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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ALDH2-CLIC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ALDH2-CLIC1
FusionPDB ID: 3868
FusionGDB2.0 ID: 3868
HgeneTgene
Gene symbol

ALDH2

CLIC1

Gene ID

217

1192

Gene namealdehyde dehydrogenase 2 family memberchloride intracellular channel 1
SynonymsALDH-E2|ALDHI|ALDMCL1C1|CLCNL1|G6|NCC27
Cytomap

12q24.12

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionaldehyde dehydrogenase, mitochondrialALDH class 2acetaldehyde dehydrogenase 2aldehyde dehydrogenase 2 family (mitochondrial)epididymis secretory sperm binding proteinliver mitochondrial ALDHnucleus-encoded mitochondrial aldehyde dehydrogenase 2chloride intracellular channel protein 1RNCC proteinchloride channel ABPhRNCCnuclear chloride ion channel 27nuclear chloride ion channel proteinp64CLCPregulatory nuclear chloride ion channel protein
Modification date2020031320200313
UniProtAcc

P05091

O00299

Ensembl transtripts involved in fusion geneENST idsENST00000261733, ENST00000416293, 
ENST00000383404, ENST00000383405, 
ENST00000400052, ENST00000400058, 
ENST00000415179, ENST00000418285, 
ENST00000420458, ENST00000422167, 
ENST00000423055, ENST00000423143, 
ENST00000423804, ENST00000425464, 
ENST00000431921, ENST00000433916, 
ENST00000434202, ENST00000435242, 
ENST00000438708, ENST00000438750, 
ENST00000442045, ENST00000447338, 
ENST00000447369, ENST00000451546, 
ENST00000456863, ENST00000457485, 
ENST00000375779, ENST00000375784, 
ENST00000375780, ENST00000395892, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 20 X 11=57208 X 10 X 4=320
# samples 219
** MAII scorelog2(21/5720*10)=-4.76755391399963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ALDH2 [Title/Abstract] AND CLIC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ALDH2(112221082)-CLIC1(31698653), # samples:3
Anticipated loss of major functional domain due to fusion event.ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ALDH2-CLIC1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCLIC1

GO:0006821

chloride transport

9139710


check buttonFusion gene breakpoints across ALDH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLIC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-A03F-01AALDH2chr12

112221082

+CLIC1chr6

31698653

-
ChimerDB4COADTCGA-AZ-4681-01AALDH2chr12

112221082

+CLIC1chr6

31698653

-
ChimerDB4READTCGA-AG-3728ALDH2chr12

112221082

+CLIC1chr6

31698653

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261733ALDH2chr12112221082+ENST00000375780CLIC1chr631698653-596300294593100
ENST00000261733ALDH2chr12112221082+ENST00000395892CLIC1chr631698653-596300294593100

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261733ENST00000375780ALDH2chr12112221082+CLIC1chr631698653-0.59376130.4062387
ENST00000261733ENST00000395892ALDH2chr12112221082+CLIC1chr631698653-0.59376130.4062387

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3868_3868_1_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000375780_length(amino acids)=100AA_BP=2
MASPMSKWQRPSNKPLLGLPQPPPFSPQRPWWFPHCYPMDTLQNGQWAGNPGALVPGWCGGRGDEGKKWGAWVRFLLWGGMSRTTYFSNK

--------------------------------------------------------------

>3868_3868_2_ALDH2-CLIC1_ALDH2_chr12_112221082_ENST00000261733_CLIC1_chr6_31698653_ENST00000395892_length(amino acids)=100AA_BP=2
MASPMSKWQRPSNKPLLGLPQPPPFSPQRPWWFPHCYPMDTLQNGQWAGNPGALVPGWCGGRGDEGKKWGAWVRFLLWGGMSRTTYFSNK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:112221082/chr6:31698653)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ALDH2

P05091

CLIC1

O00299

FUNCTION: Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757790793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757800793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757840693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834040793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834050793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000003958920893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000520693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000580893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004151790893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004182850693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004204580793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004221670693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004230550793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004231430793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004238040793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004254640693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004319210793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004339160893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004342020793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004352420893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387080793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387500793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004420450793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473380893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473690793_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004515460893_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004568630693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST000004574850693_2330242.0DomainNote=GST C-terminal
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375779072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375780072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000375784062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000383404072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000383405072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000395892082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000400052062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000400058082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000415179082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000418285062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000420458072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000422167062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423055072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423143072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000423804072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000425464062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000431921072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000433916082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000434202072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000435242082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000438708072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000438750072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000442045072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000447338082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000447369072_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000451546082_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000456863062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST00000457485062_900242.0RegionNote=Required for insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757790726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757800726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003757840626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834040726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003834050726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000003958920826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000520626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004000580826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004151790826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004182850626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004204580726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004221670626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004230550726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004231430726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004238040726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004254640626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004319210726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004339160826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004342020726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004352420826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387080726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004387500726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004420450726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473380826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004473690726_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004515460826_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004568630626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane
TgeneCLIC1chr12:112221082chr6:31698653ENST000004574850626_460242.0TransmembraneHelical%3B Note%3DAfter insertion into the membrane

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALDH2chr12:112221082chr6:31698653ENST00000261733+113262_2670518.0Nucleotide bindingNAD
HgeneALDH2chr12:112221082chr6:31698653ENST00000416293+112262_2670471.0Nucleotide bindingNAD


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>25_ALDH2_112221082_CLIC1_31698653_ranked_0.pdbALDH2112221082112221082ENST00000395892CLIC1chr631698653-
MASPMSKWQRPSNKPLLGLPQPPPFSPQRPWWFPHCYPMDTLQNGQWAGNPGALVPGWCGGRGDEGKKWGAWVRFLLWGGMSRTTYFSNK
100


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ALDH2_pLDDT.png
all structure
all structure
CLIC1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ALDH2all structure
CLIC1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ALDH2-CLIC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ALDH2-CLIC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALDH2C0001973Alcoholic Intoxication, Chronic7CTD_human;PSYGENET
HgeneALDH2C0085762Alcohol abuse7CTD_human;PSYGENET
HgeneALDH2C0001969Alcoholic Intoxication5PSYGENET
HgeneALDH2C0393756Hangover from alcohol4PSYGENET
HgeneALDH2C0236664Alcohol-Related Disorders3PSYGENET
HgeneALDH2C0001956Alcohol Use Disorder2CTD_human
HgeneALDH2C0004096Asthma2CTD_human
HgeneALDH2C0005586Bipolar Disorder2PSYGENET
HgeneALDH2C0279626Squamous cell carcinoma of esophagus2CTD_human
HgeneALDH2C0009402Colorectal Carcinoma1CTD_human
HgeneALDH2C0009404Colorectal Neoplasms1CTD_human
HgeneALDH2C0014859Esophageal Neoplasms1CTD_human
HgeneALDH2C0016382Flushing1CTD_human
HgeneALDH2C0016689Freckles1CTD_human
HgeneALDH2C0021364Male infertility1CTD_human
HgeneALDH2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneALDH2C0025209Melanosis1CTD_human
HgeneALDH2C0025218Chloasma1CTD_human
HgeneALDH2C0028796Dermatitis, Occupational1CTD_human
HgeneALDH2C0032927Precancerous Conditions1CTD_human
HgeneALDH2C0042373Vascular Diseases1CTD_human
HgeneALDH2C0086457Industrial Dermatosis1CTD_human
HgeneALDH2C0236970Alcohol-Induced Disorders1CTD_human
HgeneALDH2C0242973Ventricular Dysfunction1CTD_human
HgeneALDH2C0282313Condition, Preneoplastic1CTD_human
HgeneALDH2C0342257Complications of Diabetes Mellitus1CTD_human
HgeneALDH2C0349464Wernicke-Korsakoff Syndrome1PSYGENET
HgeneALDH2C0400966Non-alcoholic Fatty Liver Disease1CTD_human
HgeneALDH2C0520459Necrotizing Enterocolitis1CTD_human
HgeneALDH2C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALDH2C0848676Subfertility, Male1CTD_human
HgeneALDH2C0917731Male sterility1CTD_human
HgeneALDH2C2674838ALCOHOL SENSITIVITY, ACUTE1CTD_human
HgeneALDH2C3241937Nonalcoholic Steatohepatitis1CTD_human