UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level2
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein Structure

leaf

pLDDT scores

leaf

Ramachandran Plot of Fusion Protein Structure

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:FCHSD2-NUMA1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FCHSD2-NUMA1
FusionPDB ID: 30010
FusionGDB2.0 ID: 30010
HgeneTgene
Gene symbol

FCHSD2

NUMA1

Gene ID

9873

4926

Gene nameFCH and double SH3 domains 2nuclear mitotic apparatus protein 1
SynonymsNWK|NWK1|SH3MD3NMP-22|NUMA
Cytomap

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1nuclear mitotic apparatus protein 1SP-H antigencentrophilin stabilizes mitotic spindle in mitotic cellsnuclear matrix protein-22structural nuclear protein
Modification date2020031320200313
UniProtAcc

O94868

Q14980

Ensembl transtripts involved in fusion geneENST idsENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000409853, 
ENST00000458644, ENST00000409263, 
ENST00000543450, ENST00000351960, 
ENST00000358965, ENST00000393695, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score43 X 26 X 16=1788816 X 15 X 4=960
# samples 5916
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/960*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FCHSD2 [Title/Abstract] AND NUMA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FCHSD2(72600874)-NUMA1(71717309), # samples:2
Anticipated loss of major functional domain due to fusion event.FCHSD2-NUMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FCHSD2-NUMA1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNUMA1

GO:0000132

establishment of mitotic spindle orientation

21816348

TgeneNUMA1

GO:0030953

astral microtubule organization

12445386

TgeneNUMA1

GO:0060236

regulation of mitotic spindle organization

26195665

TgeneNUMA1

GO:1902365

positive regulation of protein localization to spindle pole body

16076287


check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUMA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CQ-5323-01AFCHSD2chr11

72600874

-NUMA1chr11

71717309

-
ChimerDB4HNSCTCGA-CQ-5323FCHSD2chr11

72600874

-NUMA1chr11

71717309

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311172FCHSD2chr1172600874-ENST00000351960NUMA1chr1171717309-266011121251996623
ENST00000311172FCHSD2chr1172600874-ENST00000358965NUMA1chr1171717309-266011121251996623
ENST00000311172FCHSD2chr1172600874-ENST00000393695NUMA1chr1171717309-266011121251996623
ENST00000409314FCHSD2chr1172600874-ENST00000351960NUMA1chr1171717309-283012821692166665
ENST00000409314FCHSD2chr1172600874-ENST00000358965NUMA1chr1171717309-283012821692166665
ENST00000409314FCHSD2chr1172600874-ENST00000393695NUMA1chr1171717309-283012821692166665
ENST00000409418FCHSD2chr1172600874-ENST00000351960NUMA1chr1171717309-297314253842309641
ENST00000409418FCHSD2chr1172600874-ENST00000358965NUMA1chr1171717309-297314253842309641
ENST00000409418FCHSD2chr1172600874-ENST00000393695NUMA1chr1171717309-297314253842309641
ENST00000458644FCHSD2chr1172600874-ENST00000351960NUMA1chr1171717309-255210042901888532
ENST00000458644FCHSD2chr1172600874-ENST00000358965NUMA1chr1171717309-255210042901888532
ENST00000458644FCHSD2chr1172600874-ENST00000393695NUMA1chr1171717309-255210042901888532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311172ENST00000351960FCHSD2chr1172600874-NUMA1chr1171717309-0.0140798620.98592013
ENST00000311172ENST00000358965FCHSD2chr1172600874-NUMA1chr1171717309-0.0140798620.98592013
ENST00000311172ENST00000393695FCHSD2chr1172600874-NUMA1chr1171717309-0.0140798620.98592013
ENST00000409314ENST00000351960FCHSD2chr1172600874-NUMA1chr1171717309-0.0085616170.9914384
ENST00000409314ENST00000358965FCHSD2chr1172600874-NUMA1chr1171717309-0.0085616170.9914384
ENST00000409314ENST00000393695FCHSD2chr1172600874-NUMA1chr1171717309-0.0085616170.9914384
ENST00000409418ENST00000351960FCHSD2chr1172600874-NUMA1chr1171717309-0.0137959410.986204
ENST00000409418ENST00000358965FCHSD2chr1172600874-NUMA1chr1171717309-0.0137959410.986204
ENST00000409418ENST00000393695FCHSD2chr1172600874-NUMA1chr1171717309-0.0137959410.986204
ENST00000458644ENST00000351960FCHSD2chr1172600874-NUMA1chr1171717309-0.025715170.9742848
ENST00000458644ENST00000358965FCHSD2chr1172600874-NUMA1chr1171717309-0.025715170.9742848
ENST00000458644ENST00000393695FCHSD2chr1172600874-NUMA1chr1171717309-0.025715170.9742848

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30010_30010_1_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000311172_NUMA1_chr11_71717309_ENST00000351960_length(amino acids)=623AA_BP=329
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATS
STQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLES
RPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQK

--------------------------------------------------------------

>30010_30010_2_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000311172_NUMA1_chr11_71717309_ENST00000358965_length(amino acids)=623AA_BP=329
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATS
STQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLES
RPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQK

--------------------------------------------------------------

>30010_30010_3_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000311172_NUMA1_chr11_71717309_ENST00000393695_length(amino acids)=623AA_BP=329
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATS
STQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLES
RPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQK

--------------------------------------------------------------

>30010_30010_4_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409314_NUMA1_chr11_71717309_ENST00000351960_length(amino acids)=665AA_BP=0
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVA
REHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN
SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRV
SLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNT

--------------------------------------------------------------

>30010_30010_5_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409314_NUMA1_chr11_71717309_ENST00000358965_length(amino acids)=665AA_BP=0
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVA
REHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN
SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRV
SLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNT

--------------------------------------------------------------

>30010_30010_6_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409314_NUMA1_chr11_71717309_ENST00000393695_length(amino acids)=665AA_BP=0
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVA
REHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRN
SFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRV
SLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNT

--------------------------------------------------------------

>30010_30010_7_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409418_NUMA1_chr11_71717309_ENST00000351960_length(amino acids)=641AA_BP=347
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSS
FYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQ
QRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPM
TPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATAAAIG

--------------------------------------------------------------

>30010_30010_8_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409418_NUMA1_chr11_71717309_ENST00000358965_length(amino acids)=641AA_BP=347
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSS
FYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQ
QRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPM
TPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATAAAIG

--------------------------------------------------------------

>30010_30010_9_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000409418_NUMA1_chr11_71717309_ENST00000393695_length(amino acids)=641AA_BP=347
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSS
FYSTRSAPASQASLRATSSTQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQ
QRNRVCPPHLKTCYPLESRPSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPM
TPRDRHEGRKQSTTEAQKKAAPASTKQADRRQSMAFSILNTPKKLGNSLLRRGASKKALSKASPNTRSGTRRSPRIATTTASAATAAAIG

--------------------------------------------------------------

>30010_30010_10_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000458644_NUMA1_chr11_71717309_ENST00000351960_length(amino acids)=532AA_BP=1
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAA
QLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSS
TQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESR
PSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKK

--------------------------------------------------------------

>30010_30010_11_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000458644_NUMA1_chr11_71717309_ENST00000358965_length(amino acids)=532AA_BP=1
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAA
QLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSS
TQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESR
PSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKK

--------------------------------------------------------------

>30010_30010_12_FCHSD2-NUMA1_FCHSD2_chr11_72600874_ENST00000458644_NUMA1_chr11_71717309_ENST00000393695_length(amino acids)=532AA_BP=1
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAA
QLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRKLDVEEPDSANSSFYSTRSAPASQASLRATSS
TQSLARLGSPDYGNSALLSLPGYRPTTRSSARRSQAGVSSGAPPGRNSFYMGTCQDEPEQLDDWNRIAELQQRNRVCPPHLKTCYPLESR
PSLSLGTITDEEMKTGDPQETLRRASMQPIQIAEGTGITTRQQRKRVSLEPHQGPGTPESKKATSCFPRPMTPRDRHEGRKQSTTEAQKK

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72600874/chr11:71717309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FCHSD2

O94868

NUMA1

Q14980

FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.FUNCTION: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q7G0, ECO:0000269|PubMed:11163243, ECO:0000269|PubMed:11229403, ECO:0000269|PubMed:11956313, ECO:0000269|PubMed:12445386, ECO:0000269|PubMed:16076287, ECO:0000269|PubMed:17172455, ECO:0000269|PubMed:19255246, ECO:0000269|PubMed:22327364, ECO:0000269|PubMed:23027904, ECO:0000269|PubMed:23870127, ECO:0000269|PubMed:23921553, ECO:0000269|PubMed:24109598, ECO:0000269|PubMed:24371089, ECO:0000269|PubMed:24996901, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26195665, ECO:0000269|PubMed:26765568, ECO:0000269|PubMed:27462074, ECO:0000269|PubMed:7769006, ECO:0000305|PubMed:10075938, ECO:0000305|PubMed:21816348}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000311172-10198_282291.0685.0DomainF-BAR
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409418-11208_282347.0741.0DomainF-BAR
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409853-11168_282291.0516.0DomainF-BAR
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271984_19891807.02102.0MotifNuclear localization signal
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271984_19891821.02116.0MotifNuclear localization signal
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271882_19851807.02102.0RegionTubulin-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271892_19261807.02102.0RegionGPSM2-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271981_20601807.02102.0RegionMembrane-binding domain 2
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271882_19851821.02116.0RegionTubulin-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271892_19261821.02116.0RegionGPSM2-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271981_20601821.02116.0RegionMembrane-binding domain 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000311172-1019356_397291.0685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409418-1120356_397347.0741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409853-1116356_397291.0516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000311172-1019718_721291.0685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409418-1120718_721347.0741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409853-1116718_721291.0516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000311172-1019469_530291.0685.0DomainSH3 1
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409418-1120469_530347.0741.0DomainSH3 1
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409853-1116469_530291.0516.0DomainSH3 1
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000311172-1019567_629291.0685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409418-1120567_629347.0741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72600874chr11:71717309ENST00000409853-1116567_629291.0516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneNUMA1chr11:72600874chr11:71717309ENST000003589652027213_16991807.02102.0Coiled coilOntology_term=ECO:0000255
TgeneNUMA1chr11:72600874chr11:71717309ENST000003936952027213_16991821.02116.0Coiled coilOntology_term=ECO:0000255
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271742_17481807.02102.0MotifTankyrase-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271742_17481821.02116.0MotifTankyrase-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271699_18761807.02102.0RegionMembrane-binding domain 1
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271700_21151807.02102.0RegionNote=Tail (Globular)
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271788_18101807.02102.0Region4.1-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000035896520271_2121807.02102.0RegionNote=Head (Globular)
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271699_18761821.02116.0RegionMembrane-binding domain 1
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271700_21151821.02116.0RegionNote=Tail (Globular)
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271788_18101821.02116.0Region4.1-binding domain
TgeneNUMA1chr11:72600874chr11:71717309ENST0000039369520271_2121821.02116.0RegionNote=Head (Globular)


Top

Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


Top

pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FCHSD2_pLDDT.png
all structure
all structure
NUMA1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


Top

Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUMA1EPB41, EPB41L1, YEATS4, GPSM2, TNKS, ACTR1A, SMC1A, SMC3, EPB41L2, NCOA6, PIM1, RPAP1, NPM1, BANF1, tat, HDAC5, Ranbp2, SMARCAD1, SIRT7, TERF1, TERF2IP, TERF2, CDK2, EMILIN1, RAE1, NUP98, DYNLL1, NCSTN, DDB1, ESR1, ECT2, MDC1, TP53BP1, SMURF1, VCP, HSP90AB1, HSP90AA1, CDK6, CBX6, KIAA0101, CCDC57, LMNA, YWHAQ, RPA3, RPA2, RPA1, ERG, LGR4, BRAP, DVL1, DVL2, DVL3, GMCL1, ENO1, MOV10, NXF1, BRCA1, CUL7, OBSL1, CCDC8, EZH2, SUZ12, EED, RNF2, BMI1, SUMO2, ABCE1, WDR83, GPSM1, EPB41L3, BRD4, EIF3H, CDC73, EIF3E, EIF3I, EIF3L, RPS13, SRRM1, RPL35A, RTF1, RUVBL1, ZC3H18, NTRK1, SCARNA22, PTTG1, IFI16, SSX2IP, CRK, MATR3, KIF20A, MPHOSPH8, CBX8, PAPD5, ASPM, Cbx1, Tnks, Srp72, Tnks2, DYNC1H1, KPNB1, FAM175B, BRCC3, U2AF2, SCOC, TCP10L, PDHA1, YAP1, TXNIP, MED12, CTNNB1, TCF7L2, EFTUD2, CHD3, CHD4, AGR2, MYC, CDK9, WDR76, HIST1H4A, HIST1H2BB, HIST1H2AB, HIST1H3A, KIAA1429, ACTC1, Bach1, CCND1, NR2C2, PPP1CC, ZFYVE21, XRCC6, DCAF15, BMH1, BMH2, ALYREF, SCARB2, FUS, EWSR1, TAF15, HMGB1, LRWD1, BIRC3, STAU1, WWP2, TRIM28, PLEKHA4, PINK1, WHSC1, FANCD2, GOLGA6L2, HIST1H1A, EIF5B, LYPLA2, NPR2, DDX10, LRRFIP1, RIBC1, HELZ2, MACF1, SDR42E2, VPS4B, MLYCD, LRPAP1, MMEL1, ZFYVE27, DMBX1, BIRC6, TLN1, PHIP, ORF14, LRRC31, CIT, ANLN, CHMP4B, KIF14, PRC1, PYHIN1, DEPDC1B, ARHGAP44, ARHGEF1, LRRC59, NDN, NUPR1, RBM39, nsp2, APEX1, ASF1A, HIST1H2BG, UBC, NAA40, ZBTB2, KRT4, KRT75, KRT72, KRT78, KXD1, TCP10, BTF3, EP300, FBXW7, nsp15, CCNB1, KPNA2, CCNF, TAX1BP1, SIRT6, YY1, PIGR, BRD2, BRD3, BRDT,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FCHSD2
NUMA1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to FCHSD2-NUMA1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to FCHSD2-NUMA1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUMA1C0023487Acute Promyelocytic Leukemia1CTD_human;ORPHANET
TgeneNUMA1C0162820Dermatitis, Allergic Contact1CTD_human