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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FGFR1OP-FGFR1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FGFR1OP-FGFR1
	FusionPDB ID: 30258
	FusionGDB2.0 ID: 30258
		Hgene	Tgene
	Gene symbol	FGFR1OP	FGFR1
	Gene ID	11116	2260
	Gene name	centrosomal protein 43	fibroblast growth factor receptor 1
	Synonyms	FGFR1OP\|FOP	BFGFR\|CD331\|CEK\|ECCL\|FGFBR\|FGFR-1\|FLG\|FLT-2\|FLT2\|HBGFR\|HH2\|HRTFDS\|KAL2\|N-SAM\|OGD\|bFGF-R-1
	Cytomap	6q27	8p11.23
	Type of gene	protein-coding	protein-coding
	Description	FGFR1 oncogene partnerfibroblast growth factor receptor 1 oncogene partner	fibroblast growth factor receptor 1FGFR1/PLAG1 fusionFMS-like tyrosine kinase 2basic fibroblast growth factor receptor 1fms-related tyrosine kinase 2heparin-binding growth factor receptorhydroxyaryl-protein kinaseproto-oncogene c-Fgr
	Modification date	20200313	20200329
	UniProtAcc	Q9NVK5	Q9NVK5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000349556, ENST00000366847, ENST00000476078,	ENST00000496629, ENST00000326324, ENST00000335922, ENST00000341462, ENST00000356207, ENST00000397091, ENST00000397103, ENST00000397108, ENST00000397113, ENST00000425967, ENST00000447712, ENST00000532791,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 9 X 5=315	25 X 34 X 7=5950
	# samples	6	22
	** MAII score	log2(6/315*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/5950*10)=-4.75731423955801 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FGFR1OP [Title/Abstract] AND FGFR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FGFR1OP	GO:0006469	negative regulation of protein kinase activity	17888034
Hgene	FGFR1OP	GO:0008284	positive regulation of cell proliferation	17888034
Hgene	FGFR1OP	GO:0030307	positive regulation of cell growth	17888034
Hgene	FGFR1OP	GO:0030335	positive regulation of cell migration	17888034
Tgene	FGFR1	GO:0008284	positive regulation of cell proliferation	8663044
Tgene	FGFR1	GO:0008543	fibroblast growth factor receptor signaling pathway	8663044
Tgene	FGFR1	GO:0010863	positive regulation of phospholipase C activity	18480409
Tgene	FGFR1	GO:0018108	peptidyl-tyrosine phosphorylation	8622701\|18480409
Tgene	FGFR1	GO:0043406	positive regulation of MAP kinase activity	8622701\|18480409
Tgene	FGFR1	GO:0046777	protein autophosphorylation	8622701
Tgene	FGFR1	GO:2000546	positive regulation of endothelial cell chemotaxis to fibroblast growth factor	21885851

Fusion gene breakpoints across FGFR1OP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FGFR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	FGFR1OP	chr6	167417889	+	FGFR1	chr8	38275891	-
ChimerKB4	.	.	FGFR1OP	chr6	167426995	+	FGFR1	chr8	167426995	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000425967	FGFR1	chr8	38275891	-	4344	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000397091	FGFR1	chr8	38275891	-	4344	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000447712	FGFR1	chr8	38275891	-	4343	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000341462	FGFR1	chr8	38275891	-	4343	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000532791	FGFR1	chr8	38275891	-	4251	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000397113	FGFR1	chr8	38275891	-	2754	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000356207	FGFR1	chr8	38275891	-	2752	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000335922	FGFR1	chr8	38275891	-	2751	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000326324	FGFR1	chr8	38275891	-	2750	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000397103	FGFR1	chr8	38275891	-	2548	669	213	1853	546
ENST00000366847	FGFR1OP	chr6	167417889	+	ENST00000397108	FGFR1	chr8	38275891	-	1960	669	213	1853	546
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000425967	FGFR1	chr8	38275891	-	4118	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000397091	FGFR1	chr8	38275891	-	4118	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000447712	FGFR1	chr8	38275891	-	4117	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000341462	FGFR1	chr8	38275891	-	4117	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000532791	FGFR1	chr8	38275891	-	4025	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000397113	FGFR1	chr8	38275891	-	2528	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000356207	FGFR1	chr8	38275891	-	2526	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000335922	FGFR1	chr8	38275891	-	2525	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000326324	FGFR1	chr8	38275891	-	2524	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000397103	FGFR1	chr8	38275891	-	2322	443	5	1627	540
ENST00000349556	FGFR1OP	chr6	167417889	+	ENST00000397108	FGFR1	chr8	38275891	-	1734	443	5	1627	540

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30258_30258_1_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000326324_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_2_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000335922_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_3_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000341462_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_4_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000356207_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_5_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000397091_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_6_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000397103_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_7_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000397108_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_8_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000397113_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_9_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000425967_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_10_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000447712_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_11_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000349556_FGFR1_chr8_38275891_ENST00000532791_length(amino acids)=540AA_BP=146
MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFT
LAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSE
YELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACT
QDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADF
GLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM
MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

--------------------------------------------------------------

>30258_30258_12_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000326324_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_13_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000335922_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_14_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000341462_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_15_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000356207_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_16_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000397091_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_17_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000397103_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_18_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000397108_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_19_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000397113_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_20_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000425967_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_21_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000447712_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

>30258_30258_22_FGFR1OP-FGFR1_FGFR1OP_chr6_167417889_ENST00000366847_FGFR1_chr8_38275891_ENST00000532791_length(amino acids)=546AA_BP=152
MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQF
FNLDFTLAVFQPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSADSSASMNSGVLLVRPSRLSSSGTPM
LAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN
LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT
NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLAN

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:/chr8:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FGFR1OP Q9NVK5	FGFR1 Q9NVK5
FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.	FUNCTION: May be involved in wound healing pathway. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (376) >>>376.pdbFusion protein BP residue: 146 CIF file (376) >>>376.cif	FGFR1OP	chr6	167417889	+	FGFR1	chr8	38275891	-	MAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLALEEQEK VENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVFQPETST LQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTTGEVSAD SSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGK PLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEM EMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVT EDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSD VWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMM MRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPD	540
3D view using mol* of 376 (AA BP:146)


PDB file (385) >>>385.pdbFusion protein BP residue: 152 CIF file (385) >>>385.cif	FGFR1OP	chr6	167417889	+	FGFR1	chr8	38275891	-	MSWRSKMAATAAAVVAEEDTELRDLLVQTLENSGVLNRIKAELRAAVFLA LEEQEKVENKTPLVNESLKKFLNTKDGRLVASLVAEFLQFFNLDFTLAVF QPETSTLQGLEGRENLARDLGIIEAEGTVGGPLLLEVIRRCQQKEKGPTT GEVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRD RLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLS DLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQAR RPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAA RNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCT NELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQY	546
3D view using mol* of 385 (AA BP:152)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FGFR1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FGFR1OP_FGFR1_376_pLDDT.png (AA BP:146)

FGFR1OP_FGFR1_376_pLDDT_and_active_sites.png (AA BP:146)

FGFR1OP_FGFR1_376_violinplot.png (AA BP:146)

FGFR1OP_FGFR1_385_pLDDT.png (AA BP:152)

FGFR1OP_FGFR1_385_pLDDT_and_active_sites.png (AA BP:152)

FGFR1OP_FGFR1_385_violinplot.png (AA BP:152)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

FGFR1OP_FGFR1_376.png

FGFR1OP_FGFR1_385.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
376	0.9232	4234	1.0344	2337.545	0.7157	0.4259	0.3779	0.2533	0.4942	0.5126	1.0926	Chain A: 9,11,12,13,14,15,16,17,18,19,21,22,25,26, 28,30,31,32,33,34,35,36,37,38,39,40,41,42,43,45,46 ,47,48,49,50,52,53,54,55,56,57,58,59,60,62,63,64,6 5,66,67,69,71,72,73,74,75,78,81,82,86,87,88,89,90, 91,92,93,94,95,96,97,98,99,100,101,102,103,105,155 ,156,157,158,159,160,162,181,183,184,185,186,187,1 88,189,190,191,192,193,194,195,196,197,198,200,202 ,203,204,205,206,207,208,209,210,212,216,217,218,2 19,220,221,223,224,225,226,227,228,229,230,232,233 ,234,235,237,238,239,240,241,242,243,244,245,246,2 47,248,249,250,251,252,253,254,255,256,257,258,260 ,263,264,265,266,267,268,269,270,271,272,275,276,2 79,280,281,282,283,284,285,286,288,289,290,292,293 ,294,304,305,306,310,331,335,336,337,340,341,343,3 45,346,348,350,351,352,354,356,358,359,360,361,362 ,364,365,367,368,369,370,371,372,373,374,375,376,3 77,378,379,380,381,382,383,384,385,387,388,390,391 ,392,393,394,395,396,398,403,417,418,423,424,428,4 31,432,434,435,436,438,439,445,448,449,452,453,455 ,456,457,458,459,462
385	1.027	419	1.045	1086.281	0.556	0.736	0.926	0.734	1.034	0.71	0.672	Chain A: 24,27,28,31,32,37,40,208,209,211,212,213, 214,215,216,236,238,239,240,247,248,251,252,254,25 5,259,269,285,286,287,288,289,291,292,346,347,351, 352,354,364,365,366,367,368,370,374,375,376,377,37 8,379,380,381,382,383,384,385,386,387,388,389,390, 391,396,397,399,400,401,430

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
FGFR1	FDPS, FRS3, NCAM1, FGF1, FGFR1, FRS2, PLCG1, FGF2, SHB, GRB14, BNIP2, KPNB1, CREBBP, STAT3, JAK2, SRC, NEDD4, PPP2R1B, FGF23, PTK6, ITK, NCK1, VAV1, HSP90AA1, ERBB3, CTPS2, CDK9, RPS6KA3, CDC20, TSPAN3, CEACAM21, IL20RB, LGALS8, TGFBR2, GINM1, DLK1, LTBR, TNFRSF10B, EVI2A, MREG, HEPACAM2, GOLGA7B, LDLRAD4, CRK, CTNNB1, CDH1, FGF8, SOS1, PIK3R1, PKM, FGF3, FGF5, FGF6, FGF9, FGF10, FGF17, CD44, RPS6KA1, SLA, PIK3R2, SH3BP2, NCK2, TENC1, RTN1, RTN3, PVRL1, EPHA4, YES1, L1CAM, TNK2, AKT1, PDP1, FGFR2, FAM8A1, TMEM30B, LRRN2, LITAF, C16orf58, ZDHHC11, IFNGR1, GAD1, FCGRT, IL27RA, RAET1E, SLC1A1, C14orf37, MANSC1, TPCN2, CD79B, SCN3B, C19orf45, HTR1A, FLRT1, KAL1, RASA1, CDH2, ZMYM2, FGF4, OPCML, SHC1, S100B, AGER, KLB, CDH11, TGFBR3, PTPN1, IL17RD, FBXO7, CRKL, RPN1, STOML2, DDOST, CANX, LMAN2, TMED9, RCN2, HSPA6, CDC37, HSPA2, ACTG1, ACTA1, PARD3, PGRMC1, PHGDH, ATP5B, VDAC1, VDAC2, SLC25A6, RUVBL2, RPA1, PLCG2, RAP1A, PHB, RAB1A, RAB5A, RAB8A, RAB4A, RAB14, RAB15, ARF4, RAB2B, RAB9A, COPA, SEC22B, TMEM109, STX12, CLPTM1, HSPA1L, DNAJC13, DNAJB1, TUBB4A, TUBA4A, AFAP1, TUBA1B, MTCH1, BAX, IMMT, GNB1, RAB7A, RAB11B, GAB1, PTPN11, RXRA, RARA, Nr4a2, H3F3A, Nr4a1, TH, UBC, SHE, Il17rd, PDGFRB, MFHAS1, PDK1, HEXIM1, LARP7, GNAI1, RIN1, ITGB3, KIAA1429, ERBB2, APEX1, ORF3a, ORF3b, CORO1C, HSP90AB3P, HSP90AB1, BAG2, MRPS7, MRPS31, MRPS14, P4HB, CDK1, HPX, ATP5O, LIMA1, TMOD3, CORO1B, ACTB, PLEC, RPL22L1, PPM1B, TBL2, DIMT1, SPATS2L, FARSB, HSD17B10, NUFIP2, TRMT10C, SND1, OBSCN, AIMP2, RARS, SRP19, POLRMT, MRPS2, MRPS26, BOLA2, ARGLU1, PFKFB3, MRPS6, CFL1, MRPS33, RPL22, KCTD5, HSPD1, EGFR, HULC, LDHA, MKRN2, DDX58, MLC1, IL3RA, IL32, AQP9, KCNE3, UGT1A7, GJA8, CLEC4A, AVPR1B, DEFB135, RNF149, C7orf34, EPB41L4A, CRLF2, DEFB109P1B, TBXA2R, NRSN1, OR1M1, IFNAR1, SYT2, CDH16, FBXO2, TSHR, MFI2, BCAN, CSNK1G2, CDHR4, CTSG, C1QTNF9B, PCDHA8, IZUMO1, CD8B, SFTPC, GREM2, DHFRL1, CD83, KCNC3, ANK1, PTPRN2, TMEM59, PCDHB7, P2RX4,
FGFR1OP	PPP2CA, PPP2CB, PPP2R1A, Cep350, FGFR1OP, PACS1, Fgfr1op, CEP350, NAGK, WRNIP1, ABL1, BRCA1, VASP, CEP19, POTEI, MSL3, PPP2R3C, KIAA0753, CCDC14, MED4, CEP290, OFD1, PCM1, CEP120, CEP152, ADSL, AKAP1, AKAP11, ANKHD1-EIF4EBP3, ANKRD17, BCL10, TMEM256, CC2D1A, COPS4, CRYBG3, CTTNBP2NL, DNM2, ENAH, EXOC4, GPATCH1, GPS1, HAUS8, KLC1, KLC2, KLC4, LRRC16A, LRRC47, MOB4, MRE11A, NAV1, NCOR1, NR3C1, PLK1, RAB11FIP1, RAB2A, RAB3IP, RAD50, RIPK2, RPAP2, SAV1, SLFN11, SNX30, SPATS2, SPATS2L, SRA1, SRSF2, STK3, STK4, TAF12, TXLNA, UNC45A, WDR83, CEP128, CEP135, CEP44, CEP63, CEP89, NINL, NIN, ODF2, SCLT1, SASS6, KIAA1244, XPO1, AES, BTF3, CTSC, ETF1, GNS, SP110, INPP5B, KIFC3, LAMB1, LYN, PRKACB, PRKAR2A, TTC3, DLG5, CEP170, AKAP9, RBM5, PIBF1, MAPRE1, HPS5, COBLL1, CEP131, TTLL5, N4BP3, SYNM, GOLIM4, PIK3R4, ASCC1, NCKIPSD, CCHCR1, ELP3, CEP72, CDK5RAP2, MIB1, KIAA1328, UPF3A, CSPP1, CEP78, CCDC77, CEP295, C19orf52, TBC1D31, ESCO1, SSX2IP, FOPNL, TATDN3, B3GALTL, SPICE1, CCDC138, WDR90, RABL3, CCDC18, CCDC61, Cep131, Prkacb, Prkar2a, Ppp2r1a, Lrrcc1, Ankrd26, Cep135, C7orf69, LINC01587, AIPL1, MIOS, PDE5A, BLM, SUPT5H, WDR24, PATZ1, FKBP15, HNRNPL, S100A6, RABL2B, IFT88, IFT81, IFT57, GSK3B, nsp13, SQSTM1, ORF50, SLC16A1, nsp9, nsp13ab, OGT, GOLGA1, MAPRE3, SYNE3, KRT2, TRIM52, PRKAR1B, RNF10, PIP, CDC16, DISC1, RABL2A, RITA1, DUSP16, WHAMMP3, CCDC96, P4HA3, PEX5, YES1, PPP2R1B, TADA2B, SYMPK, CSTF3, RHOA, LETM1, SPECC1L, FBXO32,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FGFR1OP
FGFR1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FGFR1OP-FGFR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FGFR1OP-FGFR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
FGFR1OP	FGFR1	Breast Invasive Ductal Carcinoma	MyCancerGenome
FGFR1OP	FGFR1	Colon Adenocarcinoma	MyCancerGenome
FGFR1OP	FGFR1	Dysembryoplastic Neuroepithelial Tumor	MyCancerGenome
FGFR1OP	FGFR1	High Grade Ovarian Serous Adenocarcinoma	MyCancerGenome
FGFR1OP	FGFR1	Invasive Breast Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	FGFR1	C1563720	Kallmann Syndrome 2 (disorder)	18	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C1845146	Holoprosencephaly, Ectrodactyly, and Bilateral Cleft Lip-Palate	6	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0011570	Mental Depression	5	PSYGENET
Tgene	FGFR1	C0011581	Depressive disorder	5	CTD_human;PSYGENET
Tgene	FGFR1	C0220658	Pfeiffer Syndrome	5	GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C0432283	Osteoglophonic dwarfism	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0041696	Unipolar Depression	4	CTD_human;PSYGENET
Tgene	FGFR1	C0406612	Encephalocraniocutaneous lipomatosis	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	FGFR1	C0005586	Bipolar Disorder	3	PSYGENET
Tgene	FGFR1	C0795998	JACKSON-WEISS SYNDROME	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C1269683	Major Depressive Disorder	3	PSYGENET
Tgene	FGFR1	C0006142	Malignant neoplasm of breast	2	CGI;CTD_human
Tgene	FGFR1	C0007131	Non-Small Cell Lung Carcinoma	2	CTD_human
Tgene	FGFR1	C0007137	Squamous cell carcinoma	2	CTD_human
Tgene	FGFR1	C0027022	Myeloproliferative disease	2	CTD_human
Tgene	FGFR1	C0162809	Kallmann Syndrome	2	CTD_human;ORPHANET
Tgene	FGFR1	C0432122	Interfrontal craniofaciosynostosis	2	GENOMICS_ENGLAND;UNIPROT
Tgene	FGFR1	C0678222	Breast Carcinoma	2	CGI;CTD_human
Tgene	FGFR1	C1257931	Mammary Neoplasms, Human	2	CTD_human
Tgene	FGFR1	C1458155	Mammary Neoplasms	2	CTD_human
Tgene	FGFR1	C4704874	Mammary Carcinoma, Human	2	CTD_human
Tgene	FGFR1	C0004114	Astrocytoma	1	CTD_human
Tgene	FGFR1	C0008924	Cleft upper lip	1	CTD_human
Tgene	FGFR1	C0008925	Cleft Palate	1	CTD_human
Tgene	FGFR1	C0010278	Craniosynostosis	1	CTD_human;GENOMICS_ENGLAND
Tgene	FGFR1	C0011573	Endogenous depression	1	CTD_human
Tgene	FGFR1	C0017638	Glioma	1	CTD_human
Tgene	FGFR1	C0018824	Heart valve disease	1	CTD_human
Tgene	FGFR1	C0024121	Lung Neoplasms	1	CTD_human
Tgene	FGFR1	C0025193	Melancholia	1	CTD_human
Tgene	FGFR1	C0036341	Schizophrenia	1	CTD_human
Tgene	FGFR1	C0085682	Hypophosphatemia	1	GENOMICS_ENGLAND
Tgene	FGFR1	C0086133	Depressive Syndrome	1	CTD_human
Tgene	FGFR1	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	FGFR1	C0205768	Subependymal Giant Cell Astrocytoma	1	CTD_human
Tgene	FGFR1	C0206726	gliosarcoma	1	ORPHANET
Tgene	FGFR1	C0242379	Malignant neoplasm of lung	1	CTD_human
Tgene	FGFR1	C0259783	mixed gliomas	1	CTD_human
Tgene	FGFR1	C0265535	Trigonocephaly	1	CTD_human;ORPHANET
Tgene	FGFR1	C0280783	Juvenile Pilocytic Astrocytoma	1	CTD_human
Tgene	FGFR1	C0280785	Diffuse Astrocytoma	1	CTD_human
Tgene	FGFR1	C0282126	Depression, Neurotic	1	CTD_human
Tgene	FGFR1	C0334579	Anaplastic astrocytoma	1	CTD_human
Tgene	FGFR1	C0334580	Protoplasmic astrocytoma	1	CTD_human
Tgene	FGFR1	C0334581	Gemistocytic astrocytoma	1	CTD_human
Tgene	FGFR1	C0334582	Fibrillary Astrocytoma	1	CTD_human
Tgene	FGFR1	C0334583	Pilocytic Astrocytoma	1	CTD_human
Tgene	FGFR1	C0334588	Giant Cell Glioblastoma	1	ORPHANET
Tgene	FGFR1	C0338070	Childhood Cerebral Astrocytoma	1	CTD_human
Tgene	FGFR1	C0338503	Septo-Optic Dysplasia	1	ORPHANET
Tgene	FGFR1	C0342384	Idiopathic hypogonadotropic hypogonadism	1	GENOMICS_ENGLAND
Tgene	FGFR1	C0376634	Craniofacial Abnormalities	1	CTD_human
Tgene	FGFR1	C0431362	Lobar Holoprosencephaly	1	ORPHANET
Tgene	FGFR1	C0547065	Mixed oligoastrocytoma	1	CTD_human
Tgene	FGFR1	C0555198	Malignant Glioma	1	CTD_human
Tgene	FGFR1	C0750935	Cerebral Astrocytoma	1	CTD_human
Tgene	FGFR1	C0750936	Intracranial Astrocytoma	1	CTD_human
Tgene	FGFR1	C0751617	Semilobar Holoprosencephaly	1	ORPHANET
Tgene	FGFR1	C1519086	Pilomyxoid astrocytoma	1	ORPHANET
Tgene	FGFR1	C1704230	Grade I Astrocytoma	1	CTD_human
Tgene	FGFR1	C1837218	Cleft palate, isolated	1	CTD_human
Tgene	FGFR1	C1852406	Cutis Gyrata Syndrome of Beare And Stevenson	1	GENOMICS_ENGLAND
Tgene	FGFR1	C2931196	Craniofacial dysostosis type 1	1	GENOMICS_ENGLAND
Tgene	FGFR1	C3150773	CHROMOSOME 8p11 MYELOPROLIFERATIVE SYNDROME	1	ORPHANET