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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:INPP5D-GIGYF2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: INPP5D-GIGYF2
	FusionPDB ID: 39830
	FusionGDB2.0 ID: 39830
		Hgene	Tgene
	Gene symbol	INPP5D	GIGYF2
	Gene ID	3635	26058
	Gene name	inositol polyphosphate-5-phosphatase D	GRB10 interacting GYF protein 2
	Synonyms	SHIP\|SHIP-1\|SHIP1\|SIP-145\|hp51CN\|p150Ship	GYF2\|PARK11\|PERQ2\|PERQ3\|TNRC15
	Cytomap	2q37.1	2q37.1
	Type of gene	protein-coding	protein-coding
	Description	phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1SH2 domain-containing inositol 5'-phosphatase 1inositol polyphosphate-5-phosphatase, 145kDinositol polyphosphate-5-phosphatase, 145kDaphosphatidylinositol 4,5-bisphosphate 5-phosphatasesignaling	GRB10-interacting GYF protein 2PERQ amino acid rich, with GYF domain 3PERQ amino acid-rich with GYF domain-containing protein 2Parkinson disease (autosomal recessive, early onset) 11trinucleotide repeat-containing gene 15 protein
	Modification date	20200313	20200313
	UniProtAcc	Q92835	Q6Y7W6
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000359570, ENST00000538935, ENST00000450745, ENST00000455936, ENST00000474278,	ENST00000452341, ENST00000482666, ENST00000373563, ENST00000373566, ENST00000409196, ENST00000409451, ENST00000409480, ENST00000409547,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 7 X 5=315	17 X 18 X 6=1836
	# samples	9	19
	** MAII score	log2(9/315*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(19/1836*10)=-3.27249473508286 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: INPP5D [Title/Abstract] AND GIGYF2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	INPP5D(233944108)-GIGYF2(233681581), # samples:2
Anticipated loss of major functional domain due to fusion event.	INPP5D-GIGYF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5D-GIGYF2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5D-GIGYF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. INPP5D-GIGYF2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GIGYF2	GO:0016441	posttranscriptional gene silencing	27157137
Tgene	GIGYF2	GO:0061157	mRNA destabilization	27157137

Fusion gene breakpoints across INPP5D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GIGYF2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CG-4449-01A	INPP5D	chr2	233944108	-	GIGYF2	chr2	233681581	+
ChimerDB4	STAD	TCGA-CG-4449-01A	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000373566	GIGYF2	chr2	233681581	+	5605	198	0	1889	629
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000373563	GIGYF2	chr2	233681581	+	3642	198	0	1889	629
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000409480	GIGYF2	chr2	233681581	+	3638	198	0	1889	629
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000409547	GIGYF2	chr2	233681581	+	3657	198	0	1889	629
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000409196	GIGYF2	chr2	233681581	+	3657	198	0	1889	629
ENST00000538935	INPP5D	chr2	233944108	+	ENST00000409451	GIGYF2	chr2	233681581	+	3638	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000373566	GIGYF2	chr2	233681581	+	5605	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000373563	GIGYF2	chr2	233681581	+	3642	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000409480	GIGYF2	chr2	233681581	+	3638	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000409547	GIGYF2	chr2	233681581	+	3657	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000409196	GIGYF2	chr2	233681581	+	3657	198	0	1889	629
ENST00000359570	INPP5D	chr2	233944108	+	ENST00000409451	GIGYF2	chr2	233681581	+	3638	198	0	1889	629

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000538935	ENST00000373566	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.001867095	0.9981329
ENST00000538935	ENST00000373563	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.00582461	0.9941754
ENST00000538935	ENST00000409480	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005967418	0.99403256
ENST00000538935	ENST00000409547	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005784684	0.9942153
ENST00000538935	ENST00000409196	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005784684	0.9942153
ENST00000538935	ENST00000409451	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005967418	0.99403256
ENST00000359570	ENST00000373566	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.001867095	0.9981329
ENST00000359570	ENST00000373563	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.00582461	0.9941754
ENST00000359570	ENST00000409480	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005967418	0.99403256
ENST00000359570	ENST00000409547	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005784684	0.9942153
ENST00000359570	ENST00000409196	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005784684	0.9942153
ENST00000359570	ENST00000409451	INPP5D	chr2	233944108	+	GIGYF2	chr2	233681581	+	0.005967418	0.99403256

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>39830_39830_1_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000373563_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_2_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000373566_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_3_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000409196_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_4_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000409451_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_5_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000409480_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_6_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000359570_GIGYF2_chr2_233681581_ENST00000409547_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_7_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000373563_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_8_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000373566_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_9_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000409196_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_10_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000409451_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_11_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000409480_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

--------------------------------------------------------------

>39830_39830_12_INPP5D-GIGYF2_INPP5D_chr2_233944108_ENST00000538935_GIGYF2_chr2_233681581_ENST00000409547_length(amino acids)=629AA_BP=65
MVPCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDKFTVQLEQERREAEMRAKREEEERKRQEE
LRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKW
AREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQS
QATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRAR
NNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEK
LLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLP

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:233944108/chr2:233681581)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
INPP5D Q92835	GIGYF2 Q6Y7W6
FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways (PubMed:8723348, PubMed:10764818, PubMed:8769125). Able also to hydrolyzes the 5-phosphate of phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (PubMed:9108392, PubMed:10764818, PubMed:8769125). Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity (PubMed:16682172). Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. {ECO:0000269\|PubMed:10764818, ECO:0000269\|PubMed:12421919, ECO:0000269\|PubMed:16682172, ECO:0000269\|PubMed:8723348, ECO:0000269\|PubMed:8769125, ECO:0000269\|PubMed:9108392}.	FUNCTION: Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931, PubMed:31439631). In the 4EHP-GYF2 complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:31439631). Also recruits and bridges the association of the 4EHP complex with the decapping effector protein DDX6, which is required for the ZFP36/TTP-mediated down-regulation of AU-rich mRNA (PubMed:31439631). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153). {ECO:0000269\|PubMed:12771153, ECO:0000269\|PubMed:22751931, ECO:0000269\|PubMed:31439631}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

1198_1252

736.0

1300.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

738_888

736.0

1300.0

Compositional bias

Note=Glu-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

1198_1252

757.0

1321.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

1198_1252

736.0

1300.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

738_888

736.0

1300.0

Compositional bias

Note=Glu-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

920_1148

66.0

1178.0

Compositional bias

Note=Pro-rich

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

5_101

66.0

1178.0

Domain

SH2

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

1019_1022

66.0

1178.0

Motif

Note=NPXY motif 2

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

1040_1051

66.0

1178.0

Motif

Note=SH3-binding 3

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

124_129

66.0

1178.0

Motif

Note=SH3-binding 1

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

912_915

66.0

1178.0

Motif

Note=NPXY motif 1

Hgene

INPP5D

chr2:233944108

chr2:233681581

ENST00000359570

969_974

66.0

1178.0

Motif

Note=SH3-binding 2

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

106_111

736.0

1300.0

Compositional bias

Note=Poly-Gly

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

118_272

736.0

1300.0

Compositional bias

Note=Arg-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

436_473

736.0

1300.0

Compositional bias

Note=Pro-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

607_1025

736.0

1300.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

106_111

757.0

1321.0

Compositional bias

Note=Poly-Gly

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

118_272

757.0

1321.0

Compositional bias

Note=Arg-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

436_473

757.0

1321.0

Compositional bias

Note=Pro-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

607_1025

757.0

1321.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

738_888

757.0

1321.0

Compositional bias

Note=Glu-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

106_111

736.0

1300.0

Compositional bias

Note=Poly-Gly

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

118_272

736.0

1300.0

Compositional bias

Note=Arg-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

436_473

736.0

1300.0

Compositional bias

Note=Pro-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

607_1025

736.0

1300.0

Compositional bias

Note=Gln-rich

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

533_581

736.0

1300.0

Domain

GYF

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

533_581

757.0

1321.0

Domain

GYF

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

533_581

736.0

1300.0

Domain

GYF

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

280_310

736.0

1300.0

Motif

DDX6 binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

40_50

736.0

1300.0

Motif

4EHP-binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

280_310

757.0

1321.0

Motif

DDX6 binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

40_50

757.0

1321.0

Motif

4EHP-binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

280_310

736.0

1300.0

Motif

DDX6 binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

40_50

736.0

1300.0

Motif

4EHP-binding motif

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000373563

547_563

736.0

1300.0

Region

Required for GRB10-binding

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409451

547_563

757.0

1321.0

Region

Required for GRB10-binding

Tgene

GIGYF2

chr2:233944108

chr2:233681581

ENST00000409547

547_563

736.0

1300.0

Region

Required for GRB10-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
INPP5D
GIGYF2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	INPP5D	chr2:233944108	chr2:233681581	ENST00000359570	+	2	29	1016_1030	66.0	1178.0	DAB2

Top

Related Drugs to INPP5D-GIGYF2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to INPP5D-GIGYF2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source