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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HNRNPUL1-CNN1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPUL1-CNN1
FusionPDB ID: 37308
FusionGDB2.0 ID: 37308
HgeneTgene
Gene symbol

HNRNPUL1

CNN1

Gene ID

11100

1264

Gene nameheterogeneous nuclear ribonucleoprotein U like 1calponin 1
SynonymsE1B-AP5|E1BAP5|HNRPUL1HEL-S-14|SMCC|Sm-Calp
Cytomap

19q13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoprotein U-like protein 1E1B 55kDa associated protein 5E1B-55 kDa-associated protein 5adenovirus early region 1B-associated protein 5calponin-1basic calponincalponin 1, basic, smooth musclecalponin H1, smooth musclecalponins, basicepididymis secretory protein Li 14
Modification date2020032720200313
UniProtAcc

Q9BUJ2

P51911

Ensembl transtripts involved in fusion geneENST idsENST00000263367, ENST00000352456, 
ENST00000378215, ENST00000392006, 
ENST00000593587, ENST00000595018, 
ENST00000602130, ENST00000594207, 
ENST00000544952, ENST00000588468, 
ENST00000535659, ENST00000592923, 
ENST00000252456, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 14 X 12=30244 X 3 X 3=36
# samples 205
** MAII scorelog2(20/3024*10)=-3.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPUL1 [Title/Abstract] AND CNN1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPUL1(41800591)-CNN1(11651891), # samples:3
Anticipated loss of major functional domain due to fusion event.HNRNPUL1-CNN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-CNN1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-CNN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPUL1-CNN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HNRNPUL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNN1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-AAMT-01AHNRNPUL1chr19

41800591

-CNN1chr19

11651891

+
ChimerDB4BLCATCGA-XF-AAMT-01AHNRNPUL1chr19

41800591

+CNN1chr19

11651891

+
ChimerDB4BLCATCGA-XF-AAMTHNRNPUL1chr19

41800591

+CNN1chr19

11651890

+
ChimerDB4BLCATCGA-XF-AAMTHNRNPUL1chr19

41800591

+CNN1chr19

11651891

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000352456HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+26691310112140709
ENST00000595018HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+26461287452117690
ENST00000392006HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+30501691442521825
ENST00000378215HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+2667130832138711
ENST00000602130HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+29301571532401782
ENST00000593587HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+26711312942142682
ENST00000263367HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651891+280414451612275704
ENST00000352456HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+26691310112140709
ENST00000595018HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+26461287452117690
ENST00000392006HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+30501691442521825
ENST00000378215HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+2667130832138711
ENST00000602130HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+29301571532401782
ENST00000593587HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+26711312942142682
ENST00000263367HNRNPUL1chr1941800591+ENST00000252456CNN1chr1911651890+280414451612275704

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000352456ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.0142770080.98572296
ENST00000595018ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.0145549280.9854451
ENST00000392006ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.025401820.97459817
ENST00000378215ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.0234826060.97651744
ENST00000602130ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.0244750530.9755249
ENST00000593587ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.0152916350.9847083
ENST00000263367ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651891+0.012747260.9872528
ENST00000352456ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.0142770080.98572296
ENST00000595018ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.0145549280.9854451
ENST00000392006ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.025401820.97459817
ENST00000378215ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.0234826060.97651744
ENST00000602130ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.0244750530.9755249
ENST00000593587ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.0152916350.9847083
ENST00000263367ENST00000252456HNRNPUL1chr1941800591+CNN1chr1911651890+0.012747260.9872528

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37308_37308_1_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000263367_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=704AA_BP=427
MRKEDPGICRWMRSWAFSYLDAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQF
QSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVC
FEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKN
GKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWA
IKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTG
RRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKT
KGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPG

--------------------------------------------------------------

>37308_37308_2_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000263367_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=704AA_BP=427
MRKEDPGICRWMRSWAFSYLDAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQF
QSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVC
FEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKN
GKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWA
IKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTG
RRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKT
KGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPG

--------------------------------------------------------------

>37308_37308_3_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000352456_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=709AA_BP=432
MGGERERGSRTWARGGVSGLEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKP
DRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVR
RGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVEL
SFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAG
KTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWI
EGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALA
SMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAG

--------------------------------------------------------------

>37308_37308_4_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000352456_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=709AA_BP=432
MGGERERGSRTWARGGVSGLEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKP
DRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVR
RGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVEL
SFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAG
KTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWI
EGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALA
SMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAG

--------------------------------------------------------------

>37308_37308_5_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000378215_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=711AA_BP=434
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKDFECGNDV
ELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPA
AGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELRE
WIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLA
LASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQ

--------------------------------------------------------------

>37308_37308_6_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000378215_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=711AA_BP=434
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKDFECGNDV
ELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPA
AGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELRE
WIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLA
LASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQ

--------------------------------------------------------------

>37308_37308_7_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000392006_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=825AA_BP=548
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSE
RIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAAR
KKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKP
HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPK
LGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELG

--------------------------------------------------------------

>37308_37308_8_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000392006_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=825AA_BP=548
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSE
RIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAAR
KKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKP
HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPK
LGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELG

--------------------------------------------------------------

>37308_37308_9_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000593587_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=682AA_BP=405
MDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR
RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPH
VVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP
HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMD
KMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFIN
KLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPG
KLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSL

--------------------------------------------------------------

>37308_37308_10_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000593587_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=682AA_BP=405
MDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDR
RGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPH
VVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYP
HVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMD
KMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFIN
KLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPG
KLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSL

--------------------------------------------------------------

>37308_37308_11_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000595018_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=690AA_BP=413
MEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRG
YFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHL
PSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEA
LGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNI
LGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDG
IILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEK
QERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEH

--------------------------------------------------------------

>37308_37308_12_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000595018_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=690AA_BP=413
MEPLGPHAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRG
YFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHL
PSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEA
LGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNI
LGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDG
IILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEK
QERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEH

--------------------------------------------------------------

>37308_37308_13_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000602130_CNN1_chr19_11651890_ENST00000252456_length(amino acids)=782AA_BP=505
MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVK
HLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQK
EALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKY
NILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLK
DGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYA
EKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGM

--------------------------------------------------------------

>37308_37308_14_HNRNPUL1-CNN1_HNRNPUL1_chr19_41800591_ENST00000602130_CNN1_chr19_11651891_ENST00000252456_length(amino acids)=782AA_BP=505
MDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPG
GYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG
RGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARDRSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVK
HLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFENYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQK
EALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSERIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKY
NILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAARKKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLK
DGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKPHDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYA
EKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPKLGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGM

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:41800591/chr19:11651891)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPUL1

Q9BUJ2

CNN1

P51911

FUNCTION: Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro. {ECO:0000269|PubMed:12489984, ECO:0000269|PubMed:9733834}.FUNCTION: Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914191_388392.0753.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+9143_37392.0753.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015191_388506.0857.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+10153_37506.0857.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015191_388406.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+10153_37406.0757.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015191_388406.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+10153_37406.0757.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015191_388506.0805.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+10153_37506.0805.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914191_388392.0753.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+9143_37392.0753.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015191_388506.0857.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+10153_37506.0857.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015191_388406.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+10153_37406.0757.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015191_388406.0757.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+10153_37406.0757.0DomainSAP
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015191_388506.0805.0DomainB30.2/SPRY
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+10153_37506.0805.0DomainSAP
TgeneCNN1chr19:41800591chr19:11651890ENST000002524560728_13121.0298.0DomainCalponin-homology (CH)
TgeneCNN1chr19:41800591chr19:11651891ENST000002524560728_13121.0298.0DomainCalponin-homology (CH)
TgeneCNN1chr19:41800591chr19:11651890ENST0000025245607164_18921.0298.0RepeatNote=Calponin-like 1
TgeneCNN1chr19:41800591chr19:11651890ENST0000025245607204_22921.0298.0RepeatNote=Calponin-like 2
TgeneCNN1chr19:41800591chr19:11651890ENST0000025245607243_26821.0298.0RepeatNote=Calponin-like 3
TgeneCNN1chr19:41800591chr19:11651891ENST0000025245607164_18921.0298.0RepeatNote=Calponin-like 1
TgeneCNN1chr19:41800591chr19:11651891ENST0000025245607204_22921.0298.0RepeatNote=Calponin-like 2
TgeneCNN1chr19:41800591chr19:11651891ENST0000025245607243_26821.0298.0RepeatNote=Calponin-like 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914613_666392.0753.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914670_689392.0753.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914692_811392.0753.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914757_845392.0753.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914806_832392.0753.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015613_666506.0857.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015670_689506.0857.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015692_811506.0857.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015757_845506.0857.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015806_832506.0857.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015613_666406.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015670_689406.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015692_811406.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015757_845406.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015806_832406.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015613_666406.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015670_689406.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015692_811406.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015757_845406.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015806_832406.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015613_666506.0805.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015670_689506.0805.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015692_811506.0805.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015757_845506.0805.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015806_832506.0805.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914613_666392.0753.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914670_689392.0753.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914692_811392.0753.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914757_845392.0753.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914806_832392.0753.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015613_666506.0857.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015670_689506.0857.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015692_811506.0857.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015757_845506.0857.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015806_832506.0857.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015613_666406.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015670_689406.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015692_811406.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015757_845406.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015806_832406.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015613_666406.0757.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015670_689406.0757.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015692_811406.0757.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015757_845406.0757.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015806_832406.0757.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015613_666506.0805.0Compositional biasNote=Gly-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015670_689506.0805.0Compositional biasNote=Asn-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015692_811506.0805.0Compositional biasNote=Pro-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015757_845506.0805.0Compositional biasNote=Tyr-rich
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015806_832506.0805.0Compositional biasNote=Gln-rich
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914612_658392.0753.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015612_658506.0857.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015612_658406.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015612_658406.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015612_658506.0805.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914612_658392.0753.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015612_658506.0857.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015612_658406.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015612_658406.0757.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015612_658506.0805.0RegionNote=Necessary for transcription repression
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914612_614392.0753.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914620_622392.0753.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914639_641392.0753.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914645_647392.0753.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000378215+914656_658392.0753.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015612_614506.0857.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015620_622506.0857.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015639_641506.0857.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015645_647506.0857.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000392006+1015656_658506.0857.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015612_614406.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015620_622406.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015639_641406.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015645_647406.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000593587+1015656_658406.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015612_614406.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015620_622406.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015639_641406.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015645_647406.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000595018+1015656_658406.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015612_614506.0805.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015620_622506.0805.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015639_641506.0805.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015645_647506.0805.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651890ENST00000602130+1015656_658506.0805.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914612_614392.0753.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914620_622392.0753.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914639_641392.0753.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914645_647392.0753.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000378215+914656_658392.0753.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015612_614506.0857.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015620_622506.0857.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015639_641506.0857.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015645_647506.0857.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000392006+1015656_658506.0857.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015612_614406.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015620_622406.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015639_641406.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015645_647406.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000593587+1015656_658406.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015612_614406.0757.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015620_622406.0757.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015639_641406.0757.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015645_647406.0757.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000595018+1015656_658406.0757.0RepeatNote=1-5
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015612_614506.0805.0RepeatNote=1-1
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015620_622506.0805.0RepeatNote=1-2
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015639_641506.0805.0RepeatNote=1-3
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015645_647506.0805.0RepeatNote=1-4
HgeneHNRNPUL1chr19:41800591chr19:11651891ENST00000602130+1015656_658506.0805.0RepeatNote=1-5


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1607_HNRNPUL1_41800591_CNN1_11651891_ranked_0.pdbHNRNPUL14180059141800591ENST00000252456CNN1chr1911651891+
MSRCRHWSGPPPFPPSPPDRKGLRGTEPWEAGPGSGATPGARAMDVRRLKVNELREELQRRGLDTRGLKAELAERLQAALEAEEPDDERE
LDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAY
RPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFDDTLVAIDTYNCDLHFKVARD
RSSGYPLTIEGFAYLWSGARASYGVRRGRVCFEMKINEEISVKHLPSTEPDPHVVRIGWSLDSCSTQLGEEPFSYGYGGTGKKSTNSRFE
NYGDKFAENDVIGCFADFECGNDVELSFTKNGKWMGIAFRIQKEALGGQALYPHVLVKNCAVEFNFGQRAEPYCSVLPGFTFIQHLPLSE
RIRGTVGPKSKAECEILMMVGLPAAGKTTWAIKHAASNPSKKYNILGTNAIMDKMRVMGLRRQRNYAGRWDVLIQQATQCLNRLIQIAAR
KKRNYILDQLAQKYDHQREQELREWIEGVTGRRIGNNFMDGLKDGIILCEFINKLQPGSVKKINESTQNWHQLENIGNFIKAITKYGVKP
HDIFEANDLFENTNHTQVQSTLLALASMAKTKGNKVNVGVKYAEKQERKFEPGKLREGRNIIGLQMGTNKFASQQGMTAYGTRRHLYDPK
LGTDQPLDQATISLQMGTNKGASQAGMTAPGTKRQIFEPGLGMEHCDTLNVSLQMGSNKGASQRGMTVYGLPRQVYDPKYCLTPEYPELG
825


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HNRNPUL1_pLDDT.png
all structure
all structure
CNN1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPUL1
CNN1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HNRNPUL1-CNN1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HNRNPUL1-CNN1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource