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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HIPK2-GRM8

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HIPK2-GRM8
FusionPDB ID: 36405
FusionGDB2.0 ID: 36405
HgeneTgene
Gene symbol

HIPK2

GRM8

Gene ID

28996

2918

Gene namehomeodomain interacting protein kinase 2glutamate metabotropic receptor 8
SynonymsPRO0593GLUR8|GPRC1H|MGLUR8|mGlu8
Cytomap

7q34

7q31.33

Type of geneprotein-codingprotein-coding
Descriptionhomeodomain-interacting protein kinase 2hHIPk2metabotropic glutamate receptor 8glutamate receptor, metabotropic 8
Modification date2020031320200313
UniProtAcc

Q9H2X6

O00222

Ensembl transtripts involved in fusion geneENST idsENST00000342645, ENST00000406875, 
ENST00000428878, 		ENST00000480995, 
ENST00000339582, ENST00000358373, 
ENST00000405249, ENST00000444921, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 13 X 12=26529 X 7 X 7=441
# samples 2510
** MAII scorelog2(25/2652*10)=-3.4070807754505
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/441*10)=-2.1407786557828
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HIPK2 [Title/Abstract] AND GRM8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HIPK2(139285163)-GRM8(126249552), # samples:3
Anticipated loss of major functional domain due to fusion event.HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HIPK2-GRM8 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIPK2

GO:0006468

protein phosphorylation

19448668

HgeneHIPK2

GO:0006978

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator

14647468

HgeneHIPK2

GO:0045766

positive regulation of angiogenesis

19046997

HgeneHIPK2

GO:0060395

SMAD protein signal transduction

12874272

TgeneGRM8

GO:0007193

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

11166323


check buttonFusion gene breakpoints across HIPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRM8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-39-5011-01AHIPK2chr7

139285163

-GRM8chr7

126249552

-
ChimerDB4LUSCTCGA-39-5011HIPK2chr7

139285162

-GRM8chr7

126249552

-
ChimerDB4LUSCTCGA-39-5011HIPK2chr7

139285163

-GRM8chr7

126249552

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406875HIPK2chr7139285163-ENST00000405249GRM8chr7126249552-26082530952557820
ENST00000428878HIPK2chr7139285163-ENST00000405249GRM8chr7126249552-258725091552536793
ENST00000406875HIPK2chr7139285162-ENST00000405249GRM8chr7126249552-26082530952557820
ENST00000428878HIPK2chr7139285162-ENST00000405249GRM8chr7126249552-258725091552536793

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406875ENST00000405249HIPK2chr7139285163-GRM8chr7126249552-0.0098667570.9901333
ENST00000428878ENST00000405249HIPK2chr7139285163-GRM8chr7126249552-0.0133057590.9866942
ENST00000406875ENST00000405249HIPK2chr7139285162-GRM8chr7126249552-0.0098667570.9901333
ENST00000428878ENST00000405249HIPK2chr7139285162-GRM8chr7126249552-0.0133057590.9866942

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36405_36405_1_HIPK2-GRM8_HIPK2_chr7_139285162_ENST00000406875_GRM8_chr7_126249552_ENST00000405249_length(amino acids)=820AA_BP=
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAV
AQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSS

--------------------------------------------------------------

>36405_36405_2_HIPK2-GRM8_HIPK2_chr7_139285162_ENST00000428878_GRM8_chr7_126249552_ENST00000405249_length(amino acids)=793AA_BP=
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIV
CPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ

--------------------------------------------------------------

>36405_36405_3_HIPK2-GRM8_HIPK2_chr7_139285163_ENST00000406875_GRM8_chr7_126249552_ENST00000405249_length(amino acids)=820AA_BP=
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAV
AQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSS

--------------------------------------------------------------

>36405_36405_4_HIPK2-GRM8_HIPK2_chr7_139285163_ENST00000428878_GRM8_chr7_126249552_ENST00000405249_length(amino acids)=793AA_BP=
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQPSAASMAAVAQRSMPLQTGTAQICARPDPFQQALIV
CPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAWQQLTGVATHTSVQHATVIPETMAGTQQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:139285163/chr7:126249552)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIPK2

Q9H2X6

GRM8

O00222

FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A. Mediates transcriptional activation of TP73. In response to TGFB, cooperates with DAXX to activate JNK. Negative regulator through phosphorylation and subsequent proteasomal degradation of CTNNB1 and the antiapoptotic factor CTBP1. In the Wnt/beta-catenin signaling pathway acts as an intermediate kinase between MAP3K7/TAK1 and NLK to promote the proteasomal degradation of MYB. Phosphorylates CBX4 upon DNA damage and promotes its E3 SUMO-protein ligase activity. Activates CREB1 and ATF1 transcription factors by phosphorylation in response to genotoxic stress. In response to DNA damage, stabilizes PML by phosphorylation. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. Promotes angiogenesis, and is involved in erythroid differentiation, especially during fetal liver erythropoiesis. Phosphorylation of RUNX1 and EP300 stimulates EP300 transcription regulation activity. Triggers ZBTB4 protein degradation in response to DNA damage. Modulates HMGA1 DNA-binding affinity. In response to high glucose, triggers phosphorylation-mediated subnuclear localization shifting of PDX1. Involved in the regulation of eye size, lens formation and retinal lamination during late embryogenesis. {ECO:0000269|PubMed:11740489, ECO:0000269|PubMed:11925430, ECO:0000269|PubMed:12851404, ECO:0000269|PubMed:12874272, ECO:0000269|PubMed:14678985, ECO:0000269|PubMed:17018294, ECO:0000269|PubMed:17960875, ECO:0000269|PubMed:18695000, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:19015637, ECO:0000269|PubMed:19046997, ECO:0000269|PubMed:19448668, ECO:0000269|PubMed:20307497, ECO:0000269|PubMed:20573984, ECO:0000269|PubMed:20637728, ECO:0000269|PubMed:20980392, ECO:0000269|PubMed:21192925, ECO:0000269|PubMed:22825850}.FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:9473604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115199_527811.66666666666661199.0DomainProtein kinase
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115199_527784.66666666666661172.0DomainProtein kinase
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115199_527811.66666666666661199.0DomainProtein kinase
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115199_527784.66666666666661172.0DomainProtein kinase
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115802_805811.66666666666661199.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115802_805811.66666666666661199.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115205_213811.66666666666661199.0Nucleotide bindingATP
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115205_213784.66666666666661172.0Nucleotide bindingATP
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115205_213811.66666666666661199.0Nucleotide bindingATP
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115205_213784.66666666666661172.0Nucleotide bindingATP
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-111597_230811.66666666666661199.0RegionTranscriptional corepression
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-111597_230784.66666666666661172.0RegionTranscriptional corepression
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-111597_230811.66666666666661199.0RegionTranscriptional corepression
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-111597_230784.66666666666661172.0RegionTranscriptional corepression
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611609_620452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611642_647452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611669_695452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611717_746452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611769_781452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611804_818452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611844_908452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611609_620452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611642_647452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611669_695452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611717_746452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611769_781452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611804_818452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611844_908452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968609_620476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968642_647476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968669_695476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968717_746476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968769_781476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968804_818476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968844_908476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510609_620452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510642_647452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510669_695452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510717_746452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510769_781452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510804_818452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510844_908452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611609_620452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611642_647452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611669_695452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611717_746452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611769_781452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611804_818452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611844_908452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611609_620452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611642_647452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611669_695452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611717_746452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611769_781452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611804_818452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611844_908452.3333333333333836.3333333333334Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968609_620476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968642_647476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968669_695476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968717_746476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968769_781476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968804_818476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968844_908476.0502.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510609_620452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510642_647452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510669_695452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510717_746452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510769_781452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510804_818452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510844_908452.3333333333333909.0Topological domainCytoplasmic
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611584_608452.3333333333333909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611621_641452.3333333333333909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611648_668452.3333333333333909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611696_716452.3333333333333909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611747_768452.3333333333333909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611782_803452.3333333333333909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611819_843452.3333333333333909.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611584_608452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611621_641452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611648_668452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611696_716452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611747_768452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611782_803452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611819_843452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968584_608476.0502.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968621_641476.0502.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968648_668476.0502.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968696_716476.0502.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968747_768476.0502.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968782_803476.0502.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968819_843476.0502.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510584_608452.3333333333333909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510621_641452.3333333333333909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510648_668452.3333333333333909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510696_716452.3333333333333909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510747_768452.3333333333333909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510782_803452.3333333333333909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510819_843452.3333333333333909.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611584_608452.3333333333333909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611621_641452.3333333333333909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611648_668452.3333333333333909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611696_716452.3333333333333909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611747_768452.3333333333333909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611782_803452.3333333333333909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611819_843452.3333333333333909.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611584_608452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611621_641452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611648_668452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611696_716452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611747_768452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611782_803452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611819_843452.3333333333333836.3333333333334TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968584_608476.0502.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968621_641476.0502.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968648_668476.0502.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968696_716476.0502.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968747_768476.0502.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968782_803476.0502.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968819_843476.0502.0TransmembraneHelical%3B Name%3D7
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510584_608452.3333333333333909.0TransmembraneHelical%3B Name%3D1
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510621_641452.3333333333333909.0TransmembraneHelical%3B Name%3D2
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510648_668452.3333333333333909.0TransmembraneHelical%3B Name%3D3
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510696_716452.3333333333333909.0TransmembraneHelical%3B Name%3D4
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510747_768452.3333333333333909.0TransmembraneHelical%3B Name%3D5
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510782_803452.3333333333333909.0TransmembraneHelical%3B Name%3D6
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510819_843452.3333333333333909.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-11151088_1094811.66666666666661199.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-11151088_1094784.66666666666661172.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-11151088_1094811.66666666666661199.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-11151088_1094784.66666666666661172.0Compositional biasNote=Poly-Ala
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115832_835811.66666666666661199.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115802_805784.66666666666661172.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115832_835784.66666666666661172.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115832_835811.66666666666661199.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115802_805784.66666666666661172.0MotifNote=Nuclear localization signal 1 (NLS1)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115832_835784.66666666666661172.0MotifNote=Nuclear localization signal 2 (NLS2)
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115873_980811.66666666666661199.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115984_1198811.66666666666661199.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115873_980784.66666666666661172.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115984_1198784.66666666666661172.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115873_980811.66666666666661199.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115984_1198811.66666666666661199.0RegionNote=Autoinhibitory domain (AID)
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115873_980784.66666666666661172.0RegionRequired for localization to nuclear speckles
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115984_1198784.66666666666661172.0RegionNote=Autoinhibitory domain (AID)
TgeneGRM8chr7:139285162chr7:126249552ENST00000339582611177_179452.3333333333333909.0RegionGlutamate binding
TgeneGRM8chr7:139285162chr7:126249552ENST00000358373611177_179452.3333333333333836.3333333333334RegionGlutamate binding
TgeneGRM8chr7:139285162chr7:126249552ENST0000040524968177_179476.0502.0RegionGlutamate binding
TgeneGRM8chr7:139285162chr7:126249552ENST00000444921510177_179452.3333333333333909.0RegionGlutamate binding
TgeneGRM8chr7:139285163chr7:126249552ENST00000339582611177_179452.3333333333333909.0RegionGlutamate binding
TgeneGRM8chr7:139285163chr7:126249552ENST00000358373611177_179452.3333333333333836.3333333333334RegionGlutamate binding
TgeneGRM8chr7:139285163chr7:126249552ENST0000040524968177_179476.0502.0RegionGlutamate binding
TgeneGRM8chr7:139285163chr7:126249552ENST00000444921510177_179452.3333333333333909.0RegionGlutamate binding
TgeneGRM8chr7:139285162chr7:126249552ENST0000033958261134_583452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST0000035837361134_583452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST000004052496834_583476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285162chr7:126249552ENST0000044492151034_583452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000033958261134_583452.3333333333333909.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000035837361134_583452.3333333333333836.3333333333334Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST000004052496834_583476.0502.0Topological domainExtracellular
TgeneGRM8chr7:139285163chr7:126249552ENST0000044492151034_583452.3333333333333909.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1599_HIPK2_139285163_GRM8_126249552_ranked_0.pdbHIPK2139285162139285163ENST00000405249GRM8chr7126249552-
MAPVYEGMASHVQVFSPHTLQSSAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVPNPSLPYEQTIVFPGST
GHIVVTSASSTSVTGQVLGGPHNLMRRSTVSLLDTYQKCGLKRKSEEIENTSSVQIIEEHPPMIQNNASGATVATATTSTATSKNSGSNS
EGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTESADDYNFVRAYECFQHK
NHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKAVCST
YLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT
PDDHEAETGIKSKEARKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH
VKSCFQNMEICKRRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLTTVHNQAPSSTSATISLANPEVSILNYPSTLYQPSAASMAAV
AQRSMPLQTGTAQICARPDPFQQALIVCPPGFQGLQASPSKHAGYSVRMENAVPIVTQAPGAQPLQIQPGLLAQQAWPSGTQQILLPPAW
QQLTGVATHTSVQHATVIPETMAGTQQLADWRNTHAHGSHYNPIMQQPALLTGHVTLPAAQPLNVGVAHVMRQQPTSTTSSRKSKQHQSS
820


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HIPK2_pLDDT.png
all structure
all structure
GRM8_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HIPK2
GRM8


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115935_1049811.66666666666661199.0AXIN1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115935_1049784.66666666666661172.0AXIN1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115935_1049811.66666666666661199.0AXIN1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115935_1049784.66666666666661172.0AXIN1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115774_876811.66666666666661199.0CTBP1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115774_876784.66666666666661172.0CTBP1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115774_876811.66666666666661199.0CTBP1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115774_876784.66666666666661172.0CTBP1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115787_897811.66666666666661199.0HMGA1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115787_897784.66666666666661172.0HMGA1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115787_897811.66666666666661199.0HMGA1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115787_897784.66666666666661172.0HMGA1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115752_897811.66666666666661199.0POU4F1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115752_897784.66666666666661172.0POU4F1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115752_897811.66666666666661199.0POU4F1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115752_897784.66666666666661172.0POU4F1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115539_844811.66666666666661199.0SKI and SMAD1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115539_844784.66666666666661172.0SKI and SMAD1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115539_844811.66666666666661199.0SKI and SMAD1
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115539_844784.66666666666661172.0SKI and SMAD1
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115846_941811.66666666666661199.0TP53 and TP73
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115846_941784.66666666666661172.0TP53 and TP73
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115846_941811.66666666666661199.0TP53 and TP73
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115846_941784.66666666666661172.0TP53 and TP73
HgeneHIPK2chr7:139285162chr7:126249552ENST00000406875-1115873_907811.66666666666661199.0UBE2I
HgeneHIPK2chr7:139285162chr7:126249552ENST00000428878-1115873_907784.66666666666661172.0UBE2I
HgeneHIPK2chr7:139285163chr7:126249552ENST00000406875-1115873_907811.66666666666661199.0UBE2I
HgeneHIPK2chr7:139285163chr7:126249552ENST00000428878-1115873_907784.66666666666661172.0UBE2I


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Related Drugs to HIPK2-GRM8


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HIPK2-GRM8


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource