UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GOPC-ROS1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GOPC-ROS1
	FusionPDB ID: 34011
	FusionGDB2.0 ID: 34011
		Hgene	Tgene
	Gene symbol	GOPC	ROS1
	Gene ID	57120	6098
	Gene name	golgi associated PDZ and coiled-coil motif containing	ROS proto-oncogene 1, receptor tyrosine kinase
	Synonyms	CAL\|FIG\|GOPC1\|PIST\|dJ94G16.2	MCF3\|ROS\|c-ros-1
	Cytomap	6q22.1	6q22.1
	Type of gene	protein-coding	protein-coding
	Description	Golgi-associated PDZ and coiled-coil motif-containing proteinCFTR-associated ligandPDZ protein interacting specifically with TC10PDZ/coiled-coil domain binding partner for the rho-family GTPase TC10dJ94G16.2 PISTfused in glioblastomagolgi-associated	proto-oncogene tyrosine-protein kinase ROSROS proto-oncogene 1 , receptor tyrosine kinasec-ros oncogene 1 , receptor tyrosine kinaseproto-oncogene c-Ros-1transmembrane tyrosine-specific protein kinasev-ros avian UR2 sarcoma virus oncogene homolog 1
	Modification date	20200327	20200314
	UniProtAcc	Q9HD26	P08922
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000467125, ENST00000052569, ENST00000368498, ENST00000535237,	ENST00000368507, ENST00000368508,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 8 X 4=160	18 X 20 X 5=1800
	# samples	5	20
	** MAII score	log2(5/160*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1800*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GOPC [Title/Abstract] AND ROS1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	GOPC-ROS1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. GOPC-ROS1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. GOPC-ROS1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. GOPC-ROS1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ROS1	GO:0001558	regulation of cell growth	16885344
Tgene	ROS1	GO:0006468	protein phosphorylation	16885344
Tgene	ROS1	GO:0032006	regulation of TOR signaling	16885344

Fusion gene breakpoints across GOPC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ROS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	GOPC	chr6	117881432	-	ROS1	chr6	117642557	-
ChimerKB3	.	.	GOPC	chr6	117888016	-	ROS1	chr6	117642557	-
ChimerKB3	.	.	GOPC	chr6	117894629	-	ROS1	chr6	117641193	-
ChimerKB3	.	.	GOPC	chr6	117896339	-	ROS1	chr6	117641193	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000368498	GOPC	chr6	117888016	-	ENST00000368508	ROS1	chr6	117642557	-	2929	1334	76	2736	886
ENST00000368498	GOPC	chr6	117888016	-	ENST00000368507	ROS1	chr6	117642557	-	2929	1334	76	2736	886
ENST00000535237	GOPC	chr6	117888016	-	ENST00000368508	ROS1	chr6	117642557	-	3083	1488	230	2890	886
ENST00000535237	GOPC	chr6	117888016	-	ENST00000368507	ROS1	chr6	117642557	-	3083	1488	230	2890	886
ENST00000052569	GOPC	chr6	117888016	-	ENST00000368508	ROS1	chr6	117642557	-	3069	1474	240	2876	878
ENST00000052569	GOPC	chr6	117888016	-	ENST00000368507	ROS1	chr6	117642557	-	3069	1474	240	2876	878
ENST00000368498	GOPC	chr6	117896339	-	ENST00000368508	ROS1	chr6	117641193	-	2185	726	76	1992	638
ENST00000368498	GOPC	chr6	117896339	-	ENST00000368507	ROS1	chr6	117641193	-	2185	726	76	1992	638
ENST00000052569	GOPC	chr6	117896339	-	ENST00000368508	ROS1	chr6	117641193	-	2325	866	240	2132	630
ENST00000052569	GOPC	chr6	117896339	-	ENST00000368507	ROS1	chr6	117641193	-	2325	866	240	2132	630

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34011_34011_1_GOPC-ROS1_GOPC_chr6_117888016_ENST00000052569_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=878AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLK
KSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLA
NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI
LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK
IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDD
LWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLAT

--------------------------------------------------------------

>34011_34011_2_GOPC-ROS1_GOPC_chr6_117888016_ENST00000052569_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=878AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
LRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLK
KSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVV
YVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLA
NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI
LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVK
IGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDD
LWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLAT

--------------------------------------------------------------

>34011_34011_3_GOPC-ROS1_GOPC_chr6_117888016_ENST00000368498_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=886AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPP
GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG
LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM
SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKD
YTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREG

--------------------------------------------------------------

>34011_34011_4_GOPC-ROS1_GOPC_chr6_117888016_ENST00000368498_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=886AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPP
GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG
LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM
SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKD
YTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREG

--------------------------------------------------------------

>34011_34011_5_GOPC-ROS1_GOPC_chr6_117888016_ENST00000535237_ROS1_chr6_117642557_ENST00000368507_length(amino acids)=886AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLVSRSSSKMERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPP
GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG
LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM
SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKD
YTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREG

--------------------------------------------------------------

>34011_34011_6_GOPC-ROS1_GOPC_chr6_117888016_ENST00000535237_ROS1_chr6_117642557_ENST00000368508_length(amino acids)=886AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLVSRSSSKMERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPP
GHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQR
GEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG
LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLM
SKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKD
YTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREG

--------------------------------------------------------------

>34011_34011_7_GOPC-ROS1_GOPC_chr6_117896339_ENST00000052569_ROS1_chr6_117641193_ENST00000368507_length(amino acids)=630AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
LRRHIAVLQAEVYGARLAAKYLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST
DQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIH
RDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSN
LDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDD
IMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD

--------------------------------------------------------------

>34011_34011_8_GOPC-ROS1_GOPC_chr6_117896339_ENST00000052569_ROS1_chr6_117641193_ENST00000368508_length(amino acids)=630AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLERELEANKKEKMKEAQLEAEVKLLRKENEA
LRRHIAVLQAEVYGARLAAKYLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGST
DQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIH
RDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSN
LDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDD
IMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD

--------------------------------------------------------------

>34011_34011_9_GOPC-ROS1_GOPC_chr6_117896339_ENST00000368498_ROS1_chr6_117641193_ENST00000368507_length(amino acids)=638AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAV
KTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVY
LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH
QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGD
VICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTH

--------------------------------------------------------------

>34011_34011_10_GOPC-ROS1_GOPC_chr6_117896339_ENST00000368498_ROS1_chr6_117641193_ENST00000368508_length(amino acids)=638AA_BP=0
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQI
NHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVK
LLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAV
KTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVY
LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH
QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGD
VICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTH

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:/chr6:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GOPC Q9HD26	ROS1 P08922
FUNCTION: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250\|UniProtKB:Q8BH60, ECO:0000269\|PubMed:11707463, ECO:0000269\|PubMed:14570915, ECO:0000269\|PubMed:15358775, ECO:0000269\|PubMed:23818989}.	FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2. {ECO:0000269\|PubMed:11094073, ECO:0000269\|PubMed:16885344}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (501) >>>501.pdbFusion protein BP residue: 0 CIF file (501) >>>501.cif	GOPC	chr6	117896339	-	ROS1	chr6	117641193	-	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDL LLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVD LKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKL ERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAK YLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDI LGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCL LNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGC VYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRK RGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSN LDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQL FRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETK NREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQ	630
3D view using mol* of 501 (AA BP:0)


PDB file (508) >>>508.pdbFusion protein BP residue: 0 CIF file (508) >>>508.cif	GOPC	chr6	117896339	-	ROS1	chr6	117641193	-	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDL LLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVD LKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKL SGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEV YGARLAAKYLDKELAGSTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEV YEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNI LKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDL CVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDI YKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGH QPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFH RIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIM PVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEP	638
3D view using mol* of 508 (AA BP:0)


PDB file (695) >>>695.pdbFusion protein BP residue: 0 CIF file (695) >>>695.cif	GOPC	chr6	117888016	-	ROS1	chr6	117642557	-	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDL LLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVD LKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKL ERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAK YLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRG RNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKE HGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQ QRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASC KDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLA NACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILG VGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLN EPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVY LERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRG EGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLD VLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFR NFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNR EGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEK	878
3D view using mol* of 695 (AA BP:0)


PDB file (698) >>>698.pdbFusion protein BP residue: 0 CIF file (698) >>>698.cif	GOPC	chr6	117888016	-	ROS1	chr6	117642557	-	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDL LLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVD LKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKL SGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEV YGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHK TVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK EAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEG GGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYE GTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILK QLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQP YPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI QDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPV ALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHA	886
3D view using mol* of 698 (AA BP:0)


PDB file (699) >>>699.pdbFusion protein BP residue: 0 CIF file (699) >>>699.cif	GOPC	chr6	117888016	-	ROS1	chr6	117642557	-	MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDL LLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVD LKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKL VSRSSSKMERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEV YGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHK TVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLG ISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHK EAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEG GGNPGASCKDTSGEIKVLQVWHRRLKNQKSAKEGVTVLINEDKELAELRG LAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYE GTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILK QLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCV DISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYK NDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQP YPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRI QDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPV ALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHA	886
3D view using mol* of 699 (AA BP:0)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GOPC_pLDDT.png

ROS1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GOPC_ROS1_501_pLDDT.png (AA BP:0)

GOPC_ROS1_501_pLDDT_and_active_sites.png (AA BP:0)

GOPC_ROS1_501_violinplot.png (AA BP:0)

GOPC_ROS1_508_pLDDT.png (AA BP:0)

GOPC_ROS1_508_pLDDT_and_active_sites.png (AA BP:0)

GOPC_ROS1_508_violinplot.png (AA BP:0)

GOPC_ROS1_695_pLDDT.png (AA BP:0)

GOPC_ROS1_695_pLDDT_and_active_sites.png (AA BP:0)

GOPC_ROS1_695_violinplot.png (AA BP:0)

GOPC_ROS1_698_pLDDT.png (AA BP:0)

GOPC_ROS1_698_pLDDT_and_active_sites.png (AA BP:0)

GOPC_ROS1_698_violinplot.png (AA BP:0)

GOPC_ROS1_699_pLDDT.png (AA BP:0)

GOPC_ROS1_699_pLDDT_and_active_sites.png (AA BP:0)

GOPC_ROS1_699_violinplot.png (AA BP:0)

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

GOPC_ROS1_501.png

GOPC_ROS1_508.png

GOPC_ROS1_695.png

GOPC_ROS1_698.png

GOPC_ROS1_699.png

Top

Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
501	1.103	326	1.197	868.476	0.53	0.692	0.904	1.794	0.484	3.708	2.663	Chain A: 33,34,37,38,40,41,42,44,45,47,48,51,52,55 ,56,59,60,61,62,63,65,66,69,70,72,73,74,76,77,79,8 0,83,181,184,185,187,188,191,192,195,196,198,199,2 02,203,206
508	1.148	222	1.257	457.219	0.445	0.723	0.942	2.592	0.357	7.254	1.124	Chain A: 37,40,41,43,44,45,47,48,51,52,54,55,62,65 ,66,69,70,72,73,74,77,200,203,204,206,207,208,210, 211,214
695	1.104006	172	1.142539	349.517	0.448718	0.797471	1.020266	1.722933	0.846454	2.035471	0.78333	Chain A: 482,483,484,485,486,487,488,489,490,509,5 11,528,541,555,557,558,559,560,561,562,563,564,567 ,568,571,615,617,621,623,632,633,634,635,636,637,6 38,640
698	1.096	177	1.12	382.445	0.454	0.815	1.074	1.554	0.95	1.636	0.554	Chain A: 490,491,492,493,494,495,496,497,498,500,5 15,517,519,533,536,540,549,563,565,566,567,568,569 ,570,571,572,575,579,618,623,625,640,641,642,643,6 44,645,646,647,648,653
699	1.072	166	1.095	438.011	0.494	0.786	1.024	1.397	0.972	1.438	0.812	Chain A: 490,491,492,493,494,495,496,497,498,500,5 15,517,519,536,540,549,565,567,568,569,570,571,572 ,575,576,579,625,629,631,640,641,642,643,644,645,6 46,647,648,661

Top

Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

Top

Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

Top

Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

Top

Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

GOPC

CFTR, RHOQ, CSPG5, ASIC3, VIM, BECN1, GRID2, GOPC, CLCN3, Stx6, Grm5, SSTR3, COPZ1, MARCH2, ADRA1D, CDKN2C, IGHG3, KPNA1, RELA, TGFBR2, CD300C, NUP62, JUN, ARIH1, DR1, BTF3L4, CBS, HSF1, LRSAM1, PPP2R5D, DPYD, FOSL2, HCK, MYLK, VTN, SSNA1, BATF, STARD3, PARK7, CERCAM, ZNF581, PID1, FAM90A1, RNF220, SEMA4G, MRPL1, AKIRIN1, CCDC102B, SLC25A18, ZNF587, MUM1, MYOCD, MORN4, RNF183, SPATA8, ZNF564, ZBTB49, FAM9B, LCLAT1, ZSCAN1, C17orf67, RPL13AP17, MOV10, NXF1, SSTR5, CCDC43, CACNG2, APBB2, CYYR1, FAM9A, CLASP2, CCDC151, TGOLN2, CRYAB, EVI2A, BTRC, KIAA0753, CEP170, TMEM17, TMEM216, DLEU1, FYCO1, TCF4, PTPRB, CDC25A, CDKN3, ZBTB5, LDOC1L, FCHSD2, ATG4D, BAP1, C5orf24, CNTLN, MIS18BP1, PML, KIF1B, ZNF264, GOLGA3, NPM2, BATF3, CENPF, FXYD1, FAM174A, RALBP1, MANBAL, FKBP11, NUPL1, PKN2, MVP, CCDC102A, TBX22, PCGF2, JUNB, ZNF488, LIMA1, CCDC8, IFNG, NOL8, TFAM, GRK6, CABLES1, FBXO28, CDH23, NOTCH1, MRPL15, ERV1, RNA15, REC107, FRS2, EGLN3, HNRNPLL, RPS6KA1, HRAS, NRAS, BET1, LAMP1, PTRH2, RPS6KA2, DUSP10, CRHR1, RHBDF2, FAM105A, C14orf105, ZNF835, PPP1R18, ZDHHC1, GEM, RALGAPB, SNX31, OSBP2, ATG9A, PLEKHA4, E, M, nsp4, nsp6, ORF3a, ORF6, ORF7a, ORF7b, S, IMMP2L, KIAA0430, BRPF3, SYDE2, C17orf80, BCAR1, Rnf183, GRM5, DNAJC17, DNAJB6, DNAJC4, B3GAT1, C17orf59, CAV1, COX8A, CXADR, DIRAS3, EBAG9, ELOVL5, ERGIC2, GJA1, GJD3, LAMP2, LAMP3, LAMTOR1, MARCKS, METTL7A, NUP155, OCLN, RAB11A, RAB2A, RAB3B, RAB5A, RAB5C, RAB9A, STX4, STX6, STX7, TMPO, ZFPL1, SLC2A4, ASPSCR1, TCEB3B, TPD52L1, TMEM136, UCN3, CPSF6, CCDC96, CEBPG, HBS1L, TRAT1, GLIS2, DDIT3, NACC2, PROK1, CXCR4, LY6G6F, MLPH, CRAMP1L, ERLIN1, METTL21B, CLDN3, TMEM9, CD247, KCNE3, CASC4, CERS4, MOG, CLDN10, SURF6, TRAM1, FAM96A, QPRT, FFAR1, FBXW7, TFRC, NRP1, FURIN, IFITM1, ANPEP, DPP4, IFITM3, TMPRSS11B, CLEC4D, ACE2, TOLLIP,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GOPC
ROS1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to GOPC-ROS1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Drug	Source	PMID
GOPC	ROS1	Crizotinib	PubMed	32652753

Top

Related Diseases to GOPC-ROS1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
GOPC	ROS1	Ovarian Cancer	PubMed	32652753
GOPC	ROS1	Lung Adenocarcinoma	MyCancerGenome
GOPC	ROS1	Conventional Glioblastoma Multiforme	MyCancerGenome
GOPC	ROS1	Colon Adenocarcinoma	MyCancerGenome
GOPC	ROS1	Dedifferentiated Liposarcoma	MyCancerGenome
GOPC	ROS1	Breast Invasive Ductal Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GOPC	C0004238	Atrial Fibrillation	1	CTD_human
Hgene	GOPC	C0025202	melanoma	1	CTD_human
Hgene	GOPC	C0235480	Paroxysmal atrial fibrillation	1	CTD_human
Hgene	GOPC	C2585653	Persistent atrial fibrillation	1	CTD_human
Hgene	GOPC	C3468561	familial atrial fibrillation	1	CTD_human
Tgene	ROS1	C0007131	Non-Small Cell Lung Carcinoma	4	CTD_human
Tgene	ROS1	C0017638	Glioma	1	CTD_human
Tgene	ROS1	C0025202	melanoma	1	CTD_human
Tgene	ROS1	C0152013	Adenocarcinoma of lung (disorder)	1	CGI;CTD_human
Tgene	ROS1	C0259783	mixed gliomas	1	CTD_human
Tgene	ROS1	C0555198	Malignant Glioma	1	CTD_human