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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:EZR-SNX9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: EZR-SNX9
	FusionPDB ID: 28130
	FusionGDB2.0 ID: 28130
		Hgene	Tgene
	Gene symbol	EZR	SNX9
	Gene ID	7430	51429
	Gene name	ezrin	sorting nexin 9
	Synonyms	CVIL\|CVL\|HEL-S-105\|VIL2	SDP1\|SH3PX1\|SH3PXD3A\|WISP
	Cytomap	6q25.3	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	ezrincytovillin 2epididymis secretory protein Li 105p81villin 2 (ezrin)	sorting nexin-9SH3 and PX domain-containing protein 1SH3 and PX domain-containing protein 3AWiskott-Aldrich syndrome protein (WASP) interactor protein
	Modification date	20200322	20200313
	UniProtAcc	P15311	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000476189, ENST00000367075, ENST00000337147, ENST00000392177,	ENST00000392185,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	26 X 22 X 10=5720	10 X 12 X 6=720
	# samples	32	13
	** MAII score	log2(32/5720*10)=-4.15987133677839 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: EZR [Title/Abstract] AND SNX9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	EZR(159239114)-SNX9(158317859), # samples:2 EZR(159239113)-SNX9(158317858), # samples:2
Anticipated loss of major functional domain due to fusion event.	EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. EZR-SNX9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	EZR	GO:0048015	phosphatidylinositol-mediated signaling	25591774
Hgene	EZR	GO:0051017	actin filament bundle assembly	10793131
Tgene	SNX9	GO:0043547	positive regulation of GTPase activity	15703209
Tgene	SNX9	GO:0045860	positive regulation of protein kinase activity	18388313
Tgene	SNX9	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	18353773
Tgene	SNX9	GO:0060988	lipid tube assembly	17948057
Tgene	SNX9	GO:0065003	protein-containing complex assembly	15703209
Tgene	SNX9	GO:0097320	plasma membrane tubulation	18388313

Fusion gene breakpoints across EZR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SNX9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-VP-A875-01A	EZR	chr6	159239114	-	SNX9	chr6	158317859	+
ChimerDB4	PRAD	TCGA-VP-A875	EZR	chr6	159239113	-	SNX9	chr6	158317858	+
ChimerDB4	PRAD	TCGA-VP-A875	EZR	chr6	159239114	-	SNX9	chr6	158317859	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000337147	EZR	chr6	159239114	-	ENST00000392185	SNX9	chr6	158317859	+	3873	146	62	1633	523
ENST00000392177	EZR	chr6	159239114	-	ENST00000392185	SNX9	chr6	158317859	+	3879	152	68	1639	523
ENST00000337147	EZR	chr6	159239113	-	ENST00000392185	SNX9	chr6	158317858	+	3873	146	62	1633	523
ENST00000392177	EZR	chr6	159239113	-	ENST00000392185	SNX9	chr6	158317858	+	3879	152	68	1639	523

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000337147	ENST00000392185	EZR	chr6	159239114	-	SNX9	chr6	158317859	+	0.000207048	0.999793
ENST00000392177	ENST00000392185	EZR	chr6	159239114	-	SNX9	chr6	158317859	+	0.000201655	0.99979836
ENST00000337147	ENST00000392185	EZR	chr6	159239113	-	SNX9	chr6	158317858	+	0.000207048	0.999793
ENST00000392177	ENST00000392185	EZR	chr6	159239113	-	SNX9	chr6	158317858	+	0.000201655	0.99979836

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>28130_28130_1_EZR-SNX9_EZR_chr6_159239113_ENST00000337147_SNX9_chr6_158317858_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------

>28130_28130_2_EZR-SNX9_EZR_chr6_159239113_ENST00000392177_SNX9_chr6_158317858_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------

>28130_28130_3_EZR-SNX9_EZR_chr6_159239114_ENST00000337147_SNX9_chr6_158317859_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------

>28130_28130_4_EZR-SNX9_EZR_chr6_159239114_ENST00000392177_SNX9_chr6_158317859_ENST00000392185_length(amino acids)=523AA_BP=28
MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD
DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC
VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP
VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP
KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:159239114/chr6:158317859)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
EZR P15311	.
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269\|PubMed:17881735, ECO:0000269\|PubMed:18270268, ECO:0000269\|PubMed:19111582}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SNX9

chr6:159239113

chr6:158317858

ENST00000392185

250_361

100.0

596.0

Domain

Tgene

SNX9

chr6:159239113

chr6:158317858

ENST00000392185

392_595

100.0

596.0

Domain

Note=BAR

Tgene

SNX9

chr6:159239114

chr6:158317859

ENST00000392185

250_361

100.0

596.0

Domain

Tgene

SNX9

chr6:159239114

chr6:158317859

ENST00000392185

392_595

100.0

596.0

Domain

Note=BAR

Tgene

SNX9

chr6:159239113

chr6:158317858

ENST00000392185

201_213

100.0

596.0

Region

Note=Critical for tubulation activity

Tgene

SNX9

chr6:159239114

chr6:158317859

ENST00000392185

201_213

100.0

596.0

Region

Note=Critical for tubulation activity

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EZR

chr6:159239113

chr6:158317858

ENST00000337147

2_295

4.0

587.0

Domain

FERM

Hgene

EZR

chr6:159239113

chr6:158317858

ENST00000367075

2_295

4.0

587.0

Domain

FERM

Hgene

EZR

chr6:159239114

chr6:158317859

ENST00000337147

2_295

4.0

587.0

Domain

FERM

Hgene

EZR

chr6:159239114

chr6:158317859

ENST00000367075

2_295

4.0

587.0

Domain

FERM

Hgene

EZR

chr6:159239113

chr6:158317858

ENST00000337147

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Hgene

EZR

chr6:159239113

chr6:158317858

ENST00000367075

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Hgene

EZR

chr6:159239114

chr6:158317859

ENST00000337147

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Hgene

EZR

chr6:159239114

chr6:158317859

ENST00000367075

115_120

4.0

587.0

Motif

[IL]-x-C-x-x-[DE] motif

Tgene

SNX9

chr6:159239113

chr6:158317858

ENST00000392185

1_62

100.0

596.0

Domain

SH3

Tgene

SNX9

chr6:159239114

chr6:158317859

ENST00000392185

1_62

100.0

596.0

Domain

SH3

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1120_EZR_159239114_SNX9_158317859_1120_EZR_159239114_SNX9_158317859_ranked_0.pdb	EZR	159239113	159239114	ENST00000392185	SNX9	chr6	158317859	+	MGQRLRCCWIVVFSGIEDTHQKPKMPKPVGSGNDPWSAWSASKSGNWESSEGWGAQPEGAGAQRNTNTPNNWDTAFGHPQAYQGPATGDD DDWDEDWDGPKSSSYFKDSESADAGGAQRGNSRASSSSMKIPLNKFPGFAKPGTEQYLLAKQLAKPKEKIPIIVGDYGPMWVYPTSTFDC VVADPRKGSKMYGLKSYIEYQLTPTNTNRSVNHRYKHFDWLYERLLVKFGSAIPIPSLPDKQVTGRFEEEFIKMRMERLQAWMTRMCRHP VISESEVFQQFLNFRDEKEWKTGKRKAERDELAGVMIFSTMEPEAPDLDLVEIEQKCEAVGKFTKAMDDGVKELLTVGQEHWKRCTGPLP KEYQKIGKALQSLATVFSSSGYQGETDLNDAITEAGKTYEEIASLVAEQPKKDLHFLMECNHEYKGFLGCFPDIIGTHKGAIEKVKESDK	523

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

EZR_pLDDT.png

SNX9_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

EZR

PRKAB1, HLA-B, GABARAPL2, MCC, BID, TNFRSF10B, FAS, MSN, RHOA, ARHGDIA, FADD, FASLG, MAPK8, CASP10, CASP8, TNFRSF1A, AHNAK, PPL, SPTA1, PRX, S100P, SCYL3, SLC9A3R2, NF2, EZR, PTK2, L1CAM, TSC1, PIK3R1, ICAM1, ICAM2, ICAM3, Tsc1, VCAM1, ADORA2B, IQGAP1, CLIC5, CD44, PALLD, SLC9A3R1, PRKCA, SELP, DLG1, CFTR, SELL, SDC2, SPN, CTNNB1, CDH1, PHLPP2, DCC, Cdk1, ELAVL1, WWP1, ISG15, BRCA1, RDX, ACTN1, DGKQ, ARPC3, FN1, GZMM, BAG3, MPP3, WFDC1, MDM2, MAPK10, FBXO6, ASB6, CROCC, FH, FKBP9, GNPDA1, GTF3C4, H2AFZ, HEXA, HEXB, PDCD10, PDCD6IP, UBA1, IPO5, MC1R, OGFOD1, PYGL, RIC8A, TRNT1, UBE2R2, XPNPEP1, CUL7, OBSL1, VPS11, ACAA2, AKR1B1, CALR, CLIC4, ECE2, EIF5A2, EIF5AL1, ENO1, ENO2, AURKA, GDI2, TPD52, FABP5, GPX4, HSD17B10, HSPA4, HSPA4L, HSPE1, HSPH1, ISYNA1, LCP1, OAT, P4HB, PDXK, PGD, PLS1, PLS3, PPA2, RCN1, SHMT2, STIP1, TAGLN2, TKT, TPD52L2, TXNRD2, UCHL3, WDR1, NTRK1, SCARNA22, PTTG1, PPME1, NOLC1, B4GALT7, TIMM13, Msn, EGFR, MCM2, Mdm2, U2AF2, ERBB2, MRPL12, MISP, TSPAN33, PTPRQ, SLC9A1, LASP1, DNM1L, FOXA1, TRIM25, HEY1, PRPF8, AAR2, PIH1D1, EFTUD2, SOCS2, ESR2, RUNX1, AGR2, MME, ZFP36L2, EEF2K, LSM1, MAP3K7, MGEA5, SRGAP2, COBL, IKBKAP, SVIL, MAPT, BCR, CAST, SHC1, NMT1, UTRN, ANK2, ANK3, ABR, GAB1, MTMR1, SNTB1, SEPT6, TAB1, PKN2, COBLL1, C6orf132, MPRIP, KIAA1211, CYFIP1, GPRIN1, R3HCC1L, PARG, SIRT2, PALM2, PHACTR4, ARFGAP1, ENAH, ZC3H15, SEPT8, USP47, DOCK7, ERBB2IP, PPP1R9B, EFHD1, SORBS1, EIF2A, TNKS1BP1, C1orf198, EPB41L1, SH2D4A, LZTFL1, CYLD, SH3GLB2, ARHGAP35, FARSB, PRMT7, ACTR10, DIP2B, ABCF2, SRP68, TRMT112, ASAP1, LIMCH1, AKAP2, WDR45, WASF2, RPA3, RPL32, POLDIP3, MACROD2, CASK, HGS, SEC16A, TIMM44, MYO1B, KIF5C, CTNND1, SRP72, AP2A1, ECD, PAK4, SLC25A5, HSPA1A, DDX6, EPHA2, TIE1, TRAPPC10, NUMB, NUP107, RPS13, OCRL, AKAP12, DST, NOTCH2, TCHH, FCHO2, KIAA0196, HDAC1, SCRIB, GOLGB1, KARS, RABEP1, PCBP2, TBR1, SEL1L2, FAM21A, FTSJ3, ABI1, EHBP1, NDRG1, SYAP1, FERMT2, CCDC124, CYFIP2, AHCYL2, PGAM5, TRAPPC9, FAM129B, TRIOBP, PEAK1, ELP3, PALMD, FAM207A, KLC4, LIN7C, DDX18, LYAR, ABI2, ITSN2, RAI14, FAM135A, ADD3, SWAP70, BAIAP2L1, TNIK, MYH13, MYO6, ICAM5, PACSIN2, SNX6, NCKAP1, TRAPPC1, NUMBL, DSG2, SKA2, EGLN1, PDLIM1, EIF4G3, EPB41, LRBA, AFD1, SNTB2, ITSN1, WDR44, HAUS6, FAM101B, DVL3, BCL11A, PLEKHA1, KIAA1429, ATG16L1, ACTC1, PHB, NEDD4, PODXL, GBF1, KRAS, HADHB, VDAC1, VDAC2, ABCC6, BIRC3, PARK2, PINK1, FANCD2, ORF3a, DUSP6, PTPN12, RAC1, SH2D3C, ERBB3, LRRC6, ZSWIM2, WDR37, S, USP1, CIT, ANLN, AURKB, CHMP4B, KIF14, PRNP, Arhgap28, ARHGEF15, HNRNPH1, SUMO2, NDN, NUPR1, RBM39, LGALS9, PMAIP1, CD274, DDRGK1, TP53, ACTB, SEPT9, ABLIM1, ACTN4, ATP2B1, BASP1, BSG, CCDC18, CDCA3, CORO1C, CTNNAL1, DEPDC1B, DLG5, DTNA, EFNB2, EPB41L5, FLOT2, FRS2, HNRNPA1L2, ITGB1, KIAA1549, KIAA1671, KIDINS220, LIMA1, LMO7, LSR, MARK2, MARK3, MB21D2, MYO5C, NEBL, OCLN, PALM2-AKAP2, PPFIBP1, PPP1R18, PPP1R9A, PPP6R1, PROSER2, PTPN14, RAP1GDS1, RASAL2, SH3D19, SLC12A2, SLC1A5, SLC29A1, SLC38A2, SLC39A14, SLC39A6, SLC3A2, SLC4A7, SLC6A8, SLC7A5, SNAP23, SPTAN1, STK10, VANGL1, VANGL2, YES1, YKT6, ZDHHC5, ANKRD26, ANKRD28, APBB1, APC, ARHGAP21, ARHGEF12, ATP1A1, CALD1, CDC42BPA, CTNNA1, DBN1, DIAPH3, DYNC1I2, DYNC1LI1, EFNB1, GOLGA3, H3F3A, HLA-A, IFT74, INA, IRS2, JMY, KANK2, KIF15, LPP, LUZP1, MACF1, MINK1, NBEA, PI4KA, PLEKHA5, RAPH1, REPS1, RTN1, SDCCAG3, SLAIN2, SLC6A15, STAU2, SYNJ1, TANC1, TDRD3, TJP1, nsp3, E, nsp3ab, SLC26A4-AS1, GOT1, ZNF622, TREML1, nsp11, nsp12, nsp13, nsp14, nsp16, nsp8, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
EZR
SNX9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	EZR	chr6:159239113	chr6:158317858	ENST00000337147	-	1	13	244_586	4.0	587.0	SCYL3
Hgene	EZR	chr6:159239113	chr6:158317858	ENST00000367075	-	2	14	244_586	4.0	587.0	SCYL3
Hgene	EZR	chr6:159239114	chr6:158317859	ENST00000337147	-	1	13	244_586	4.0	587.0	SCYL3
Hgene	EZR	chr6:159239114	chr6:158317859	ENST00000367075	-	2	14	244_586	4.0	587.0	SCYL3

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Related Drugs to EZR-SNX9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to EZR-SNX9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EZR	C0033578	Prostatic Neoplasms	3	CTD_human
Hgene	EZR	C0376358	Malignant neoplasm of prostate	3	CTD_human
Hgene	EZR	C0007097	Carcinoma	1	CTD_human
Hgene	EZR	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Hgene	EZR	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	EZR	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	EZR	C0027627	Neoplasm Metastasis	1	CTD_human
Hgene	EZR	C0029408	Degenerative polyarthritis	1	CTD_human
Hgene	EZR	C0086743	Osteoarthrosis Deformans	1	CTD_human
Hgene	EZR	C0205696	Anaplastic carcinoma	1	CTD_human
Hgene	EZR	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Hgene	EZR	C0205698	Undifferentiated carcinoma	1	CTD_human
Hgene	EZR	C0205699	Carcinomatosis	1	CTD_human
Hgene	EZR	C1257925	Mammary Carcinoma, Animal	1	CTD_human