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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KAT6A-TRAPPC9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KAT6A-TRAPPC9
FusionPDB ID: 41218
FusionGDB2.0 ID: 41218
HgeneTgene
Gene symbol

KAT6A

TRAPPC9

Gene ID

7994

83696

Gene namelysine acetyltransferase 6Atrafficking protein particle complex 9
SynonymsARTHS|MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220IBP|IKBKBBP|MRT13|NIBP|T1|TRS120
Cytomap

8p11.21

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptiontrafficking protein particle complex subunit 9IKK2 binding proteinNIK and IKK-beta binding proteinNIK- and IKBKB-binding proteinTRAPP 120 kDa subunittularik gene 1 protein
Modification date2020031320200313
UniProtAcc

Q92794

.
Ensembl transtripts involved in fusion geneENST idsENST00000265713, ENST00000396930, 
ENST00000406337, ENST00000485568, 
ENST00000522504, ENST00000389327, 
ENST00000389328, ENST00000438773, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 32 X 13=1081620 X 19 X 14=5320
# samples 4240
** MAII scorelog2(42/10816*10)=-4.68663391861606
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(40/5320*10)=-3.73335434061383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KAT6A [Title/Abstract] AND TRAPPC9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KAT6A(41905896)-TRAPPC9(141034176), # samples:3
Anticipated loss of major functional domain due to fusion event.KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KAT6A-TRAPPC9 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358


check buttonFusion gene breakpoints across KAT6A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRAPPC9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A7AW-01AKAT6Achr8

41905896

-TRAPPC9chr8

141034176

-
ChimerDB4PRADTCGA-KK-A7AWKAT6Achr8

41905896

-TRAPPC9chr8

141034176

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265713KAT6Achr841905896-ENST00000389327TRAPPC9chr8141034176-262110124121902496
ENST00000265713KAT6Achr841905896-ENST00000389328TRAPPC9chr8141034176-262110124121902496
ENST00000265713KAT6Achr841905896-ENST00000438773TRAPPC9chr8141034176-261910124121902496
ENST00000396930KAT6Achr841905896-ENST00000389327TRAPPC9chr8141034176-275311445442034496
ENST00000396930KAT6Achr841905896-ENST00000389328TRAPPC9chr8141034176-275311445442034496
ENST00000396930KAT6Achr841905896-ENST00000438773TRAPPC9chr8141034176-275111445442034496
ENST00000485568KAT6Achr841905896-ENST00000389327TRAPPC9chr8141034176-262110124121902496
ENST00000485568KAT6Achr841905896-ENST00000389328TRAPPC9chr8141034176-262110124121902496
ENST00000485568KAT6Achr841905896-ENST00000438773TRAPPC9chr8141034176-261910124121902496

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265713ENST00000389327KAT6Achr841905896-TRAPPC9chr8141034176-0.0047329960.99526703
ENST00000265713ENST00000389328KAT6Achr841905896-TRAPPC9chr8141034176-0.0047329960.99526703
ENST00000265713ENST00000438773KAT6Achr841905896-TRAPPC9chr8141034176-0.0046662940.99533373
ENST00000396930ENST00000389327KAT6Achr841905896-TRAPPC9chr8141034176-0.0043227830.9956772
ENST00000396930ENST00000389328KAT6Achr841905896-TRAPPC9chr8141034176-0.0043227830.9956772
ENST00000396930ENST00000438773KAT6Achr841905896-TRAPPC9chr8141034176-0.0042650580.99573493
ENST00000485568ENST00000389327KAT6Achr841905896-TRAPPC9chr8141034176-0.0047329960.99526703
ENST00000485568ENST00000389328KAT6Achr841905896-TRAPPC9chr8141034176-0.0047329960.99526703
ENST00000485568ENST00000438773KAT6Achr841905896-TRAPPC9chr8141034176-0.0046662940.99533373

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41218_41218_1_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000265713_TRAPPC9_chr8_141034176_ENST00000389327_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_2_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000265713_TRAPPC9_chr8_141034176_ENST00000389328_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_3_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000265713_TRAPPC9_chr8_141034176_ENST00000438773_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_4_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000396930_TRAPPC9_chr8_141034176_ENST00000389327_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_5_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000396930_TRAPPC9_chr8_141034176_ENST00000389328_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_6_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000396930_TRAPPC9_chr8_141034176_ENST00000438773_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_7_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000485568_TRAPPC9_chr8_141034176_ENST00000389327_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_8_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000485568_TRAPPC9_chr8_141034176_ENST00000389328_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

>41218_41218_9_KAT6A-TRAPPC9_KAT6A_chr8_41905896_ENST00000485568_TRAPPC9_chr8_141034176_ENST00000438773_length(amino acids)=496AA_BP=200
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:41905896/chr8:141034176)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

.
FUNCTION: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. {ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546, ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-21795_171200.02005.0DomainH15
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-31895_171200.02005.0DomainH15
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-31895_171200.02005.0DomainH15
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171_144200.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-21752_166200.02005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181_144200.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-31852_166200.02005.0RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181_144200.02005.0RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-31852_166200.02005.0RegionNote=Required for nuclear localization

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171019_1026200.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171069_1078200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171147_1150200.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171221_1242200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171267_1302200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171411_1414200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171593_1597200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171643_1704200.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171897_1977200.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217371_379200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217788_801200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217989_995200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181019_1026200.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181069_1078200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181147_1150200.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181221_1242200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181267_1302200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181411_1414200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181593_1597200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181643_1704200.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181897_1977200.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318371_379200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318788_801200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318989_995200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181019_1026200.02005.0Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181069_1078200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181147_1150200.02005.0Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181221_1242200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181267_1302200.02005.0Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181411_1414200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181593_1597200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181643_1704200.02005.0Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181897_1977200.02005.0Compositional biasNote=Met-rich
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318371_379200.02005.0Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318788_801200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318989_995200.02005.0Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217504_778200.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318504_778200.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318504_778200.02005.0DomainMYST-type HAT
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171913_1948200.02005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217488_778200.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217645_649200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217654_660200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181913_1948200.02005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318488_778200.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318645_649200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318654_660200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181913_1948200.02005.0RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318488_778200.02005.0RegionNote=Catalytic
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318645_649200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318654_660200.02005.0RegionAcetyl-CoA binding
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217206_265200.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217259_313200.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217537_562200.02005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318206_265200.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318259_313200.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318537_562200.02005.0Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318206_265200.02005.0Zinc fingerPHD-type 1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318259_313200.02005.0Zinc fingerPHD-type 2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318537_562200.02005.0Zinc fingerC2HC MYST-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1050_KAT6A_41905896_TRAPPC9_141034176_1050_KAT6A_41905896_TRAPPC9_141034176_ranked_0.pdbKAT6A4190589641905896ENST00000438773TRAPPC9chr8141034176-
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKTLEAVLNFKYSGGPGHTEGYYRNLSLGLHVEVEPSVFFTRVSTLPATSTRQCHLLLDVFNSTEHELTVST
RSSEALILHAGECQRMAIQVDKFNFESFPESPGEKGQFANPKQLEEERREARGLEIHSKLGICWRIPSLKRSGEASVEGLLNQLVLEHLQ
LAPLQWDVLVDGQPCDREAVAACQVGDPVRLEVRLTNRSPRSVGPFALTVVPFQDHQNGVHNYDLHDTVSFVGSSTFYLDAVQPSGQSAC
496


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KAT6A_pLDDT.png
all structure
all structure
TRAPPC9_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KAT6AING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, Myo1c, Rpl35, Tpx2, Srsf1, Tubgcp6, HEMGN, HNRNPL, KIAA1429, RANGAP1, BRD1, BRPF3, ING4, KAT7, JADE3, KAT6B, JADE2, JADE1, HIST1H2BO, HRG, CSNK2A2, APEX1, CENPA, DANCR, ZBTB2, CSNK2B, CSNK2A1, RFWD2, HSPD1, CMAS, HIST2H2BF, CASP2, TRIM65, HGH1, TTC4, PPP2R5C, OTUD3, DBNL, PIP4K2C, ATIC, NUDT12, B3GALTL, ATG4B, PABPN1, DEK, SF3A3,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KAT6Aall structure
TRAPPC9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217144_664200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171517_1741200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318144_664200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181517_1741200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318144_664200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181517_1741200.02005.0PML
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-217312_664200.02005.0RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-318312_664200.02005.0RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-318312_664200.02005.0RUNX1-1
HgeneKAT6Achr8:41905896chr8:141034176ENST00000265713-2171517_1642200.02005.0RUNX1-2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000396930-3181517_1642200.02005.0RUNX1-2
HgeneKAT6Achr8:41905896chr8:141034176ENST00000406337-3181517_1642200.02005.0RUNX1-2


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Related Drugs to KAT6A-TRAPPC9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KAT6A-TRAPPC9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC4225396MENTAL RETARDATION, AUTOSOMAL DOMINANT 323CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneKAT6AC4511003Acute myeloid leukemia with t(8;16)(p11;p13) translocation2ORPHANET
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human
HgeneKAT6AC0033578Prostatic Neoplasms1CTD_human
HgeneKAT6AC0205833Medullomyoblastoma1CTD_human
HgeneKAT6AC0278510Childhood Medulloblastoma1CTD_human
HgeneKAT6AC0278876Adult Medulloblastoma1CTD_human
HgeneKAT6AC0376358Malignant neoplasm of prostate1CTD_human
HgeneKAT6AC0751291Desmoplastic Medulloblastoma1CTD_human
HgeneKAT6AC1275668Melanotic medulloblastoma1CTD_human