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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ITM2B-RB1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ITM2B-RB1
	FusionPDB ID: 40625
	FusionGDB2.0 ID: 40625
		Hgene	Tgene
	Gene symbol	ITM2B	RB1
	Gene ID	9445	5925
	Gene name	integral membrane protein 2B	RB transcriptional corepressor 1
	Synonyms	ABRI\|BRI\|BRI2\|BRICD2B\|E25B\|E3-16\|FBD\|RDGCA\|imBRI2	OSRC\|PPP1R130\|RB\|p105-Rb\|p110-RB1\|pRb\|pp110
	Cytomap	13q14.2	13q14.2
	Type of gene	protein-coding	protein-coding
	Description	integral membrane protein 2BABri/ADan amyloid peptideBRICHOS domain containing 2Bepididymis secretory sperm binding proteinimmature BRI2transmembrane protein BRI	retinoblastoma-associated proteinGOS563 exon 17 substitution mutation causes premature stopexon 17 tumor GOS561 substitution mutation causes premature stopprepro-retinoblastoma-associated proteinprotein phosphatase 1, regulatory subunit 130retinoblas
	Modification date	20200313	20200329
	UniProtAcc	Q9Y287	RB1CC1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000378549, ENST00000378565,	ENST00000484879, ENST00000267163,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 11 X 13=2002	13 X 16 X 11=2288
	# samples	26	27
	** MAII score	log2(26/2002*10)=-2.94485844580754 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/2288*10)=-3.08305573972756 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ITM2B [Title/Abstract] AND RB1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RB1(48881542)-ITM2B(48827944), # samples:6 ITM2B(48830519)-RB1(49027129), # samples:2
Anticipated loss of major functional domain due to fusion event.	ITM2B-RB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITM2B-RB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ITM2B-RB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ITM2B-RB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RB1-ITM2B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RB1-ITM2B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ITM2B-RB1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. ITM2B-RB1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. ITM2B-RB1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ITM2B	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process	16027166\|18524908
Tgene	RB1	GO:0043550	regulation of lipid kinase activity	16286473
Tgene	RB1	GO:0045892	negative regulation of transcription, DNA-templated	10783144\|12065415\|19223331
Tgene	RB1	GO:2000679	positive regulation of transcription regulatory region DNA binding	25100735

Fusion gene breakpoints across ITM2B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AN-A0FX-01A	ITM2B	chr13	48833083	+	RB1	chr13	49037867	+
ChimerDB4	BRCA	TCGA-AN-A0FX	ITM2B	chr13	48833083	+	RB1	chr13	49037866	+
ChimerDB4	GBM	TCGA-19-1389-02A	ITM2B	chr13	48830519	+	RB1	chr13	49027129	+
ChimerDB4	HNSC	TCGA-HD-7832	ITM2B	chr13	48828072	+	RB1	chr13	48916734	+
ChimerDB4	LUSC	TCGA-56-8307-01A	ITM2B	chr13	48828071	+	RB1	chr13	49027128	+
ChimerDB4	LUSC	TCGA-56-8307	ITM2B	chr13	48828072	+	RB1	chr13	49027128	+
ChimerDB4	LUSC	TCGA-56-8307	ITM2B	chr13	48828072	+	RB1	chr13	49027129	+
ChimerDB4	LUSC	TCGA-56-8307	ITM2B	chr13	48830519	+	RB1	chr13	49027128	+
ChimerDB4	LUSC	TCGA-56-8307	ITM2B	chr13	48830519	+	RB1	chr13	49027129	+
ChimerDB4	OV	TCGA-29-1777-01A	ITM2B	chr13	48807613	+	RB1	chr13	48934153	+
ChimerDB4	OV	TCGA-61-2109-01A	ITM2B	chr13	48807613	+	RB1	chr13	48916735	+
ChimerDB4	OV	TCGA-61-2109	ITM2B	chr13	48807613	+	RB1	chr13	48916734	+
ChimerDB4	SARC	TCGA-DX-A6YU-01A	ITM2B	chr13	48807612	+	RB1	chr13	49051490	+
ChimerDB4	SARC	TCGA-DX-A6YU	ITM2B	chr13	48807613	+	RB1	chr13	49051490	+
ChimerDB4	UCS	TCGA-N6-A4VE	ITM2B	chr13	48807613	+	RB1	chr13	48947541	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000378565	ITM2B	chr13	48828072	+	ENST00000267163	RB1	chr13	49027128	+	3456	449	59	1540	493
ENST00000378549	ITM2B	chr13	48828072	+	ENST00000267163	RB1	chr13	49027128	+	3411	404	14	1495	493
ENST00000378565	ITM2B	chr13	48830519	+	ENST00000267163	RB1	chr13	49027128	+	3663	656	59	1747	562
ENST00000378565	ITM2B	chr13	48807613	+	ENST00000267163	RB1	chr13	48916734	+	4758	320	59	2842	927
ENST00000378549	ITM2B	chr13	48807613	+	ENST00000267163	RB1	chr13	48916734	+	4713	275	14	2797	927
ENST00000378565	ITM2B	chr13	48830519	+	ENST00000267163	RB1	chr13	49027129	+	3663	656	59	1747	562
ENST00000378565	ITM2B	chr13	48828072	+	ENST00000267163	RB1	chr13	49027129	+	3456	449	59	1540	493
ENST00000378549	ITM2B	chr13	48828072	+	ENST00000267163	RB1	chr13	49027129	+	3411	404	14	1495	493
ENST00000378565	ITM2B	chr13	48807613	+	ENST00000267163	RB1	chr13	48916735	+	4758	320	59	2842	927
ENST00000378549	ITM2B	chr13	48807613	+	ENST00000267163	RB1	chr13	48916735	+	4713	275	14	2797	927
ENST00000378565	ITM2B	chr13	48828071	+	ENST00000267163	RB1	chr13	49027128	+	3456	449	59	1540	493
ENST00000378549	ITM2B	chr13	48828071	+	ENST00000267163	RB1	chr13	49027128	+	3411	404	14	1495	493

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378565	ENST00000267163	ITM2B	chr13	48828072	+	RB1	chr13	49027128	+	0.000283638	0.99971634
ENST00000378549	ENST00000267163	ITM2B	chr13	48828072	+	RB1	chr13	49027128	+	0.000265303	0.9997347
ENST00000378565	ENST00000267163	ITM2B	chr13	48830519	+	RB1	chr13	49027128	+	0.000205904	0.99979407
ENST00000378565	ENST00000267163	ITM2B	chr13	48807613	+	RB1	chr13	48916734	+	7.78E-05	0.99992216
ENST00000378549	ENST00000267163	ITM2B	chr13	48807613	+	RB1	chr13	48916734	+	7.66E-05	0.99992335
ENST00000378565	ENST00000267163	ITM2B	chr13	48830519	+	RB1	chr13	49027129	+	0.000205904	0.99979407
ENST00000378565	ENST00000267163	ITM2B	chr13	48828072	+	RB1	chr13	49027129	+	0.000283638	0.99971634
ENST00000378549	ENST00000267163	ITM2B	chr13	48828072	+	RB1	chr13	49027129	+	0.000265303	0.9997347
ENST00000378565	ENST00000267163	ITM2B	chr13	48807613	+	RB1	chr13	48916735	+	7.78E-05	0.99992216
ENST00000378549	ENST00000267163	ITM2B	chr13	48807613	+	RB1	chr13	48916735	+	7.66E-05	0.99992335
ENST00000378565	ENST00000267163	ITM2B	chr13	48828071	+	RB1	chr13	49027128	+	0.000283638	0.99971634
ENST00000378549	ENST00000267163	ITM2B	chr13	48828071	+	RB1	chr13	49027128	+	0.000265303	0.9997347

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>40625_40625_1_ITM2B-RB1_ITM2B_chr13_48807613_ENST00000378549_RB1_chr13_48916734_ENST00000267163_length(amino acids)=927AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKGGY
IQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSI
STEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDT
RIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSN
LDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVR
LYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGN
LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQ
ATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKF
KIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKS
PYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKL

--------------------------------------------------------------

>40625_40625_2_ITM2B-RB1_ITM2B_chr13_48807613_ENST00000378549_RB1_chr13_48916735_ENST00000267163_length(amino acids)=927AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKGGY
IQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSI
STEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDT
RIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSN
LDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVR
LYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGN
LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQ
ATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKF
KIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKS
PYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKL

--------------------------------------------------------------

>40625_40625_3_ITM2B-RB1_ITM2B_chr13_48807613_ENST00000378565_RB1_chr13_48916734_ENST00000267163_length(amino acids)=927AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKGGY
IQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSI
STEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDT
RIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSN
LDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVR
LYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGN
LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQ
ATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKF
KIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKS
PYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKL

--------------------------------------------------------------

>40625_40625_4_ITM2B-RB1_ITM2B_chr13_48807613_ENST00000378565_RB1_chr13_48916735_ENST00000267163_length(amino acids)=927AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKGGY
IQKKKELWGICIFIAAVDLDEMSFTFTELQKNIEISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSI
STEINSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRTPRRGQNRSARIAKQLENDT
RIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLGLVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSN
LDEEVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEIGSQRYKLGVR
LYYRVMESMLKSEEERLSIQNFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGN
LTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQ
ATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKF
KIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKS
PYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKL

--------------------------------------------------------------

>40625_40625_5_ITM2B-RB1_ITM2B_chr13_48828071_ENST00000378549_RB1_chr13_49027128_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_6_ITM2B-RB1_ITM2B_chr13_48828071_ENST00000378565_RB1_chr13_49027128_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_7_ITM2B-RB1_ITM2B_chr13_48828072_ENST00000378549_RB1_chr13_49027128_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_8_ITM2B-RB1_ITM2B_chr13_48828072_ENST00000378549_RB1_chr13_49027129_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_9_ITM2B-RB1_ITM2B_chr13_48828072_ENST00000378565_RB1_chr13_49027128_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_10_ITM2B-RB1_ITM2B_chr13_48828072_ENST00000378565_RB1_chr13_49027129_ENST00000267163_length(amino acids)=493AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKK
KGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMM
CSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSS
PLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEA

--------------------------------------------------------------

>40625_40625_11_ITM2B-RB1_ITM2B_chr13_48830519_ENST00000378565_RB1_chr13_49027128_ENST00000267163_length(amino acids)=562AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISV
PVPEFADSDPANIVHDFNKDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAF
QTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVT
AYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKIS
EGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTS

--------------------------------------------------------------

>40625_40625_12_ITM2B-RB1_ITM2B_chr13_48830519_ENST00000378565_RB1_chr13_49027129_ENST00000267163_length(amino acids)=562AA_BP=1
MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD
DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISV
PVPEFADSDPANIVHDFNKDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAF
QTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVT
AYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKIS
EGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:48881542/chr13:48827944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ITM2B Q9Y287	RB1 RB1CC1
FUNCTION: Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.; FUNCTION: Mature BRI2 (mBRI2) functions as a modulator of the amyloid-beta A4 precursor protein (APP) processing leading to a strong reduction in the secretion of secretase-processed amyloid-beta protein 40 and amyloid-beta protein 42.; FUNCTION: Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers.	1594

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITM2B

chr13:48828071

chr13:49027128

ENST00000378565

1_54

82.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48828072

chr13:48916734

ENST00000378565

1_54

82.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48828072

chr13:49027128

ENST00000378565

1_54

82.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48828072

chr13:49027129

ENST00000378565

1_54

82.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48830519

chr13:49027128

ENST00000378565

1_54

151.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48830519

chr13:49027129

ENST00000378565

1_54

151.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48828071

chr13:49027128

ENST00000378565

55_75

82.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48828072

chr13:48916734

ENST00000378565

55_75

82.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48828072

chr13:49027128

ENST00000378565

55_75

82.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48828072

chr13:49027129

ENST00000378565

55_75

82.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48830519

chr13:49027128

ENST00000378565

55_75

151.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48830519

chr13:49027129

ENST00000378565

55_75

151.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

860_876

88.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

860_876

88.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

860_876

565.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

860_876

88.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

860_876

565.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

860_876

565.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

860_876

565.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

860_876

565.0

929.0

Motif

Bipartite nuclear localization signal

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

373_579

88.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

373_771

88.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

580_639

88.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

640_771

88.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

373_579

88.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

373_771

88.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

580_639

88.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

640_771

88.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

580_639

565.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

640_771

565.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

373_579

88.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

373_771

88.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

580_639

88.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

640_771

88.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

580_639

565.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

640_771

565.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

580_639

565.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

640_771

565.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

580_639

565.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

640_771

565.0

929.0

Region

Note=Domain B

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

580_639

565.0

929.0

Region

Note=Spacer

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

640_771

565.0

929.0

Region

Note=Domain B

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ITM2B

chr13:48807613

chr13:48916734

ENST00000378565

137_231

39.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48807613

chr13:48916735

ENST00000378565

137_231

39.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48828071

chr13:49027128

ENST00000378565

137_231

82.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48828072

chr13:48916734

ENST00000378565

137_231

82.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48828072

chr13:49027128

ENST00000378565

137_231

82.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48828072

chr13:49027129

ENST00000378565

137_231

82.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48830519

chr13:49027128

ENST00000378565

137_231

151.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48830519

chr13:49027129

ENST00000378565

137_231

151.0

267.0

Domain

BRICHOS

Hgene

ITM2B

chr13:48807613

chr13:48916734

ENST00000378565

1_54

39.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48807613

chr13:48916734

ENST00000378565

76_266

39.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48807613

chr13:48916735

ENST00000378565

1_54

39.0

267.0

Topological domain

Cytoplasmic

Hgene

ITM2B

chr13:48807613

chr13:48916735

ENST00000378565

76_266

39.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48828071

chr13:49027128

ENST00000378565

76_266

82.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48828072

chr13:48916734

ENST00000378565

76_266

82.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48828072

chr13:49027128

ENST00000378565

76_266

82.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48828072

chr13:49027129

ENST00000378565

76_266

82.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48830519

chr13:49027128

ENST00000378565

76_266

151.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48830519

chr13:49027129

ENST00000378565

76_266

151.0

267.0

Topological domain

Lumenal

Hgene

ITM2B

chr13:48807613

chr13:48916734

ENST00000378565

55_75

39.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

ITM2B

chr13:48807613

chr13:48916735

ENST00000378565

55_75

39.0

267.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

10_18

88.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48807613

chr13:48916734

ENST00000267163

20_29

88.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

10_18

88.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48807613

chr13:48916735

ENST00000267163

20_29

88.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

10_18

565.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

20_29

565.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

10_18

88.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48828072

chr13:48916734

ENST00000267163

20_29

88.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

10_18

565.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

20_29

565.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

10_18

565.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

20_29

565.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

10_18

565.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

20_29

565.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

10_18

565.0

929.0

Compositional bias

Note=Poly-Ala

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

20_29

565.0

929.0

Compositional bias

Note=Poly-Pro

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

373_579

565.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48828071

chr13:49027128

ENST00000267163

373_771

565.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

373_579

565.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48828072

chr13:49027128

ENST00000267163

373_771

565.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

373_579

565.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48828072

chr13:49027129

ENST00000267163

373_771

565.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

373_579

565.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48830519

chr13:49027128

ENST00000267163

373_771

565.0

929.0

Region

Note=Pocket%3B binds T and E1A

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

373_579

565.0

929.0

Region

Note=Domain A

Tgene

RB1

chr13:48830519

chr13:49027129

ENST00000267163

373_771

565.0

929.0

Region

Note=Pocket%3B binds T and E1A

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1205_ITM2B_48830519_RB1_49027129_1205_ITM2B_48830519_RB1_49027129_ranked_0.pdb	ITM2B	48828071	48830519	ENST00000267163	RB1	chr13	49027129	+	MPPRSFPNLFSRPEPLPEPGRRGCNRSREPAARAPSPPPPFEGAPGRAMVKVTFNSALAQKEAKKDEPKSGEEALIIPPDAVAVDCKDPD DVVPVGQRRAWCWCMCFGLAFMLAGVILGGAYLYKYFALQPDDVYYCGIKYIKDDVILNEPSADAPAALYQTIEENIKIFEEEEVEFISV PVPEFADSDPANIVHDFNKDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAF QTQKPLKSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKIIVT AYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHIPRSPYKFPSSPLRIPGGNIYISPLKSPYKIS EGLPTPTKMTPRSRILVSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEMTS	562

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ITM2B_pLDDT.png

RB1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ITM2B
RB1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to ITM2B-RB1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to ITM2B-RB1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source