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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FN1-ALK

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FN1-ALK
	FusionPDB ID: 30790
	FusionGDB2.0 ID: 30790
		Hgene	Tgene
	Gene symbol	FN1	ALK
	Gene ID	2335	238
	Gene name	fibronectin 1	ALK receptor tyrosine kinase
	Synonyms	CIG\|ED-B\|FINC\|FN\|FNZ\|GFND\|GFND2\|LETS\|MSF\|SMDCF	CD246\|NBLST3
	Cytomap	2q35	2p23.2-p23.1
	Type of gene	protein-coding	protein-coding
	Description	fibronectincold-insoluble globulinepididymis secretory sperm binding proteinmigration-stimulating factor	ALK tyrosine kinase receptorCD246 antigenanaplastic lymphoma receptor tyrosine kinasemutant anaplastic lymphoma kinase
	Modification date	20200329	20200329
	UniProtAcc	P02751	Q96BT7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000323926, ENST00000336916, ENST00000345488, ENST00000346544, ENST00000354785, ENST00000356005, ENST00000357009, ENST00000357867, ENST00000359671, ENST00000421182, ENST00000432072, ENST00000443816, ENST00000446046, ENST00000426059, ENST00000490833,	ENST00000431873, ENST00000498037, ENST00000389048,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	47 X 49 X 13=29939	56 X 74 X 20=82880
	# samples	48	57
	** MAII score	log2(48/29939*10)=-5.96284781832542 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(57/82880*10)=-7.18391827352181 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FN1 [Title/Abstract] AND ALK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	FN1-ALK seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. FN1-ALK seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. FN1-ALK seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FN1	GO:0001932	regulation of protein phosphorylation	11792823
Hgene	FN1	GO:0008284	positive regulation of cell proliferation	25834989
Hgene	FN1	GO:0010628	positive regulation of gene expression	25834989
Hgene	FN1	GO:0018149	peptide cross-linking	3997886
Hgene	FN1	GO:0034446	substrate adhesion-dependent cell spreading	16236823
Hgene	FN1	GO:0035987	endodermal cell differentiation	23154389
Hgene	FN1	GO:0048146	positive regulation of fibroblast proliferation	25834989
Hgene	FN1	GO:0051702	interaction with symbiont	12167537\|12421310\|19429745
Hgene	FN1	GO:0070372	regulation of ERK1 and ERK2 cascade	11792823
Hgene	FN1	GO:1901166	neural crest cell migration involved in autonomic nervous system development	26571399
Hgene	FN1	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	25834989
Hgene	FN1	GO:2001202	negative regulation of transforming growth factor-beta secretion	25834989
Tgene	ALK	GO:0016310	phosphorylation	9174053
Tgene	ALK	GO:0046777	protein autophosphorylation	9174053

Fusion gene breakpoints across FN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ALK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	FN1	chr2	216261859	-	ALK	chr2	29448431	-
ChimerKB3	.	.	FN1	chr2	216263979	-	ALK	chr2	29446394	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000421182	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6115	3869	10	5664	1884
ENST00000357867	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000323926	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000336916	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000354785	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6220	3974	115	5769	1884
ENST00000357009	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000346544	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000345488	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000359671	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000446046	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000443816	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6121	3875	16	5670	1884
ENST00000432072	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6115	3869	10	5664	1884
ENST00000356005	FN1	chr2	216261859	-	ENST00000389048	ALK	chr2	29448431	-	6116	3870	11	5665	1884
ENST00000357009	FN1	chr2	216263979	-	ENST00000389048	ALK	chr2	29446394	-	5755	3614	11	3682	1223

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>30790_30790_1_FN1-ALK_FN1_chr2_216261859_ENST00000323926_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_2_FN1-ALK_FN1_chr2_216261859_ENST00000336916_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_3_FN1-ALK_FN1_chr2_216261859_ENST00000345488_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_4_FN1-ALK_FN1_chr2_216261859_ENST00000346544_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_5_FN1-ALK_FN1_chr2_216261859_ENST00000354785_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_6_FN1-ALK_FN1_chr2_216261859_ENST00000356005_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_7_FN1-ALK_FN1_chr2_216261859_ENST00000357009_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_8_FN1-ALK_FN1_chr2_216261859_ENST00000357867_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_9_FN1-ALK_FN1_chr2_216261859_ENST00000359671_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_10_FN1-ALK_FN1_chr2_216261859_ENST00000421182_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_11_FN1-ALK_FN1_chr2_216261859_ENST00000432072_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

--------------------------------------------------------------

>30790_30790_12_FN1-ALK_FN1_chr2_216261859_ENST00000443816_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

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>30790_30790_13_FN1-ALK_FN1_chr2_216261859_ENST00000446046_ALK_chr2_29448431_ENST00000389048_length(amino acids)=1884AA_BP=1285
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL
QPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLS
PPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS
TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNH
QNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPG
PVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEERSPAAPPPLPT
TSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPPSELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE

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>30790_30790_14_FN1-ALK_FN1_chr2_216263979_ENST00000357009_ALK_chr2_29446394_ENST00000389048_length(amino acids)=1223AA_BP=1201
MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQPPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGP
GPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEE
TCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEK
CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS
VQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT
YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDAD
QKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTC
FGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQP
SHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATS
ESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP
DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSD
TVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTT
KLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTL

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:/chr2:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FN1 P02751	ALK Q96BT7
FUNCTION: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (PubMed:3024962, PubMed:3900070, PubMed:3593230, PubMed:7989369). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (By similarity). Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). {ECO:0000250\|UniProtKB:P11276, ECO:0000269\|PubMed:3024962, ECO:0000269\|PubMed:34089617, ECO:0000269\|PubMed:3593230, ECO:0000269\|PubMed:3900070, ECO:0000269\|PubMed:7989369}.; FUNCTION: [Anastellin]: Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. {ECO:0000269\|PubMed:11209058, ECO:0000269\|PubMed:15665290, ECO:0000269\|PubMed:19379667, ECO:0000269\|PubMed:8114919}.	FUNCTION: Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323, PubMed:31079898). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). {ECO:0000269\|PubMed:19293182, ECO:0000269\|PubMed:20123966, ECO:0000269\|PubMed:20308323, ECO:0000269\|PubMed:21285950, ECO:0000269\|PubMed:31079898}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (862) >>>862.pdbFusion protein BP residue: 1201 CIF file (862) >>>862.cif	FN1	chr2	216263979	-	ALK	chr2	29446394	-	MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQ PPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGPGPGLLLLAVQ CLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQW ERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERP KDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYML ECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTC LGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGR GEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVV YSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNS NGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAA HEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLR DQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSE TGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVF ITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNS YTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQY LDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSV TLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQF VEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVT GLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLV RWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVS LVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGF	1223
3D view using mol* of 862 (AA BP:1201)


PDB file (1050)CIF file (1050) >>>1050.cif	FN1	chr2	216261859	-	ALK	chr2	29448431	-	MCCTGGGEGTPGASGKRGPAATTSLVLCIPSVPPPVPFPTLWPPPSWRRQ PPGGIRRDFSRRLRREANLVATCLPVRASLPHRLNMLRGPGPGLLLLAVQ CLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQW ERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERP KDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYML ECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTC LGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGR GEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVV YSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFT YNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNS NGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAA HEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLR DQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSE TGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVF ITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNS YTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGET TPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQY LDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPP DTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSV TLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQF VEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVT GLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLV RWTPPRAQITGYRLTVGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVS LVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGF KLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAP IVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPVSPTPEPHLPLSLI LSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTS TIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVS GMPNDPSPLQVAVKTLPEVCSEQDELDFLMEALIISKFNHQNIVRCIGVS LQSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACG CQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKG GCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQ EVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYC TQDPDVINTALPIEYGPLVEEEEKVPVRPKDPEGVPPLLVSQQAKREEER SPAAPPPLPTTSSGKAAKKPTAAEISVRVPRGPAVEGGHVNMAFSQSNPP SELHKVHGSRNKPTSLWNPTYGSWFTEKPTKKNNPIAKKEPHDRGNLGLE GSCTVPPNVATGRLPGASLLLEPSSLTANMKEVPLFRLRHFPCGNVNYGY	1884
3D view using mol* of 1050 (AA BP:)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FN1_pLDDT.png

ALK_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FN1_ALK_862_pLDDT.png (AA BP:1201)

FN1_ALK_862_pLDDT_and_active_sites.png (AA BP:1201)

FN1_ALK_862_violinplot.png (AA BP:1201)

FN1_ALK_1050_pLDDT_and_active_sites.png (AA BP:)

FN1_ALK_1050_violinplot.png (AA BP:)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

FN1_ALK_862.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
862	0.974	117	0.944	318.647	0.603	0.66	0.934	0.231	1.203	0.192	1.02	Chain A: 699,700,701,702,703,704,705,707,708,710,7 11,712,781,782,783,784,785,786,787,788,789,790,791 ,792,793,794,795,796
1050	1.076	120	1.125	302.183	0.551	0.739	0.9	0.794	0.793	1.002	2.087	Chain A: 259,1384,1386,1388,1389,1394,1412,1414,14 44,1460,1461,1462,1463,1464,1465,1466,1467,1470,14 71,1474,1517,1518,1520,1524,1533,1534

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

FN1

NOV, COL7A1, FASLG, TGFBI, CXCL12, PKD1, LACRT, IGFBP3, MIA, AMBP, TNC, VHL, LPA, GSN, HSPG2, C1QA, ITGB6, ITGA5, TGM2, CD44, MYOC, CRP, APCS, F13A1, MEP1A, MEP1B, ITGB7, REG3A, SDC2, TSHR, FBLN1, FBLN2, PLG, PLAT, TRIB3, EGFR, env, ATXN7, GRB2, SIRT7, ATXN10, APOA1, ALB, MYC, ITGB1, TLN1, PXN, ITGA4, UBE2N, EPN1, ATP5C1, PRMT5, RPN1, STIP1, RCC1, RPL13A, MRPS23, ILF3, PSMA6, NUP205, RAC1, NAA15, SNRNP70, NHP2L1, RAB5C, LGALS1, PSMB2, MCM6, RPL36, DIMT1, HIP1R, VDAC2, STMN1, PPIL1, UPF1, LYPLA1, PLEC, DRG1, DDX39B, MIF, RPL22, HIST1H4F, HIST2H4B, HIST1H4L, HIST1H4I, HIST1H4A, HIST1H4J, HIST1H4K, HIST1H4D, HIST1H4E, HIST1H4C, HIST1H4H, HIST1H4B, HIST2H4A, FBL, DDX21, KRT9, RPS18, PPIH, TRIM28, PDCD6, SRM, RPS19, HSPE1, RPL17, RPS8, ZW10, NDUFA9, NHP2, PELP1, ERLIN2, POLR2C, LRBA, SLC3A2, RPA2, PSMG1, TKT, PSMG2, FLOT2, GLUD1, PSMC6, MRPS34, FDFT1, RNH1, C1QBP, PSMD13, DDX18, ARF6, RSU1, SAR1A, ILK, HMGA1, COPG1, PFKL, SEPT9, NUP210, CPNE1, BAG2, CLIC2, PSMA2, COMT, EIF3K, SEC61B, TTC9C, SPTBN1, EIF4H, NDUFV2, KARS, RBBP4, PRPF19, NDUFA2, TPR, QARS, G6PD, UBE2L3, ACACA, RAE1, IPO4, PAICS, RPL6, NARS, VPS28, RPLP2, MDN1, GSTK1, RPL15, EMG1, CLIC5, PTGES3, NAT10, STX4, PPID, PAFAH1B2, LASP1, PDCD5, NDUFA5, PRKCB, SNRPE, CAP1, U2AF1, SNRPB, VPS35, DLD, KRT31, NECAP2, PSMD5, CELF2, RPA1, HMGB1, SLC5A3, SUB1, RPL29, FLOT1, DNAJB1, AP2A2, SRP14, AHNAK, STXBP3, IDI1, PRPS2, RAB7A, PRPF4, HADHA, LCP1, ITGAV, RTCB, RPL31, PGAM5, AIMP2, DHX30, SLC25A1, POLR1C, DAB2, CPSF6, NOP58, KIDINS220, MRPL13, PDLIM5, COPE, ACLY, KRT5, FAU, IGF2BP3, EIF2S3, ACOT13, ST13, CLTB, SUPT5H, CKAP5, ARHGEF1, BAG6, APOBEC3C, APOBEC3D, CLNS1A, LSM12, CNN2, TK1, NAPG, APOLD1, DDX47, ABCF1, GDI2, VPS26A, BROX, GSTO1, PGK1, PDAP1, PSMB5, RPL28, RBM12, SNAP23, RPS15, FEN1, GNAI3, COX2, PRMT1, EIF3F, ALDH1B1, SNRPA, KANK2, CNOT1, NCBP1, PFKP, ARL2, SNX15, GAR1, USP15, RPS23, SEC22B, OLA1, SEC23B, SRSF1, SF3B1, SET, SMCHD1, TTLL12, BZW2, GALE, NUP155, HNRNPDL, ARPC4, TFAM, HMGB2, SSBP1, COPB1, NACA, ATP6V1B2, PHGDH, MAP4, PUF60, AKR1C1, YES1, EPB41, DBN1, ESYT2, PDHB, RPS26, SEC24C, YWHAG, RCC2, CBX3, TUBB6, RAB11A, EIF5B, RAB35, SSB, HNRNPH2, EZR, USP39, SIPA1, KIAA0368, MRPS28, PCNA, SF3A3, SNRPD3, SEPT2, HIST1H2AA, PKM, YWHAH, IMPDH2, KRT81, CAND1, C14orf166, CSNK2A1, MPP1, H2AFV, ACTR3, LRRC59, CORO1B, PTPRCAP, PSMB3, EIF5, IGF2R, SRSF3, HDAC1, YWHAQ, BMP2K, TRAP1, RAB10, QKI, PDIA6, TPM3, MRTO4, PPP2CA, MCM2, RAP1B, AARS, ALDOA, HIST1H2BJ, RPL8, ENO1, KPNA2, MYL1, STON2, KRT18, IQGAP1, MACF1, IPO5, FLNB, VASP, HNRNPF, TARS, VCL, ANP32B, PPP2R1A, MYH9, FARSB, XPO1, ATP5A1, ATP5B, ESYT1, NCL, CCAR2, YBX1, HSD17B10, PPA1, MATR3, RPL23A, RPL23AP42, PA2G4, HSPA5, GART, UBE2M, GSTP1, RPL7, EFTUD2, SF1, LDHA, KRT2, DIAPH1, ANXA1, SYNCRIP, SRSF9, EEF2, PPP1CA, YWHAE, XRCC5, SND1, HNRNPK, DDX1, CCT2, PRDX6, YWHAZ, TOMM34, RANBP1, FUS, CCT4, XRCC6, SMAP2, TUBB4B, ACP1, RPS13, RPSA, TAGLN2, HNRNPA3, TCP1, CCT8, EIF3E, VIM, GAPDH, HNRNPH1, RPS9, TARDBP, HNRNPU, CLIC1, DDAH2, TUBA1B, KRT8, HSPD1, PI4KA, SCRIB, PSMB1, RUVBL2, PSMD11, EPS15, RPL27A, PSMA5, TIA1, ARPC3, EIF3B, MLLT4, CORO1C, RPS25, NDUFS3, RALY, MYH10, RAP2B, DHX15, PRDX3, YWHAB, RPL35, MYL4, KRT10, GTPBP4, GMPS, LY6G5B, CSNK2B, GLRX3, PDCD10, CAPZA1, DDX6, RPL21, LDHB, MYL6, MSN, RPS24, CACYBP, CPSF7, EEF1B2, NAPA, RPL10A, SF3B6, YTHDF2, ALYREF, SRI, RPS7, ANXA2, MAPRE1, RPS17, FSCN1, HIST1H1B, MDH2, MCM3, ZYX, AP2M1, NPM1, FERMT3, AP2B1, CAPZB, RPL18, RPL14, RPL5, DYNC1H1, RPS2, RPS16, HSPA1B, HSPA1A, ILF2, RPL24, PSMA7, RPS3A, GCN1L1, PFN1, RPL23, RPLP0, TUFM, RPS11, CCT3, PRDX1, VAPA, RPL4, EIF4A1, TFRC, CCT5, ACTN4, PICALM, KPNB1, KRT1, CFL1, XPO5, CCT6A, EEF1D, TOP2A, RBMX, CCT7, HSP90AA1, RPS10, CLTC, ELAVL1, RPL12, HIST1H2BK, PHB, STOM, AP2A1, FLNC, FLNA, AKR7A2, KRT16, IGF2BP2, PCMT1, IST1, RPS21, EIF4G1, CAPN1, KHSRP, CDK1, VARS, HBZ, HBA2, HBA1, EIF3L, SNRNP200, DDOST, NQO1, RSL1D1, RBM3, RFC4, CIRBP, SDHA, EIF4G2, DECR1, MBNL1, DNM2, UBAP2L, RPS20, MARS, CSE1L, RBM14, SNRPF, SLC25A5, ESD, KIF2C, PABPC4, IGF2BP1, SARNP, H2AFY, TCERG1, HNRNPAB, RAVER1, CLTA, RPS27, PHB2, PABPC1, LMNB1, FUBP3, EWSR1, HSPB1, MCM5, BUB3, MCM7, GNB2L1, HNRNPM, RPS15A, PRPF8, RPL9, RPS4X, IARS, HIST1H1D, PRKDC, RPL26, TIAL1, RPS12, HNRNPA0, RPL10, EEF1A1, NTPCR, NUDT21, ACTB, RPL7A, RPS3, HSP90AB1, ACTR2, PRDX2, FUBP1, EIF4A3, HNRNPH3, HNRNPA2B1, APRT, FASN, PARP1, ATAD3A, EPRS, RPL30, RPS14, LMNA, RAN, RPL11, YARS, KRT19, SFPQ, HNRNPC, HIST1H2AD, HSPA8, RPS27A, UBB, UBC, CAPNS1, SNRPD1, DARS, NONO, VAMP8, TUBB, RPL3, RPS5, EIF3D, DHX9, DAZAP1, VCP, LARS, PTBP1, EIF2S1, RPL13, DDX3X, RPS6, LRPPRC, HNRNPA1, RPS28, DDX17, RBM4, HIST2H3A, HIST2H3C, SNRPD2, PCBP2, DDX5, G3BP1, HNRNPR, PCBP1, HSPA9, EIF3A, HNRNPD, EEF1G, HNRNPL, PPIA, PPIAP22, ACTG1, SERPINA1, TF, IGKV3-20, FGA, ITIH2, IGLL5, C1QC, SERPINF2, SERPINA6, CPB2, SERPINA7, SERPINA4, C9, C4BPA, C4A, C3, C1S, FGG, ITIH1, F2, FGB, ITIH4, CFB, C6, CASP14, C1QB, TAB1, RBL1, FAM86B3P, CDKN2A, HRG, SMAD4, RARA, STAT5A, NR0B2, RPS6KA5, DUSP10, TAB2, PELI2, UBQLN1, LGALS3, CER1, LGALS8, LGALS9, TEAD4, COL8A2, HIF1A, SYMPK, CTR9, HGF, KLK3, COLQ, MMP2, ZKSCAN4, MMP9, MEPE, LGALS3BP, ERP44, FKBP9, PRSS2, FAM19A4, MTNR1A, ITGA2B, ITGB3, CLEC14A, KAL1, TIMD4, ITGB5, RNF123, VEGFA, MB21D1, KIAA1429, METTL14, WTAP, DISC1, MTDH, AGRN, DYRK1A, SQSTM1, FANCD2, nsp6, ITGA3, SGCA, SH3GLB1, TTN, LTBP1, Apc2, WDR76, INSIG1, AR, HOXA1, WDR5, ECM1, CGA, CSTL1, TCF7, PPP2R2B, FBXO2, SCGB2A2, GNG8, LAIR2, NPTXR, TMED5, EGFL7, C1QTNF1, LGALS7, SEC23A, CCR1, MAT2B, RDH11, PHC1, KLK10, RHBDD1, UBE2U, AGPAT1, THBS1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FN1
ALK

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FN1-ALK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
FN1	ALK	Alk Inhibitor Lorlatinib	PubMed	33007314

Top

Related Diseases to FN1-ALK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
FN1	ALK	Inflammatory Myofibroblastic Tumors	PubMed	33007314
FN1	ALK	Lung Adenocarcinoma	MyCancerGenome
FN1	ALK	Acute Myeloid Leukemia	MyCancerGenome
FN1	ALK	Cancer Of Unknown Primary	MyCancerGenome
FN1	ALK	Diffuse Large B-Cell Lymphoma	MyCancerGenome
FN1	ALK		MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	FN1	C0020538	Hypertensive disease	2	CTD_human
Hgene	FN1	C0432221	Spondylometaphyseal dysplasia, 'corner fracture' type	2	GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FN1	C0000786	Spontaneous abortion	1	CTD_human
Hgene	FN1	C0000822	Abortion, Tubal	1	CTD_human
Hgene	FN1	C0003504	Aortic Valve Insufficiency	1	CTD_human
Hgene	FN1	C0006142	Malignant neoplasm of breast	1	CTD_human;UNIPROT
Hgene	FN1	C0007097	Carcinoma	1	CTD_human
Hgene	FN1	C0007621	Neoplastic Cell Transformation	1	CTD_human
Hgene	FN1	C0010346	Crohn Disease	1	CTD_human
Hgene	FN1	C0011849	Diabetes Mellitus	1	CTD_human
Hgene	FN1	C0011881	Diabetic Nephropathy	1	CTD_human
Hgene	FN1	C0017636	Glioblastoma	1	CTD_human
Hgene	FN1	C0017667	Nodular glomerulosclerosis	1	CTD_human
Hgene	FN1	C0017668	Focal glomerulosclerosis	1	CTD_human
Hgene	FN1	C0024667	Animal Mammary Neoplasms	1	CTD_human
Hgene	FN1	C0024668	Mammary Neoplasms, Experimental	1	CTD_human
Hgene	FN1	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	FN1	C0034069	Pulmonary Fibrosis	1	CTD_human
Hgene	FN1	C0041956	Ureteral obstruction	1	CTD_human
Hgene	FN1	C0085762	Alcohol abuse	1	PSYGENET
Hgene	FN1	C0086432	Hyalinosis, Segmental Glomerular	1	CTD_human
Hgene	FN1	C0149721	Left Ventricular Hypertrophy	1	CTD_human
Hgene	FN1	C0156147	Crohn's disease of large bowel	1	CTD_human
Hgene	FN1	C0205696	Anaplastic carcinoma	1	CTD_human
Hgene	FN1	C0205697	Carcinoma, Spindle-Cell	1	CTD_human
Hgene	FN1	C0205698	Undifferentiated carcinoma	1	CTD_human
Hgene	FN1	C0205699	Carcinomatosis	1	CTD_human
Hgene	FN1	C0267380	Crohn's disease of the ileum	1	CTD_human
Hgene	FN1	C0334588	Giant Cell Glioblastoma	1	CTD_human
Hgene	FN1	C0345967	Malignant mesothelioma	1	CTD_human
Hgene	FN1	C0678202	Regional enteritis	1	CTD_human
Hgene	FN1	C0678222	Breast Carcinoma	1	CTD_human
Hgene	FN1	C0949272	IIeocolitis	1	CTD_human
Hgene	FN1	C1257925	Mammary Carcinoma, Animal	1	CTD_human
Hgene	FN1	C1257931	Mammary Neoplasms, Human	1	CTD_human
Hgene	FN1	C1458155	Mammary Neoplasms	1	CTD_human
Hgene	FN1	C1621958	Glioblastoma Multiforme	1	CTD_human
Hgene	FN1	C1866075	GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2 (disorder)	1	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	FN1	C3830362	Early Pregnancy Loss	1	CTD_human
Hgene	FN1	C3888104	Glomerulopathy with fibronectin deposits	1	CTD_human;ORPHANET
Hgene	FN1	C4552766	Miscarriage	1	CTD_human
Hgene	FN1	C4704874	Mammary Carcinoma, Human	1	CTD_human
Hgene	FN1	C4721507	Alveolitis, Fibrosing	1	CTD_human
Tgene	ALK	C0007131	Non-Small Cell Lung Carcinoma	28	CGI;CTD_human
Tgene	ALK	C0027819	Neuroblastoma	13	CGI;CTD_human;ORPHANET
Tgene	ALK	C0152013	Adenocarcinoma of lung (disorder)	8	CGI;CTD_human
Tgene	ALK	C2751681	NEUROBLASTOMA, SUSCEPTIBILITY TO, 3	8	CLINGEN;UNIPROT
Tgene	ALK	C0206180	Ki-1+ Anaplastic Large Cell Lymphoma	6	CGI;CTD_human
Tgene	ALK	C0334121	Inflammatory Myofibroblastic Tumor	4	CGI;CTD_human;ORPHANET
Tgene	ALK	C0018199	Granuloma, Plasma Cell	3	CTD_human
Tgene	ALK	C0007621	Neoplastic Cell Transformation	2	CTD_human
Tgene	ALK	C0027627	Neoplasm Metastasis	2	CTD_human
Tgene	ALK	C0238463	Papillary thyroid carcinoma	2	ORPHANET
Tgene	ALK	C0001973	Alcoholic Intoxication, Chronic	1	PSYGENET
Tgene	ALK	C0006118	Brain Neoplasms	1	CGI;CTD_human
Tgene	ALK	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	ALK	C0007134	Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C0011570	Mental Depression	1	PSYGENET
Tgene	ALK	C0011581	Depressive disorder	1	PSYGENET
Tgene	ALK	C0027643	Neoplasm Recurrence, Local	1	CTD_human
Tgene	ALK	C0036341	Schizophrenia	1	PSYGENET
Tgene	ALK	C0079744	Diffuse Large B-Cell Lymphoma	1	CTD_human
Tgene	ALK	C0085269	Plasma Cell Granuloma, Pulmonary	1	CTD_human
Tgene	ALK	C0153633	Malignant neoplasm of brain	1	CGI;CTD_human
Tgene	ALK	C0278601	Inflammatory Breast Carcinoma	1	CTD_human
Tgene	ALK	C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Tgene	ALK	C0678222	Breast Carcinoma	1	CTD_human
Tgene	ALK	C0750974	Brain Tumor, Primary	1	CTD_human
Tgene	ALK	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Tgene	ALK	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Tgene	ALK	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	ALK	C1266042	Chromophobe Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1266043	Sarcomatoid Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1266044	Collecting Duct Carcinoma of the Kidney	1	CTD_human
Tgene	ALK	C1306837	Papillary Renal Cell Carcinoma	1	CTD_human
Tgene	ALK	C1332079	Anaplastic Large Cell Lymphoma, ALK-Positive	1	ORPHANET
Tgene	ALK	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	ALK	C1527390	Neoplasms, Intracranial	1	CTD_human
Tgene	ALK	C2931189	Neural crest tumor	1	ORPHANET
Tgene	ALK	C3899155	hereditary neuroblastoma	1	GENOMICS_ENGLAND
Tgene	ALK	C4704874	Mammary Carcinoma, Human	1	CTD_human