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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ESR1-ASPH

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ESR1-ASPH
FusionPDB ID: 27535
FusionGDB2.0 ID: 27535
HgeneTgene
Gene symbol

ESR1

ASPH

Gene ID

2099

444

Gene nameestrogen receptor 1aspartate beta-hydroxylase
SynonymsER|ESR|ESRA|ESTRR|Era|NR3A1AAH|BAH|CASQ2BP1|FDLAB|HAAH|JCTN|junctin
Cytomap

6q25.1-q25.2

8q12.3

Type of geneprotein-codingprotein-coding
Descriptionestrogen receptorE2 receptor alphaER-alphaestradiol receptorestrogen nuclear receptor alphaestrogen receptor alpha E1-E2-1-2estrogen receptor alpha E1-N2-E2-1-2nuclear receptor subfamily 3 group A member 1oestrogen receptor alphaaspartyl/asparaginyl beta-hydroxylaseA beta H-J-JASP beta-hydroxylasecardiac junctinhumbugjunctatepeptide-aspartate beta-dioxygenase
Modification date2020032920200315
UniProtAcc

P03372

Q6ICH7

Ensembl transtripts involved in fusion geneENST idsENST00000206249, ENST00000338799, 
ENST00000427531, ENST00000440973, 
ENST00000443427, ENST00000456483, 
ENST00000406599, ENST00000482101, 
ENST00000356457, ENST00000379449, 
ENST00000389204, ENST00000445642, 
ENST00000517661, ENST00000517847, 
ENST00000517856, ENST00000517903, 
ENST00000518068, ENST00000522603, 
ENST00000522835, ENST00000522919, 
ENST00000523897, ENST00000379454, 
ENST00000541428, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 18 X 8=302417 X 17 X 5=1445
# samples 3519
** MAII scorelog2(35/3024*10)=-3.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1445*10)=-2.92699816905709
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ESR1 [Title/Abstract] AND ASPH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ESR1(152201906)-ASPH(62416068), # samples:4
Anticipated loss of major functional domain due to fusion event.ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ESR1-ASPH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneESR1

GO:0006366

transcription by RNA polymerase II

15831516

HgeneESR1

GO:0010629

negative regulation of gene expression

21695196

HgeneESR1

GO:0030520

intracellular estrogen receptor signaling pathway

9841876

HgeneESR1

GO:0032355

response to estradiol

15304487

HgeneESR1

GO:0043124

negative regulation of I-kappaB kinase/NF-kappaB signaling

7651415|16043358

HgeneESR1

GO:0043433

negative regulation of DNA-binding transcription factor activity

10816575

HgeneESR1

GO:0043627

response to estrogen

11581164

HgeneESR1

GO:0045893

positive regulation of transcription, DNA-templated

9841876|20074560

HgeneESR1

GO:0045899

positive regulation of RNA polymerase II transcriptional preinitiation complex assembly

9841876

HgeneESR1

GO:0045944

positive regulation of transcription by RNA polymerase II

11544182|12047722|15345745|15831516|18563714

HgeneESR1

GO:0051091

positive regulation of DNA-binding transcription factor activity

9328340|10681512

HgeneESR1

GO:0071392

cellular response to estradiol stimulus

15831516

TgeneASPH

GO:0045862

positive regulation of proteolysis

18387192

TgeneASPH

GO:0097202

activation of cysteine-type endopeptidase activity

18387192


check buttonFusion gene breakpoints across ESR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASPH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201905

+ASPHchr8

62416067

-
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201906

-ASPHchr8

62416068

-
ChimerDB4BRCATCGA-A2-A3KD-01AESR1chr6

152201906

+ASPHchr8

62416068

-
ChimerDB4BRCATCGA-A2-A3KDESR1chr6

152201906

+ASPHchr8

62416068

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440973ESR1chr6152201906+ENST00000541428ASPHchr862416068-408311303701212280
ENST00000338799ESR1chr6152201906+ENST00000541428ASPHchr862416068-5173222014602302280
ENST00000456483ESR1chr6152201906+ENST00000541428ASPHchr862416068-39319782181060280
ENST00000443427ESR1chr6152201906+ENST00000541428ASPHchr862416068-397410212611103280
ENST00000206249ESR1chr6152201906+ENST00000541428ASPHchr862416068-407511223621204280
ENST00000427531ESR1chr6152201906+ENST00000541428ASPHchr862416068-3426473205555116
ENST00000440973ESR1chr6152201905+ENST00000541428ASPHchr862416067-408311303701212280
ENST00000338799ESR1chr6152201905+ENST00000541428ASPHchr862416067-5173222014602302280
ENST00000456483ESR1chr6152201905+ENST00000541428ASPHchr862416067-39319782181060280
ENST00000443427ESR1chr6152201905+ENST00000541428ASPHchr862416067-397410212611103280
ENST00000206249ESR1chr6152201905+ENST00000541428ASPHchr862416067-407511223621204280
ENST00000427531ESR1chr6152201905+ENST00000541428ASPHchr862416067-3426473205555116

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440973ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0011740210.99882597
ENST00000338799ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009990050.99900097
ENST00000456483ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009811840.9990188
ENST00000443427ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0010183430.99898165
ENST00000206249ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.0009478880.9990521
ENST00000427531ENST00000541428ESR1chr6152201906+ASPHchr862416068-0.053744060.9462559
ENST00000440973ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0011740210.99882597
ENST00000338799ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009990050.99900097
ENST00000456483ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009811840.9990188
ENST00000443427ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0010183430.99898165
ENST00000206249ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.0009478880.9990521
ENST00000427531ENST00000541428ESR1chr6152201905+ASPHchr862416067-0.053744060.9462559

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>27535_27535_1_ESR1-ASPH_ESR1_chr6_152201905_ENST00000206249_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_2_ESR1-ASPH_ESR1_chr6_152201905_ENST00000338799_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_3_ESR1-ASPH_ESR1_chr6_152201905_ENST00000427531_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=116AA_BP=89
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG

--------------------------------------------------------------

>27535_27535_4_ESR1-ASPH_ESR1_chr6_152201905_ENST00000440973_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_5_ESR1-ASPH_ESR1_chr6_152201905_ENST00000443427_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_6_ESR1-ASPH_ESR1_chr6_152201905_ENST00000456483_ASPH_chr8_62416067_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_7_ESR1-ASPH_ESR1_chr6_152201906_ENST00000206249_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_8_ESR1-ASPH_ESR1_chr6_152201906_ENST00000338799_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_9_ESR1-ASPH_ESR1_chr6_152201906_ENST00000427531_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=116AA_BP=89
MASTNDKGSMAMESAKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGG

--------------------------------------------------------------

>27535_27535_10_ESR1-ASPH_ESR1_chr6_152201906_ENST00000440973_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_11_ESR1-ASPH_ESR1_chr6_152201906_ENST00000443427_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

>27535_27535_12_ESR1-ASPH_ESR1_chr6_152201906_ENST00000456483_ASPH_chr8_62416068_ENST00000541428_length(amino acids)=280AA_BP=253
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:152201906/chr8:62416068)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ESR1

P03372

ASPH

Q6ICH7

FUNCTION: Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1. {ECO:0000269|PubMed:10681512, ECO:0000269|PubMed:10816575, ECO:0000269|PubMed:11477071, ECO:0000269|PubMed:11682626, ECO:0000269|PubMed:14764652, ECO:0000269|PubMed:15078875, ECO:0000269|PubMed:15891768, ECO:0000269|PubMed:16043358, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16684779, ECO:0000269|PubMed:17922032, ECO:0000269|PubMed:17932106, ECO:0000269|PubMed:18247370, ECO:0000269|PubMed:19350539, ECO:0000269|PubMed:20074560, ECO:0000269|PubMed:20705611, ECO:0000269|PubMed:21330404, ECO:0000269|PubMed:22083956, ECO:0000269|PubMed:7651415, ECO:0000269|PubMed:9328340}.FUNCTION: May function as 2-oxoglutarate-dependent dioxygenase. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48185_250253.33333333333334484.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_250253.33333333333334596.0DNA bindingNuclear receptor
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_250253.33333333333334484.0DNA bindingNuclear receptor
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48185_205253.33333333333334484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48221_245253.33333333333334484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49185_205253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49221_245253.33333333333334596.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48185_205253.33333333333334484.0Zinc fingerNR C4-type
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48221_245253.33333333333334484.0Zinc fingerNR C4-type
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701490_1020314.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003794490590_1020204.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003892040690_1020226.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201690_1020651.6666666666666Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701590_1020300.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301590_1020299.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801390_1020271.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000005226030590_1020211.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501490_1020257.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701490_1020314.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000003794490590_1020204.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000003892040690_1020226.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201690_1020651.6666666666666Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701590_1020300.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301590_1020299.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801390_1020271.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST000005226030590_1020211.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501490_1020257.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014111_3120314.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014323_3320314.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000003564570149_290314.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905111_3120204.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905323_3320204.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000379449059_290204.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406111_3120226.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406323_3320226.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000389204069_290226.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016111_3120651.6666666666666Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016323_3320651.6666666666666Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000004456420169_290651.6666666666666Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015111_3120300.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015323_3320300.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005178470159_290300.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015111_3120299.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015323_3320299.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005179030159_290299.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013111_3120271.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013323_3320271.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005180680139_290271.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305111_3120211.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305323_3320211.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST00000522603059_290211.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014111_3120257.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014323_3320257.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST000005228350149_290257.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014111_3120314.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014323_3320314.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000003564570149_290314.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905111_3120204.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905323_3320204.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000379449059_290204.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406111_3120226.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406323_3320226.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000389204069_290226.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016111_3120651.6666666666666Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016323_3320651.6666666666666Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000004456420169_290651.6666666666666Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015111_3120300.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015323_3320300.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005178470159_290300.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015111_3120299.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015323_3320299.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005179030159_290299.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013111_3120271.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013323_3320271.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005180680139_290271.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305111_3120211.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305323_3320211.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST00000522603059_290211.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014111_3120257.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014323_3320257.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST000005228350149_290257.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014688_6900314.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905688_6900204.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406688_6900226.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016688_6900651.6666666666666Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015688_6900300.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015688_6900299.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013688_6900271.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305688_6900211.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014688_6900257.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325688_690679.6666666666666730.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014688_6900314.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905688_6900204.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406688_6900226.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016688_6900651.6666666666666Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015688_6900300.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015688_6900299.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013688_6900271.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305688_6900211.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014688_6900257.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325688_690679.6666666666666730.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014341_3740314.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014454_4870314.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014489_5210314.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000356457014525_5570314.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905341_3740204.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905454_4870204.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905489_5210204.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000037944905525_5570204.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406341_3740226.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406454_4870226.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406489_5210226.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000038920406525_5570226.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016341_3740651.6666666666666RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016454_4870651.6666666666666RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016489_5210651.6666666666666RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000445642016525_5570651.6666666666666RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015341_3740300.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015454_4870300.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015489_5210300.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000517847015525_5570300.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015341_3740299.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015454_4870299.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015489_5210299.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000517903015525_5570299.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013341_3740271.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013454_4870271.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013489_5210271.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000518068013525_5570271.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305341_3740211.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305454_4870211.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305489_5210211.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST0000052260305525_5570211.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014341_3740257.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014454_4870257.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014489_5210257.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST00000522835014525_5570257.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014341_3740314.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014454_4870314.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014489_5210314.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000356457014525_5570314.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905341_3740204.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905454_4870204.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905489_5210204.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000037944905525_5570204.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406341_3740226.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406454_4870226.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406489_5210226.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000038920406525_5570226.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016341_3740651.6666666666666RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016454_4870651.6666666666666RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016489_5210651.6666666666666RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000445642016525_5570651.6666666666666RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015341_3740300.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015454_4870300.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015489_5210300.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517847015525_5570300.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015341_3740299.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015454_4870299.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015489_5210299.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000517903015525_5570299.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013341_3740271.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013454_4870271.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013489_5210271.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000518068013525_5570271.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305341_3740211.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305454_4870211.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305489_5210211.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST0000052260305525_5570211.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014341_3740257.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014454_4870257.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014489_5210257.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST00000522835014525_5570257.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST000003564570141_530314.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701475_7580314.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000379449051_530204.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000003794490575_7580204.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000389204061_530226.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000003892040675_7580226.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000004456420161_530651.6666666666666Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201675_7580651.6666666666666Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005178470151_530300.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701575_7580300.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005179030151_530299.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301575_7580299.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005180680131_530271.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801375_7580271.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000522603051_530211.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST000005226030575_7580211.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST000005228350141_530257.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501475_7580257.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000003564570141_530314.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701475_7580314.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000379449051_530204.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000003794490575_7580204.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000389204061_530226.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000003892040675_7580226.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000004456420161_530651.6666666666666Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201675_7580651.6666666666666Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005178470151_530300.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701575_7580300.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005179030151_530299.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301575_7580299.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005180680131_530271.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801375_7580271.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST00000522603051_530211.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST000005226030575_7580211.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST000005228350141_530257.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501475_7580257.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST0000035645701454_740314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000003794490554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000003892040654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000044564201654_740651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051784701554_740300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051790301554_740299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000051806801354_740271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST000005226030554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST0000052283501454_740257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000035645701454_740314.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000003794490554_740204.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000003892040654_740226.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000044564201654_740651.6666666666666TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051784701554_740300.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051790301554_740299.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000051806801354_740271.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST000005226030554_740211.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST0000052283501454_740257.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48311_547253.33333333333334484.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_547253.33333333333334596.0DomainNR LBD
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_547253.33333333333334484.0DomainNR LBD
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48251_310253.33333333333334484.0RegionNote=Hinge
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48264_595253.33333333333334484.0RegionNote=Self-association
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48311_595253.33333333333334484.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49251_310253.33333333333334596.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49264_595253.33333333333334596.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49311_595253.33333333333334596.0RegionNote=Transactivation AF-2
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48251_310253.33333333333334484.0RegionNote=Hinge
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48264_595253.33333333333334484.0RegionNote=Self-association
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48311_595253.33333333333334484.0RegionNote=Transactivation AF-2
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232590_102708.6666666666666759.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232590_102679.6666666666666730.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232590_102708.6666666666666759.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232590_102679.6666666666666730.0Calcium bindingOntology_term=ECO:0000305
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325111_312708.6666666666666759.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325323_332708.6666666666666759.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST0000037945423259_29708.6666666666666759.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325111_312679.6666666666666730.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325323_332679.6666666666666730.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201905chr8:62416067ENST0000054142823259_29679.6666666666666730.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325111_312708.6666666666666759.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325323_332708.6666666666666759.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST0000037945423259_29708.6666666666666759.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325111_312679.6666666666666730.0Compositional biasNote=Glu-rich
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325323_332679.6666666666666730.0Compositional biasNote=Poly-Lys
TgeneASPHchr6:152201906chr8:62416068ENST0000054142823259_29679.6666666666666730.0Compositional biasNote=Ser-rich
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325688_690708.6666666666666759.0Region2-oxoglutarate binding
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325688_690708.6666666666666759.0Region2-oxoglutarate binding
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325341_374708.6666666666666759.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325454_487708.6666666666666759.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325489_521708.6666666666666759.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST000003794542325525_557708.6666666666666759.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325341_374679.6666666666666730.0RepeatNote=TPR 1
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325454_487679.6666666666666730.0RepeatNote=TPR 2
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325489_521679.6666666666666730.0RepeatNote=TPR 3
TgeneASPHchr6:152201905chr8:62416067ENST000005414282325525_557679.6666666666666730.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325341_374708.6666666666666759.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325454_487708.6666666666666759.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325489_521708.6666666666666759.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST000003794542325525_557708.6666666666666759.0RepeatNote=TPR 4
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325341_374679.6666666666666730.0RepeatNote=TPR 1
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325454_487679.6666666666666730.0RepeatNote=TPR 2
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325489_521679.6666666666666730.0RepeatNote=TPR 3
TgeneASPHchr6:152201906chr8:62416068ENST000005414282325525_557679.6666666666666730.0RepeatNote=TPR 4
TgeneASPHchr6:152201905chr8:62416067ENST0000037945423251_53708.6666666666666759.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232575_758708.6666666666666759.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST0000054142823251_53679.6666666666666730.0Topological domainCytoplasmic
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232575_758679.6666666666666730.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST0000037945423251_53708.6666666666666759.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232575_758708.6666666666666759.0Topological domainLumenal
TgeneASPHchr6:152201906chr8:62416068ENST0000054142823251_53679.6666666666666730.0Topological domainCytoplasmic
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232575_758679.6666666666666730.0Topological domainLumenal
TgeneASPHchr6:152201905chr8:62416067ENST00000379454232554_74708.6666666666666759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201905chr8:62416067ENST00000541428232554_74679.6666666666666730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000379454232554_74708.6666666666666759.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneASPHchr6:152201906chr8:62416068ENST00000541428232554_74679.6666666666666730.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>485_ESR1_152201906_ASPH_62416068_ranked_0.pdbESR1152201905152201906ENST00000541428ASPHchr862416068-
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAYEFNAAAAANAQVYGQTGLPYGPGSEAAAFG
SNGLGGFPPLNSVSPSPLMLLHPPPQLSPFLQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMKGGPGRKARCSSLMTPLST
280


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ESR1_pLDDT.png
all structure
all structure
ASPH_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ESR1
ASPH


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneESR1chr6:152201905chr8:62416067ENST00000206249+38262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000338799+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000440973+510262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000443427+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201905chr8:62416067ENST00000456483+48262_595253.33333333333334484.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000206249+38262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000338799+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000440973+510262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000443427+49262_595253.33333333333334596.0AKAP13
HgeneESR1chr6:152201906chr8:62416068ENST00000456483+48262_595253.33333333333334484.0AKAP13


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Related Drugs to ESR1-ASPH


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ESR1-ASPH


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource