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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HNRNPH1-ERG

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPH1-ERG
FusionPDB ID: 37190
FusionGDB2.0 ID: 37190
HgeneTgene
Gene symbol

HNRNPH1

ERG

Gene ID

3187

2078

Gene nameheterogeneous nuclear ribonucleoprotein H1ETS transcription factor ERG
SynonymsHNRPH|HNRPH1|hnRNPHerg-3|p55
Cytomap

5q35.3

21q22.2

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein Hepididymis secretory sperm binding proteinheterogeneous nuclear ribonucleoprotein H1 (H)transcriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian
Modification date2020032020200320
UniProtAcc

P31943

Q9Y282

Ensembl transtripts involved in fusion geneENST idsENST00000329433, ENST00000356731, 
ENST00000393432, ENST00000442819, 
ENST00000510411, ENST00000524180, 
ENST00000511300, 		ENST00000429727, 
ENST00000485493, ENST00000288319, 
ENST00000398897, ENST00000398905, 
ENST00000398907, ENST00000398910, 
ENST00000398911, ENST00000398919, 
ENST00000417133, ENST00000442448, 
ENST00000453032, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 18 X 8=302421 X 74 X 12=18648
# samples 2196
** MAII scorelog2(21/3024*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(96/18648*10)=-4.27984269352035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPH1 [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPH1(179047893)-ERG(39755845), # samples:3
Anticipated loss of major functional domain due to fusion event.HNRNPH1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HNRNPH1-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPH1

GO:0043484

regulation of RNA splicing

16946708

TgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across HNRNPH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LAMLTCGA-AB-2814-03AHNRNPH1chr5

179047893

-ERGchr21

39755845

-
ChimerDB4LAMLTCGA-AB-2814_61673AAXX_7HNRNPH1chr5

179047893

-ERGchr21

39755845

-
ChimerDB4LAMLTCGA-AB-2814_61J4GAAXX_7HNRNPH1chr5

179047893

-ERGchr21

39755845

-
ChimerDB4LAMLTCGA-AB-2814HNRNPH1chr5

179047892

-ERGchr21

39755845

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393432HNRNPH1chr5179047892-ENST00000288319ERGchr2139755845-44415441471064305
ENST00000442819HNRNPH1chr5179047892-ENST00000398897ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047892-ENST00000398911ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047892-ENST00000398910ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047892-ENST00000417133ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047892-ENST00000453032ERGchr2139755845-13125141171034305
ENST00000356731HNRNPH1chr5179047892-ENST00000398897ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047892-ENST00000398911ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047892-ENST00000398910ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047892-ENST00000417133ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047892-ENST00000453032ERGchr2139755845-2731193315362453305
ENST00000329433HNRNPH1chr5179047892-ENST00000398897ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047892-ENST00000398911ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047892-ENST00000398910ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047892-ENST00000417133ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047892-ENST00000453032ERGchr2139755845-123043235952305
ENST00000510411HNRNPH1chr5179047892-ENST00000398897ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047892-ENST00000398911ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047892-ENST00000398910ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047892-ENST00000417133ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047892-ENST00000453032ERGchr2139755845-123143336953305
ENST00000393432HNRNPH1chr5179047893-ENST00000288319ERGchr2139755845-44415441471064305
ENST00000442819HNRNPH1chr5179047893-ENST00000398897ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047893-ENST00000398911ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047893-ENST00000398910ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047893-ENST00000417133ERGchr2139755845-44115141171034305
ENST00000442819HNRNPH1chr5179047893-ENST00000453032ERGchr2139755845-13125141171034305
ENST00000356731HNRNPH1chr5179047893-ENST00000398897ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047893-ENST00000398911ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047893-ENST00000398910ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047893-ENST00000417133ERGchr2139755845-5830193315362453305
ENST00000356731HNRNPH1chr5179047893-ENST00000453032ERGchr2139755845-2731193315362453305
ENST00000329433HNRNPH1chr5179047893-ENST00000398897ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047893-ENST00000398911ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047893-ENST00000398910ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047893-ENST00000417133ERGchr2139755845-432943235952305
ENST00000329433HNRNPH1chr5179047893-ENST00000453032ERGchr2139755845-123043235952305
ENST00000510411HNRNPH1chr5179047893-ENST00000398897ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047893-ENST00000398911ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047893-ENST00000398910ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047893-ENST00000417133ERGchr2139755845-433043336953305
ENST00000510411HNRNPH1chr5179047893-ENST00000453032ERGchr2139755845-123143336953305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393432ENST00000288319HNRNPH1chr5179047892-ERGchr2139755845-0.000570820.99942917
ENST00000442819ENST00000398897HNRNPH1chr5179047892-ERGchr2139755845-0.0005808710.9994191
ENST00000442819ENST00000398911HNRNPH1chr5179047892-ERGchr2139755845-0.0005808710.9994191
ENST00000442819ENST00000398910HNRNPH1chr5179047892-ERGchr2139755845-0.0005808710.9994191
ENST00000442819ENST00000417133HNRNPH1chr5179047892-ERGchr2139755845-0.0005808710.9994191
ENST00000442819ENST00000453032HNRNPH1chr5179047892-ERGchr2139755845-0.0018472490.9981527
ENST00000356731ENST00000398897HNRNPH1chr5179047892-ERGchr2139755845-0.0008900990.9991099
ENST00000356731ENST00000398911HNRNPH1chr5179047892-ERGchr2139755845-0.0008900990.9991099
ENST00000356731ENST00000398910HNRNPH1chr5179047892-ERGchr2139755845-0.0008900990.9991099
ENST00000356731ENST00000417133HNRNPH1chr5179047892-ERGchr2139755845-0.0008900990.9991099
ENST00000356731ENST00000453032HNRNPH1chr5179047892-ERGchr2139755845-0.0033342680.9966658
ENST00000329433ENST00000398897HNRNPH1chr5179047892-ERGchr2139755845-0.0005615880.99943835
ENST00000329433ENST00000398911HNRNPH1chr5179047892-ERGchr2139755845-0.0005615880.99943835
ENST00000329433ENST00000398910HNRNPH1chr5179047892-ERGchr2139755845-0.0005615880.99943835
ENST00000329433ENST00000417133HNRNPH1chr5179047892-ERGchr2139755845-0.0005615880.99943835
ENST00000329433ENST00000453032HNRNPH1chr5179047892-ERGchr2139755845-0.0016829830.998317
ENST00000510411ENST00000398897HNRNPH1chr5179047892-ERGchr2139755845-0.0005612570.9994387
ENST00000510411ENST00000398911HNRNPH1chr5179047892-ERGchr2139755845-0.0005612570.9994387
ENST00000510411ENST00000398910HNRNPH1chr5179047892-ERGchr2139755845-0.0005612570.9994387
ENST00000510411ENST00000417133HNRNPH1chr5179047892-ERGchr2139755845-0.0005612570.9994387
ENST00000510411ENST00000453032HNRNPH1chr5179047892-ERGchr2139755845-0.0016688820.9983311

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37190_37190_1_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000329433_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_2_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000329433_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_3_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000329433_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_4_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000329433_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_5_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000329433_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_6_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000356731_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_7_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000356731_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_8_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000356731_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_9_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000356731_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_10_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000356731_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_11_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000393432_ERG_chr21_39755845_ENST00000288319_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_12_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000442819_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_13_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000442819_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_14_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000442819_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_15_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000442819_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_16_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000442819_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_17_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000510411_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_18_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000510411_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_19_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000510411_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_20_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000510411_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_21_HNRNPH1-ERG_HNRNPH1_chr5_179047892_ENST00000510411_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_22_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000329433_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_23_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000329433_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_24_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000329433_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_25_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000329433_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_26_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000329433_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_27_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000356731_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_28_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000356731_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_29_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000356731_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_30_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000356731_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_31_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000356731_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_32_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000393432_ERG_chr21_39755845_ENST00000288319_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_33_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000442819_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_34_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000442819_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_35_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000442819_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_36_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000442819_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_37_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000442819_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_38_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000510411_ERG_chr21_39755845_ENST00000398897_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_39_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000510411_ERG_chr21_39755845_ENST00000398910_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_40_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000510411_ERG_chr21_39755845_ENST00000398911_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_41_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000510411_ERG_chr21_39755845_ENST00000417133_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

>37190_37190_42_HNRNPH1-ERG_HNRNPH1_chr5_179047893_ENST00000510411_ERG_chr21_39755845_ENST00000453032_length(amino acids)=305AA_BP=132
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179047893/chr21:39755845)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPH1

P31943

ERG

Q9Y282

FUNCTION: This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG). {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:16946708}.FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313111_188132.33333333333334130.66666666666666DomainRRM 2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-31311_90132.33333333333334130.66666666666666DomainRRM 1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313289_364132.33333333333334130.66666666666666DomainRRM 3
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-41411_90132.33333333333334646.0DomainRRM 1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-41411_90132.33333333333334655.6666666666666DomainRRM 1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313111_188132.33333333333334130.66666666666666DomainRRM 2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-31311_90132.33333333333334130.66666666666666DomainRRM 1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313289_364132.33333333333334130.66666666666666DomainRRM 3
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-41411_90132.33333333333334646.0DomainRRM 1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-41411_90132.33333333333334655.6666666666666DomainRRM 1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313234_433132.33333333333334130.66666666666666RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313354_392132.33333333333334130.66666666666666RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313234_433132.33333333333334130.66666666666666RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313354_392132.33333333333334130.66666666666666RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313234_249132.33333333333334130.66666666666666RepeatNote=1-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313354_372132.33333333333334130.66666666666666RepeatNote=2-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313374_392132.33333333333334130.66666666666666RepeatNote=2-2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000356731-313418_433132.33333333333334130.66666666666666RepeatNote=1-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313234_249132.33333333333334130.66666666666666RepeatNote=1-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313354_372132.33333333333334130.66666666666666RepeatNote=2-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313374_392132.33333333333334130.66666666666666RepeatNote=2-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000356731-313418_433132.33333333333334130.66666666666666RepeatNote=1-2
TgeneERGchr5:179047892chr21:39755845ENST00000288319810311_391306.3333333333333480.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST0000039889779311_391190.33333333333334364.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST00000398911810311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST000003989191012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST000004171331012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST00000442448911311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr5:179047892chr21:39755845ENST0000045303279311_391214.33333333333334388.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST00000288319810311_391306.3333333333333480.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST0000039889779311_391190.33333333333334364.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST00000398911810311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST000003989191012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST000004171331012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST00000442448911311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr5:179047893chr21:39755845ENST0000045303279311_391214.33333333333334388.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414111_188132.33333333333334646.0DomainRRM 2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414289_364132.33333333333334646.0DomainRRM 3
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414111_188132.33333333333334655.6666666666666DomainRRM 2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414289_364132.33333333333334655.6666666666666DomainRRM 3
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414111_188132.33333333333334646.0DomainRRM 2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414289_364132.33333333333334646.0DomainRRM 3
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414111_188132.33333333333334655.6666666666666DomainRRM 2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414289_364132.33333333333334655.6666666666666DomainRRM 3
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414234_433132.33333333333334646.0RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414354_392132.33333333333334646.0RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414234_433132.33333333333334655.6666666666666RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414354_392132.33333333333334655.6666666666666RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414234_433132.33333333333334646.0RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414354_392132.33333333333334646.0RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414234_433132.33333333333334655.6666666666666RegionNote=2 X 16 AA Gly-rich approximate repeats
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414354_392132.33333333333334655.6666666666666RegionNote=2 X 19 AA perfect repeats
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414234_249132.33333333333334646.0RepeatNote=1-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414354_372132.33333333333334646.0RepeatNote=2-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414374_392132.33333333333334646.0RepeatNote=2-2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000393432-414418_433132.33333333333334646.0RepeatNote=1-2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414234_249132.33333333333334655.6666666666666RepeatNote=1-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414354_372132.33333333333334655.6666666666666RepeatNote=2-1
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414374_392132.33333333333334655.6666666666666RepeatNote=2-2
HgeneHNRNPH1chr5:179047892chr21:39755845ENST00000442819-414418_433132.33333333333334655.6666666666666RepeatNote=1-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414234_249132.33333333333334646.0RepeatNote=1-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414354_372132.33333333333334646.0RepeatNote=2-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414374_392132.33333333333334646.0RepeatNote=2-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000393432-414418_433132.33333333333334646.0RepeatNote=1-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414234_249132.33333333333334655.6666666666666RepeatNote=1-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414354_372132.33333333333334655.6666666666666RepeatNote=2-1
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414374_392132.33333333333334655.6666666666666RepeatNote=2-2
HgeneHNRNPH1chr5:179047893chr21:39755845ENST00000442819-414418_433132.33333333333334655.6666666666666RepeatNote=1-2
TgeneERGchr5:179047892chr21:39755845ENST00000288319810113_199306.3333333333333480.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST0000039889779113_199190.33333333333334364.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST00000398911810113_199289.3333333333333463.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST000003989191012113_199313.3333333333333487.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST000004171331012113_199313.3333333333333487.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST00000442448911113_199289.3333333333333463.0DomainPNT
TgeneERGchr5:179047892chr21:39755845ENST0000045303279113_199214.33333333333334388.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST00000288319810113_199306.3333333333333480.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST0000039889779113_199190.33333333333334364.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST00000398911810113_199289.3333333333333463.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST000003989191012113_199313.3333333333333487.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST000004171331012113_199313.3333333333333487.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST00000442448911113_199289.3333333333333463.0DomainPNT
TgeneERGchr5:179047893chr21:39755845ENST0000045303279113_199214.33333333333334388.0DomainPNT


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>552_HNRNPH1_179047893_ERG_39755845_ranked_0.pdbHNRNPH1179047893179047893ENST00000453032ERGchr2139755845-
MMLGTEGGEGFVVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRETMGHRYVEVFKSNN
VEMDWVLKHTGPNSPDTANDGFVRLRGLPFGCSKEEIVQFFSGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGER
KSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSS
305


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HNRNPH1_pLDDT.png
all structure
all structure
ERG_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPH1
ERGall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HNRNPH1-ERG


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HNRNPH1-ERG


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneERGC0033578Prostatic Neoplasms7CTD_human
TgeneERGC0376358Malignant neoplasm of prostate7CTD_human
TgeneERGC0023418leukemia1CTD_human
TgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human