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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GOLGA4-HSPA8

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GOLGA4-HSPA8
	FusionPDB ID: 33899
	FusionGDB2.0 ID: 33899
		Hgene	Tgene
	Gene symbol	GOLGA4	HSPA8
	Gene ID	2803	3312
	Gene name	golgin A4	heat shock protein family A (Hsp70) member 8
	Synonyms	CRPF46\|GCP2\|GOLG\|MU-RMS-40.18\|p230	HEL-33\|HEL-S-72p\|HSC54\|HSC70\|HSC71\|HSP71\|HSP73\|HSPA10\|LAP-1\|LAP1\|NIP71
	Cytomap	3p22.2	11q24.1
	Type of gene	protein-coding	protein-coding
	Description	golgin subfamily A member 4256 kDa golgin72.1 proteincentrosome-related protein F46golgi autoantigen, golgin subfamily a, 4golgin-240golgin-245protein 72.1trans-Golgi p230	heat shock cognate 71 kDa proteinLPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kDa protein 8heat shock
	Modification date	20200313	20200327
	UniProtAcc	Q13439	P11142
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356847, ENST00000361924, ENST00000444882, ENST00000435830,	ENST00000534319, ENST00000227378, ENST00000453788, ENST00000526110, ENST00000526862, ENST00000533540, ENST00000534624, ENST00000532636,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	24 X 16 X 11=4224	20 X 20 X 4=1600
	# samples	27	23
	** MAII score	log2(27/4224*10)=-3.96757852230762 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/1600*10)=-2.79836613883035 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GOLGA4 [Title/Abstract] AND HSPA8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GOLGA4(37292975)-HSPA8(122930976), # samples:3
Anticipated loss of major functional domain due to fusion event.	GOLGA4-HSPA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GOLGA4-HSPA8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GOLGA4-HSPA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GOLGA4-HSPA8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GOLGA4	GO:0043001	Golgi to plasma membrane protein transport	15265687
Hgene	GOLGA4	GO:0045773	positive regulation of axon extension	22705394
Tgene	HSPA8	GO:0042026	protein refolding	21231916\|25719862
Tgene	HSPA8	GO:0045892	negative regulation of transcription, DNA-templated	10722728
Tgene	HSPA8	GO:0046034	ATP metabolic process	23921388
Tgene	HSPA8	GO:1902904	negative regulation of supramolecular fiber organization	23921388

Fusion gene breakpoints across GOLGA4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HSPA8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-GM-A2DF-01A	GOLGA4	chr3	37292975	-	HSPA8	chr11	122930976	-
ChimerDB4	BRCA	TCGA-GM-A2DF-01A	GOLGA4	chr3	37292975	+	HSPA8	chr11	122930976	-
ChimerDB4	BRCA	TCGA-GM-A2DF	GOLGA4	chr3	37292975	+	HSPA8	chr11	122930976	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000361924	GOLGA4	chr3	37292975	+	ENST00000532636	HSPA8	chr11	122930976	-	2311	536	374	2065	563
ENST00000444882	GOLGA4	chr3	37292975	+	ENST00000532636	HSPA8	chr11	122930976	-	2241	466	304	1995	563
ENST00000356847	GOLGA4	chr3	37292975	+	ENST00000532636	HSPA8	chr11	122930976	-	2236	461	299	1990	563

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000361924	ENST00000532636	GOLGA4	chr3	37292975	+	HSPA8	chr11	122930976	-	0.00267951	0.9973205
ENST00000444882	ENST00000532636	GOLGA4	chr3	37292975	+	HSPA8	chr11	122930976	-	0.003068354	0.9969317
ENST00000356847	ENST00000532636	GOLGA4	chr3	37292975	+	HSPA8	chr11	122930976	-	0.003091395	0.9969086

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33899_33899_1_GOLGA4-HSPA8_GOLGA4_chr3_37292975_ENST00000356847_HSPA8_chr11_122930976_ENST00000532636_length(amino acids)=563AA_BP=54
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------

>33899_33899_2_GOLGA4-HSPA8_GOLGA4_chr3_37292975_ENST00000361924_HSPA8_chr11_122930976_ENST00000532636_length(amino acids)=563AA_BP=54
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------

>33899_33899_3_GOLGA4-HSPA8_GOLGA4_chr3_37292975_ENST00000444882_HSPA8_chr11_122930976_ENST00000532636_length(amino acids)=563AA_BP=54
MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII
NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL
RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF
FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY
EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR
DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:37292975/chr11:122930976)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GOLGA4 Q13439	HSPA8 P11142
FUNCTION: Involved in vesicular trafficking at the Golgi apparatus level. May play a role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with MACF1. Involved in endosome-to-Golgi trafficking (PubMed:29084197). {ECO:0000269\|PubMed:15265687, ECO:0000269\|PubMed:29084197}.	FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488, PubMed:12526792). The affinity of HSP70 for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. HSP70 goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The HSP70-associated co-chaperones are of three types: J-domain co-chaperones HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24318877, PubMed:27474739, PubMed:24121476, PubMed:26865365). Plays a critical role in mitochondrial import, delivers preproteins to the mitochondrial import receptor TOMM70 (PubMed:12526792). Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:10722728, PubMed:11276205). Participates in the ER-associated degradation (ERAD) quality control pathway in conjunction with J domain-containing co-chaperones and the E3 ligase STUB1 (PubMed:23990462). Interacts with VGF-derived peptide TLQP-21 (PubMed:28934328). {ECO:0000269\|PubMed:10722728, ECO:0000269\|PubMed:11276205, ECO:0000269\|PubMed:12526792, ECO:0000269\|PubMed:21148293, ECO:0000269\|PubMed:21150129, ECO:0000269\|PubMed:23018488, ECO:0000269\|PubMed:23990462, ECO:0000269\|PubMed:24318877, ECO:0000269\|PubMed:24732912, ECO:0000269\|PubMed:27474739, ECO:0000269\|PubMed:27916661, ECO:0000269\|PubMed:28934328, ECO:0000303\|PubMed:24121476, ECO:0000303\|PubMed:26865365}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000227378

202_204

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000227378

268_275

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000453788

202_204

137.0

494.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000453788

268_275

137.0

494.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000532636

202_204

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000532636

268_275

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000534624

202_204

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000534624

268_275

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000227378

394_509

137.0

647.0

Region

Substrate-binding domain (SBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000453788

394_509

137.0

494.0

Region

Substrate-binding domain (SBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000532636

394_509

137.0

647.0

Region

Substrate-binding domain (SBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000534624

394_509

137.0

647.0

Region

Substrate-binding domain (SBD)

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000356847

133_2185

54.0

2244.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000361924

133_2185

54.0

2306.3333333333335

Coiled coil

Ontology_term=ECO:0000255

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000356847

252_2096

54.0

2244.0

Compositional bias

Note=Glu-rich

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000361924

252_2096

54.0

2306.3333333333335

Compositional bias

Note=Glu-rich

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000356847

2168_2215

54.0

2244.0

Domain

GRIP

Hgene

GOLGA4

chr3:37292975

chr11:122930976

ENST00000361924

2168_2215

54.0

2306.3333333333335

Domain

GRIP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000227378

12_15

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000453788

12_15

137.0

494.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000532636

12_15

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000534624

12_15

137.0

647.0

Nucleotide binding

Note=ATP

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000227378

2_386

137.0

647.0

Region

Nucleotide-binding domain (NBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000453788

2_386

137.0

494.0

Region

Nucleotide-binding domain (NBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000532636

2_386

137.0

647.0

Region

Nucleotide-binding domain (NBD)

Tgene

HSPA8

chr3:37292975

chr11:122930976

ENST00000534624

2_386

137.0

647.0

Region

Nucleotide-binding domain (NBD)

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1207_GOLGA4_37292975_HSPA8_122930976_1207_GOLGA4_37292975_HSPA8_122930976_ranked_0.pdb	GOLGA4	37292975	37292975	ENST00000532636	HSPA8	chr11	122930976	-	MFKKLKQKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRETVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRII NEPTAAAIAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRAVRRL RTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDF FNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVY EGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQR DKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPG	563

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GOLGA4_pLDDT.png

HSPA8_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GOLGA4
HSPA8

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	GOLGA4	chr3:37292975	chr11:122930976	ENST00000356847	+	2	23	133_203	54.0	2244.0	MACF1
Hgene	GOLGA4	chr3:37292975	chr11:122930976	ENST00000361924	+	2	24	133_203	54.0	2306.3333333333335	MACF1

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Related Drugs to GOLGA4-HSPA8

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to GOLGA4-HSPA8

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source