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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GNAS-CLIP1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GNAS-CLIP1
FusionPDB ID: 33613
FusionGDB2.0 ID: 33613
HgeneTgene
Gene symbol

GNAS

CLIP1

Gene ID

2778

6249

Gene nameGNAS complex locusCAP-Gly domain containing linker protein 1
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVICLIP|CLIP-170|CLIP170|CYLN1|RSN
Cytomap

20q13.32

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha CAP-Gly domain-containing linker protein 1cytoplasmic linker protein 1cytoplasmic linker protein 170 alpha-2cytoplasmic linker protein CLIP-170restin (Reed-Steinberg cell-expressed intermediate filament-associated protein)
Modification date2020032920200313
UniProtAcc

P63092

P30622

Ensembl transtripts involved in fusion geneENST idsENST00000265620, ENST00000306090, 
ENST00000313949, ENST00000354359, 
ENST00000371075, ENST00000371085, 
ENST00000371095, ENST00000371100, 
ENST00000371102, ENST00000464624, 
ENST00000306120, ENST00000371081, 
ENST00000371098, ENST00000371099, 
ENST00000536634, ENST00000540539, 
ENST00000302528, ENST00000358808, 
ENST00000361654, ENST00000537178, 
ENST00000540338, ENST00000545889, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 25 X 16=1760012 X 12 X 6=864
# samples 5113
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/864*10)=-2.73251968913501
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GNAS [Title/Abstract] AND CLIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GNAS(57486241)-CLIP1(122819252), # samples:2
Anticipated loss of major functional domain due to fusion event.GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
GNAS-CLIP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KICHTCGA-KN-8435-01AGNASchr20

57486241

-CLIP1chr12

122819252

-
ChimerDB4THCATCGA-DE-A2OL-01AGNASchr20

57486241

-CLIP1chr12

122819252

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371100GNASchr2057486241-ENST00000361654CLIP1chr12122819252-7221402953136651044
ENST00000371100GNASchr2057486241-ENST00000545889CLIP1chr12122819252-7219402953136651044
ENST00000371100GNASchr2057486241-ENST00000302528CLIP1chr12122819252-7219402953136651044
ENST00000371100GNASchr2057486241-ENST00000358808CLIP1chr12122819252-7219402953136651044
ENST00000371100GNASchr2057486241-ENST00000537178CLIP1chr12122819252-6610402953136651044
ENST00000371100GNASchr2057486241-ENST00000540338CLIP1chr12122819252-5819402953136651044
ENST00000371102GNASchr2057486241-ENST00000361654CLIP1chr12122819252-66303438330741023
ENST00000371102GNASchr2057486241-ENST00000545889CLIP1chr12122819252-66283438330741023
ENST00000371102GNASchr2057486241-ENST00000302528CLIP1chr12122819252-66283438330741023
ENST00000371102GNASchr2057486241-ENST00000358808CLIP1chr12122819252-66283438330741023
ENST00000371102GNASchr2057486241-ENST00000537178CLIP1chr12122819252-60193438330741023
ENST00000371102GNASchr2057486241-ENST00000540338CLIP1chr12122819252-52283438330741023
ENST00000371095GNASchr2057486241-ENST00000361654CLIP1chr12122819252-5123193119823679565
ENST00000371095GNASchr2057486241-ENST00000545889CLIP1chr12122819252-5121193119823679565
ENST00000371095GNASchr2057486241-ENST00000302528CLIP1chr12122819252-5121193119823679565
ENST00000371095GNASchr2057486241-ENST00000358808CLIP1chr12122819252-5121193119823679565
ENST00000371095GNASchr2057486241-ENST00000537178CLIP1chr12122819252-4512193119823679565
ENST00000371095GNASchr2057486241-ENST00000540338CLIP1chr12122819252-3721193119823679565
ENST00000371085GNASchr2057486241-ENST00000361654CLIP1chr12122819252-5164197220233720565
ENST00000371085GNASchr2057486241-ENST00000545889CLIP1chr12122819252-5162197220233720565
ENST00000371085GNASchr2057486241-ENST00000302528CLIP1chr12122819252-5162197220233720565
ENST00000371085GNASchr2057486241-ENST00000358808CLIP1chr12122819252-5162197220233720565
ENST00000371085GNASchr2057486241-ENST00000537178CLIP1chr12122819252-4553197220233720565
ENST00000371085GNASchr2057486241-ENST00000540338CLIP1chr12122819252-3762197220233720565
ENST00000354359GNASchr2057486241-ENST00000361654CLIP1chr12122819252-5167197520263723565
ENST00000354359GNASchr2057486241-ENST00000545889CLIP1chr12122819252-5165197520263723565
ENST00000354359GNASchr2057486241-ENST00000302528CLIP1chr12122819252-5165197520263723565
ENST00000354359GNASchr2057486241-ENST00000358808CLIP1chr12122819252-5165197520263723565
ENST00000354359GNASchr2057486241-ENST00000537178CLIP1chr12122819252-4556197520263723565
ENST00000354359GNASchr2057486241-ENST00000540338CLIP1chr12122819252-3765197520263723565
ENST00000265620GNASchr2057486241-ENST00000361654CLIP1chr12122819252-5058186619173614565
ENST00000265620GNASchr2057486241-ENST00000545889CLIP1chr12122819252-5056186619173614565
ENST00000265620GNASchr2057486241-ENST00000302528CLIP1chr12122819252-5056186619173614565
ENST00000265620GNASchr2057486241-ENST00000358808CLIP1chr12122819252-5056186619173614565
ENST00000265620GNASchr2057486241-ENST00000537178CLIP1chr12122819252-4447186619173614565
ENST00000265620GNASchr2057486241-ENST00000540338CLIP1chr12122819252-3656186619173614565
ENST00000306090GNASchr2057486241-ENST00000361654CLIP1chr12122819252-4834164216933390565
ENST00000306090GNASchr2057486241-ENST00000545889CLIP1chr12122819252-4832164216933390565
ENST00000306090GNASchr2057486241-ENST00000302528CLIP1chr12122819252-4832164216933390565
ENST00000306090GNASchr2057486241-ENST00000358808CLIP1chr12122819252-4832164216933390565
ENST00000306090GNASchr2057486241-ENST00000537178CLIP1chr12122819252-4223164216933390565
ENST00000306090GNASchr2057486241-ENST00000540338CLIP1chr12122819252-3432164216933390565

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371100ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0029541220.99704593
ENST00000371100ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0029601530.99703985
ENST00000371100ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0029601530.99703985
ENST00000371100ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0029601530.99703985
ENST00000371100ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0041776690.9958223
ENST00000371100ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0069701130.9930299
ENST00000371102ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0015005820.9984994
ENST00000371102ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0015036690.9984963
ENST00000371102ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0015036690.9984963
ENST00000371102ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0015036690.9984963
ENST00000371102ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.002329360.9976706
ENST00000371102ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0043299370.9956701
ENST00000371095ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0009667840.9990332
ENST00000371095ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0009685650.9990314
ENST00000371095ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0009685650.9990314
ENST00000371095ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0009685650.9990314
ENST00000371095ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0015195330.9984805
ENST00000371095ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0029339640.9970661
ENST00000371085ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0010058050.9989942
ENST00000371085ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0010080010.998992
ENST00000371085ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0010080010.998992
ENST00000371085ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0010080010.998992
ENST00000371085ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0015973080.99840266
ENST00000371085ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0030502920.99694973
ENST00000354359ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0010186060.9989814
ENST00000354359ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0010209250.9989791
ENST00000354359ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0010209250.9989791
ENST00000354359ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0010209250.9989791
ENST00000354359ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0016226840.9983773
ENST00000354359ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0030707490.9969292
ENST00000265620ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0009262280.99907374
ENST00000265620ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0009279760.99907196
ENST00000265620ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0009279760.99907196
ENST00000265620ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0009279760.99907196
ENST00000265620ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0014285070.9985715
ENST00000265620ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0029074510.9970925
ENST00000306090ENST00000361654GNASchr2057486241-CLIP1chr12122819252-0.0009797820.9990202
ENST00000306090ENST00000545889GNASchr2057486241-CLIP1chr12122819252-0.0009815270.99901843
ENST00000306090ENST00000302528GNASchr2057486241-CLIP1chr12122819252-0.0009815270.99901843
ENST00000306090ENST00000358808GNASchr2057486241-CLIP1chr12122819252-0.0009815270.99901843
ENST00000306090ENST00000537178GNASchr2057486241-CLIP1chr12122819252-0.0015372930.9984627
ENST00000306090ENST00000540338GNASchr2057486241-CLIP1chr12122819252-0.0039273890.99607265

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33613_33613_1_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_2_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_3_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_4_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_5_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_6_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000265620_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_7_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_8_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_9_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_10_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_11_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_12_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000306090_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_13_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_14_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_15_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_16_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_17_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_18_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000354359_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_19_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_20_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_21_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_22_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_23_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_24_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371085_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_25_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_26_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_27_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_28_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_29_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_30_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371095_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=565AA_BP=
MQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQL
KLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLD
TEDKLKGAREENSGLLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL
LTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQK
SISITSALLTEKDAELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDTQADEDERAQESQI
DFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSDDQEKQSKKKPRLFCDICDCFDLHDTEDCPTQAQMSEDPPHSTHHGSRG

--------------------------------------------------------------

>33613_33613_31_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_32_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_33_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_34_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_35_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_36_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371100_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33613_33613_37_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000302528_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

>33613_33613_38_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000358808_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

>33613_33613_39_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000361654_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

>33613_33613_40_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000537178_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

>33613_33613_41_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000540338_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

>33613_33613_42_GNAS-CLIP1_GNAS_chr20_57486241_ENST00000371102_CLIP1_chr12_122819252_ENST00000545889_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:57486241/chr12:122819252)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

P63092

CLIP1

P30622

FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.FUNCTION: Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. {ECO:0000269|PubMed:12433698, ECO:0000269|PubMed:17563362, ECO:0000269|PubMed:17889670}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313641_6671159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313730_7561159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212641_6671145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212730_7561145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr12:122819252ENST00000313949-131378_142729.666666666666626.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57486241chr12:122819252ENST00000371075-131378_142730.666666666666636.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313358_5221159.01038.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212358_5221145.01024.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-121239_394501.0380.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-131339_394500.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-131339_394517.0396.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-131339_394516.0395.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-121239_394502.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313682_10371159.01038.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212682_10371145.01024.0DomainG-alpha
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212197_204501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212223_227501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212292_295501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-121247_55501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313197_204500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313223_227500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313292_295500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-131347_55500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313197_204517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313223_227517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313292_295517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-131347_55517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313197_204516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313223_227516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313292_295516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-131347_55516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212197_204502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212223_227502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212292_295502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-121247_55502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313690_6981159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313840_8471159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313866_8701159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313935_9381159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212690_6981145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212840_8471145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212866_8701145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212935_9381145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212196_204501.0380.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212219_228501.0380.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212288_295501.0380.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-1212364_369501.0380.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000265620-121242_55501.0380.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313196_204500.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313219_228500.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313288_295500.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-1313364_369500.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000306090-131342_55500.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313196_204517.0396.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313219_228517.0396.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313288_295517.0396.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-1313364_369517.0396.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000354359-131342_55517.0396.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313196_204516.0395.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313219_228516.0395.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313288_295516.0395.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-1313364_369516.0395.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371085-131342_55516.0395.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212196_204502.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212219_228502.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212288_295502.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-1212364_369502.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371095-121242_55502.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-13131007_10121159.01038.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313685_6981159.01038.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313839_8471159.01038.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313862_8711159.01038.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371100-1313931_9381159.01038.0RegionG4 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-12121007_10121145.01024.0RegionG5 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212685_6981145.01024.0RegionG1 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212839_8471145.01024.0RegionG2 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212862_8711145.01024.0RegionG3 motif
HgeneGNASchr20:57486241chr12:122819252ENST00000371102-1212931_9381145.01024.0RegionG4 motif
TgeneCLIP1chr20:57486241chr12:122819252ENST000003025289241417_1434845.01428.0Zinc fingerCCHC-type
TgeneCLIP1chr20:57486241chr12:122819252ENST0000035880810251417_1434845.01428.0Zinc fingerCCHC-type
TgeneCLIP1chr20:57486241chr12:122819252ENST000005371789241417_1434810.01393.0Zinc fingerCCHC-type
TgeneCLIP1chr20:57486241chr12:122819252ENST0000054033810251417_1434856.01439.0Zinc fingerCCHC-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr12:122819252ENST00000306120-11238_4760.0626.0Compositional biasPro-rich
HgeneGNASchr20:57486241chr12:122819252ENST00000371098-1478_142020.333333333333332Compositional biasGlu-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST00000302528924350_1353845.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCLIP1chr20:57486241chr12:122819252ENST000003588081025350_1353845.01428.0Coiled coilOntology_term=ECO:0000255
TgeneCLIP1chr20:57486241chr12:122819252ENST00000537178924350_1353810.01393.0Coiled coilOntology_term=ECO:0000255
TgeneCLIP1chr20:57486241chr12:122819252ENST000005403381025350_1353856.01439.0Coiled coilOntology_term=ECO:0000255
TgeneCLIP1chr20:57486241chr12:122819252ENST00000302528924143_204845.01428.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST00000302528924304_331845.01428.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST000003588081025143_204845.01428.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST000003588081025304_331845.01428.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST00000537178924143_204810.01393.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST00000537178924304_331810.01393.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST000005403381025143_204856.01439.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST000005403381025304_331856.01439.0Compositional biasNote=Ser-rich
TgeneCLIP1chr20:57486241chr12:122819252ENST00000302528924232_274845.01428.0DomainCAP-Gly 2
TgeneCLIP1chr20:57486241chr12:122819252ENST0000030252892478_120845.01428.0DomainCAP-Gly 1
TgeneCLIP1chr20:57486241chr12:122819252ENST000003588081025232_274845.01428.0DomainCAP-Gly 2
TgeneCLIP1chr20:57486241chr12:122819252ENST00000358808102578_120845.01428.0DomainCAP-Gly 1
TgeneCLIP1chr20:57486241chr12:122819252ENST00000537178924232_274810.01393.0DomainCAP-Gly 2
TgeneCLIP1chr20:57486241chr12:122819252ENST0000053717892478_120810.01393.0DomainCAP-Gly 1
TgeneCLIP1chr20:57486241chr12:122819252ENST000005403381025232_274856.01439.0DomainCAP-Gly 2
TgeneCLIP1chr20:57486241chr12:122819252ENST00000540338102578_120856.01439.0DomainCAP-Gly 1
TgeneCLIP1chr20:57486241chr12:122819252ENST0000030252892497_101845.01428.0RegionImportant for tubulin binding
TgeneCLIP1chr20:57486241chr12:122819252ENST00000358808102597_101845.01428.0RegionImportant for tubulin binding
TgeneCLIP1chr20:57486241chr12:122819252ENST0000053717892497_101810.01393.0RegionImportant for tubulin binding
TgeneCLIP1chr20:57486241chr12:122819252ENST00000540338102597_101856.01439.0RegionImportant for tubulin binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1824_GNAS_57486241_CLIP1_122819252_ranked_0.pdbGNAS5748624157486241ENST00000540338CLIP1chr12122819252-
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF
1044


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
CLIP1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
CLIP1MTOR, IQGAP1, CDC42, RAC1, PAFAH1B1, Gorasp1, CALM1, BIN1, MAPRE1, TUBA1A, TUBB, AMOT, BUB3, MAEA, PSMC2, HDAC6, CADPS, CHD4, GPS1, DCTN1, DYNC1H1, Mapre1, Smurf2, PCGF1, DPPA4, NANOG, POU5F1, TSC22D2, GORASP1, BMP1, DAB2IP, RUNDC3A, BRCA1, ZNF598, UBE2M, KIAA1429, DCAF15, BICD1, REL, ORF3a, SERBP1, nsp2, CLIP4, NINL, ORF6, DDX58, AGAP3, CKAP2, CLASP1, CLASP2, DNAJA2, IKBKAP, ELP4, EXOC4, HINT1, HMMR, HNRNPA1L2, IARS2, KIF15, MAP7, MAST4, PLEKHA5, RPS6KA3, SIRT2, SLAIN1, TCHP, TEX9, BIRC6, CAMSAP1, DRG1, KIAA0368, MAP7D1, MAP7D2, MAP7D3, SF3B3, SLAIN2, MAPRE3, TRIM36, PPP2R2B, RABEP1, SRRT, OR2A4, GOT1, RABEP2, SYCE1, MBNL1, SSUH2, C18orf21, AGPAT1, CCR1, FBXO32, CDK1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GNAS
CLIP1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GNAS-CLIP1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GNAS-CLIP1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource