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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:JUP-TTLL6

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: JUP-TTLL6
	FusionPDB ID: 41081
	FusionGDB2.0 ID: 41081
		Hgene	Tgene
	Gene symbol	JUP	TTLL6
	Gene ID	3728	284076
	Gene name	junction plakoglobin	tubulin tyrosine ligase like 6
	Synonyms	CTNNG\|DP3\|DPIII\|PDGB\|PKGB	TTL.6
	Cytomap	17q21.2	17q21.32
	Type of gene	protein-coding	protein-coding
	Description	junction plakoglobincatenin (cadherin-associated protein), gamma 80kDadesmoplakin IIIdesmoplakin-3	tubulin polyglutamylase TTLL6tubulin tyrosine ligase-like family member 6tubulin--tyrosine ligase-like protein 6
	Modification date	20200313	20200320
	UniProtAcc	P14923	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000310706, ENST00000393930, ENST00000393931, ENST00000540235,	ENST00000470462, ENST00000393382, ENST00000433608,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	22 X 25 X 12=6600	2 X 2 X 2=8
	# samples	32	3
	** MAII score	log2(32/6600*10)=-4.36632221424582 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)	PubMed: JUP [Title/Abstract] AND TTLL6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	JUP(39925221)-TTLL6(46865361), # samples:2 JUP(39925220)-TTLL6(46865361), # samples:2
Anticipated loss of major functional domain due to fusion event.	JUP-TTLL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JUP-TTLL6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. JUP-TTLL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. JUP-TTLL6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. JUP-TTLL6 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. JUP-TTLL6 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	JUP	GO:0002159	desmosome assembly	22889254
Hgene	JUP	GO:0042127	regulation of cell proliferation	17924338
Hgene	JUP	GO:0042307	positive regulation of protein import into nucleus	10825188\|14661054
Hgene	JUP	GO:0050982	detection of mechanical stimulus	18937352
Hgene	JUP	GO:0051091	positive regulation of DNA-binding transcription factor activity	14661054
Hgene	JUP	GO:0071681	cellular response to indole-3-methanol	10868478
Hgene	JUP	GO:0098609	cell-cell adhesion	18937352

Fusion gene breakpoints across JUP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTLL6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A4OW-01A	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-
ChimerDB4	ESCA	TCGA-L5-A4OW	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-
ChimerDB4	ESCA	TCGA-L5-A4OW	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000540235	JUP	chr17	39925221	-	ENST00000433608	TTLL6	chr17	46865361	-	2722	707	0	1982	660
ENST00000540235	JUP	chr17	39925221	-	ENST00000393382	TTLL6	chr17	46865361	-	2716	707	0	1982	660
ENST00000393930	JUP	chr17	39925221	-	ENST00000433608	TTLL6	chr17	46865361	-	2939	924	217	2199	660
ENST00000393930	JUP	chr17	39925221	-	ENST00000393382	TTLL6	chr17	46865361	-	2933	924	217	2199	660
ENST00000310706	JUP	chr17	39925221	-	ENST00000433608	TTLL6	chr17	46865361	-	2841	826	119	2101	660
ENST00000310706	JUP	chr17	39925221	-	ENST00000393382	TTLL6	chr17	46865361	-	2835	826	119	2101	660
ENST00000540235	JUP	chr17	39925220	-	ENST00000433608	TTLL6	chr17	46865361	-	2722	707	0	1982	660
ENST00000540235	JUP	chr17	39925220	-	ENST00000393382	TTLL6	chr17	46865361	-	2716	707	0	1982	660
ENST00000393930	JUP	chr17	39925220	-	ENST00000433608	TTLL6	chr17	46865361	-	2939	924	217	2199	660
ENST00000393930	JUP	chr17	39925220	-	ENST00000393382	TTLL6	chr17	46865361	-	2933	924	217	2199	660
ENST00000310706	JUP	chr17	39925220	-	ENST00000433608	TTLL6	chr17	46865361	-	2841	826	119	2101	660
ENST00000310706	JUP	chr17	39925220	-	ENST00000393382	TTLL6	chr17	46865361	-	2835	826	119	2101	660

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000540235	ENST00000433608	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.011921693	0.9880783
ENST00000540235	ENST00000393382	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.01223112	0.9877688
ENST00000393930	ENST00000433608	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.011905685	0.9880944
ENST00000393930	ENST00000393382	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.012243288	0.9877567
ENST00000310706	ENST00000433608	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.012832661	0.9871673
ENST00000310706	ENST00000393382	JUP	chr17	39925221	-	TTLL6	chr17	46865361	-	0.013185506	0.9868145
ENST00000540235	ENST00000433608	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.011921693	0.9880783
ENST00000540235	ENST00000393382	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.01223112	0.9877688
ENST00000393930	ENST00000433608	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.011905685	0.9880944
ENST00000393930	ENST00000393382	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.012243288	0.9877567
ENST00000310706	ENST00000433608	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.012832661	0.9871673
ENST00000310706	ENST00000393382	JUP	chr17	39925220	-	TTLL6	chr17	46865361	-	0.013185506	0.9868145

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41081_41081_1_JUP-TTLL6_JUP_chr17_39925220_ENST00000310706_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_2_JUP-TTLL6_JUP_chr17_39925220_ENST00000310706_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_3_JUP-TTLL6_JUP_chr17_39925220_ENST00000393930_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_4_JUP-TTLL6_JUP_chr17_39925220_ENST00000393930_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_5_JUP-TTLL6_JUP_chr17_39925220_ENST00000540235_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_6_JUP-TTLL6_JUP_chr17_39925220_ENST00000540235_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_7_JUP-TTLL6_JUP_chr17_39925221_ENST00000310706_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_8_JUP-TTLL6_JUP_chr17_39925221_ENST00000310706_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_9_JUP-TTLL6_JUP_chr17_39925221_ENST00000393930_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_10_JUP-TTLL6_JUP_chr17_39925221_ENST00000393930_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_11_JUP-TTLL6_JUP_chr17_39925221_ENST00000540235_TTLL6_chr17_46865361_ENST00000393382_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

>41081_41081_12_JUP-TTLL6_JUP_chr17_39925221_ENST00000540235_TTLL6_chr17_46865361_ENST00000433608_length(amino acids)=660AA_BP=235
MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACGRQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMC
PGVSGEDSSLLLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKEASRRALM
GSPQLVAAVVRTMQNTSDLDTARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLRIEEAKGFRAVQLKKTETYEKENCGGFRLIYPSLN
SEKYEKFFQDNNSLFQNTVASRAREEYARQLIQELRLKREKKPFQMKKKVEMQGESAGEQVRKKGMRGWQQKQQQKDKAATQASKQYIQP
LTLVSYTPDLLLSVRGERKNETDSSLNQEAPTEEASSVFPKLTSAKPFSSLPDLRNINLSSSKLEPSKPNFSIKEAKSASAVNVFTGTVH
LTSVETTPESTTQLSISPKSPPTLAVTASSEYSGPETDRVVSFKCKKQQTPPHLTQKKMLKSFLPTKSKSFWESPNTNWTLLKSDMNKPH
LISELLTKLQLSGKLSFFPAHYNPKLGMNNLSQNPSLPGECHSRSDSSGEKRQLDVSSLLLQSPQSYNVTLRDLLVIATPAQLDPRPCRS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:39925221/chr17:46865361)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
JUP P14923	.
FUNCTION: Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). {ECO:0000250}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

132_171

235.66666666666666

968.6666666666666

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

172_215

235.66666666666666

968.6666666666666

Repeat

Note=ARM 2

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

132_171

235.66666666666666

936.0

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

172_215

235.66666666666666

936.0

Repeat

Note=ARM 2

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

132_171

235.66666666666666

746.0

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

172_215

235.66666666666666

746.0

Repeat

Note=ARM 2

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

132_171

235.66666666666666

968.6666666666666

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

172_215

235.66666666666666

968.6666666666666

Repeat

Note=ARM 2

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

132_171

235.66666666666666

936.0

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

172_215

235.66666666666666

936.0

Repeat

Note=ARM 2

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

132_171

235.66666666666666

746.0

Repeat

Note=ARM 1

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

172_215

235.66666666666666

746.0

Repeat

Note=ARM 2

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000433608

203_206

159.66666666666666

801.0

Nucleotide binding

ATP binding

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000433608

203_206

159.66666666666666

801.0

Nucleotide binding

ATP binding

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000433608

372_451

159.66666666666666

801.0

Region

c-MTBD region

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000433608

372_451

159.66666666666666

801.0

Region

c-MTBD region

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

216_255

235.66666666666666

968.6666666666666

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

258_297

235.66666666666666

968.6666666666666

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

298_341

235.66666666666666

968.6666666666666

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

342_381

235.66666666666666

968.6666666666666

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

383_420

235.66666666666666

968.6666666666666

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

423_464

235.66666666666666

968.6666666666666

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

470_510

235.66666666666666

968.6666666666666

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

512_551

235.66666666666666

968.6666666666666

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

574_613

235.66666666666666

968.6666666666666

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000310706

615_661

235.66666666666666

968.6666666666666

Repeat

Note=ARM 12

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

216_255

235.66666666666666

936.0

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

258_297

235.66666666666666

936.0

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

298_341

235.66666666666666

936.0

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

342_381

235.66666666666666

936.0

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

383_420

235.66666666666666

936.0

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

423_464

235.66666666666666

936.0

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

470_510

235.66666666666666

936.0

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

512_551

235.66666666666666

936.0

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

574_613

235.66666666666666

936.0

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393930

615_661

235.66666666666666

936.0

Repeat

Note=ARM 12

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

216_255

235.66666666666666

746.0

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

258_297

235.66666666666666

746.0

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

298_341

235.66666666666666

746.0

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

342_381

235.66666666666666

746.0

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

383_420

235.66666666666666

746.0

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

423_464

235.66666666666666

746.0

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

470_510

235.66666666666666

746.0

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

512_551

235.66666666666666

746.0

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

574_613

235.66666666666666

746.0

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925220

chr17:46865361

ENST00000393931

615_661

235.66666666666666

746.0

Repeat

Note=ARM 12

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

216_255

235.66666666666666

968.6666666666666

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

258_297

235.66666666666666

968.6666666666666

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

298_341

235.66666666666666

968.6666666666666

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

342_381

235.66666666666666

968.6666666666666

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

383_420

235.66666666666666

968.6666666666666

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

423_464

235.66666666666666

968.6666666666666

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

470_510

235.66666666666666

968.6666666666666

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

512_551

235.66666666666666

968.6666666666666

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

574_613

235.66666666666666

968.6666666666666

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000310706

615_661

235.66666666666666

968.6666666666666

Repeat

Note=ARM 12

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

216_255

235.66666666666666

936.0

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

258_297

235.66666666666666

936.0

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

298_341

235.66666666666666

936.0

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

342_381

235.66666666666666

936.0

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

383_420

235.66666666666666

936.0

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

423_464

235.66666666666666

936.0

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

470_510

235.66666666666666

936.0

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

512_551

235.66666666666666

936.0

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

574_613

235.66666666666666

936.0

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393930

615_661

235.66666666666666

936.0

Repeat

Note=ARM 12

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

216_255

235.66666666666666

746.0

Repeat

Note=ARM 3

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

258_297

235.66666666666666

746.0

Repeat

Note=ARM 4

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

298_341

235.66666666666666

746.0

Repeat

Note=ARM 5

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

342_381

235.66666666666666

746.0

Repeat

Note=ARM 6

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

383_420

235.66666666666666

746.0

Repeat

Note=ARM 7

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

423_464

235.66666666666666

746.0

Repeat

Note=ARM 8

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

470_510

235.66666666666666

746.0

Repeat

Note=ARM 9

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

512_551

235.66666666666666

746.0

Repeat

Note=ARM 10

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

574_613

235.66666666666666

746.0

Repeat

Note=ARM 11

Hgene

JUP

chr17:39925221

chr17:46865361

ENST00000393931

615_661

235.66666666666666

746.0

Repeat

Note=ARM 12

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000393382

58_401

466.6666666666667

1070.0

Domain

TTL

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000433608

58_401

159.66666666666666

801.0

Domain

TTL

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000393382

58_401

466.6666666666667

1070.0

Domain

TTL

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000433608

58_401

159.66666666666666

801.0

Domain

TTL

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000393382

203_206

466.6666666666667

1070.0

Nucleotide binding

ATP binding

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000393382

203_206

466.6666666666667

1070.0

Nucleotide binding

ATP binding

Tgene

TTLL6

chr17:39925220

chr17:46865361

ENST00000393382

372_451

466.6666666666667

1070.0

Region

c-MTBD region

Tgene

TTLL6

chr17:39925221

chr17:46865361

ENST00000393382

372_451

466.6666666666667

1070.0

Region

c-MTBD region

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

JUP_pLDDT.png

TTLL6_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
JUP
TTLL6

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000310706	-	4	15	574_661	235.66666666666666	968.6666666666666	DSC1
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000393930	-	4	15	574_661	235.66666666666666	936.0	DSC1
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000393931	-	4	14	574_661	235.66666666666666	746.0	DSC1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000310706	-	4	15	574_661	235.66666666666666	968.6666666666666	DSC1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000393930	-	4	15	574_661	235.66666666666666	936.0	DSC1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000393931	-	4	14	574_661	235.66666666666666	746.0	DSC1
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000310706	-	4	15	132_297	235.66666666666666	968.6666666666666	DSC1 and DSG1
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000393930	-	4	15	132_297	235.66666666666666	936.0	DSC1 and DSG1
Hgene	JUP	chr17:39925220	chr17:46865361	ENST00000393931	-	4	14	132_297	235.66666666666666	746.0	DSC1 and DSG1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000310706	-	4	15	132_297	235.66666666666666	968.6666666666666	DSC1 and DSG1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000393930	-	4	15	132_297	235.66666666666666	936.0	DSC1 and DSG1
Hgene	JUP	chr17:39925221	chr17:46865361	ENST00000393931	-	4	14	132_297	235.66666666666666	746.0	DSC1 and DSG1

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Related Drugs to JUP-TTLL6

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to JUP-TTLL6

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source