UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA2-CCNB1IP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA2-CCNB1IP1
	FusionPDB ID: 36822
	FusionGDB2.0 ID: 36822
		Hgene	Tgene
	Gene symbol	HMGA2	CCNB1IP1
	Gene ID	8091	57820
	Gene name	high mobility group AT-hook 2	cyclin B1 interacting protein 1
	Synonyms	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9	C14orf18\|HEI10
	Cytomap	12q14.3	14q11.2
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C	E3 ubiquitin-protein ligase CCNB1IP1RING-type E3 ubiquitin transferase CCNB1IP1cyclin B1 interacting protein 1, E3 ubiquitin protein ligaseepididymis secretory sperm binding proteinhuman enhancer of invasion 10
	Modification date	20200329	20200313
	UniProtAcc	P52926	Q9NPC3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354636, ENST00000393577, ENST00000393578, ENST00000403681, ENST00000425208, ENST00000536545, ENST00000541363,	ENST00000557114, ENST00000353689, ENST00000358932, ENST00000398160, ENST00000398163, ENST00000398169, ENST00000437553,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 25 X 15=16125	6 X 5 X 6=180
	# samples	43	6
	** MAII score	log2(43/16125*10)=-5.22881869049588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA2 [Title/Abstract] AND CCNB1IP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	HMGA2-CCNB1IP1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-CCNB1IP1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. HMGA2-CCNB1IP1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Hgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Hgene	HMGA2	GO:0006284	base-excision repair	19465398
Hgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Hgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Hgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Hgene	HMGA2	GO:0031052	chromosome breakage	19549901
Hgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Hgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Hgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Hgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Hgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Hgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Hgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Hgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Hgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Hgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Hgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Hgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Hgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Hgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Hgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Hgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Hgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Hgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Hgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Hgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Hgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642

Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCNB1IP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	HMGA2	chr12	66221867	+	CCNB1IP1	chr14	20779911	-
ChimerKB3	.	.	HMGA2	chr12	66221867	+	CCNB1IP1	chr14	20781960	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	2057	1338	114	992	292
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	2055	1338	114	992	292
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	2055	1338	114	992	292
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	2054	1338	114	992	292
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	2054	1338	114	992	292
ENST00000403681	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1996	1338	114	992	292
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1290	571	373	1107	244
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1288	571	373	1107	244
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1288	571	373	1107	244
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1287	571	373	1107	244
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1287	571	373	1107	244
ENST00000541363	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1229	571	373	1107	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1065	346	148	882	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1063	346	148	882	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1063	346	148	882	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1062	346	148	882	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1062	346	148	882	244
ENST00000393577	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1004	346	148	882	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1728	1009	811	1545	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000393578	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1667	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1728	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000425208	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1667	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1728	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000536545	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1667	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000398160	CCNB1IP1	chr14	20781960	-	1728	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000398169	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000358932	CCNB1IP1	chr14	20781960	-	1726	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000437553	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000353689	CCNB1IP1	chr14	20781960	-	1725	1009	811	1545	244
ENST00000354636	HMGA2	chr12	66221867	+	ENST00000398163	CCNB1IP1	chr14	20781960	-	1667	1009	811	1545	244

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36822_36822_1_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_2_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_3_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_4_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_5_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_6_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000354636_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_7_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_8_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_9_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_10_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_11_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_12_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393577_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_13_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_14_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_15_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_16_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_17_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_18_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000393578_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_19_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_20_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_21_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_22_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_23_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_24_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000403681_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36822_36822_25_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_26_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_27_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_28_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_29_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_30_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000425208_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_31_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_32_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_33_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_34_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_35_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_36_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000536545_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_37_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000353689_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_38_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000358932_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_39_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000398160_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_40_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000398163_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_41_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000398169_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

>36822_36822_42_HMGA2-CCNB1IP1_HMGA2_chr12_66221867_ENST00000541363_CCNB1IP1_chr14_20781960_ENST00000437553_length(amino acids)=244AA_BP=66
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEK
IYTQQIQSKDVELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRLRNITIANHEGTLEPSMIAQSGVLGFPLGNN

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr14:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA2 P52926	CCNB1IP1 Q9NPC3
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.	FUNCTION: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. {ECO:0000250, ECO:0000269\|PubMed:12612082, ECO:0000269\|PubMed:17297447}.; FUNCTION: E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (42) >>>42.pdbFusion protein BP residue: 66 CIF file (42) >>>42.cif	HMGA2	chr12	66221867	+	CCNB1IP1	chr14	20781960	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKVHQERLYQEYNFSKAEGHLKQMEKIYTQQIQSKD VELTSMKGEVTSMKKVLEEYKKKFSDISEKLMERNRQYQKLQGLYDSLRL RNITIANHEGTLEPSMIAQSGVLGFPLGNNSKFPLDNTPVRNRGDGDGDF	244
3D view using mol* of 42 (AA BP:66)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_pLDDT.png

CCNB1IP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_CCNB1IP1_42_PAE.png (AA BP:66)

HMGA2_CCNB1IP1_42_pLDDT.png (AA BP:66)

HMGA2_CCNB1IP1_42_pLDDT_and_active_sites.png (AA BP:66)

HMGA2_CCNB1IP1_42_violinplot.png (AA BP:66)

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

HMGA2_CCNB1IP1_42.png

Top

Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
42	0.285	4	0.173	11.319	0.879	0.468	0.76	0	0.908	0	1.214	Chain A: 132,133,136

Top

Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
42	ZINC000006661227	DB00117	Histidine	-4.41097	-6.13117
42	ZINC000000901736	DB08847	Hydroxyproline	-5.28651	-5.28651
42	ZINC000000901791	DB08847	Hydroxyproline	-5.23315	-5.23315
42	ZINC000000388081	DB05381	Histamine	-4.72907	-5.18407
42	ZINC000008015016	DB14078	Medronic acid	-4.72396	-5.03756
42	ZINC000000895457	DB08847	Hydroxyproline	-4.97432	-4.97432
42	ZINC000000057624	DB00368	Norepinephrine	-4.86949	-4.88699
42	ZINC000001530427	DB00828	Fosfomycin	-4.17204	-4.79754
42	ZINC000000001795	DB00627	Niacin	-4.72828	-4.73788
42	ZINC000018203737	DB12243	Edaravone	-4.29709	-4.64849
42	ZINC000000001011	DB03793	Benzoic acid	-4.64262	-4.64312
42	ZINC000006382803	DB00352	Tioguanine	-4.4903	-4.6407
42	ZINC000003872520	DB00609	Ethionamide	-4.60797	-4.60887
42	ZINC000006827695	DB04160	Pyrophosphoric acid	-4.37057	-4.60407
42	ZINC000100071256	DB00302	Tranexamic acid	-4.56273	-4.56273
42	ZINC000019166988	DB01168	Procarbazine	-3.76834	-4.56134
42	ZINC000003830990	DB11868	Etiracetam	-4.53097	-4.53097
42	ZINC000003813042	DB00819	Acetazolamide	-4.14854	-4.49514
42	ZINC000001530710	DB00347	Trimethadione	-4.45701	-4.45701
42	ZINC000004658290	DB01033	Mercaptopurine	-4.32975	-4.45255

Top

Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000006661227	DB00117	Histidine	Small molecule	N[C@@H](CC1=CNC=N1)C(O)=O	Investigational\|Nutraceutical
ZINC000000388081	DB05381	Histamine	Small molecule	NCCC1=CNC=N1	Approved\|Investigational
ZINC000008015016	DB14078	Medronic acid	Small molecule	OP(O)(=O)CP(O)(O)=O	Approved\|Investigational
ZINC000000895457	DB08847	Hydroxyproline	Small molecule	O[C@H]1CN[C@@H](C1)C(O)=O	Experimental
ZINC000000057624	DB00368	Norepinephrine	Small molecule	NC[C@H](O)C1=CC(O)=C(O)C=C1	Approved
ZINC000001530427	DB00828	Fosfomycin	Small molecule	C[C@@H]1O[C@@H]1P(O)(O)=O	Approved
ZINC000000001795	DB00627	Niacin	Small molecule	OC(=O)C1=CN=CC=C1	Approved\|Investigational\|Nutraceutical
ZINC000018203737	DB12243	Edaravone	Small molecule	CC1=NN(C(=O)C1)C1=CC=CC=C1	Approved\|Investigational
ZINC000000001011	DB03793	Benzoic acid	Small molecule	OC(=O)C1=CC=CC=C1	Approved\|Investigational
ZINC000006382803	DB00352	Tioguanine	Small molecule	NC1=NC(=S)C2=C(N1)N=CN2	Approved
ZINC000003872520	DB00609	Ethionamide	Small molecule	CCC1=NC=CC(=C1)C(N)=S	Approved
ZINC000006827695	DB04160	Pyrophosphoric acid	Small molecule	OP(O)(=O)OP(O)(O)=O	Approved\|Experimental
ZINC000100071256	DB00302	Tranexamic acid	Small molecule	NC[C@H]1CC[C@@H](CC1)C(O)=O	Approved
ZINC000019166988	DB01168	Procarbazine	Small molecule	CNNCC1=CC=C(C=C1)C(=O)NC(C)C	Approved\|Investigational
ZINC000003830990	DB11868	Etiracetam	Small molecule	CCC(N1CCCC1=O)C(N)=O	Investigational
ZINC000003813042	DB00819	Acetazolamide	Small molecule	CC(=O)NC1=NN=C(S1)S(N)(=O)=O	Approved\|Vet_approved
ZINC000001530710	DB00347	Trimethadione	Small molecule	CN1C(=O)OC(C)(C)C1=O	Approved
ZINC000004658290	DB01033	Mercaptopurine	Small molecule	S=C1N=CNC2=C1NC=N2	Approved

Top

Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000006661227	155.156	3.597	347.829	55.206	197.445	95.178	0	540.364	4	5	9.347	2	27.796	0	1
ZINC000006661227	155.156	7.316	349.6	56.285	192.72	100.595	0	541.639	4	4.5	9.411	2	29.52	0	1
ZINC000006661227	155.156	4.315	349.278	54.019	197.311	97.948	0	541.424	4	5	9.302	2	27.853	0	1
ZINC000000901736	131.131	7.153	314.17	135.996	178.173	0	0	473.484	3	5.2	10.208	2	29.805	0	1
ZINC000000901791	131.131	6.501	313.341	137.584	175.758	0	0	472.641	3	5.2	10.211	2	30.301	0	1
ZINC000000388081	111.146	4.788	315.231	92.229	118.535	104.468	0	466.776	3	2.5	9.295	2	65.253	0	0
ZINC000000388081	111.146	5.535	313.532	90.818	116.688	106.026	0	465.559	3	3	9.188	2	64.917	0	0
ZINC000000388081	111.146	4.794	316.569	91.628	116.549	108.393	0	470.468	3	2.5	9.292	2	65.823	0	0
ZINC000008015016	176.002	3.602	323.868	34.991	281.713	0	7.164	486.492	0	6	9.674	1	16.795	0	1
ZINC000008015016	176.002	13.068	326.073	33.644	285.397	0	7.032	489.653	0	6	9.876	1	16.139	0	1
ZINC000000895457	131.131	7.237	313.333	137.57	175.763	0	0	472.628	3	5.2	10.259	2	30.299	0	1
ZINC000000057624	169.18	3.43	375.225	57.715	204.72	112.79	0	592.168	5	4.2	8.952	2	46.791	0	0
ZINC000000057624	169.18	2.409	366.478	58.999	201.357	106.122	0	584.369	5	4.2	8.77	2	47.306	0	0
ZINC000001530427	138.06	3.887	281.455	138.894	139.604	0	2.957	430.064	0	5	10.059	2	51.912	0	0
ZINC000001530427	138.06	5.453	278.103	138.515	135.214	0	4.374	425.173	0	5	9.691	2	52.68	0	0
ZINC000000001795	123.111	4.24	302.099	0	134.143	167.956	0	449.108	1	3.5	10.657	2	68.969	0	0
ZINC000000001795	123.111	4.501	300.772	0	131.945	168.826	0	447.811	1	3.5	10.574	2	69.375	0	0
ZINC000018203737	174.202	2.325	404.431	94.128	58.961	251.341	0	640.161	1	1	9.04	3	100	0	0
ZINC000018203737	174.202	3.578	409.548	143.42	64.553	201.575	0	650.246	0	3.5	9.401	3	95.307	0	0
ZINC000018203737	174.202	2.598	402.429	94.16	56.932	251.337	0	637.516	1	1	8.913	3	100	0	0
ZINC000018203737	174.202	6.978	408.81	94.825	70.219	243.766	0	645.326	1	4	8.853	3	91.844	0	0
ZINC000000001011	122.123	6.349	307.296	0	105.705	201.591	0	460.206	1	2	10.216	3	80.778	0	0
ZINC000006382803	167.188	2.913	334.099	0	174.672	82.562	76.865	508.157	4	5	8.609	3	68.386	0	0
ZINC000006382803	167.188	10.353	334.237	0	175.326	82.487	76.423	508.122	4	5	8.464	3	68.28	0	0
ZINC000006382803	167.188	3.972	333.764	0	164.061	91.943	77.76	507.032	3.8	4	8.378	3	69.616	0	0
ZINC000003872520	166.24	5.779	389.783	134.318	76.164	107.123	72.178	612.111	2	3	8.839	3	93.101	0	0
ZINC000006827695	177.975	6.525	306.442	0	295.843	0	10.598	452.056	0	6	10.264	1	12.586	0	1
ZINC000006827695	177.975	7.967	307.033	0	297.79	0	9.242	451.967	0	6	9.969	1	12.143	0	1
ZINC000006827695	177.975	13.968	307.126	0	292.724	0	14.402	453.526	0	6	10.429	1	13.383	0	1
ZINC000100071256	157.212	3.359	370.682	221.707	148.974	0	0	595.834	3	3	9.575	2	44.326	0	0
ZINC000019166988	221.302	5.151	533.024	317.386	79.069	136.569	0	867.035	3	4.5	9.068	2	63.825	0	0
ZINC000019166988	221.302	2.959	530.183	307.979	87	135.203	0	867.507	3	4.5	9.071	2	62.562	0	0
ZINC000019166988	221.302	4.898	530.515	312.568	81.955	135.993	0	866.079	3	4.5	9.171	2	63.376	0	0
ZINC000003830990	170.211	3.555	386.854	254.13	132.723	0	0	627.855	2	5.5	9.607	2	59.075	0	0
ZINC000003813042	222.236	10.822	416.404	94.538	260.918	14.245	46.703	640.311	3	9	10.285	2	43.871	0	0
ZINC000003813042	222.236	10.907	412.902	94.521	257.879	14.117	46.385	634.316	3	9	10.128	2	44.356	0	0
ZINC000003813042	222.236	11.92	405.408	94.157	255.901	12.947	42.403	630.64	3	9	10.317	2	44.715	0	0
ZINC000003813042	222.236	11.78	408.084	93.891	260.202	11.433	42.558	634.982	3	7.5	10.448	2	38.873	0	1
ZINC000003813042	222.236	10.949	404.987	93.89	257.508	11.439	42.151	629.437	3	7.5	10.291	2	39.282	0	1
ZINC000001530710	143.142	2.184	332.852	236.637	96.215	0	0	519.71	0	4	10.645	3	83.471	0	0
ZINC000004658290	152.173	0.253	317.034	0	116.169	124.004	76.86	478.242	2	4.5	8.913	3	76.928	0	0
ZINC000004658290	152.173	6.839	316.545	0	107.798	131.011	77.736	477.355	1.8	3.5	9.117	3	80.844	0	0
ZINC000004658290	152.173	8.404	316.811	0	116.585	123.822	76.404	477.905	2	4.5	8.685	3	76.837	0	0

Top

Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000006661227	N[C@@H](Cc1c[nH]cn1)C(=O)O	0.111712349	0.411573576
ZINC000000901736	O=C(O)[C@@H]1C[C@H](O)CN1	0.099278267	0.470163896
ZINC000000901791	O=C(O)[C@@H]1C[C@@H](O)CN1	0.099278267	0.470163896
ZINC000000388081	NCCc1cnc[nH]1	0.212944784	0.352067312
ZINC000008015016	O=P(O)(O)CP(=O)(O)O	0.097212655	0.606313084
ZINC000000895457	O=C(O)[C@H]1C[C@H](O)CN1	0.099278267	0.470163896
ZINC000000057624	NC[C@H](O)c1ccc(O)c(O)c1	0.18714743	0.309816979
ZINC000001530427	C[C@@H]1O[C@@H]1P(=O)(O)O	0.044403663	0.415791867
ZINC000000001795	O=C(O)c1cccnc1	0.556974396	0.499160568
ZINC000018203737	CC1=NN(c2ccccc2)C(=O)C1	0.327562384	0.370968878
ZINC000000001011	O=C(O)c1ccccc1	0.946563484	0.614283961
ZINC000006382803	Nc1nc2nc[nH]c2c(=S)[nH]1	0.10005457	0.571375233
ZINC000003872520	CCc1cc(C(N)=S)ccn1	0.286096832	0.394963295
ZINC000006827695	O=P(O)(O)OP(=O)(O)O	0.128142747	0.580031414
ZINC000100071256	NC[C@H]1CC[C@@H](C(=O)O)CC1	0.34357774	0.472488357
ZINC000019166988	CNNCc1ccc(C(=O)NC(C)C)cc1	0.371521135	0.443020826
ZINC000003830990	CC[C@H](C(N)=O)N1CCCC1=O	0.157335861	0.410047131
ZINC000003813042	CC(=O)Nc1nnc(S(N)(=O)=O)s1	0.232013304	0.421010261
ZINC000001530710	CN1C(=O)OC(C)(C)C1=O	0.171423375	0.460469273
ZINC000004658290	S=c1[nH]cnc2nc[nH]c12	0.101927094	0.621755098

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HMGA2

RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA2
CCNB1IP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to HMGA2-CCNB1IP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to HMGA2-CCNB1IP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Hgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Hgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Hgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Hgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Hgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Hgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Hgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET