UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ABCD3-DPYD

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ABCD3-DPYD
	FusionPDB ID: 325
	FusionGDB2.0 ID: 325
		Hgene	Tgene
	Gene symbol	ABCD3	DPYD
	Gene ID	5825	1806
	Gene name	ATP binding cassette subfamily D member 3	dihydropyrimidine dehydrogenase
	Synonyms	ABC43\|CBAS5\|PMP70\|PXMP1\|ZWS2	DHP\|DHPDHASE\|DPD
	Cytomap	1p21.3	1p21.3
	Type of gene	protein-coding	protein-coding
	Description	ATP-binding cassette sub-family D member 370 kDa peroxisomal membrane proteinATP-binding cassette, sub-family D (ALD), member 3Peroxisomal membrane protein-1 (70kD)dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))peroxiso	dihydropyrimidine dehydrogenase [NADP(+)]dihydrothymine dehydrogenasedihydrouracil dehydrogenase
	Modification date	20200313	20200313
	UniProtAcc	P28288	Q12882
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000484213, ENST00000370214, ENST00000394233, ENST00000454898, ENST00000536817, ENST00000315713,	ENST00000370192, ENST00000306031, ENST00000423006, ENST00000474241,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 5 X 4=120	12 X 12 X 7=1008
	# samples	6	13
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1008*10)=-2.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ABCD3 [Title/Abstract] AND DPYD [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ABCD3(94956803)-DPYD(97981497), # samples:3
Anticipated loss of major functional domain due to fusion event.	ABCD3-DPYD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCD3-DPYD seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCD3-DPYD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABCD3-DPYD seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABCD3	GO:0007031	peroxisome organization	9425230
Tgene	DPYD	GO:0006210	thymine catabolic process	10410956
Tgene	DPYD	GO:0006212	uracil catabolic process	1512248\|18075467
Tgene	DPYD	GO:0006214	thymidine catabolic process	1512248

Fusion gene breakpoints across ABCD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DPYD (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-CH-5764-01A	ABCD3	chr1	94956803	-	DPYD	chr1	97981497	-
ChimerDB4	PRAD	TCGA-CH-5764-01A	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-
ChimerDB4	PRAD	TCGA-CH-5764	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394233	ABCD3	chr1	94956803	+	ENST00000370192	DPYD	chr1	97981497	-	3945	1158	102	2711	869
ENST00000454898	ABCD3	chr1	94956803	+	ENST00000370192	DPYD	chr1	97981497	-	4311	1524	66	3077	1003
ENST00000536817	ABCD3	chr1	94956803	+	ENST00000370192	DPYD	chr1	97981497	-	4200	1413	132	2966	944
ENST00000370214	ABCD3	chr1	94956803	+	ENST00000370192	DPYD	chr1	97981497	-	4197	1410	24	2963	979

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394233	ENST00000370192	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-	0.0001108	0.99988914
ENST00000454898	ENST00000370192	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-	0.000132643	0.9998673
ENST00000536817	ENST00000370192	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-	0.0002146	0.99978536
ENST00000370214	ENST00000370192	ABCD3	chr1	94956803	+	DPYD	chr1	97981497	-	6.29E-05	0.99993706

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>325_325_1_ABCD3-DPYD_ABCD3_chr1_94956803_ENST00000370214_DPYD_chr1_97981497_ENST00000370192_length(amino acids)=979AA_BP=462
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATP
NGDVLIRDLNFESQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNV
SPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMG
ERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVS
GTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPAT
VSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVA

--------------------------------------------------------------

>325_325_2_ABCD3-DPYD_ABCD3_chr1_94956803_ENST00000394233_DPYD_chr1_97981497_ENST00000370192_length(amino acids)=869AA_BP=352
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFESQYGASVS
AKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSS
FLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICR
WVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALP
GFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKL
PSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDS

--------------------------------------------------------------

>325_325_3_ABCD3-DPYD_ABCD3_chr1_94956803_ENST00000454898_DPYD_chr1_97981497_ENST00000370192_length(amino acids)=1003AA_BP=486
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGYFMETWREKSDEVMGELTDHVTHCKKSGKPPLQNNEKEGKKERAVVDKVFFSR
LIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRV
RLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTR
LRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRP
FLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPL
IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFESQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRR
AFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTE
LAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLM
GLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCT
GLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIK
DVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYE

--------------------------------------------------------------

>325_325_4_ABCD3-DPYD_ABCD3_chr1_94956803_ENST00000536817_DPYD_chr1_97981497_ENST00000370192_length(amino acids)=944AA_BP=427
MPAPQAAPRPRPARKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRY
LLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIV
LYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHN
FILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELM
QVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFESQYGASVSAKPELPLFYTPIDLV
DISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYW
CQSVTELKADFPDNIVIASIMCSYNKNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLT
PNVTDIVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAES
GLQFLHSGASVLQVCSAIQNQDFTVIEDYCTGLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIA
ENKIRLKEQNVAFSPLKRNCFIPKRPIPTIKDVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94956803/chr1:97981497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ABCD3 P28288	DPYD Q12882
FUNCTION: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). {ECO:0000269\|PubMed:11248239, ECO:0000269\|PubMed:25168382}.	FUNCTION: Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

85_372

462.0

660.0

Domain

ABC transmembrane type-1

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

1_124

462.0

660.0

Region

Note=Targeting to peroxisomes

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

1_124

352.0

550.0

Region

Note=Targeting to peroxisomes

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

126_146

462.0

660.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

224_244

462.0

660.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

313_333

462.0

660.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

84_104

462.0

660.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

126_146

352.0

550.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

224_244

352.0

550.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

313_333

352.0

550.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

84_104

352.0

550.0

Transmembrane

Helical

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

944_976

508.0

1026.0

Domain

4Fe-4S ferredoxin-type 2

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

978_1007

508.0

1026.0

Domain

4Fe-4S ferredoxin-type 3

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

574_575

508.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

793_795

508.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

816_817

508.0

1026.0

Nucleotide binding

FMN

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

668_670

508.0

1026.0

Region

Substrate binding

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

736_737

508.0

1026.0

Region

Substrate binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

440_659

0.0

237.0

Domain

ABC transporter

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

85_372

0.0

237.0

Domain

ABC transmembrane type-1

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

440_659

462.0

660.0

Domain

ABC transporter

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

440_659

352.0

550.0

Domain

ABC transporter

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

85_372

352.0

550.0

Domain

ABC transmembrane type-1

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

473_480

0.0

237.0

Nucleotide binding

ATP

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000370214

473_480

462.0

660.0

Nucleotide binding

ATP

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000394233

473_480

352.0

550.0

Nucleotide binding

ATP

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

1_124

0.0

237.0

Region

Note=Targeting to peroxisomes

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

126_146

0.0

237.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

224_244

0.0

237.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

313_333

0.0

237.0

Transmembrane

Helical

Hgene

ABCD3

chr1:94956803

chr1:97981497

ENST00000315713

84_104

0.0

237.0

Transmembrane

Helical

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

69_100

508.0

1026.0

Domain

4Fe-4S ferredoxin-type 1

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

194_198

508.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

218_226

508.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

340_343

508.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

364_365

508.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

437_439

508.0

1026.0

Nucleotide binding

NADP

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

480_489

508.0

1026.0

Nucleotide binding

FAD

Tgene

DPYD

chr1:94956803

chr1:97981497

ENST00000370192

481_487

508.0

1026.0

Nucleotide binding

NADP

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1790_ABCD3_94956803_DPYD_97981497_ranked_0.pdb	ABCD3	94956803	94956803	ENST00000370192	DPYD	chr1	97981497	-	MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGYFMETWREKSDEVMGELTDHVTHCKKSGKPPLQNNEKEGKKERAVVDKVFFSR LIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRV RLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTR LRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRP FLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPL IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFESQYGASVSAKPELPLFYTPIDLVDISVEMAGLKFINPFGLASATPATSTSMIRR AFEAGWGFALTKTFSLDKDIVTNVSPRIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKNDWTE LAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQIPFFAKLTPNVTDIVSIARAAKEGGANGVTATNTVSGLM GLKSDGTPWPAVGIAKRTTYGGVSGTAIRPIALRAVTSIARALPGFPILATGGIDSAESGLQFLHSGASVLQVCSAIQNQDFTVIEDYCT GLKALLYLKSIEELQDWDGQSPATVSHQKGKPVPRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSPLKRNCFIPKRPIPTIK DVIGKALQYLGTFGELSNVEQVVAMIDEEMCINCGKCYMTCNDSGYQAIQFDPETHLPTITDTCTGCTLCLSVCPIVDCIKMVSRTTPYE	1003

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ABCD3_pLDDT.png

DPYD_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ABCD3
DPYD

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	ABCD3	chr1:94956803	chr1:97981497	ENST00000315713	+	1	9	1_199	0.0	237.0	PEX19

Top

Related Drugs to ABCD3-DPYD

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ABCD3-DPYD

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source