RUFY1, KIAA1279, PDIA3, ACTA1, SF3A3, DCTN4, CUL2, WARS, PGM2, NELFB, XPO5, UGP2, HSP90B1, GSR, SHMT2, IPO11, EIF3E, RDX, DNAJB1, KIAA1598, AARS, EFTUD1, HEATR5B, ENAH, TNPO1, LIG1, NRD1, DLD, STRA6, PAFAH1B1, NT5C2, SSRP1, NTRK3, HDGFRP2, EIF3G, CSE1L, ACAT1, TBCD, NAA10, MTHFD1, RALA, EIF3A, PRPS1, ISOC1, IPO7, HNRNPD, GAPDH, U2AF1, SUPT5H, PSMD8, RPS6KA1, NUF2, GDAP1, VPS26A, TUBB2B, CDH2, TMOD1, CBR1, HDLBP, CS, HSPD1, LMAN1, EIF3B, DDB1, PSMD1, DPYSL2, STRAP, RTN4, FLNA, AHCY, HSD17B4, GOLIM4, SPTAN1, IPO4, PKM, EIF3I, SF1, BZW2, XPO7, ACADVL, STAG2, DPP9, RECQL, GDI1, GARS, MMS19, EIF2A, IPO5, TCOF1, RAB5C, SAP30BP, VDAC1, TUBA1A, SEPT2, DBNL, PLAA, TOMM70A, NOMO1, ISYNA1, CTNNA2, EEF1B2, PAK4, NELFCD, GSPT1, KPNB1, MAP1A, COPS4, YWHAZ, KPNA2, EIF4B, PLS3, COPS3, HSPBP1, AP1B1, NASP, DDX39A, LUC7L2, APMAP, SEC31A, SRSF2, TXNRD1, ATP1A3, RRM2, COG7, FSD1, PRDX4, DCPS, NCAM1, NUDCD1, NAA25, RPL9, NPLOC4, YWHAB, ATP1B1, LSS, DNAAF5, METTL16, COPS6, XPNPEP1, ELAC2, PUS7, CCT3, SFN, AGL, PAPOLA, SRSF11, ALDH2, PSME2, CKMT1B, LDHB, PSMA7, RAB11A, PPP2R1A, GNAO1, LUC7L, COPS5, IMPA1, RRM1, PPID, DPP3, KIAA0368, SLC1A5, YARS, NUP50, TPM4, ITGB1, SARS, SEZ6L2, GTF2F2, GART, ALDOC, PSMD11, EIF6, DFFA, RAP1GDS1, NELFA, CARS, CCT4, P4HB, FSCN1, PSMD13, PSMA5, CCT5, PAPSS1, OSBP, SAE1, ATP6V1A, LMAN2, YWHAE, SRP54, IDE, SNX2, RPSA, BZW1, SND1, UBQLN1, MAPK1, CALR, MARCKSL1, SUGT1, TBC1D4, GLRX3, LETM1, HMGB1, EIF3H, SLC9A3R1, DDX42, LAP3, PRKCSH, EEF2, PSMD6, BCAP31, ANXA11, ACTN1, CCT6A, PSMA4, ANXA5, CCT7, EIF3L, FUBP1, SSB, PGM1, MAPRE1, UBA2, AMPD2, PPAT, CLIC1, CCT2, ECHS1, LTA4H, USP14, CCT8, ANK2, PDIA4, TPR, NRCAM, MAT2A, HTATSF1, THOP1, RANBP1, RSRC2, NMT1, AK2, EEF1G, TPM3, PSMA3, EIF4H, GLUD1, CAP1, TKT, ATP5B, TXNL1, STIP1, HMGB2, GGH, HSPB1, CALU, RPL17, PSMA1, RSRC1, ST13, PRDX6, EIF3J, PNPT1, APEX1, TARS, MARCKS, PSMA6, EEF1A1, COPB2, NUDT5, HSPA1A, ERO1L, ME2, RPH3A, ESD, EIF5, ADSL, RUFY3, DPYSL5, ANXA6, NUDC, NANS, GOT2, GLDC, PSAT1, SET, PAK2, UBA6, UCHL1, L1CAM, PGLS, MAP1B, CCDC124, EIF3M, VAT1, PAFAH1B3, ALDOA, IRGQ, UBQLN2, NACA, OLA1, ACTN4, ARHGDIA, PSMD7, CACYBP, PSMA2, CPNE1, MDH2, PGAM1, DDX46, ACAT2, ALCAM, HARS, CKB, FKBP4, ASNA1, GPI, INA, HYOU1, CHGA, MDH1, EZR, ANP32A, UBA1, ARG1, ANP32B, PAICS, ATIC, TPI1, PPA1, TALDO1, PGK1, DDX39B, TLN1, AKR1B1, ENO1, NGFR, TPTE, GGA1, GGA2, GGA3, USP36, NDFIP1, SOCS2, CDK12, EPHB4, NDUFA4L2, AKT1, SLC5A5, DOT1L, AKT2, SHC4, TRAF4, PTPN6, ERBB2, EGR1, HIPK2, POU4F2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EPHB2
NTRK1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to EPHB2-NTRK1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to EPHB2-NTRK1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	NTRK1	C0020074	HSAN Type IV	17	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	NTRK1	C0238463	Papillary thyroid carcinoma	3	ORPHANET
Tgene	NTRK1	C0002768	Congenital Pain Insensitivity	1	ORPHANET
Tgene	NTRK1	C0005586	Bipolar Disorder	1	CTD_human
Tgene	NTRK1	C0005587	Depression, Bipolar	1	CTD_human
Tgene	NTRK1	C0017638	Glioma	1	CTD_human
Tgene	NTRK1	C0020075	Hereditary Sensory Autonomic Neuropathy, Type 5	1	CTD_human;ORPHANET
Tgene	NTRK1	C0024713	Manic Disorder	1	CTD_human
Tgene	NTRK1	C0027796	Neuralgia	1	CTD_human
Tgene	NTRK1	C0027819	Neuroblastoma	1	CTD_human
Tgene	NTRK1	C0033958	Psychosis, Brief Reactive	1	CTD_human
Tgene	NTRK1	C0033975	Psychotic Disorders	1	CTD_human
Tgene	NTRK1	C0036337	Schizoaffective Disorder	1	CTD_human
Tgene	NTRK1	C0036341	Schizophrenia	1	CTD_human
Tgene	NTRK1	C0036358	Schizophreniform Disorders	1	CTD_human
Tgene	NTRK1	C0038870	Neuralgia, Supraorbital	1	CTD_human
Tgene	NTRK1	C0042656	Neuralgia, Vidian	1	CTD_human
Tgene	NTRK1	C0234247	Neuralgia, Atypical	1	CTD_human
Tgene	NTRK1	C0234249	Neuralgia, Stump	1	CTD_human
Tgene	NTRK1	C0259783	mixed gliomas	1	CTD_human
Tgene	NTRK1	C0273115	Lung Injury	1	CTD_human
Tgene	NTRK1	C0338831	Manic	1	CTD_human
Tgene	NTRK1	C0423711	Neuralgia, Perineal	1	CTD_human
Tgene	NTRK1	C0423712	Neuralgia, Iliohypogastric Nerve	1	CTD_human
Tgene	NTRK1	C0555198	Malignant Glioma	1	CTD_human
Tgene	NTRK1	C0598589	Inherited neuropathies	1	GENOMICS_ENGLAND
Tgene	NTRK1	C0751371	Neuralgia, Ilioinguinal	1	CTD_human
Tgene	NTRK1	C0751372	Nerve Pain	1	CTD_human
Tgene	NTRK1	C0751373	Paroxysmal Nerve Pain	1	CTD_human
Tgene	NTRK1	C0752347	Lewy Body Disease	1	CTD_human
Tgene	NTRK1	C1833921	Familial medullary thyroid carcinoma	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	NTRK1	C2350344	Chronic Lung Injury	1	CTD_human