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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GAS7-MYH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GAS7-MYH1
FusionPDB ID: 32563
FusionGDB2.0 ID: 32563
HgeneTgene
Gene symbol

GAS7

MYH1

Gene ID

8522

4619

Gene namegrowth arrest specific 7myosin heavy chain 1
Synonyms-HEL71|MYHSA1|MYHa|MyHC-2X/D|MyHC-2x
Cytomap

17p13.1

17p13.1

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 7myosin-1epididymis luminal protein 71myHC-IIx/dmyosin heavy chain 2xmyosin heavy chain IIx/dmyosin heavy chain, skeletal muscle, adult 1myosin, heavy chain 1, skeletal muscle, adultmyosin, heavy polypeptide 1, skeletal muscle, adult
Modification date2020031320200313
UniProtAcc

O60861

Q7Z406

Ensembl transtripts involved in fusion geneENST idsENST00000540214, ENST00000432992, 
ENST00000323816, ENST00000396115, 
ENST00000437099, ENST00000542249, 
ENST00000578655, ENST00000579158, 
ENST00000580865, ENST00000583882, 
ENST00000585266, 		ENST00000226207, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 14 X 7=14701 X 1 X 2=2
# samples 172
** MAII scorelog2(17/1470*10)=-3.11220950358603
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: GAS7 [Title/Abstract] AND MYH1 [Title/Abstract] AND fusion [Title/Abstract]

The landscape and therapeutic relevance of cancer-associated transcript fusions (pmid: 25500544)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GAS7(10101525)-MYH1(10415863), # samples:6
Anticipated loss of major functional domain due to fusion event.GAS7-MYH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-MYH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-MYH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-MYH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GAS7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRCTCGA-BP-4342-01AGAS7chr17

10101525

-MYH1chr17

10415863

-
ChimerDB4KIRPTCGA-BQ-7049GAS7chr17

10101524

-MYH1chr17

10415863

-
ChimerDB4LUADTCGA-97-8172-01AGAS7chr17

10101525

-MYH1chr17

10415863

-
ChimerDB4LUADTCGA-97-8172GAS7chr17

10101524

-MYH1chr17

10415863

-
ChimerDB4STADTCGA-BR-4366-01AGAS7chr17

10101525

-MYH1chr17

10415863

-
ChimerDB4STADTCGA-MX-A666-01AGAS7chr17

10101525

-MYH1chr17

10415863

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432992GAS7chr1710101524-ENST00000226207MYH1chr1710415863-52653448051551691
ENST00000432992GAS7chr1710101525-ENST00000226207MYH1chr1710415863-52653448051551691

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432992ENST00000226207GAS7chr1710101524-MYH1chr1710415863-0.0162636020.98373646
ENST00000432992ENST00000226207GAS7chr1710101525-MYH1chr1710415863-0.0162636020.98373646

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32563_32563_1_GAS7-MYH1_GAS7_chr17_10101524_ENST00000432992_MYH1_chr17_10415863_ENST00000226207_length(amino acids)=1691AA_BP=83
MGPRGAAAQPVGLGGNAGCAVNPGAKAMSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLESA
IEILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVG
ALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGM
DLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLIHYAGTVDYNIAGWLDKNKDPLNETV
VGLYQKSAMKTLALLFVGATGAEAEAGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLR
CNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQL
ITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELE
EKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV
EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK
LEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE
EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN
METVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK
AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL
EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN
LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV
ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE
IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD
TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL

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>32563_32563_2_GAS7-MYH1_GAS7_chr17_10101525_ENST00000432992_MYH1_chr17_10415863_ENST00000226207_length(amino acids)=1691AA_BP=83
MGPRGAAAQPVGLGGNAGCAVNPGAKAMSGARCRTLYPFSGERHGQGLRFAAGELITLLQVPDGGWWEGEKEDGLRGWFPASYVQLLESA
IEILGFTSDERVSIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAAYLQNLNSADLLKALCYPRVKVGNEYVTKGQTVQQVYNAVG
ALAKAVYDKMFLWMVTRINQQLDTKQPRQYFIGVLDIAGFEIFDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGM
DLAACIELIEKPMGIFSILEEECMFPKATDTSFKNKLYEQHLGKSNNFQKPKPAKGKPEAHFSLIHYAGTVDYNIAGWLDKNKDPLNETV
VGLYQKSAMKTLALLFVGATGAEAEAGGGKKGGKKKGSSFQTVSALFRENLNKLMTNLRSTHPHFVRCIIPNETKTPGAMEHELVLHQLR
CNGVLEGIRICRKGFPSRILYADFKQRYKVLNASAIPEGQFIDSKKASEKLLGSIDIDHTQYKFGHTKVFFKAGLLGLLEEMRDEKLAQL
ITRTQAMCRGFLARVEYQKMVERRESIFCIQYNVRAFMNVKHWPWMKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELE
EKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKV
EKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRK
LEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELE
EISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASN
METVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIK
AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL
EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKRENKN
LQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIV
ESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAE
IEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQD
TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:10101525/chr17:10415863)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS7

O60861

MYH1

Q7Z406

FUNCTION: May play a role in promoting maturation and morphological differentiation of cerebellar neurons.FUNCTION: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS7chr17:10101524chr17:10415863ENST00000432992-1141_6261.0477.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000432992-1141_6261.0477.0DomainSH3
TgeneMYH1chr17:10101524chr17:10415863ENST000002262071040843_1939336.01940.0Coiled coilOntology_term=ECO:0000255
TgeneMYH1chr17:10101525chr17:10415863ENST000002262071040843_1939336.01940.0Coiled coilOntology_term=ECO:0000255
TgeneMYH1chr17:10101524chr17:10415863ENST000002262071040785_814336.01940.0DomainIQ
TgeneMYH1chr17:10101525chr17:10415863ENST000002262071040785_814336.01940.0DomainIQ
TgeneMYH1chr17:10101524chr17:10415863ENST000002262071040659_681336.01940.0RegionActin-binding
TgeneMYH1chr17:10101524chr17:10415863ENST000002262071040761_775336.01940.0RegionActin-binding
TgeneMYH1chr17:10101525chr17:10415863ENST000002262071040659_681336.01940.0RegionActin-binding
TgeneMYH1chr17:10101525chr17:10415863ENST000002262071040761_775336.01940.0RegionActin-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS7chr17:10101524chr17:10415863ENST00000323816-115309_4190417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000396115-17309_4190182.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000432992-114309_41961.0477.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000437099-114309_4190413.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000580865-110309_4190337.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000585266-114309_4190417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000323816-115309_4190417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000396115-17309_4190182.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000432992-114309_41961.0477.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000437099-114309_4190413.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000580865-110309_4190337.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101525chr17:10415863ENST00000585266-114309_4190417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:10101524chr17:10415863ENST00000323816-11567_700417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000396115-1767_700182.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000432992-11467_7061.0477.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000437099-11467_700413.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000580865-11067_700337.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000585266-11467_700417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000323816-11567_700417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000396115-1767_700182.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000432992-11467_7061.0477.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000437099-11467_700413.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000580865-11067_700337.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101525chr17:10415863ENST00000585266-11467_700417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:10101524chr17:10415863ENST00000323816-115196_4560417.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000323816-1151_620417.0DomainSH3
HgeneGAS7chr17:10101524chr17:10415863ENST00000323816-11577_1100417.0DomainWW
HgeneGAS7chr17:10101524chr17:10415863ENST00000396115-17196_4560182.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000396115-171_620182.0DomainSH3
HgeneGAS7chr17:10101524chr17:10415863ENST00000396115-1777_1100182.0DomainWW
HgeneGAS7chr17:10101524chr17:10415863ENST00000432992-114196_45661.0477.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000432992-11477_11061.0477.0DomainWW
HgeneGAS7chr17:10101524chr17:10415863ENST00000437099-114196_4560413.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000437099-1141_620413.0DomainSH3
HgeneGAS7chr17:10101524chr17:10415863ENST00000437099-11477_1100413.0DomainWW
HgeneGAS7chr17:10101524chr17:10415863ENST00000580865-110196_4560337.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000580865-1101_620337.0DomainSH3
HgeneGAS7chr17:10101524chr17:10415863ENST00000580865-11077_1100337.0DomainWW
HgeneGAS7chr17:10101524chr17:10415863ENST00000585266-114196_4560417.0DomainF-BAR
HgeneGAS7chr17:10101524chr17:10415863ENST00000585266-1141_620417.0DomainSH3
HgeneGAS7chr17:10101524chr17:10415863ENST00000585266-11477_1100417.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000323816-115196_4560417.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000323816-1151_620417.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000323816-11577_1100417.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000396115-17196_4560182.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000396115-171_620182.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000396115-1777_1100182.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000432992-114196_45661.0477.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000432992-11477_11061.0477.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000437099-114196_4560413.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000437099-1141_620413.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000437099-11477_1100413.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000580865-110196_4560337.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000580865-1101_620337.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000580865-11077_1100337.0DomainWW
HgeneGAS7chr17:10101525chr17:10415863ENST00000585266-114196_4560417.0DomainF-BAR
HgeneGAS7chr17:10101525chr17:10415863ENST00000585266-1141_620417.0DomainSH3
HgeneGAS7chr17:10101525chr17:10415863ENST00000585266-11477_1100417.0DomainWW
TgeneMYH1chr17:10101524chr17:10415863ENST00000226207104033_82336.01940.0DomainMyosin N-terminal SH3-like
TgeneMYH1chr17:10101524chr17:10415863ENST00000226207104086_782336.01940.0DomainMyosin motor
TgeneMYH1chr17:10101525chr17:10415863ENST00000226207104033_82336.01940.0DomainMyosin N-terminal SH3-like
TgeneMYH1chr17:10101525chr17:10415863ENST00000226207104086_782336.01940.0DomainMyosin motor
TgeneMYH1chr17:10101524chr17:10415863ENST000002262071040179_186336.01940.0Nucleotide bindingATP
TgeneMYH1chr17:10101525chr17:10415863ENST000002262071040179_186336.01940.0Nucleotide bindingATP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
GAS7_pLDDT.png
all structure
all structure
MYH1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
GAS7PACSIN1, GAS7, ATXN1L, CREB3L2, HNRNPU, KHDRBS1, SF1, SF3A1, SFPQ, RPLP0, ABI1, CYFIP1, CYFIP2, DIAPH1, FMNL1, WAS, WASF2, APBB1IP, NCKAP1, NCKAP1L, GAPDH, WDYHV1, NCKIPSD, CDC37, LSM4, YIF1A, MCRS1, MYBPC2, BRD4, DDX58,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GAS7all structure
MYH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GAS7-MYH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GAS7-MYH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS7C0028754Obesity1CTD_human