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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GNAS-SIAE

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GNAS-SIAE
FusionPDB ID: 33645
FusionGDB2.0 ID: 33645
HgeneTgene
Gene symbol

GNAS

SIAE

Gene ID

2778

54414

Gene nameGNAS complex locussialic acid acetylesterase
SynonymsAHO|C20orf45|GNAS1|GPSA|GSA|GSP|NESP|PITA3|POH|SCG6|SgVIAIS6|CSE-C|CSEC|LSE|YSG2
Cytomap

20q13.32

11q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein ALEXprotein GNASprotein SCG6 (secretogranin VI)G protein subunit alpha Sadenylate cyclase-stimulating G alpha proteinalternative gene product encoded by XL-exonextra large alphas proteinguanine nucleotide binding protein (G protein), alpha sialate O-acetylesteraseH-Lsecytosolic sialic acid 9-O-acetylesterase homologsialic acid-specific acetylesterase II
Modification date2020032920200313
UniProtAcc

P63092

.
Ensembl transtripts involved in fusion geneENST idsENST00000265620, ENST00000306090, 
ENST00000313949, ENST00000354359, 
ENST00000371075, ENST00000371085, 
ENST00000371095, ENST00000371100, 
ENST00000371102, ENST00000464624, 
ENST00000306120, ENST00000371081, 
ENST00000371098, ENST00000371099, 
ENST00000525730, ENST00000545756, 
ENST00000263593, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score44 X 25 X 16=1760034 X 6 X 15=3060
# samples 5134
** MAII scorelog2(51/17600*10)=-5.10893437155316
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/3060*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GNAS [Title/Abstract] AND SIAE [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GNAS(57486241)-SIAE(124543777), # samples:2
Anticipated loss of major functional domain due to fusion event.GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GNAS-SIAE seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSIAE

GO:0005975

carbohydrate metabolic process

23308225


check buttonFusion gene breakpoints across GNAS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SIAE (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-BJ-A192-01AGNASchr20

57486241

-SIAEchr11

124543777

-
ChimerDB4THCATCGA-ET-A3BQ-01BGNASchr20

57486241

-SIAEchr11

124543777

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371100GNASchr2057486241-ENST00000263593SIAEchr11124543777-9612402953136651044
ENST00000371102GNASchr2057486241-ENST00000263593SIAEchr11124543777-90213438330741023
ENST00000371095GNASchr2057486241-ENST00000263593SIAEchr11124543777-7514193118763675599
ENST00000371085GNASchr2057486241-ENST00000263593SIAEchr11124543777-7555197219173716599
ENST00000354359GNASchr2057486241-ENST00000263593SIAEchr11124543777-7558197519203719599
ENST00000265620GNASchr2057486241-ENST00000263593SIAEchr11124543777-7449186618113610599
ENST00000306090GNASchr2057486241-ENST00000263593SIAEchr11124543777-7225164215933386597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371100ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0008226420.9991774
ENST00000371102ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0003496730.99965036
ENST00000371095ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0006026090.9993974
ENST00000371085ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0006399390.99936
ENST00000354359ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.000646620.99935335
ENST00000265620ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0005860540.99941397
ENST00000306090ENST00000263593GNASchr2057486241-SIAEchr11124543777-0.0005118570.9994881

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33645_33645_1_GNAS-SIAE_GNAS_chr20_57486241_ENST00000265620_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=599AA_BP=5
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------

>33645_33645_2_GNAS-SIAE_GNAS_chr20_57486241_ENST00000306090_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=597AA_BP=5
MCCAALKKIKIKIKCEQKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPLIL
WADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLEKI
NFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSAVC
WLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINYNT
DLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFGSI
HPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSLTL

--------------------------------------------------------------

>33645_33645_3_GNAS-SIAE_GNAS_chr20_57486241_ENST00000354359_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=599AA_BP=5
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------

>33645_33645_4_GNAS-SIAE_GNAS_chr20_57486241_ENST00000371085_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=599AA_BP=5
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------

>33645_33645_5_GNAS-SIAE_GNAS_chr20_57486241_ENST00000371095_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=599AA_BP=5
MCCAALKKIKIKIKCEQRKKKKKTTAAEKGRVQPSPEVAGGCEDCKRVESASPPPRPRPCREPTFPVLGGGQILASMVAPGLVLGLVLPL
ILWADRSAGIGFRFASYINNDMVLQKEPAGAVIWGFGTPGATVTVTLRQGQETIMKKVTSVKAHSDTWMVVLDPMKPGGPFEVMAQQTLE
KINFTLRVHDVLFGDVWLCSGQSNMQMTVLQIFNATRELSNTAAYQSVRILSVSPIQAEQELEDLVAVDLQWSKPTSENLGHGYFKYMSA
VCWLFGRHLYDTLQYPIGLIASSWGGTPIEAWSSGRSLKACGVPKQGSIPYDSVTGPSKHSVLWNAMIHPLCNMTLKGVVWYQGESNINY
NTDLYNCTFPALIEDWRETFHRGSQGQTERFFPFGLVQLSSDLSKKSSDDGFPQIRWHQTADFGYVPNPKMPNTFMAVAMDLCDRDSPFG
SIHPRDKQTVAYRLHLGARALAYGEKNLTFEGPLPEKIELLAHKGLLNLTYYQQIQVQKKDNKIFEISCCSDHRCKWLPASMNTVSTQSL

--------------------------------------------------------------

>33645_33645_6_GNAS-SIAE_GNAS_chr20_57486241_ENST00000371100_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=1044AA_BP=
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF

--------------------------------------------------------------

>33645_33645_7_GNAS-SIAE_GNAS_chr20_57486241_ENST00000371102_SIAE_chr11_124543777_ENST00000263593_length(amino acids)=1023AA_BP=
MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNPAFREAGA
HGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ
VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSAVRLTPAA
NAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE
MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAP
ADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP
PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRSESPQPKA
SRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGDSEKATK
VQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDK
IDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALN
LFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:57486241/chr11:124543777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNAS

P63092

.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161). {ECO:0000269|PubMed:12391161, ECO:0000269|PubMed:17110384, ECO:0000269|PubMed:21488135, ECO:0000269|PubMed:26206488, ECO:0000269|PubMed:8702665}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313641_6671159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313730_7561159.01038.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212641_6671145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212730_7561145.01024.0Coiled coilOntology_term=ECO:0000255
HgeneGNASchr20:57486241chr11:124543777ENST00000313949-131378_142729.666666666666626.333333333333332Compositional biasGlu-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371075-131378_142730.666666666666636.333333333333336Compositional biasGlu-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313358_5221159.01038.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212358_5221145.01024.0Compositional biasAla-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121239_394501.0380.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131339_394500.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131339_394517.0396.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131339_394516.0395.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121239_394502.0381.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313682_10371159.01038.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212682_10371145.01024.0DomainG-alpha
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212197_204501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212223_227501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212292_295501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121247_55501.0380.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313197_204500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313223_227500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313292_295500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131347_55500.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313197_204517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313223_227517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313292_295517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131347_55517.0396.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313197_204516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313223_227516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313292_295516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131347_55516.0395.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212197_204502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212223_227502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212292_295502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121247_55502.0381.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313690_6981159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313840_8471159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313866_8701159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313935_9381159.01038.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212690_6981145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212840_8471145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212866_8701145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212935_9381145.01024.0Nucleotide bindingGTP
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212196_204501.0380.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212219_228501.0380.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212288_295501.0380.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-1212364_369501.0380.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000265620-121242_55501.0380.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313196_204500.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313219_228500.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313288_295500.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-1313364_369500.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000306090-131342_55500.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313196_204517.0396.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313219_228517.0396.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313288_295517.0396.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-1313364_369517.0396.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000354359-131342_55517.0396.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313196_204516.0395.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313219_228516.0395.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313288_295516.0395.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-1313364_369516.0395.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371085-131342_55516.0395.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212196_204502.0381.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212219_228502.0381.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212288_295502.0381.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-1212364_369502.0381.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371095-121242_55502.0381.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-13131007_10121159.01038.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313685_6981159.01038.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313839_8471159.01038.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313862_8711159.01038.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371100-1313931_9381159.01038.0RegionG4 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-12121007_10121145.01024.0RegionG5 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212685_6981145.01024.0RegionG1 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212839_8471145.01024.0RegionG2 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212862_8711145.01024.0RegionG3 motif
HgeneGNASchr20:57486241chr11:124543777ENST00000371102-1212931_9381145.01024.0RegionG4 motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGNASchr20:57486241chr11:124543777ENST00000306120-11238_4760.0626.0Compositional biasPro-rich
HgeneGNASchr20:57486241chr11:124543777ENST00000371098-1478_142020.333333333333332Compositional biasGlu-rich


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1825_GNAS_57486241_SIAE_124543777_ranked_0.pdbGNAS5748624157486241ENST00000263593SIAEchr11124543777-
MRGRHRVMGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIPVENDGEACGPPEVSRPNFQVLNP
AFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQPGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRG
CSQLLLQVPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPPGLSRVIAQVDGSSQFAAVAASSA
VRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSPWMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPP
VEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDS
GAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSP
EIQAADPPTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRRRKPQRNLLRNFLVQAFGGCFGRS
ESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKRAEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNG
EGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVR
ACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVAS
SSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYF
1044


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

all structure
SIAE_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GNAS
SIAE


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GNAS-SIAE


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GNAS-SIAE


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource