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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ERG-EWSR1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ERG-EWSR1
	FusionPDB ID: 27340
	FusionGDB2.0 ID: 27340
		Hgene	Tgene
	Gene symbol	ERG	EWSR1
	Gene ID	2078	2130
	Gene name	ETS transcription factor ERG	EWS RNA binding protein 1
	Synonyms	erg-3\|p55	EWS\|EWS-FLI1\|bK984G1.4
	Cytomap	21q22.2	22q12.2
	Type of gene	protein-coding	protein-coding
	Description	transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian	RNA-binding protein EWSEWS RNA-binding protein variant 6Ewing sarcoma breakpoint region 1Ewings sarcoma EWS-Fli1 (type 1) oncogene
	Modification date	20200320	20200329
	UniProtAcc	Q9Y282	Q01844
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000288319, ENST00000398905, ENST00000398907, ENST00000398911, ENST00000398919, ENST00000453032, ENST00000398897, ENST00000398910, ENST00000417133, ENST00000442448, ENST00000429727, ENST00000485493,	ENST00000331029, ENST00000332035, ENST00000332050, ENST00000333395, ENST00000397938, ENST00000406548, ENST00000414183,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 16 X 5=1520	17 X 58 X 10=9860
	# samples	31	48
	** MAII score	log2(31/1520*10)=-2.29373120305671 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/9860*10)=-4.36048133565676 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ERG [Title/Abstract] AND EWSR1 [Title/Abstract] AND fusion [Title/Abstract] Ewing sarcoma with ERG gene rearrangements: A molecular study focusing on the prevalence of FUS-ERG and common pitfalls in detecting EWSR1-ERG fusions by FISH (pmid: 26690869)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EWSR1(29683123)-ERG(39764366), # samples:2 ERG(39762959)-EWSR1(29682948), # samples:1
Anticipated loss of major functional domain due to fusion event.	EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. EWSR1-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. ERG-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. ERG-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. ERG-EWSR1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. ERG-EWSR1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ERG-EWSR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ERG	GO:0045944	positive regulation of transcription by RNA polymerase II	18195090\|23913826

Fusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EWSR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+
ChiTaRS5.0	N/A	S82338	ERG	chr21	39762959	-	EWSR1	chr22	29682948	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398897	ERG	chr21	39762917	-	ENST00000332050	EWSR1	chr22	29682912	+	2288	754	971	1924	317
ENST00000398897	ERG	chr21	39762917	-	ENST00000397938	EWSR1	chr22	29682912	+	2508	754	995	2143	382
ENST00000398897	ERG	chr21	39762917	-	ENST00000406548	EWSR1	chr22	29682912	+	2316	754	995	2140	381
ENST00000398897	ERG	chr21	39762917	-	ENST00000331029	EWSR1	chr22	29682912	+	2394	754	995	2029	344
ENST00000398897	ERG	chr21	39762917	-	ENST00000414183	EWSR1	chr22	29682912	+	2323	754	995	2140	381
ENST00000398897	ERG	chr21	39762917	-	ENST00000333395	EWSR1	chr22	29682912	+	1419	754	114	1055	313
ENST00000398897	ERG	chr21	39762917	-	ENST00000332035	EWSR1	chr22	29682912	+	2319	754	995	2143	382
ENST00000398910	ERG	chr21	39762917	-	ENST00000332050	EWSR1	chr22	29682912	+	2591	1057	177	1301	374
ENST00000398910	ERG	chr21	39762917	-	ENST00000397938	EWSR1	chr22	29682912	+	2811	1057	177	1358	393
ENST00000398910	ERG	chr21	39762917	-	ENST00000406548	EWSR1	chr22	29682912	+	2619	1057	177	1358	393
ENST00000398910	ERG	chr21	39762917	-	ENST00000331029	EWSR1	chr22	29682912	+	2697	1057	177	1358	393
ENST00000398910	ERG	chr21	39762917	-	ENST00000414183	EWSR1	chr22	29682912	+	2626	1057	177	1358	393
ENST00000398910	ERG	chr21	39762917	-	ENST00000333395	EWSR1	chr22	29682912	+	1722	1057	177	1358	393
ENST00000398910	ERG	chr21	39762917	-	ENST00000332035	EWSR1	chr22	29682912	+	2622	1057	177	1358	393
ENST00000417133	ERG	chr21	39762917	-	ENST00000332050	EWSR1	chr22	29682912	+	2660	1126	177	1370	397
ENST00000417133	ERG	chr21	39762917	-	ENST00000397938	EWSR1	chr22	29682912	+	2880	1126	177	1427	416
ENST00000417133	ERG	chr21	39762917	-	ENST00000406548	EWSR1	chr22	29682912	+	2688	1126	177	1427	416
ENST00000417133	ERG	chr21	39762917	-	ENST00000331029	EWSR1	chr22	29682912	+	2766	1126	177	1427	416
ENST00000417133	ERG	chr21	39762917	-	ENST00000414183	EWSR1	chr22	29682912	+	2695	1126	177	1427	416
ENST00000417133	ERG	chr21	39762917	-	ENST00000333395	EWSR1	chr22	29682912	+	1791	1126	177	1427	416
ENST00000417133	ERG	chr21	39762917	-	ENST00000332035	EWSR1	chr22	29682912	+	2691	1126	177	1427	416
ENST00000442448	ERG	chr21	39762917	-	ENST00000332050	EWSR1	chr22	29682912	+	2674	1140	263	1384	373
ENST00000442448	ERG	chr21	39762917	-	ENST00000397938	EWSR1	chr22	29682912	+	2894	1140	263	1441	392
ENST00000442448	ERG	chr21	39762917	-	ENST00000406548	EWSR1	chr22	29682912	+	2702	1140	263	1441	392
ENST00000442448	ERG	chr21	39762917	-	ENST00000331029	EWSR1	chr22	29682912	+	2780	1140	263	1441	392
ENST00000442448	ERG	chr21	39762917	-	ENST00000414183	EWSR1	chr22	29682912	+	2709	1140	263	1441	392
ENST00000442448	ERG	chr21	39762917	-	ENST00000333395	EWSR1	chr22	29682912	+	1805	1140	263	1441	392
ENST00000442448	ERG	chr21	39762917	-	ENST00000332035	EWSR1	chr22	29682912	+	2705	1140	263	1441	392

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27340_27340_1_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000331029_length(amino acids)=344AA_BP=
MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYL
DKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGG
DRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRG

--------------------------------------------------------------

>27340_27340_2_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000332035_length(amino acids)=382AA_BP=
MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIY
VQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSM
RGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCK
APKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRG

--------------------------------------------------------------

>27340_27340_3_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000332050_length(amino acids)=317AA_BP=
MDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEW
FDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRA
GDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGG

--------------------------------------------------------------

>27340_27340_4_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000333395_length(amino acids)=313AA_BP=213
MSRTQQLISRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILL
FQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAA
QPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKL

--------------------------------------------------------------

>27340_27340_5_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000397938_length(amino acids)=382AA_BP=
MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIY
VQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSM
RGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCK
APKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRG

--------------------------------------------------------------

>27340_27340_6_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000406548_length(amino acids)=381AA_BP=
MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYV
QGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMR
GGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKA
PKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGG

--------------------------------------------------------------

>27340_27340_7_ERG-EWSR1_ERG_chr21_39762917_ENST00000398897_EWSR1_chr22_29682912_ENST00000414183_length(amino acids)=381AA_BP=
MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGMGAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYV
QGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMR
GGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKA
PKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGG

--------------------------------------------------------------

>27340_27340_8_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000331029_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_9_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000332035_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_10_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000332050_length(amino acids)=374AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_11_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000333395_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_12_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000397938_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_13_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000406548_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_14_ERG-EWSR1_ERG_chr21_39762917_ENST00000398910_EWSR1_chr22_29682912_ENST00000414183_length(amino acids)=393AA_BP=293
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPAAQPSPSTVPKT
EDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAA

--------------------------------------------------------------

>27340_27340_15_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000331029_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_16_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000332035_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_17_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000332050_length(amino acids)=397AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_18_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000333395_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_19_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000397938_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_20_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000406548_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_21_ERG-EWSR1_ERG_chr21_39762917_ENST00000417133_EWSR1_chr22_29682912_ENST00000414183_length(amino acids)=416AA_BP=316
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAW
TGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLP

--------------------------------------------------------------

>27340_27340_22_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000331029_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_23_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000332035_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_24_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000332050_length(amino acids)=373AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_25_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000333395_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_26_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000397938_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_27_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000406548_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

>27340_27340_28_ERG-EWSR1_ERG_chr21_39762917_ENST00000442448_EWSR1_chr22_29682912_ENST00000414183_length(amino acids)=392AA_BP=292
MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRN
SPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCK
MTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTE
DQRPQLDPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAAT

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:29683123/chr22:39764366)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ERG Q9Y282	EWSR1 Q01844
FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (72) >>>72.pdbFusion protein BP residue: 213 CIF file (72) >>>72.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MSRTQQLISRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMT TNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELC KMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLM HARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPY QILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMVNKA AMGSSLPLVTHPKLDPTAKLQVNIANRAAATGSRVHSDRTTPVAWVFMGR	313
3D view using mol* of 72 (AA BP:213)


PDB file (77) >>>77.pdbFusion protein BP residue: CIF file (77) >>>77.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLDDLADFFKQCGVVKM NKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKAAVEWFDGKDFQGSK LKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPGGPGGPGGPMGRMGG RGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCPNPGCGNQNFAWRTE CNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGRGGLMDRGGPGGMFR GGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPLMEQMGGRRGGRGGP	317
3D view using mol* of 77 (AA BP:)


PDB file (107) >>>107.pdbFusion protein BP residue: CIF file (107) >>>107.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRDPDEDSDNSA IYVQGLNDSVTLDDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGD ATVSYEDPPTAKAAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPRE GRGMPPPLRGGPGGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGG GNVQHRAGDWQCPNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGD RGRGGPGGMRGGRGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGG	344
3D view using mol* of 107 (AA BP:)


PDB file (130) >>>130.pdbFusion protein BP residue: 292 CIF file (130) >>>130.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHG HPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRL VMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQ	373
3D view using mol* of 130 (AA BP:292)


PDB file (131) >>>131.pdbFusion protein BP residue: 293 CIF file (131) >>>131.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA TQRITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSR LVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKL	374
3D view using mol* of 131 (AA BP:293)


PDB file (139) >>>139.pdbFusion protein BP residue: CIF file (139) >>>139.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGM GAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTLD DLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAKA AVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGPG GPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQCP NPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGGR GGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGPL	381
3D view using mol* of 139 (AA BP:)


PDB file (140) >>>140.pdbFusion protein BP residue: CIF file (140) >>>140.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MGVYGQESGGFSGPGENRSMSGPDNRGRGRGGFDRGGMSRGGRGGGRGGM GSAGERGGFNKPGGPMDEGPDLDLGPPVDPDEDSDNSAIYVQGLNDSVTL DDLADFFKQCGVVKMNKRTGQPMIHIYLDKETGKPKGDATVSYEDPPTAK AAVEWFDGKDFQGSKLKVSLARKKPPMNSMRGGLPPREGRGMPPPLRGGP GGPGGPGGPMGRMGGRGGDRGGFPPRGPRGSRGNPSGGGNVQHRAGDWQC PNPGCGNQNFAWRTECNQCKAPKPEGFLPPPFPPPGGDRGRGGPGGMRGG RGGLMDRGGPGGMFRGGRGGDRGGFRGGRGMDRGGFGGGRRGGPGGPPGP	382
3D view using mol* of 140 (AA BP:)


PDB file (146)	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTDLPYEPPRRSAWTGHG HPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSRL VMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKLQ	392

PDB file (149) >>>149.pdbFusion protein BP residue: 293 CIF file (149) >>>149.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA TQRITTRPAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPAIPLHSR LVMIRAVTLSRTPMGNRAAMDSRVAMVNKAAMGSSLPLVTHPKLDPTAKL	393
3D view using mol* of 149 (AA BP:293)


PDB file (155) >>>155.pdbFusion protein BP residue: 316 CIF file (155) >>>155.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQL DPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMV	397
3D view using mol* of 155 (AA BP:316)


PDB file (178) >>>178.pdbFusion protein BP residue: 316 CIF file (178) >>>178.cif	ERG	chr21	39762917	-	EWSR1	chr22	29682912	+	MKDMIQTVPDPAAHIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSD YGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKG GKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVR QWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLS HLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEA TQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQL DPYQILGPTSSRLANPAIPLHSRLVMIRAVTLSRTPMGNRAAMDSRVAMV NKAAMGSSLPLVTHPKLDPTAKLQVNIANRAAATGSRVHSDRTTPVAWVF	416
3D view using mol* of 178 (AA BP:316)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ERG_pLDDT.png

EWSR1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ERG_EWSR1_72_PAE.png (AA BP:213)

ERG_EWSR1_72_pLDDT.png (AA BP:213)

ERG_EWSR1_72_pLDDT_and_active_sites.png (AA BP:213)

ERG_EWSR1_72_violinplot.png (AA BP:213)

ERG_EWSR1_77_PAE.png (AA BP:)

ERG_EWSR1_77_pLDDT.png (AA BP:)

ERG_EWSR1_77_pLDDT_and_active_sites.png (AA BP:)

ERG_EWSR1_77_violinplot.png (AA BP:)

ERG_EWSR1_107_PAE.png (AA BP:)

ERG_EWSR1_107_pLDDT.png (AA BP:)

ERG_EWSR1_107_pLDDT_and_active_sites.png (AA BP:)

ERG_EWSR1_107_violinplot.png (AA BP:)

ERG_EWSR1_130_PAE.png (AA BP:292)

ERG_EWSR1_130_pLDDT.png (AA BP:292)

ERG_EWSR1_130_pLDDT_and_active_sites.png (AA BP:292)

ERG_EWSR1_130_violinplot.png (AA BP:292)

ERG_EWSR1_131_PAE.png (AA BP:293)

ERG_EWSR1_131_pLDDT.png (AA BP:293)

ERG_EWSR1_131_pLDDT_and_active_sites.png (AA BP:293)

ERG_EWSR1_131_violinplot.png (AA BP:293)

ERG_EWSR1_139_PAE.png (AA BP:)

ERG_EWSR1_139_pLDDT.png (AA BP:)

ERG_EWSR1_139_pLDDT_and_active_sites.png (AA BP:)

ERG_EWSR1_139_violinplot.png (AA BP:)

ERG_EWSR1_140_PAE.png (AA BP:)

ERG_EWSR1_140_pLDDT.png (AA BP:)

ERG_EWSR1_146_PAE.png (AA BP:)

ERG_EWSR1_149_PAE.png (AA BP:293)

ERG_EWSR1_149_pLDDT.png (AA BP:293)

ERG_EWSR1_149_pLDDT_and_active_sites.png (AA BP:293)

ERG_EWSR1_149_violinplot.png (AA BP:293)

ERG_EWSR1_155_PAE.png (AA BP:316)

ERG_EWSR1_155_pLDDT.png (AA BP:316)

ERG_EWSR1_155_pLDDT_and_active_sites.png (AA BP:316)

ERG_EWSR1_155_violinplot.png (AA BP:316)

ERG_EWSR1_178_PAE.png (AA BP:316)

ERG_EWSR1_178_pLDDT.png (AA BP:316)

ERG_EWSR1_178_pLDDT_and_active_sites.png (AA BP:316)

ERG_EWSR1_178_violinplot.png (AA BP:316)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

ERG_EWSR1_72.png

ERG_EWSR1_77.png

ERG_EWSR1_107.png

ERG_EWSR1_130.png

ERG_EWSR1_139.png

ERG_EWSR1_140.png

ERG_EWSR1_146.png

ERG_EWSR1_149.png

ERG_EWSR1_155.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
72	1.064	131	1.144	461.335	0.612	0.669	0.816	1.209	0.605	1.999	0.949	Chain A: 134,138,139,142,199,200,202,203,204,206,2 07,210,216,217,218,220,221,224,225,227,228,231,232 ,243,246,247,248,249,250,251,252
77	0.616	28	0.469	78.89	0.708	0.64	0.923	0.328	1.265	0.259	0.644	Chain A: 176,177,178,179,182,184,192,193,194,195,2 02
107	0.632	34	0.512	107.702	0.707	0.605	0.829	0.035	1.225	0.029	1.113	Chain A: 40,41,44,45,48,134,135
130	1.08	98	1.13	267.197	0.572	0.752	1.054	1.462	0.773	1.892	1.725	Chain A: 160,197,200,201,203,204,207,208,304,307,3 08,309,311,312,313,314,315,316,318,319,320,322,323 ,325,326
131	1.055	323	1.102	825.258	0.546	0.717	0.918	1.047	0.824	1.271	1.055	Chain A: 139,140,141,142,152,160,196,197,200,201,2 04,205,206,208,209,210,211,213,217,220,221,222,224 ,225,226,227,228,298,301,302,303,304,305,306,307,3 08,309,310,311,312,314,317,320,321,323,324,326,327 ,328,330,331,332,334
139	0.654	39	0.604	87.465	0.678	0.59	0.86	0.434	1.033	0.421	0.598	Chain A: 240,241,242,243,246,247,248,256,257,258,2 59,266,267
146	1.043	295	1.088	693.546	0.489	0.706	0.952	0.922	0.847	1.089	0.722	Chain A: 132,133,134,135,136,139,151,154,155,158,1 59,201,204,205,208,210,213,217,218,221,222,297,298 ,301,302,304,305,306,308,309,310,311,374,375,376,3 77,378,379,380,381,382
149	1.011	227	1.035	772.093	0.507	0.703	0.935	0.632	1.004	0.629	0.647	Chain A: 129,130,131,132,133,134,139,155,158,159,1 60,201,204,205,208,210,213,217,218,221,222,225,227 ,228,230,231,233,234,236,237,238,239,298,301,302,3 05,306,309,375,376,377,378,379,380,381,382
155	1.03	408	1.091	1366.512	0.626	0.659	0.837	0.943	0.748	1.261	1.06	Chain A: 132,133,134,135,136,137,138,139,140,141,1 43,144,148,151,152,154,155,158,159,160,197,200,201 ,203,204,205,207,208,209,210,211,212,213,215,218,2 19,221,222,225,227,303,306,307,308,309,310,311,312 ,313,314,318,319,320,321,322,323,324,325,326,327,3 28,329,330,331,332,333,334,335,337,338,339,340,342 ,343,346,347,350
178	1.033	492	1.069	1515.031	0.507	0.711	0.945	0.851	0.914	0.932	0.687	Chain A: 130,132,133,134,135,139,154,155,158,159,1 60,201,204,205,210,211,213,215,217,218,220,221,222 ,224,225,227,230,231,234,235,236,237,238,239,240,3 08,309,312,313,315,318,319,321,322,325,326,328,329 ,330,331,332,333,335,336,337,340,341,344,395,397,3 98,399,400,401,402,403,404,405,406,407,408

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
ERG	JUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,
EWSR1	PRTFDC1, ZDHHC3, MSC, SLC22A24, MYO1F, KXD1, KHDRBS2, DNAJB3, FASN, NLE1, MNS1, PRUNE2, WWP2, NDUFB1, BNIP3L, NSUN4, KRR1, WWP1, RMND5B, SLC1A1, RASL11B, DFFA, WDR37, RPS15A, CPSF6, C11orf16, YY1AP1, RNF183, MTCP1, TULP2, RBPMS, KEL, MYOZ2, FAM131C, HMGA1, NPPB, HERPUD1, CD177, RPL31, VPS72, ACTL6A, RAD23A, MAGEA11, CFDP1, DMRTB1, CXADR, ZNF165, SSBP2, TPGS2, RAB37, CETP, NDUFV1, DYNLL2, NBPF3, CEACAM5, GPBP1L1, SERP2, GNPDA1, C19orf57, ELAVL3, ELAVL4, LILRA3, BAD, CCDC7, MRPS18B, CUEDC2, CNST, TSPAN3, CCDC91, TRIM37, NINL, NTNG2, CPSF7, PGLS, EPT1, MYL6, SMAD4, TMSB4Y, TRPV5, MVK, MAPK1IP1L, MDFI, MTMR9, PLSCR1, RALYL, PDHX, C10orf12, RHOXF2, MATK, SALL2, AGT, KCNMB1, SUV39H2, SMNDC1, ARHGDIA, PUF60, GSK3B, ILK, CD2BP2, BARD1, CREBBP, BTK, SF1, SNRPC, ELK1, PTK2B, CALM1, POU4F1, EZH2, IRF3, TONSL, RFX3, HLTF, SUPT4H1, ZNF184, HIST1H2BN, BLZF1, HDAC3, FXR2, HMGN4, POLR3A, ECD, ZBTB1, SCMH1, SUZ12, E2F8, TRIM5, ZNF383, DHX9, SMN1, PCM1, RAD21, NDRG1, CEBPA, ELAVL1, SIRT7, HNRNPA1, TSG101, TP53, POLR2A, YBX1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, KCND3, ATN1, ATXN3, ERCC5, HBP1, HSPA2, PCBP1, USP7, SRSF5, TMEM126A, SAP30BP, GORASP2, MBD3, MRPS9, HAX1, SFXN1, ITGA5, TCIRG1, RNF168, GEMIN5, HAS1, MTCH1, NDUFA5, MCAT, MRPL57, HDAC2, ESR1, FN1, VCAM1, ITGA4, CD81, PRMT1, SF3B4, EP300, PRRC2A, EWSR1, FUS, ITGB5, NONO, TRAF3, HNRNPUL1, EPAS1, CHERP, CDK12, ITCH, WBP4, rev, RPA3, RPA2, RPA1, HSPA5, RIOK2, TRAF1, TRAF2, SEC24D, TFG, SEC24A, SSBP3, PRR13, ATPAF2, PEF1, JUN, CUL7, OBSL1, CCDC8, RNF2, BMI1, EGFR, ABL1, SRPK1, ABCE1, PRMT8, RPS6KB2, ACAA2, ACAT1, EIF4H, ANXA2, HIP1R, PICALM, POR, NTRK1, SCARNA22, NPM1, KRT2, PRDX2, S100A9, YWHAZ, DDX17, PCLO, ANXA6, SEC24C, GIPC1, CSRP2, FHL1, HNRNPA3, CTTN, MARCKSL1, PARP1, SERPINB3, CCDC50, KIF2A, KRT6B, HIST1H1D, STK38, H2AFV, PACSIN2, U2AF1, RSL24D1, XRCC5, ESYT3, RPL29, SDF2L1, LRP1B, MSN, SEC23A, RPL7A, SNX18, PPIL1, RPS27A, IGHM, SUMO3, GTF2I, RUVBL1, KRT16, RBM8A, RPL8, SRSF9, ZC3HAV1L, GAPDH, ETV3, IGF2R, COL5A2, HNRNPD, ANP32B, WAC, TFAP2A, TTN, CBR3, ARGLU1, HNRNPAB, SRRT, ATP1B3, COPS7B, PRR12, ATF3, NOMO3, NOMO1, NOMO2, EYA3, C1orf198, MAZ, U2AF2, SSB, TRA2B, C1orf52, HMGB1, HMGB1P10, RPRD1A, HNRNPH3, EIF5A2, C1orf131, SEC13, MAPRE1, CSTF2T, SRSF3, LENG1, UPF1, HDGFRP2, RPS10P7, RPS10P11, RPS10, RPS10P13, RPS10P4, RPS10P22, DACH1, ANO1, NCOR1, MLX, SUMO1P3, SUMO1, WIZ, PFDN6, ARFIP2, ZHX3, EEF1B2, MBIP, BAG6, DENND2A, PRCC, SRSF1, EIF4ENIF1, SPTAN1, CDCA8, PLS3, API5P1, API5, PSMA4, DNTTIP1, AKAP8, NCOA3, SMTN, FBRS, SMARCE1, ERC1, WBP11, SPTBN1, NFRKB, OLA1, ZNF207, R3HDM1, TRIM33, SAFB, UBFD1, SRSF7, SRSF2, GATA6, VDAC1P1, VDAC1, IL16, GMNN, ILF2, MED4, QKI, VCL, MFAP1, SNAP29, PADI1, BCL9, BCL9L, PKM, GPATCH11, CASC3, PSMC6, CACYBP, RPL12P6, RPL12P32, RPL12P14, RPL12, RPL12P2, RPL12P35, RPL12P19, TPI1, TPI1P1, CHAF1A, MIA3, CIC, SDCBP, CA2, FKBP3, ACE, NKX2-5, CSTF2, PFDN2, UBTF, FAM207A, LOC729774, BRD8, C12orf45, C1orf35, TCF20, SOD1, SPAG7, MED8, ETS2, ALDOC, FKBP4, INCENP, CEP85, CECR2, TFE3, SUPT16HP1, SUPT16H, MAPT, HTATSF1, RPS18P12, RPS18P5, KPNA2, TMX1, CKAP4, HSPE1, COPRS, PTGES3, LAMP2, ERLIN2, CTNNBL1, TOMM22, NRBF2, C9orf78, NCOA6, MED26, RANBP1, LOC389842, LOC727803, HMGB3, CANX, PUS7, RPSAP19, RPSA, RPSAP18, RPSAP58, RPSAP15, RPSAP8, RPSAP9, RPSAP12, RPSAP29, RPSAP61, ARHGAP17, USF1, PSIP1, SNRPEP2, SNRPE, NUDT5, PPM1G, OTUB1, AHCY, COPS3, NSMCE2, SAE1, PROSER1, GRWD1, CREB5, TAF9B, RBM33, EDF1, PGK1, FAM114A2, SRRM1, RAD23B, CIAPIN1, CIAPIN1P, LRRC59, PABPN1, KMT2A, RPRD1B, GPATCH8, CCDC43, DGCR14, PPP1R2, ERICH1, EIF5A, EIF5AL1, BAG3, PCNA, SOX7, PNISR, FAM168A, MED15, SRSF11, SIRT1, RSF1, MAML1, HPRT1, SPDL1, CRTC3, CEP55, CDV3, ALYREF, RNF40, STOML2, DGCR8, NUCKS1, UBN2, PSMD7, WNT10A, HMBS, KHDRBS1, VBP1, NCSTN, CDCA2, SFSWAP, ZRANB2, DDB1, RBBP6, ZEB1, SRSF6, LOC644422, EIF2S1, RFX5, RPS19, RPS19P3, TALDO1, CWC15, CDCA5, LOC645086, C11orf58, TXN, STX12, PHRF1, BSG, TAF4, SH3GL1, LIN37, HRNR, FAM192A, RRBP1, KIAA0907, GOLGB1, PAX9, P4HB, CHMP5, LDHB, CALR, SUMO2P1, SUMO2, PDIA6, AHSA1, EN2, CCDC124, RPLP0P6, RPLP0P2, RPLP0P3, RPLP0, NIPBL, PDLIM4, PRKCSH, C15orf39, HNRNPDL, PDIA4, NUP210, RPLP2P3, RPLP2, PRDX4, DAZAP1, UBE2T, PHAX, AMOT, MARCKS, LOC284685, SMARCC1, BCORL1, RFC4, GLRX3, ANP32E, HYOU1, NPM3, ATF7IP, SARNP, TRA2A, HDGF, STIP1, PELP1, KCTD12, GLO1, PCF11, CLIC1, DNAJC8, RNF114, SLC4A1AP, FAM50A, GTF2A1, PRPF40A, CDC37, PPIAP22, PPIA, SMARCC2, MEGF11, KIAA1143, DENR, LAMP1, MYBL2, PITX1, UBE2MP1, UBE2M, CHTF8, OTX1, NACA, FNBP4, GTF2F2, GLTSCR1, GTF2E1, PQBP1, EMD, RNF113A, GPALPP1, SNRPA, RRP15, RPS25, RPS25P8, GMEB2, LNPEP, DNAJB1, IGBP1P1, IGBP1, HINT1, ARID1A, PPIB, ANXA11, MATR3, Sgol2, PPARGC1A, MCM2, Ksr1, UBASH3B, SFPQ, CAPN13, HEY1, BRCA1, MTCH2, PPIE, TBX3, BMP4, CTNNB1, GSK3A, HNF1B, TCF7L2, TRIP4, YAF2, ZNF217, AAR2, PIH1D1, EFTUD2, TNIP2, CHD3, CHD4, HEXIM1, MEPCE, LARP7, RUNX1, AGR2, RECQL4, REST, CDK9, SMARCA4, DDIT3, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H1, RC3H2, ATG16L1, PHB, DISC1, NR2C2, UBQLN2, ZFYVE21, XRCC6, AGRN, USP19, HIST1H4A, APEX1, DDX5, SNRNP70, SNRPB, SNRPD1, SNRPD2, SNRPD3, RNU1-1, RBMX, HNRNPM, HNRNPA2B1, TAF15, DDX3X, TARDBP, CLINT1, HNRNPL, NUMA1, ZFR, SNRNP200, ZNF326, HNRNPK, SF3B1, TOE1, HSPA8, SNRPB2, DDX20, GOT2, ILF3, PRPF6, ZNF638, HNRNPF, HNRNPH1, HNRNPR, VCP, CAD, CCAR2, DDX23, GEMIN4, HSPA1A, PCMTD1, POTEF, PRMT5, RBM45, SAFB2, SF3B2, SF3B3, SNRPF, SRSF4, THRAP3, TIA1, TTC7A, ZCCHC8, ITFG1, ARAF, BRD7, SOX2, ARIH2, PLEKHA4, NGB, OPTN, ZC3H18, CELF1, MKI67, INS, Apc2, FBP1, N, ZNF768, SYNCRIP, KDM5C, DDX58, OGT, SPOP, UFL1, DDRGK1, WDR5, TPX2, MALL, SOX21, POU3F3, PTP4A3, TRIM8, RCHY1, nsp14, SOX5,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ERG
EWSR1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ERG-EWSR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ERG-EWSR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
ERG	EWSR1	Ewing Sarcoma Undifferentiated Pleomorphic Sarcoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ERG	C0033578	Prostatic Neoplasms	7	CTD_human
Hgene	ERG	C0376358	Malignant neoplasm of prostate	7	CTD_human
Hgene	ERG	C0023418	leukemia	1	CTD_human
Hgene	ERG	C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	ERG	C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Hgene	ERG	C0023467	Leukemia, Myelocytic, Acute	1	CTD_human
Hgene	ERG	C0026998	Acute Myeloid Leukemia, M1	1	CTD_human
Hgene	ERG	C0279980	Extra-osseous Ewing's sarcoma	1	ORPHANET
Hgene	ERG	C1879321	Acute Myeloid Leukemia (AML-M2)	1	CTD_human
Hgene	ERG	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human
Tgene	EWSR1	C0553580	Ewings sarcoma	3	CTD_human;ORPHANET
Tgene	EWSR1	C0002736	Amyotrophic Lateral Sclerosis	1	GENOMICS_ENGLAND
Tgene	EWSR1	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	EWSR1	C0206651	Clear Cell Sarcoma of Soft Tissue	1	ORPHANET
Tgene	EWSR1	C0206663	Neuroectodermal Tumor, Primitive	1	CTD_human
Tgene	EWSR1	C0279980	Extra-osseous Ewing's sarcoma	1	ORPHANET
Tgene	EWSR1	C0334584	Spongioblastoma	1	CTD_human
Tgene	EWSR1	C0334596	Medulloepithelioma	1	CTD_human
Tgene	EWSR1	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	EWSR1	C0700367	Ependymoblastoma	1	CTD_human
Tgene	EWSR1	C0751675	Cerebral Primitive Neuroectodermal Tumor	1	CTD_human
Tgene	EWSR1	C1275278	Extraskeletal Myxoid Chondrosarcoma	1	ORPHANET