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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ERG-TMPRSS2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ERG-TMPRSS2
FusionPDB ID: 27380
FusionGDB2.0 ID: 27380
HgeneTgene
Gene symbol

ERG

TMPRSS2

Gene ID

2078

7113

Gene nameETS transcription factor ERGtransmembrane serine protease 2
Synonymserg-3|p55PP9284|PRSS10
Cytomap

21q22.2

21q22.3

Type of geneprotein-codingprotein-coding
Descriptiontranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets aviantransmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2
Modification date2020032020200313
UniProtAcc

Q9Y282

O15393

Ensembl transtripts involved in fusion geneENST idsENST00000398910, ENST00000398911, 
ENST00000398919, ENST00000417133, 
ENST00000442448, ENST00000398897, 
ENST00000485493, ENST00000288319, 
ENST00000398905, ENST00000398907, 
ENST00000429727, ENST00000453032, 
ENST00000332149, ENST00000398585, 
ENST00000458356, ENST00000497881, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 16 X 5=152028 X 34 X 5=4760
# samples 3135
** MAII scorelog2(31/1520*10)=-2.29373120305671
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(35/4760*10)=-3.76553474636298
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ERG [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract]

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer (pmid: 16254181)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)TMPRSS2(42880008)-ERG(39817544), # samples:352
ERG(39947586)-TMPRSS2(42852529), # samples:5
Anticipated loss of major functional domain due to fusion event.ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
TMPRSS2-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
ERG-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826

TgeneTMPRSS2

GO:0006508

proteolysis

21068237|24227843

TgeneTMPRSS2

GO:0046598

positive regulation of viral entry into host cell

21068237|24227843


check buttonFusion gene breakpoints across ERG (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMPRSS2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5739-01AERGchr21

39874175

+TMPRSS2chr21

42872875

-
ChimerDB4PRADTCGA-EJ-7793-01AERGchr21

39947585

-TMPRSS2chr21

42866504

-
ChimerDB4PRADTCGA-EJ-7793-01AERGchr21

39947586

-TMPRSS2chr21

42866505

-
ChimerDB4PRADTCGA-EJ-7793ERGchr21

39947586

-TMPRSS2chr21

42866505

-
ChimerDB4PRADTCGA-EJ-8469-01AERGchr21

39872216

-TMPRSS2chr21

42861415

+
ChimerDB4PRADTCGA-EJ-A65D-01AERGchr21

39947586

-TMPRSS2chr21

42852529

-
ChimerDB4PRADTCGA-EJ-A65DERGchr21

39947586

-TMPRSS2chr21

42852529

-
ChimerDB4PRADTCGA-HC-7747-01AERGchr21

39947585

-TMPRSS2chr21

42861519

-
ChimerDB4PRADTCGA-HC-7747-01AERGchr21

39947586

-TMPRSS2chr21

42861520

-
ChimerDB4PRADTCGA-J4-A67S-01AERGchr21

39947585

-TMPRSS2chr21

42870115

-
ChimerDB4PRADTCGA-J4-A67S-01AERGchr21

39947586

-TMPRSS2chr21

42870116

-
ChimerDB4PRADTCGA-J9-A52B-01AERGchr21

39744930

-TMPRSS2chr21

42870045

+
ChimerDB4PRADTCGA-J9-A52B-01AERGchr21

39744989

-TMPRSS2chr21

42870045

+
ChimerDB4PRADTCGA-J9-A52B-01AERGchr21

39835397

-TMPRSS2chr21

42870045

+
ChimerDB4PRADTCGA-V1-A8WS-01AERGchr21

39947585

-TMPRSS2chr21

42852528

-
ChimerDB4PRADTCGA-V1-A8WS-01AERGchr21

39947586

-TMPRSS2chr21

42852529

-
ChimerDB4PRADTCGA-V1-A8WSERGchr21

39947585

-TMPRSS2chr21

42852529

-
ChimerDB4PRADTCGA-V1-A8WSERGchr21

39947586

-TMPRSS2chr21

42852529

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000398911ERGchr2139947586-ENST00000332149TMPRSS2chr2142866505-32431881401651503
ENST00000398911ERGchr2139947586-ENST00000398585TMPRSS2chr2142866505-32411881401651503
ENST00000398911ERGchr2139947586-ENST00000458356TMPRSS2chr2142866505-17851881401651503
ENST00000398919ERGchr2139947586-ENST00000332149TMPRSS2chr2142866505-33893342861797503
ENST00000398919ERGchr2139947586-ENST00000398585TMPRSS2chr2142866505-33873342861797503
ENST00000398919ERGchr2139947586-ENST00000458356TMPRSS2chr2142866505-19313342861797503
ENST00000398910ERGchr2139947586-ENST00000332149TMPRSS2chr2142852529-28502251641258364
ENST00000398910ERGchr2139947586-ENST00000398585TMPRSS2chr2142852529-28482251641258364
ENST00000398910ERGchr2139947586-ENST00000458356TMPRSS2chr2142852529-13922251641258364
ENST00000417133ERGchr2139947586-ENST00000332149TMPRSS2chr2142852529-28502251641258364
ENST00000417133ERGchr2139947586-ENST00000398585TMPRSS2chr2142852529-28482251641258364
ENST00000417133ERGchr2139947586-ENST00000458356TMPRSS2chr2142852529-13922251641258364
ENST00000442448ERGchr2139947586-ENST00000332149TMPRSS2chr2142852529-29363112501344364
ENST00000442448ERGchr2139947586-ENST00000398585TMPRSS2chr2142852529-29343112501344364
ENST00000442448ERGchr2139947586-ENST00000458356TMPRSS2chr2142852529-14783112501344364
ENST00000398910ERGchr2139947586-ENST00000332149TMPRSS2chr2142861520-30572251641465433
ENST00000398910ERGchr2139947586-ENST00000398585TMPRSS2chr2142861520-30552251641465433
ENST00000398910ERGchr2139947586-ENST00000458356TMPRSS2chr2142861520-15992251641465433
ENST00000417133ERGchr2139947586-ENST00000332149TMPRSS2chr2142861520-30572251641465433
ENST00000417133ERGchr2139947586-ENST00000398585TMPRSS2chr2142861520-30552251641465433
ENST00000417133ERGchr2139947586-ENST00000458356TMPRSS2chr2142861520-15992251641465433
ENST00000442448ERGchr2139947586-ENST00000332149TMPRSS2chr2142861520-31433112501551433
ENST00000442448ERGchr2139947586-ENST00000398585TMPRSS2chr2142861520-31413112501551433
ENST00000442448ERGchr2139947586-ENST00000458356TMPRSS2chr2142861520-16853112501551433
ENST00000398910ERGchr2139947585-ENST00000332149TMPRSS2chr2142852529-28502251641258364
ENST00000398910ERGchr2139947585-ENST00000398585TMPRSS2chr2142852529-28482251641258364
ENST00000398910ERGchr2139947585-ENST00000458356TMPRSS2chr2142852529-13922251641258364
ENST00000417133ERGchr2139947585-ENST00000332149TMPRSS2chr2142852529-28502251641258364
ENST00000417133ERGchr2139947585-ENST00000398585TMPRSS2chr2142852529-28482251641258364
ENST00000417133ERGchr2139947585-ENST00000458356TMPRSS2chr2142852529-13922251641258364
ENST00000442448ERGchr2139947585-ENST00000332149TMPRSS2chr2142852529-29363112501344364
ENST00000442448ERGchr2139947585-ENST00000398585TMPRSS2chr2142852529-29343112501344364
ENST00000442448ERGchr2139947585-ENST00000458356TMPRSS2chr2142852529-14783112501344364
ENST00000398911ERGchr2139947585-ENST00000332149TMPRSS2chr2142866504-32431881401651503
ENST00000398911ERGchr2139947585-ENST00000398585TMPRSS2chr2142866504-32411881401651503
ENST00000398911ERGchr2139947585-ENST00000458356TMPRSS2chr2142866504-17851881401651503
ENST00000398919ERGchr2139947585-ENST00000332149TMPRSS2chr2142866504-33893342861797503
ENST00000398919ERGchr2139947585-ENST00000398585TMPRSS2chr2142866504-33873342861797503
ENST00000398919ERGchr2139947585-ENST00000458356TMPRSS2chr2142866504-19313342861797503
ENST00000398910ERGchr2139947585-ENST00000332149TMPRSS2chr2142852528-28502251641258364
ENST00000398910ERGchr2139947585-ENST00000398585TMPRSS2chr2142852528-28482251641258364
ENST00000398910ERGchr2139947585-ENST00000458356TMPRSS2chr2142852528-13922251641258364
ENST00000417133ERGchr2139947585-ENST00000332149TMPRSS2chr2142852528-28502251641258364
ENST00000417133ERGchr2139947585-ENST00000398585TMPRSS2chr2142852528-28482251641258364
ENST00000417133ERGchr2139947585-ENST00000458356TMPRSS2chr2142852528-13922251641258364
ENST00000442448ERGchr2139947585-ENST00000332149TMPRSS2chr2142852528-29363112501344364
ENST00000442448ERGchr2139947585-ENST00000398585TMPRSS2chr2142852528-29343112501344364
ENST00000442448ERGchr2139947585-ENST00000458356TMPRSS2chr2142852528-14783112501344364
ENST00000398910ERGchr2139947585-ENST00000332149TMPRSS2chr2142861519-30572251641465433
ENST00000398910ERGchr2139947585-ENST00000398585TMPRSS2chr2142861519-30552251641465433
ENST00000398910ERGchr2139947585-ENST00000458356TMPRSS2chr2142861519-15992251641465433
ENST00000417133ERGchr2139947585-ENST00000332149TMPRSS2chr2142861519-30572251641465433
ENST00000417133ERGchr2139947585-ENST00000398585TMPRSS2chr2142861519-30552251641465433
ENST00000417133ERGchr2139947585-ENST00000458356TMPRSS2chr2142861519-15992251641465433
ENST00000442448ERGchr2139947585-ENST00000332149TMPRSS2chr2142861519-31433112501551433
ENST00000442448ERGchr2139947585-ENST00000398585TMPRSS2chr2142861519-31413112501551433
ENST00000442448ERGchr2139947585-ENST00000458356TMPRSS2chr2142861519-16853112501551433

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398911ENST00000332149ERGchr2139947586-TMPRSS2chr2142866505-0.0023740950.9976259
ENST00000398911ENST00000398585ERGchr2139947586-TMPRSS2chr2142866505-0.0024241440.9975758
ENST00000398911ENST00000458356ERGchr2139947586-TMPRSS2chr2142866505-0.0040714950.99592847
ENST00000398919ENST00000332149ERGchr2139947586-TMPRSS2chr2142866505-0.0024591030.99754095
ENST00000398919ENST00000398585ERGchr2139947586-TMPRSS2chr2142866505-0.0025054340.9974946
ENST00000398919ENST00000458356ERGchr2139947586-TMPRSS2chr2142866505-0.0045888420.9954112
ENST00000398910ENST00000332149ERGchr2139947586-TMPRSS2chr2142852529-0.0031208730.9968791
ENST00000398910ENST00000398585ERGchr2139947586-TMPRSS2chr2142852529-0.003155120.9968449
ENST00000398910ENST00000458356ERGchr2139947586-TMPRSS2chr2142852529-0.0033542020.99664575
ENST00000417133ENST00000332149ERGchr2139947586-TMPRSS2chr2142852529-0.0031208730.9968791
ENST00000417133ENST00000398585ERGchr2139947586-TMPRSS2chr2142852529-0.003155120.9968449
ENST00000417133ENST00000458356ERGchr2139947586-TMPRSS2chr2142852529-0.0033542020.99664575
ENST00000442448ENST00000332149ERGchr2139947586-TMPRSS2chr2142852529-0.0030079820.996992
ENST00000442448ENST00000398585ERGchr2139947586-TMPRSS2chr2142852529-0.003045660.9969543
ENST00000442448ENST00000458356ERGchr2139947586-TMPRSS2chr2142852529-0.0038970580.9961029
ENST00000398910ENST00000332149ERGchr2139947586-TMPRSS2chr2142861520-0.0040628570.9959371
ENST00000398910ENST00000398585ERGchr2139947586-TMPRSS2chr2142861520-0.0040976440.99590236
ENST00000398910ENST00000458356ERGchr2139947586-TMPRSS2chr2142861520-0.0073895370.9926105
ENST00000417133ENST00000332149ERGchr2139947586-TMPRSS2chr2142861520-0.0040628570.9959371
ENST00000417133ENST00000398585ERGchr2139947586-TMPRSS2chr2142861520-0.0040976440.99590236
ENST00000417133ENST00000458356ERGchr2139947586-TMPRSS2chr2142861520-0.0073895370.9926105
ENST00000442448ENST00000332149ERGchr2139947586-TMPRSS2chr2142861520-0.0039126410.9960873
ENST00000442448ENST00000398585ERGchr2139947586-TMPRSS2chr2142861520-0.0039465690.99605346
ENST00000442448ENST00000458356ERGchr2139947586-TMPRSS2chr2142861520-0.0071495590.9928504
ENST00000398910ENST00000332149ERGchr2139947585-TMPRSS2chr2142852529-0.0031208730.9968791
ENST00000398910ENST00000398585ERGchr2139947585-TMPRSS2chr2142852529-0.003155120.9968449
ENST00000398910ENST00000458356ERGchr2139947585-TMPRSS2chr2142852529-0.0033542020.99664575
ENST00000417133ENST00000332149ERGchr2139947585-TMPRSS2chr2142852529-0.0031208730.9968791
ENST00000417133ENST00000398585ERGchr2139947585-TMPRSS2chr2142852529-0.003155120.9968449
ENST00000417133ENST00000458356ERGchr2139947585-TMPRSS2chr2142852529-0.0033542020.99664575
ENST00000442448ENST00000332149ERGchr2139947585-TMPRSS2chr2142852529-0.0030079820.996992
ENST00000442448ENST00000398585ERGchr2139947585-TMPRSS2chr2142852529-0.003045660.9969543
ENST00000442448ENST00000458356ERGchr2139947585-TMPRSS2chr2142852529-0.0038970580.9961029
ENST00000398911ENST00000332149ERGchr2139947585-TMPRSS2chr2142866504-0.0023740950.9976259
ENST00000398911ENST00000398585ERGchr2139947585-TMPRSS2chr2142866504-0.0024241440.9975758
ENST00000398911ENST00000458356ERGchr2139947585-TMPRSS2chr2142866504-0.0040714950.99592847
ENST00000398919ENST00000332149ERGchr2139947585-TMPRSS2chr2142866504-0.0024591030.99754095
ENST00000398919ENST00000398585ERGchr2139947585-TMPRSS2chr2142866504-0.0025054340.9974946
ENST00000398919ENST00000458356ERGchr2139947585-TMPRSS2chr2142866504-0.0045888420.9954112
ENST00000398910ENST00000332149ERGchr2139947585-TMPRSS2chr2142852528-0.0031208730.9968791
ENST00000398910ENST00000398585ERGchr2139947585-TMPRSS2chr2142852528-0.003155120.9968449
ENST00000398910ENST00000458356ERGchr2139947585-TMPRSS2chr2142852528-0.0033542020.99664575
ENST00000417133ENST00000332149ERGchr2139947585-TMPRSS2chr2142852528-0.0031208730.9968791
ENST00000417133ENST00000398585ERGchr2139947585-TMPRSS2chr2142852528-0.003155120.9968449
ENST00000417133ENST00000458356ERGchr2139947585-TMPRSS2chr2142852528-0.0033542020.99664575
ENST00000442448ENST00000332149ERGchr2139947585-TMPRSS2chr2142852528-0.0030079820.996992
ENST00000442448ENST00000398585ERGchr2139947585-TMPRSS2chr2142852528-0.003045660.9969543
ENST00000442448ENST00000458356ERGchr2139947585-TMPRSS2chr2142852528-0.0038970580.9961029
ENST00000398910ENST00000332149ERGchr2139947585-TMPRSS2chr2142861519-0.0040628570.9959371
ENST00000398910ENST00000398585ERGchr2139947585-TMPRSS2chr2142861519-0.0040976440.99590236
ENST00000398910ENST00000458356ERGchr2139947585-TMPRSS2chr2142861519-0.0073895370.9926105
ENST00000417133ENST00000332149ERGchr2139947585-TMPRSS2chr2142861519-0.0040628570.9959371
ENST00000417133ENST00000398585ERGchr2139947585-TMPRSS2chr2142861519-0.0040976440.99590236
ENST00000417133ENST00000458356ERGchr2139947585-TMPRSS2chr2142861519-0.0073895370.9926105
ENST00000442448ENST00000332149ERGchr2139947585-TMPRSS2chr2142861519-0.0039126410.9960873
ENST00000442448ENST00000398585ERGchr2139947585-TMPRSS2chr2142861519-0.0039465690.99605346
ENST00000442448ENST00000458356ERGchr2139947585-TMPRSS2chr2142861519-0.0071495590.9928504

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27380_27380_1_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852528_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_2_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852528_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_3_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852528_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_4_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_5_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_6_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_7_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42861519_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_8_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42861519_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_9_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398910_TMPRSS2_chr21_42861519_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_10_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398911_TMPRSS2_chr21_42866504_ENST00000332149_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_11_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398911_TMPRSS2_chr21_42866504_ENST00000398585_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_12_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398911_TMPRSS2_chr21_42866504_ENST00000458356_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_13_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398919_TMPRSS2_chr21_42866504_ENST00000332149_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_14_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398919_TMPRSS2_chr21_42866504_ENST00000398585_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_15_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000398919_TMPRSS2_chr21_42866504_ENST00000458356_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_16_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852528_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_17_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852528_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_18_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852528_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_19_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_20_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_21_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_22_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42861519_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_23_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42861519_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_24_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000417133_TMPRSS2_chr21_42861519_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_25_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852528_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_26_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852528_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_27_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852528_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_28_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_29_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_30_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_31_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42861519_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_32_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42861519_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_33_ERG-TMPRSS2_ERG_chr21_39947585_ENST00000442448_TMPRSS2_chr21_42861519_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_34_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_35_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_36_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_37_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42861520_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_38_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42861520_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_39_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398910_TMPRSS2_chr21_42861520_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_40_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398911_TMPRSS2_chr21_42866505_ENST00000332149_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_41_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398911_TMPRSS2_chr21_42866505_ENST00000398585_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_42_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398911_TMPRSS2_chr21_42866505_ENST00000458356_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_43_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398919_TMPRSS2_chr21_42866505_ENST00000332149_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_44_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398919_TMPRSS2_chr21_42866505_ENST00000398585_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_45_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000398919_TMPRSS2_chr21_42866505_ENST00000458356_length(amino acids)=503AA_BP=16
MKDMIQTVPDPAAHIKGSPPAIGPYYENHGYQPENPYPAQPTVVPTVYEVHPAQYYPSPVPQYAPRVLTQASNPVVCTQPKSPSGTVCTS
KTKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCVRLYGPNFILQVYSSQRKSWH
PVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGG
ESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALM
KLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG

--------------------------------------------------------------

>27380_27380_46_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_47_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_48_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_49_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42861520_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_50_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42861520_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_51_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000417133_TMPRSS2_chr21_42861520_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_52_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000332149_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_53_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000398585_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_54_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42852529_ENST00000458356_length(amino acids)=364AA_BP=20
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM

--------------------------------------------------------------

>27380_27380_55_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42861520_ENST00000332149_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

--------------------------------------------------------------

>27380_27380_56_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42861520_ENST00000398585_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

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>27380_27380_57_ERG-TMPRSS2_ERG_chr21_39947586_ENST00000442448_TMPRSS2_chr21_42861520_ENST00000458356_length(amino acids)=433AA_BP=20
MGWLTEGHDSDCPGPSSSYQETKKALCITLTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRCV
RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSL
RCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVE
KVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:42880008/chr21:39817544)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ERG

Q9Y282

TMPRSS2

O15393

FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000332149414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000332149414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000398585414256_489185.33333333333334530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000458356414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000458356414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000332149414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000332149414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000398585414256_489185.33333333333334530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000458356414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000458356414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000332149214112_14979.33333333333333493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000332149214150_24279.33333333333333493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000332149214256_48979.33333333333333493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000398585214150_242116.33333333333333530.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000398585214256_489116.33333333333333530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000458356214112_14979.33333333333333493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000458356214150_24279.33333333333333493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000458356214256_48979.33333333333333493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000332149114112_1495.0493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000332149114150_2425.0493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000332149114256_4895.0493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000398585114112_14942.0530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000398585114150_24242.0530.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000398585114256_48942.0530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000458356114112_1495.0493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000458356114150_2425.0493.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000458356114256_4895.0493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000332149414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000332149414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000398585414256_489185.33333333333334530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000458356414150_242148.33333333333334493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000458356414256_489148.33333333333334493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000332149214112_14979.33333333333333493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000332149214150_24279.33333333333333493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000332149214256_48979.33333333333333493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000398585214150_242116.33333333333333530.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000398585214256_489116.33333333333333530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000458356214112_14979.33333333333333493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000458356214150_24279.33333333333333493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000458356214256_48979.33333333333333493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000332149114112_1495.0493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000332149114150_2425.0493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000332149114256_4895.0493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000398585114112_14942.0530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000398585114150_24242.0530.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000398585114256_48942.0530.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000458356114112_1495.0493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000458356114150_2425.0493.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000458356114256_4895.0493.0DomainPeptidase S1
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000332149214106_49279.33333333333333493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000458356214106_49279.33333333333333493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000332149114106_4925.0493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000398585114106_49242.0530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42866504ENST00000458356114106_4925.0493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000332149214106_49279.33333333333333493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000458356214106_49279.33333333333333493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000332149114106_4925.0493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000398585114106_49242.0530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42866505ENST00000458356114106_4925.0493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42861519ENST0000033214921485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42861519ENST0000045835621485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42866504ENST0000033214911485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42866504ENST0000039858511485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42866504ENST0000045835611485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42861520ENST0000033214921485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42861520ENST0000045835621485_10579.33333333333333493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42866505ENST0000033214911485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42866505ENST0000039858511485_10542.0530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42866505ENST0000045835611485_1055.0493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneERGchr21:39947585chr21:42852528ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852529ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42861519ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947585chr21:42866504ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42852529ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42861520ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000288319-110311_3910480.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000398897-29311_3910364.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000398911-210311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000398919-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000417133-312311_39113.0487.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000442448-311311_39113.0463.0DNA bindingETS
HgeneERGchr21:39947586chr21:42866505ENST00000453032-19311_3910388.0DNA bindingETS
HgeneERGchr21:39947585chr21:42852528ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42852528ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42852529ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42861519ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947585chr21:42866504ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42852529ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42861520ENST00000453032-19113_1990388.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000288319-110113_1990480.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000398897-29113_1990364.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000398911-210113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000398919-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000417133-312113_19913.0487.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000442448-311113_19913.0463.0DomainPNT
HgeneERGchr21:39947586chr21:42866505ENST00000453032-19113_1990388.0DomainPNT
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000332149414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000398585414112_149185.33333333333334530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000398585414150_242185.33333333333334530.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000458356414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000332149414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000398585414112_149185.33333333333334530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000398585414150_242185.33333333333334530.0DomainSRCR
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000458356414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000398585214112_149116.33333333333333530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000332149414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000398585414112_149185.33333333333334530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000398585414150_242185.33333333333334530.0DomainSRCR
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000458356414112_149148.33333333333334493.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000398585214112_149116.33333333333333530.0DomainLDL-receptor class A
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000332149414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852528ENST000003321494141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000398585414106_492185.33333333333334530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852528ENST000003985854141_84185.33333333333334530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852528ENST00000458356414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852528ENST000004583564141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000332149414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852529ENST000003321494141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000398585414106_492185.33333333333334530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852529ENST000003985854141_84185.33333333333334530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852529ENST00000458356414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42852529ENST000004583564141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42861519ENST000003321492141_8479.33333333333333493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42861519ENST00000398585214106_492116.33333333333333530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947585chr21:42861519ENST000003985852141_84116.33333333333333530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42861519ENST000004583562141_8479.33333333333333493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42866504ENST000003321491141_845.0493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42866504ENST000003985851141_8442.0530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42866504ENST000004583561141_845.0493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000332149414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42852529ENST000003321494141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000398585414106_492185.33333333333334530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42852529ENST000003985854141_84185.33333333333334530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42852529ENST00000458356414106_492148.33333333333334493.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42852529ENST000004583564141_84148.33333333333334493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42861520ENST000003321492141_8479.33333333333333493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42861520ENST00000398585214106_492116.33333333333333530.0Topological domainExtracellular
TgeneTMPRSS2chr21:39947586chr21:42861520ENST000003985852141_84116.33333333333333530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42861520ENST000004583562141_8479.33333333333333493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42866505ENST000003321491141_845.0493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42866505ENST000003985851141_8442.0530.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947586chr21:42866505ENST000004583561141_845.0493.0Topological domainCytoplasmic
TgeneTMPRSS2chr21:39947585chr21:42852528ENST0000033214941485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42852528ENST0000039858541485_105185.33333333333334530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42852528ENST0000045835641485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42852529ENST0000033214941485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42852529ENST0000039858541485_105185.33333333333334530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42852529ENST0000045835641485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947585chr21:42861519ENST0000039858521485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42852529ENST0000033214941485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42852529ENST0000039858541485_105185.33333333333334530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42852529ENST0000045835641485_105148.33333333333334493.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTMPRSS2chr21:39947586chr21:42861520ENST0000039858521485_105116.33333333333333530.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>715_ERG_39947586_TMPRSS2_42852529_ranked_0.pdbERG3994758539947586ENST00000458356TMPRSS2chr2142852529-
MGWLTEGHDSDCPGPSSSYQVRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLNTSAGN
VDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHW
TAFAGILRQSFMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGATEEKGKTSEVLN
AAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQM
364


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ERG_pLDDT.png
all structure
all structure
TMPRSS2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,
TMPRSS2CLK1, HNRNPL, DCAF4, S, ACE2, STX7, SCD, PLP2, PLLP, MOSPD3, UPK2, SELK, C3orf52, IGFBP5, SEC22A, PLP1, CLN6, TMEM128, C14orf1, CFHR5, TMEM243, TMEM60, CXCL9, BNIP2, CNIH3, PGAP2, TMEM218, TMEM86A, CMTM7, ZFPL1, BMP10, TMEM79, SLC35A1, SFTPC, VAMP5, FAXDC2, STX8, NINJ2, CLEC7A, C2CD2L, CNIH2, BNIP3, DEFB103A, DEFB103B, TMEM11, C17orf62, TMEM86B, ADIPOQ, EDDM3B, BRICD5, PTTG1IP, PTCH1, ANKRD46, TMEM222, C1QL4, TMEM120B, FAM3C, TMEM229B, PLN, CTXN3, TNF, SMIM1, AQP1, TMPRSS2, DNASE2, MYO1C, PGRMC1, NDUFA4, ADAM10, CLGN, SEC16A, SPINT2, COCH, B4GAT1, XPOT, MYO1B, LANCL1, CALU, PLXNA2, GPC4, BANF1, CPD, CLPX, STC2, SLIT2, MYO1D, ERLIN2, BAG2, TFRC, HLA-A, TP53, RPN1, RPN2, GNAI2, APP, ITGB1, INSR, GLA, GPI, ITGAV, CTSD, APRT, IGF1R, MET, GNAI3, CLTA, CALM2, HLA-C, DLAT, HSPA5, LAMC1, LAMP1, IGF2R, PDIA4, P4HA1, HSP90B1, PVR, RPA2, ATP2A2, PFKL, CDH2, MSH3, RPA1, CALR, RPA3, LONP1, TGFBR1, DDOST, HADHA, ECE1, DNM2, FXR2, PLXNA3, ATP1B3, HADHB, SEC61A1, GNB1, NOMO3, PRKDC, TFAM, SLC7A5, PFKP, KIF23, FMR1, PTK7, ADAM15, CUL2, SCARB2, WRN, DSC3, ITIH4, GANAB, KARS, RCN1, SAFB, IMMT, HSD17B12, UBR4, QSOX2, RRM2B, MON2, YTHDF3, PABPN1, PLD3, PELP1, TTC13, CNNM3, IPO4, FAR1, GGH, ERLEC1, RBM33, DNAJA3, RBM14, PPP1R9B, SDF2, NEU1, GRWD1, AIF1L, NTPCR, FUCA2, EDEM3, RACGAP1, RAB18, TMEM106B, CHPF2, GNG12, DNAJB11, EGFL7, DDX20, ADAMTS1, LNPEP, ITM2B, MRPL11, HYOU1, AFG3L2, YTHDF2, SUPT16H, PDHX, IPO5, SAP18, HGS, SPTBN2, PLXNB2, ARPC3, ACTN4, TRIM13, PDCD6, MPDU1, SEC22B, ATP6AP2, STAM2, ARL6IP5, UFL1, SEC31A, STBD1, SMC2, SEC24A, SEC24B, ACSL3, CDK1, SRPR, SPTB, MTHFD1, ACTN1, ETFA, RAB6A, VDAC1, HMOX2, MYH10, DEK, ATP5C1, NAMPT, VDAC2, QARS, TUFM, SERPINH1, BCAP31, PSMD7, CLCN7, SLC25A1, YARS, EPPK1, RAB10, ABCE1, RHOA, CNBP, TPM4, SLC25A11, LMNB2, CKAP4, GOLGA3, TWF1, TRAP1, STX5, DDX39B, RAB3GAP1, PON2, PPA1, SEC23A, SEC23B, NDUFA9, ATP6V1F, INF2, ANO6, ACTBL2, MIA3, CDKAL1, KIAA0368, C19orf70, SLC25A24, HUWE1, MEGF8, KTN1, COMTD1, ANKLE2, VRK2, ZDHHC17, DNAH10, NUP93, MMGT1, TMEM199, ATPAF2, EMC1, PDZD8, NBEA, MOSPD2, PDCD6IP, SYNE2, UBXN4, CCDC47, LRRC59, C7orf55, DDRGK1, NGLY1, CDK5RAP3, CCDC115, CLCC1, OSBPL9, RBM15, CGRRF1, ESYT1, NDC1, EFHD1, OSBPL8, KIAA1715, LSG1, RAB1B, TMX1, GORASP2, SFXN1, XPO5, VEZT, JPH1, BIRC6, AAAS, TOMM22, DDX19A, SMPD4, TMOD3, EMC3, VAPA, CEP72, LARS, DPM3, DHCR7, UBA2, AASS, ATP6V1H, SLC25A13, STOML2, RAB21, MYO6, VDAC3, AUP1, SEC23IP,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ERGall structure
TMPRSS2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ERG-TMPRSS2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ERG-TMPRSS2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneERGC0033578Prostatic Neoplasms7CTD_human
HgeneERGC0376358Malignant neoplasm of prostate7CTD_human
HgeneERGC0023418leukemia1CTD_human
HgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
HgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
HgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
HgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
HgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneTMPRSS2C0033578Prostatic Neoplasms4CTD_human
TgeneTMPRSS2C0376358Malignant neoplasm of prostate4CTD_human